| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
it was found that tbr primarily targets stat3 and erk signaling during the induction of apoptosis in several human leukemia cell lines. |
2015-07-07 |
2023-08-13 |
human |
| Songyang Liu, Wei Zhang, Kai Liu, Yingchao Wang, Bai Ji, Yahui Li. Synergistic effects of co-expression plasmid‑based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo. Oncology reports. vol 32. issue 6. 2015-06-26. PMID:25242535. |
gene associated with retinoid-interferon-induced mortality 19 (grim-19), a signal transducer and activator of transcription 3 (stat3)-inhibitory protein, was identified as a potential tumor suppressor associated with growth inhibition and cell apoptosis. |
2015-06-26 |
2023-08-13 |
mouse |
| Zhiqiang Han, Xiaoli Wang, Liang Ma, Lijuan Chen, Min Xiao, Liang Huang, Yang Cao, Jian Bai, Ding Ma, Jianfeng Zhou, Zhenya Hon. Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25261365. |
in this study we show that the stat3 small molecule inhibitor stattic caused s-phase accumulation at low-dose levels and led to massive apoptosis at a relatively high-dose level in prostate cancer cells. |
2015-06-25 |
2023-08-13 |
human |
| Guangchao Li, Likun Zhao, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Jianxin Dai, Huafeng Wei, Yajun Gu. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25327561. |
genetic or pharmacological inhibition of stat3 disrupted stat3-dependent positive feedback loop and recovered the trastuzumab sensitivity partially due to increased apoptosis induction. |
2015-06-25 |
2023-08-13 |
Not clear |
| Valeria Poli, Annalisa Camporeal. STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance. Frontiers in oncology. vol 5. 2015-06-24. PMID:26106584. |
stat3 can, however, also localize to mitochondria, where its serine-phosphorylated (s-p) form preserves mitochondrial oxidative phosphorylation and controls the opening of the mitochondrial permeability transition pore, also promoting survival and resistance to apoptosis in response to specific signals/oncogenes such as ras. |
2015-06-24 |
2023-08-13 |
Not clear |
| U Bharadwaj, T K Eckols, M Kolosov, M M Kasembeli, A Adam, D Torres, X Zhang, L E Dobrolecki, W Wei, M T Lewis, B Dave, J C Chang, M D Landis, C J Creighton, M A Mancini, D J Tweard. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene. vol 34. issue 11. 2015-06-19. PMID:24681959. |
pl inhibited anchorage-independent and anchorage-dependent growth of multiple breast cancer cell lines having increased pstat3 or total stat3, and induced apoptosis. |
2015-06-19 |
2023-08-12 |
mouse |
| Meng Zhang, Zhi-Gang Bian, Yi Zhang, Jia-He Wang, Liang Kan, Xin Wang, Hui-Yan Niu, Ping H. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25242136. |
cucurbitacin b inhibits proliferation and induces apoptosis via stat3 pathway inhibition in a549 lung cancer cells. |
2015-06-19 |
2023-08-13 |
Not clear |
| I G Chae, D-H Kim, J Kundu, C-H Jeong, J K Kundu, K-S Chu. Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. Free radical research. vol 48. issue 11. 2015-06-16. PMID:25096910. |
generation of ros by cay10598 leads to inactivation of stat3 signaling and induction of apoptosis in human colon cancer hct116 cells. |
2015-06-16 |
2023-08-13 |
human |
| Yong Ai, Fenghua Kang, Zhangjian Huang, Xiaowen Xue, Yisheng Lai, Sixun Peng, Jide Tian, Yihua Zhan. Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer. Journal of medicinal chemistry. vol 58. issue 5. 2015-06-15. PMID:25675144. |
furthermore, 4c triggered hct-8 and hct-8/5-fu cell apoptosis more strongly than cddo-me, inhibited the hif-1α, stat3, akt, and erk signaling, and induced the nitration of p-gp, mrp1, and bcrp proteins in hct-8/5-fu cells. |
2015-06-15 |
2023-08-13 |
mouse |
| Weijie Du, Zhenwei Pan, Xu Chen, Leimin Wang, Ying Zhang, Shuang Li, Haihai Liang, Chaoqian Xu, Yong Zhang, Yanping Wu, Hongli Shan, Yanjie L. By targeting Stat3 microRNA-17-5p promotes cardiomyocyte apoptosis in response to ischemia followed by reperfusion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 34. issue 3. 2015-06-09. PMID:25200830. |
by targeting stat3 microrna-17-5p promotes cardiomyocyte apoptosis in response to ischemia followed by reperfusion. |
