| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huaxiang Liu, Guixiang Liu, Yanwen B. CNTF regulates neurite outgrowth and neuronal migration through JAK2/STAT3 and PI3K/Akt signaling pathways of DRG explants with gp120-induced neurotoxicity in vitro. Neuroscience letters. vol 569. 2014-12-09. PMID:24708926. |
these data imply that cntf improved neuronal status by promoting gap-43 expression and inhibiting apoptosis through jak2/signal transducer and activator of transcription 3 (stat3) and pi3k/akt signaling pathways of drg neurons with gp120-induced neurotoxicity. |
2014-12-09 |
2023-08-13 |
Not clear |
| Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast cancer research : BCR. vol 15. issue 4. 2014-12-08. PMID:23938089. |
novel sorafenib analogues induce apoptosis through shp-1 dependent stat3 inactivation in human breast cancer cells. |
2014-12-08 |
2023-08-12 |
human |
| A P Renjini, Shiny Titus, Prashanth Narayan, Megha Murali, Rajesh Kumar Jha, Malini Laloray. STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition. Journal of cell science. vol 127. issue Pt 8. 2014-12-05. PMID:24481815. |
stat3 functionally associates with mcl-1 in the mammalian breast cancer cell line mcf7 that overexpresses stat3 and mcl-1, which leads to an increased rate of apoptosis and decreased cellular invasion, disrupting the emt. |
2014-12-05 |
2023-08-12 |
Not clear |
| Laura Mack, Boris Brill, Natalia Delis, Corina Borghouts, Axel Weber, Bernd Grone. Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA. Hormone molecular biology and clinical investigation. vol 10. issue 2. 2014-12-03. PMID:25436683. |
stat3 is activated in skin lesions by the local application of imiquimod, a ligand of tlr7, and inhibited by the recombinant peptide aptamer rs3-pa. abstract signal transducer and activator of transcription 3 (stat3) assumes central functions in the regulation of apoptosis, proliferation, angiogenesis, and immune responses in normal cells. |
2014-12-03 |
2023-08-13 |
mouse |
| Ki-Woong Park, Juthika Kundu, In-Gyeong Chae, Do-Hee Kim, Mi-Hee Yu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24481553. |
carnosol induces apoptosis through generation of ros and inactivation of stat3 signaling in human colon cancer hct116 cells. |
2014-11-26 |
2023-08-12 |
human |
| Ki-Woong Park, Juthika Kundu, In-Gyeong Chae, Do-Hee Kim, Mi-Hee Yu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24481553. |
taken together, our study provides the first report that carnosol induced apoptosis in hct116 cells via generation of ros, induction of p53, activation of caspases and inhibition of stat3 signaling pathway. |
2014-11-26 |
2023-08-12 |
human |
| Dongwoo Nam, Junho Song, Sung-Moo Kim, Shu Yuan Chiang, Ji-Sung Kim, Won-Seok Chung, Hyeung-Jin Jang, Sang Hoon Jung, Young-Soon Na, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. 8-hydrocalamenene, derived from Reynoutria elliptica, suppresses constitutive STAT3 activation, inhibiting proliferation and enhancing chemosensitization of human multiple myeloma cells. Journal of medicinal food. vol 17. issue 3. 2014-11-17. PMID:24476219. |
based on the evidence that anti-inflammatory agents frequently exert antiproliferative activity, we tested two sesquiterpene derivatives, 8-hydrocalamenene (hc) and 8,14-dihydrocalamenene (dhc), for their ability to induce apoptosis and suppress signal transducer and activator of transcription 3 (stat3) activation in multiple myeloma (mm) u266 cells. |
2014-11-17 |
2023-08-12 |
human |
| Sung-Moo Kim, Jong Hyun Lee, Gautam Sethi, Chulwon Kim, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells. Cancer letters. vol 354. issue 1. 2014-11-17. PMID:25130169. |
bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of stat3 signaling pathway in tumor cells. |
2014-11-17 |
2023-08-13 |
Not clear |
| Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang, Jinbo Yan. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Molecular cancer therapeutics. vol 13. issue 3. 2014-11-12. PMID:24401319. |
