| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Bello, Dania Vazquez-Blomquist, Jamilet Miranda, Yanelda Garcia, Lidia Ines Novoa, Daniel Palenzuela, Iraldo Bell. Regulation by IFN-α/IFN-γ co-formulation (HerberPAG®) of genes involved in interferon-STAT-pathways and apoptosis in U87MG. Current topics in medicinal chemistry. vol 14. issue 3. 2014-10-04. PMID:24304312. |
some of the genes involved in the first steps of ifns signaling pathways (stat1 and stat3) and apoptosis events (tp53, bax, bcl-2, bad, caspase3 (casp3), caspase8 (casp8) and caspase9 (casp9)) were studied. |
2014-10-04 |
2023-08-12 |
Not clear |
| Dan Hu, Lei Wan, Michael Chen, Yi Caudle, Gene LeSage, Qinchuan Li, Deling Yi. Essential role of IL-10/STAT3 in chronic stress-induced immune suppression. Brain, behavior, and immunity. vol 36. 2014-10-02. PMID:24513872. |
interestingly, blocking antibody against il-10 receptor and inhibition of stat3 by stat3 inhibitor s3i-201 attenuates stress-induced lymphocyte apoptosis. |
2014-10-02 |
2023-08-12 |
mouse |
| Han Chen, Yongli Guan, Gu Yuan, Qiang Zhang, Naijie Jin. A perylene derivative regulates HIF-1α and Stat3 signaling pathways. Bioorganic & medicinal chemistry. vol 22. issue 4. 2014-09-29. PMID:24485121. |
tel03 blocks the expression of both hif-1α and stat3, regulated oncogenes (e.g., bcl-2, vegf, glut1, and others) in cancer cells, and induces cancer cell apoptosis. |
2014-09-29 |
2023-08-12 |
Not clear |
| Yang Xu, Ying Shi, Qi Yuan, Xuli Liu, Bin Yan, Ling Chen, Yongguang Tao, Ya Ca. Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells. Journal of experimental & clinical cancer research : CR. vol 32. 2014-09-26. PMID:24499623. |
signal transducer and activator of transcription 3 (stat3) is a master transcriptional regulator in proliferation and apoptosis. |
2014-09-26 |
2023-08-12 |
Not clear |
| Shruti Chowdhari, Neeru Sain. hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. Journal of cellular physiology. vol 229. issue 11. 2014-09-25. PMID:24610393. |
we further show that overexpression of hsa-mir-4516 downregulates stat3, p-stat3, cdk6, and ube2n proteins that are consistently upregulated in psoriasis and induces apoptosis in hacat cells. |
2014-09-25 |
2023-08-12 |
human |
| Jian-Ping Wang, Zhi-Tang Yang, Cong Liu, Yuan-Hong He, Shan-Shan Zha. L-carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemia. Brain research. vol 1507. 2014-09-18. PMID:23454231. |
these results indicate that l-carnosine plays an important role in inhibiting neuronal cell apoptosis through stat3 signaling pathway after acute cerebral ischemia. |
2014-09-18 |
2023-08-12 |
rat |
| Yong-Qian Jiang, Zhi-Xiang Zhou, You-Lin J. Suppression of EGFR-STAT3 signaling inhibits tumorigenesis in a lung cancer cell line. International journal of clinical and experimental medicine. vol 7. issue 8. 2014-09-18. PMID:25232393. |
egfr and stat3 protein expression, cell apoptosis rate, cell proliferation, cell invasion, and cell division were analyzed and compared. |
2014-09-18 |
2023-08-13 |
Not clear |
| Qian Li, Chunling Pan, Di Teng, Li Lin, Yurong Kou, Elaine M Haase, Frank A Scannapieco, Yaping Pa. Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. Microbes and infection. vol 16. issue 1. 2014-09-11. PMID:24140557. |
porphyromonas gingivalis modulates pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the stat3 signaling pathway. |
2014-09-11 |
2023-08-12 |
Not clear |
| Qian Li, Chunling Pan, Di Teng, Li Lin, Yurong Kou, Elaine M Haase, Frank A Scannapieco, Yaping Pa. Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. Microbes and infection. vol 16. issue 1. 2014-09-11. PMID:24140557. |
p. gingivalis invasion transiently inhibited p. aeruginosa-induced apoptosis in respiratory epithelial cells via the signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2014-09-11 |
2023-08-12 |
Not clear |
| Shasha Li, Saul J Priceman, Hong Xin, Wang Zhang, Jiehui Deng, Yong Liu, Jiabin Huang, Wenshan Zhu, Mingjie Chen, Wei Hu, Xiaomin Deng, Jian Zhang, Hua Yu, Guangyuan H. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma. PloS one. vol 8. issue 12. 2014-09-11. PMID:24324713. |
expression of the constitutively active form of stat3 blocked icaritin-induced apoptosis, while sirna directed against stat3 potentiated apoptosis. |
2014-09-11 |
2023-08-12 |
mouse |
| Xubin Wei, Gang Wang, Wei Li, Xupang Hu, Qinghong Huang, Ke Xu, Wenjia Lou, Jia Wu, Chen Liang, Qibin Lou, Chen Qian, Li Li. Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24253664. |
