| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Qing Ge, Xiao-Feng Xu, Bo Yang, Zhe Chen, Ru-Bin Chen. Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25041018. |
saponins from rubus parvifolius l. induce apoptosis in human chronic myeloid leukemia cells through ampk activation and stat3 inhibition. |
2015-04-07 |
2023-08-13 |
human |
| Murali M Yallapu, Sheema Khan, Diane M Maher, Mara C Ebeling, Vasudha Sundram, Neeraj Chauhan, Aditya Ganju, Swathi Balakrishna, Brij K Gupta, Nadeem Zafar, Meena Jaggi, Subhash C Chauha. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials. vol 35. issue 30. 2015-03-30. PMID:25028336. |
it also suppresses stat3 and akt phosphorylation and leads to apoptosis via inhibition of key anti-apoptotic proteins, mcl-1, bcl-xl and caused induction of parp cleavage. |
2015-03-30 |
2023-08-13 |
mouse |
| Fang Tian, Lijie Dong, Yu Zhou, Yan Shao, Wenbo Li, Hong Zhang, Fei Wan. Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25116684. |
moreover, the forced expression of akt, erk and stat3 could induce a significant suppression of apoptosis in these cells after treatment of rapamycin. |
2015-03-30 |
2023-08-13 |
Not clear |
| Meiyu Peng, Bingqing Huang, Qi Zhang, Shuyu Fu, Dan Wang, Xixi Cheng, Xi Wu, Zhenyi Xue, Lijuan Zhang, Da Zhang, Yurong Da, Yun Dai, Qing Yang, Zhi Yao, Liang Qiao, Rongxin Zhan. Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. Cancer letters. vol 354. issue 2. 2015-03-13. PMID:25128650. |
embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of stat3 and activation of p53 signaling pathways. |
2015-03-13 |
2023-08-13 |
Not clear |
| Kazuhiro Yamamoto, Atsushi Mizumoto, Kohji Nishimura, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Tsutomu Nakagawa, Takeshi Hirano, Midori Hira. Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3). PloS one. vol 9. issue 7. 2015-03-04. PMID:25013907. |
thus, stat3 activation mediating apoptosis suppressors may be a key factor in sorafenib and sunitinib-induced keratinocyte cytotoxicity. |
2015-03-04 |
2023-08-13 |
human |
| Ying-Chao Wang, Ji-Lin Wang, Xuan Kong, Tian-Tian Sun, Hao-Yan Chen, Jie Hong, Jing-Yuan Fan. CD24 mediates gastric carcinogenesis and promotes gastric cancer progression via STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24327257. |
taken together, our results indicate that cd24 mediates gastric carcinogenesis and may promote gc progression by suppressing apoptosis and promoting invasion, with the activation of stat3 playing a critical role. |
2015-02-26 |
2023-08-12 |
Not clear |
| Qinchuan Liang, Chenkai Ma, Yang Zhao, Guodong Gao, Jie M. Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386409. |
recent studies have revealed that knockdown of signal transducers and activators of transcription 3 (stat3) expression by rnai induces apoptosis in astrocytoma cell. |
2015-02-23 |
2023-08-12 |
human |
| Emma Stuart, Michael Buchert, Tracy Putoczki, Stefan Thiem, Ryan Farid, Joachim Elzer, Dennis Huszar, Paul M Waring, Toby J Phesse, Matthias Erns. Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Molecular cancer therapeutics. vol 13. issue 2. 2015-02-19. PMID:24398427. |
we find that systemic administration of azd1480 readily replicates this effect, which is associated with reduced stat3 activation and correlates with diminished tumor cell proliferation and increased apoptosis. |
2015-02-19 |
2023-08-12 |
mouse |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
thymoquinone induces apoptosis in human colon cancer hct116 cells through inactivation of stat3 by blocking jak2- and src‑mediated phosphorylation of egf receptor tyrosine kinase. |
2015-02-12 |
2023-08-13 |
human |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
collectively, our study revealed that tq induced apoptosis in hct116 cells by blocking stat3 signaling via inhibition of jak2- and src-mediated phosphorylation of egfr tyrosine kinase. |
2015-02-12 |
2023-08-13 |
human |
| Gui-Min Wang, Zhong-Xi Ren, Pei-Song Wang, Chang Su, Wen-Xin Zhang, Zeng-Guang Liu, Ling Zhang, Xue-Jian Zhao, Guang Che. Plasmid-based Stat3-specific siRNA and GRIM-19 inhibit the growth of thyroid cancer cells in vitro and in vivo. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24899100. |
gene associated with retinoid-ifn-induced mortality 19 (grim-19), a stat3-inhibitory protein, was identified as a potential tumor suppressor associated with growth inhibition and cell apoptosis by targeting the transcription factor stat3 for inhibition. |
2015-02-12 |
2023-08-13 |
Not clear |
| L-J Liu, K-H Leung, D S-H Chan, Y-T Wang, D-L Ma, C-H Leun. Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell death & disease. vol 5. 2015-02-12. PMID:24922077. |
stat3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, inflammation, and immunity. |
2015-02-12 |
2023-08-13 |
Not clear |
| Guangwen Shu, Jing Yang, Wenhao Zhao, Chan Xu, Zongguo Hong, Zhinan Mei, Xinzhou Yan. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:24997323. |
suppression of stat3 signaling is involved in kurarinol-induced hcc cell apoptosis. |
2015-02-06 |
2023-08-13 |
mouse |
| Guangwen Shu, Jing Yang, Wenhao Zhao, Chan Xu, Zongguo Hong, Zhinan Mei, Xinzhou Yan. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:24997323. |
suppressing stat3 signaling is implicated in kurarinol-mediated hcc cell apoptosis. |
2015-02-06 |
2023-08-13 |
mouse |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
in addition, morusin down-regulated expression of stat3 target genes encoding bcl-xl, bcl-2, survivin, c-myc and cyclin d1, which are involved in regulation of apoptosis and cell cycle. |
2015-01-28 |
2023-08-13 |
human |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
furthermore, morusin induced apoptosis in human prostate cancer cells by reducing stat3 activity. |
2015-01-28 |
2023-08-13 |
human |
| Sung-Lyul Lim, Sang-Yoon Park, Sukmin Kang, Dain Park, Sung-Hoon Kim, Jae-Young Um, Hyeung-Jin Jang, Jun-Hee Lee, Chul-Ho Jeong, Jung-Hee Jang, Kwang Seok Ahn, Seok-Geun Le. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. American journal of cancer research. vol 5. issue 1. 2015-01-28. PMID:25628938. |
taken together, these results suggest that morusin could be a potentially therapeutic agent for prostate cancer by reducing stat3 activity and inducing apoptosis. |
2015-01-28 |
2023-08-13 |
human |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
signal transducer and activator of transcription-3 (stat3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
here we show that treatment of human ags gastric cancer cells with the janus kinase (jak) inhibitor wp1066 dose-, and time-dependently inhibits stat3 phosphorylation, in conjunction with reduced jak2 phosphorylation, reduced proliferation and increased apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
these results show that wp1066 can block proliferation, reduce inflammation and induce apoptosis in gastric tumour cells by inhibiting stat3 phosphorylation, and that many cytokines and growth factors that promote gastric tumour growth are regulated by stat3-dependent mechanisms. |
2015-01-23 |
2023-08-13 |
mouse |