inhibiting egfr, stat3, and nf-κb by combination of tkis with tpca-1 showed increased sensitivity and enhanced apoptosis induced by gefitinib. |
2014-11-12 |
2023-08-12 |
human |
| Chulwon Kim, Somi K Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung-Hoon Kim, Gautam Sethi, Kwang Seok Ah. β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23765383. |
the effect of cpo on stat3 activation, associated protein kinases and phosphatase, stat3-regulated gene products and apoptosis was investigated using both functional proteomics tumor pathway technology platform and different tumor cell lines. |
2014-11-03 |
2023-08-12 |
Not clear |
| Chulwon Kim, Somi K Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung-Hoon Kim, Gautam Sethi, Kwang Seok Ah. β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23765383. |
the inhibition of stat3 activation by cpo inhibited proliferation, induced apoptosis and abrogated the invasive potential of tumor cells. |
2014-11-03 |
2023-08-12 |
Not clear |
| Rebeca Fernandez-Ruiz, Elaine Vieira, Pablo M Garcia-Roves, Ramon Gomi. Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587334. |
furthermore, the ablation of ptp1b is able to regulate key proteins involved in the proliferation and/or apoptosis pathways, such as stat3, akt, erk1/2 and p53 in isolated islets from ptp1b knockout (ptp1b (-)/(-)) mice. |
2014-10-28 |
2023-08-12 |
mouse |
| Nagarjuna Vasagiri, Vijay Kumar Kutal. Molecular mechanism of interaction of mitocurcumin-1 with Akt1 and STAT3: an in silico approach. Indian journal of biochemistry & biophysics. vol 51. issue 4. 2014-10-23. PMID:25296502. |
we found that such conjugation significantly increased the uptake of curcumin in various cancer cells and caused cancer cell death by inducing apoptosis by decreasing the phosphorylation of akt1 (thr308) and stat3 (tyr705). |
2014-10-23 |
2023-08-13 |
Not clear |
| Yunyun Li, Zhongzu Zhang, Xiuxia Liu, Tingting Huang, Wenfeng He, Yang Shen, Xin Liu, Kui Hong, Qing Ca. miR-124 functions as a tumor suppressor in the endometrial carcinoma cell line HEC-1B partly by suppressing STAT3. Molecular and cellular biochemistry. vol 388. issue 1-2. 2014-10-21. PMID:24287565. |
restored stat3 expression through treatment with il-6 cytokine partly abolished mir-124-mediated cell cycle arrest and apoptosis induction. |
2014-10-21 |
2023-08-12 |
human |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating stat3 signaling. |
2014-10-21 |
2023-08-12 |
Not clear |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
accordingly, small interfering rna (sirna)-mediated stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. |
2014-10-21 |
2023-08-12 |
Not clear |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
in vivo, metformin downregulated stat3 activity and bcl-2 expression, induced apoptosis and autophagy, and inhibited tumor growth. |
2014-10-21 |
2023-08-12 |
Not clear |
| Malvika H Solanki, Prodyot K Chatterjee, Madhu Gupta, Xiangying Xue, Andrei Plagov, Margot H Metz, Rachel Mintz, Pravin C Singhal, Christine N Met. Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation. American journal of physiology. Renal physiology. vol 307. issue 4. 2014-10-21. PMID:24944268. |
magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., erk1/2, p53, and stat3). |
2014-10-21 |
2023-08-13 |
mouse |
| Nicholas Don-Doncow, Zilma Escobar, Martin Johansson, Sven Kjellström, Victor Garcia, Eduardo Munoz, Olov Sterner, Anders Bjartell, Rebecka Hellste. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24755219. |
the fungal metabolite galiellalactone, a stat3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active stat3 and induces apoptosis of prostate cancer stem cell-like cells expressing phosphorylated stat3 (pstat3). |
2014-10-07 |
2023-08-13 |
Not clear |
| Wei Lin, Liangpu Zheng, Qunchuan Zhuang, Jinyan Zhao, Zhiyun Cao, Jianwei Zeng, Shan Lin, Wei Xu, Jun Pen. Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. BMC complementary and alternative medicine. vol 13. 2014-10-06. PMID:23800091. |
spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. |
2014-10-06 |
2023-08-12 |
mouse |