2015-06-09 |
2023-08-13 |
Not clear |
| Yi-Xin Wang, Hong Cai, Gang Jiang, Tian-Bao Zhou, Hai W. Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 16. 2015-06-08. PMID:25169527. |
silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer mgc803 cells via stat3 pathway inhibition. |
2015-06-08 |
2023-08-13 |
human |
| Zongyuan Yang, Yi Liu, Jing Liao, Cheng Gong, Chaoyang Sun, Xiaoshui Zhou, Xiao Wei, Taoran Zhang, Qinglei Gao, Ding Ma, Gang Che. Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling. The FEBS journal. vol 282. issue 6. 2015-06-02. PMID:25611565. |
tumors from mice treated with cddp in combination with qu pretreatment had repressed stat3 phosphorylation, lower bcl-2 and higher apoptosis levels compared with those from the other groups. |
2015-06-02 |
2023-08-13 |
mouse |
| Zhigang Cheng, Ling Li, Xueying Mo, Lu Zhang, Yongqiu Xie, Qulian Guo, Yunjiao Wan. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092271. |
non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating stat3 and reducing apoptosis. |
2015-05-26 |
2023-08-13 |
rat |
| Zhigang Cheng, Ling Li, Xueying Mo, Lu Zhang, Yongqiu Xie, Qulian Guo, Yunjiao Wan. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092271. |
the signal transducer and activator of transcription 3 (stat3) signaling pathway has been implicated in cell apoptosis and inflammatory processes. |
2015-05-26 |
2023-08-13 |
rat |
| Zhigang Cheng, Ling Li, Xueying Mo, Lu Zhang, Yongqiu Xie, Qulian Guo, Yunjiao Wan. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092271. |
in the present study, we investigated the role of phosphorylated stat3 (p-stat3)-mediated apoptosis and inflammation following non-invasive remote limb iptc (nripoc) using a classic rat model of focal cerebral ischemia. |
2015-05-26 |
2023-08-13 |
rat |
| Zhigang Cheng, Ling Li, Xueying Mo, Lu Zhang, Yongqiu Xie, Qulian Guo, Yunjiao Wan. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092271. |
these results indicate that the protective effects of nripoc against cerebral i/r injury may be related to the attenuation of neuronal apoptosis and inflammation through the activation of stat3. |
2015-05-26 |
2023-08-13 |
rat |
| Karolina Swiatek-Machado, Jakub Mieczkowski, Aleksandra Ellert-Miklaszewska, Piotr Swierk, Izabela Fokt, Slawomir Szymanski, Stanislaw Skora, Wiesław Szeja, Grzegorz Grynkiewicz, Bogdan Lesyng, Waldemar Priebe, Bozena Kaminsk. Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells. Cancer biology & therapy. vol 13. issue 8. 2015-05-22. PMID:22555804. |
constitutive activation of stats, in particular stat3, is observed in a large number of human tumors, including gliomas and may contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis, thus it emerges as a promising target for anti-cancer therapy. |
2015-05-22 |
2023-08-12 |
human |
| Jong Hyun Lee, Chulwon Kim, Sung-Hoon Kim, Gautam Sethi, Kwang Seok Ah. Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway. Cancer letters. vol 360. issue 2. 2015-05-19. PMID:25697480. |
the effect of farnesol (foh) on stat3 activation, associated protein kinases, its regulated gene products, cellular proliferation, and apoptosis was examined. |
2015-05-19 |
2023-08-13 |
mouse |
| Xuequan Feng, Jingchao Wu, Xinnyu Xu, Hongsheng Liu, Jun Liu, Jialin Li, Biao Zhang, Jinhuan Wan. [A preliminary study about the interaction between basic fibroblast growth factor and signal transducer and activator of transcription 3 in glioma apoptosis]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 52. issue 12. 2015-05-17. PMID:25622587. |
to study the relationship of basic fibroblast growth factor (bfgf) and signal transducer and activator of transcription 3(stat3) in glioma apoptosis and possible mechanisms of its interaction. |
2015-05-17 |
2023-08-13 |
Not clear |
| Kiyoshi Takeda, Tsuneyasu Kaisho, Nobuaki Yoshida, Junji Takeda, Tadamitsu Kishimoto, Shizuo Akir. Correction: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 7. 2015-05-14. PMID:25795790. |
correction: stat3 activation is responsible for il-6-dependent t cell proliferation through preventing apoptosis: generation and characterization of t cell-specific stat3-deficient mice. |
2015-05-14 |
2023-08-13 |
mouse |