| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liping Guo, Ke Li, Yan Ma, Huaiming Niu, Jun Li, Xin Shao, Na Li, Yuehui Sun, Haixiong Wan. MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction. Human cell. 2024-04-24. PMID:38656742. |
in the mi rat model, mir-322-5p overexpression partially eliminated mi-induced changes in myocardial enzymes and oxidative stress markers, improved mi-caused impairment on cardiac functions, inhibited myocardial apoptosis, attenuated mi-caused alterations in tgf-β, p-smad2, p-smad4, and smad7 protein levels. |
2024-04-24 |
2024-04-28 |
rat |
| Wei Lin, Lianglei Hou, Jialyu Tang, Anwu Huang, Zhuyin Ji. Mir-195-5p targets Smad7 regulation of the Wnt/β-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells. BMC cardiovascular disorders. vol 24. issue 1. 2024-04-23. PMID:38654161. |
vsmc differentiation was induced using sodium β-glycerophosphate, and we investigated the effects of transfecting cells with mir-195-5p mimics, vectors overexpressing smad7, and the wnt/β-catenin pathway inhibitor (kya1797k) on vsmc differentiation by determining cell viability and apoptosis, and the mrna and protein expression of factors associated with osteogenic differentiation and the wnt/β-catenin pathway. |
2024-04-23 |
2024-04-26 |
Not clear |
| Lianhua Kong, Juncong Ma, Li Dong, Chuanlong Zhu, Jie Zhang, Jun L. Metformin exerts anti-liver fibrosis effect based on the regulation of gut microbiota homeostasis and multi-target synergy. Heliyon. vol 10. issue 2. 2024-01-30. PMID:38288020. |
furthermore, metformin inhibited liver cell apoptosis, tgf-β1 expression and timp-1, while promoting smad7 expression, mmp-1 and mmp-2 in fibrotic mice. |
2024-01-30 |
2024-02-01 |
mouse |
| Changliang Liu, Jiahui Wu, Ming Li, Rui Gao, Xueying Zhang, Shixin Ye-Lehmann, Jiangning Song, Tao Zhu, Chan Che. Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery. Journal of neuroinflammation. vol 20. issue 1. 2023-07-28. PMID:37507781. |
however, whether smad7 participates in the regulatory process of neuroinflammation and apoptosis in the development of pocd is still unknown. |
2023-07-28 |
2023-08-14 |
mouse |
| Wei Dong, Chen Dong, Jianbing Zhu, Yaofu Zheng, Junfei Weng, Leilei Liu, Yang Ruan, Xu Fang, Jin Chen, Wenyu Liu, Xiaoping Peng, Xuanying Che. HIF-1α-induced upregulated miR-322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/β-catenin/HIF-1α, thereby improving myocardial ischemia-reperfusion injury. Cell biology international. 2023-03-23. PMID:36950834. |
smad7 knockdown or smurf2 knockdown increased ogd/r-treated h9c2 cell viability and suppressed the apoptosis. |
2023-03-23 |
2023-08-14 |
Not clear |
| Mai Tuyet Nguyen, Min-Ah Lee, Young-Kook Kim, Hyun Kook, Dongtak Jeong, Seung Pil Jang, Tae Hwan Kwak, Woo Jin Par. The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB. PloS one. vol 17. issue 8. 2022-08-02. PMID:35917315. |
smad7 is one of the downstream targets of ccn5 and it was previously shown to potentiate apoptosis in epithelial cells through inhibition of nfκb. |
2022-08-02 |
2023-08-14 |
Not clear |
| Mai Tuyet Nguyen, Min-Ah Lee, Young-Kook Kim, Hyun Kook, Dongtak Jeong, Seung Pil Jang, Tae Hwan Kwak, Woo Jin Par. The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB. PloS one. vol 17. issue 8. 2022-08-02. PMID:35917315. |
in accordance with these reports, when the expression of smad7 was suppressed using a sirna, nfκb signaling was enhanced, and ccn5 did not induce apoptosis. |
2022-08-02 |
2023-08-14 |
Not clear |
| Saurav Bhowmick, Saleena Alikunju, P M Abdul-Munee. NADPH oxidase-induced activation of transforming growth factor-beta-1 causes neuropathy by suppressing antioxidant signaling pathways in alcohol use disorder. Neuropharmacology. 2022-05-18. PMID:35584723. |
further, using tgf-β type i receptor (tgf-βri) inhibitor sb431542 and tgf-β antagonist smad7, we established that the alcohol-induced activation of tgf-β1 impairs antioxidant signaling pathways and leads to neuroinflammation and apoptosis. |
2022-05-18 |
2023-08-13 |
mouse |
| Yin-Zhao Jia, Jing Liu, Geng-Qiao Wang, Zi-Fang Son. miR-484: A Potential Biomarker in Health and Disease. Frontiers in oncology. vol 12. 2022-03-31. PMID:35356223. |
the mir-484 targets that have effects on inflammation, apoptosis and mitochondrial function include smad7, fis1, yap1 and bcl2l13. |
2022-03-31 |
2023-08-13 |
Not clear |
| Shuai Cao, Chao Li, Long Li, Gaoliang Zhou, Yongjin Jiang, Jun Fen. Circular RNA hsa_circ_0000848 Regulates Cardiomyocyte Proliferation and Apoptosis Under Hypoxia via Recruiting ELAVL1 and Stabilizing SMAD7 mRNA. Anatolian journal of cardiology. vol 26. issue 3. 2022-03-29. PMID:35346905. |
circular rna hsa_circ_0000848 regulates cardiomyocyte proliferation and apoptosis under hypoxia via recruiting elavl1 and stabilizing smad7 mrna. |