our data revealed that i) in crc cells, stat3 was continuously activated by phosphorylation, and socs3 was at a relative low expression level; and ii) adcn305-cppsocs3 inhibited the continuous activation of the jak/stat3 pathway, suppressed crc cell growth and induced apoptosis, in vitro and in vivo. |
2014-09-05 |
2023-08-12 |
Not clear |
| Elena Butturini, Alessandra Carcereri de Prati, Giulia Chiavegato, Antonella Rigo, Elisabetta Cavalieri, Elena Darra, Sofia Mariott. Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs. Free radical biology & medicine. vol 65. 2014-09-02. PMID:24095958. |
stat3 is a transcription factor constitutively activated in a variety of cancers that has a critical role in the inhibition of apoptosis and induction of chemoresistance. |
2014-09-02 |
2023-08-12 |
Not clear |
| Elena Butturini, Alessandra Carcereri de Prati, Giulia Chiavegato, Antonella Rigo, Elisabetta Cavalieri, Elena Darra, Sofia Mariott. Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs. Free radical biology & medicine. vol 65. 2014-09-02. PMID:24095958. |
inhibition of the stat3 signaling pathway suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting that direct inhibition of stat3 function is a viable therapeutic approach. |
2014-09-02 |
2023-08-12 |
Not clear |
| Yonghe Li, Pui-Kai Li, Michael J Roberts, Rebecca C Arend, Rajeev S Samant, Donald J Buchsbau. Multi-targeted therapy of cancer by niclosamide: A new application for an old drug. Cancer letters. vol 349. issue 1. 2014-08-28. PMID:24732808. |
niclosamide not only inhibits the wnt/β-catenin, mtorc1, stat3, nf-κb and notch signaling pathways, but also targets mitochondria in cancer cells to induce cell cycle arrest, growth inhibition and apoptosis. |
2014-08-28 |
2023-08-13 |
Not clear |
| Henrike K Resemann, Christine J Watson, Bethan Lloyd-Lewi. The Stat3 paradox: a killer and an oncogene. Molecular and cellular endocrinology. vol 382. issue 1. 2014-08-26. PMID:23827176. |
stat3 induces transcriptional activation of genes involved in the inflammatory response, and in seemingly contradictory cellular events such as apoptosis, differentiation and stem cell maintenance. |
2014-08-26 |
2023-08-12 |
Not clear |
| Anita C G Chua, Borut R S Klopcic, Desiree S Ho, S Kristine Fu, Cynthia H Forrest, Kevin D Croft, John K Olynyk, Ian C Lawrance, Debbie Trinde. Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PloS one. vol 8. issue 11. 2014-08-26. PMID:24223168. |
intestinal inflammation and tumor development were assessed by endoscopy and histology, gene expression by real-time pcr, stat3 phosphorylation by immunoblot, cytokines by elisa and apoptosis by tunel assay. |
2014-08-26 |
2023-08-12 |
mouse |
| Carolina Hoyo-Becerra, Anastasia Huebener, Martin Trippler, Melanie Lutterbeck, Zijian J Liu, Kurt Truebner, Thomas Bajanowski, Guido Gerken, Dirk M Hermann, Joerg F Schlaa. Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons. PloS one. vol 8. issue 12. 2014-08-25. PMID:24391741. |
using cultured mouse hippocampal and prefrontal neurons we show that costimulation with murine ifn (mifn) and the tlr3 agonist poly(i:c) promotes the expression of the described driis, at the same time inducing pro-inflammatory cytokine expression through stat1 and stat3 activation, promoting neuronal apoptosis. |
2014-08-25 |
2023-08-12 |
mouse |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Jong-Kyu Woo, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu K. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. Anticancer research. vol 34. issue 6. 2014-08-21. PMID:24922650. |
induction of caspase-dependent apoptosis by apigenin by inhibiting stat3 signaling in her2-overexpressing mda-mb-453 breast cancer cells. |
2014-08-21 |
2023-08-13 |
Not clear |
| Aruljothi Subramaniam, Muthu K Shanmugam, Tina H Ong, Feng Li, Ekambaram Perumal, Luxi Chen, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Kam M Hui, Gautam Seth. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. British journal of pharmacology. vol 170. issue 4. 2014-08-19. PMID:23848338. |
emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of stat3. |
2014-08-19 |
2023-08-12 |
Not clear |
| Uri Rozovski, Ji Yuan Wu, David M Harris, Zhiming Liu, Ping Li, Inbal Hazan-Halevy, Alessandra Ferrajoli, Jan A Burger, Susan O'Brien, Nitin Jain, Srdan Verstovsek, William G Wierda, Michael J Keating, Zeev Estro. Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells. Blood. vol 123. issue 24. 2014-08-12. PMID:24778152. |
incubation of cll cells with the jak1/2 inhibitor ruxolitinib inhibited igm-induced stat3 phosphorylation and induced apoptosis of igm-stimulated but not unstimulated cll cells in a dose- and time-dependent manner. |
2014-08-12 |
2023-08-13 |
Not clear |