2022-03-29 |
2023-08-13 |
Not clear |
| Fei Liu, Tao Li, Xiaoan Zha. Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p. Bioengineered. vol 13. issue 2. 2022-01-24. PMID:35068324. |
furthermore, keloid fibroblasts apoptosis level was assessed adopting flow cytometry, and the relevancy between mir-21-5p and circptpn12, mir-21-5p, and smad7 was assessed by dual luciferase assay. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yiping Hu, Juan He, Lianhua He, Bihua Xu, Qingwen Wan. Expression and function of Smad7 in autoimmune and inflammatory diseases. Journal of molecular medicine (Berlin, Germany). vol 99. issue 9. 2021-10-29. PMID:34059951. |
specifically, smad7 can not only attenuate growth inhibition, fibrosis, apoptosis, inflammation, and inflammatory t cell differentiation, but also promotes epithelial cells migration or disease development. |
2021-10-29 |
2023-08-13 |
Not clear |
| Xian-Pei Zhou, Qi-Wei Li, Zi-Zhen Shu, Yang Li. TP53-mediated miR-2861 promotes osteogenic differentiation of BMSCs by targeting Smad7. Molecular and cellular biochemistry. 2021-10-28. PMID:34709507. |
smad7 was identified to be the downstream target of mir-2861, and knockdown of smad7 notably reversed mir-2861 inhibitor-induced inhibition of osteogenic differentiation and promotion of apoptosis in bmscs. |
2021-10-28 |
2023-08-13 |
rat |
| Min-Feng Wu, Qing-Yu Zeng, Jian-Hua Huang, Hong-Wei Wan. The role of Smad7 in cutaneous wound healing. Italian journal of dermatology and venereology. vol 156. issue 1. 2021-10-25. PMID:32938156. |
moreover, smad7 promotes wound healing by regulating cytokines and controlling growth, differentiation and apoptosis of cells, which may be exploited to cure the disease. |
2021-10-25 |
2023-08-13 |
Not clear |
| Wenchang Lv, Yuping Ren, Min Wu, Xiao Luo, Jing Yu, Qi Zhang, Yiping W. Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro. Burns : journal of the International Society for Burn Injuries. vol 47. issue 6. 2021-10-04. PMID:33323304. |
subsequently, the results of molecular biology experiments determine that mir-424-3p targeting smad7 significantly enhanced the ability of cell proliferation, migration and collagen secretion after transfection with mir-424-3p mimic, while the apoptosis rate was significantly reduced. |
2021-10-04 |
2023-08-13 |
Not clear |
| Xiaodong Zhang, Yige Chen, Min Yang, Jinnan Shang, Yiliang Xu, Liang Zhang, Xudong Wu, Yueyun Ding, Yuanyuan Liu, Mingxing Chu, Zongjun Yi. MiR-21-5p actions at the Smad7 gene during pig ovarian granulosa cell apoptosis. Animal reproduction science. vol 223. 2021-09-13. PMID:33217624. |
mir-21-5p actions at the smad7 gene during pig ovarian granulosa cell apoptosis. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiaodong Zhang, Yige Chen, Min Yang, Jinnan Shang, Yiliang Xu, Liang Zhang, Xudong Wu, Yueyun Ding, Yuanyuan Liu, Mingxing Chu, Zongjun Yi. MiR-21-5p actions at the Smad7 gene during pig ovarian granulosa cell apoptosis. Animal reproduction science. vol 223. 2021-09-13. PMID:33217624. |
in the present study, associations were evaluated between mir-21-5p and the extent of smad7 protein production in regulation of ovarian granulosa cell (pgc) apoptosis. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiaodong Zhang, Yige Chen, Min Yang, Jinnan Shang, Yiliang Xu, Liang Zhang, Xudong Wu, Yueyun Ding, Yuanyuan Liu, Mingxing Chu, Zongjun Yi. MiR-21-5p actions at the Smad7 gene during pig ovarian granulosa cell apoptosis. Animal reproduction science. vol 223. 2021-09-13. PMID:33217624. |
when there was an enhanced abundance of mir-21-5p and decreased abundance of smad7 there were similar effects in pgcs, including inducing proliferation, inhibiting apoptosis, increasing the number of cells in s and g2/m phases, increasing serum estradiol, and decreasing serum progesterone concentrations. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiaodong Zhang, Yige Chen, Min Yang, Jinnan Shang, Yiliang Xu, Liang Zhang, Xudong Wu, Yueyun Ding, Yuanyuan Liu, Mingxing Chu, Zongjun Yi. MiR-21-5p actions at the Smad7 gene during pig ovarian granulosa cell apoptosis. Animal reproduction science. vol 223. 2021-09-13. PMID:33217624. |
overall, results from the present study indicate that mir-21-5p has actions on the smad7 mrna transcript during the process of ovarian granulosa cell apoptosis in pigs. |
2021-09-13 |
2023-08-13 |
Not clear |
| Meng Zhu, Ning Zhang, Shuixiang He, Xinlan L. Exosomal miR-106a derived from gastric cancer promotes peritoneal metastasis via direct regulation of Smad7. Cell cycle (Georgetown, Tex.). vol 19. issue 10. 2021-07-12. PMID:32267797. |
the mcs regain the viability, apoptosis reduction and smad7 expression after rescue experiment conducted in mir-106a-enriched gc-exos. |
2021-07-12 |
2023-08-13 |
Not clear |