| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Snehal Dabir, Amy Kluge, Karen McColl, Yu Liu, Minh Lam, Balazs Halmos, Gary Wildey, Afshin Dowlat. PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. International journal of cancer. vol 134. issue 5. 2014-02-12. PMID:23959540. |
microarray experiments were performed to discover stat3-independent mediators of pias3-induced apoptosis by comparing the apoptotic gene expression signature induced by pias3 overexpression with that induced by stat3 sirna. |
2014-02-12 |
2023-08-12 |
human |
| Jennifer E Kim, Mira Patel, Jacob Ruzevick, Christopher M Jackson, Michael Li. STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications. Cancers. vol 6. issue 1. 2014-02-12. PMID:24518612. |
nevertheless, some studies show that stat3 also participates in terminal differentiation and apoptosis of various cell lines and in glioma with phosphatase and tensin homolog (pten)-deficient genetic backgrounds. |
2014-02-12 |
2023-08-12 |
Not clear |
| Ruchi Ghildiyal, Deobrat Dixit, Ellora Se. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22753156. |
the ability of bibu to abrogate akt and stat3 activation, induce apoptosis and prevent execution of autophagy warrants its investigation as a potent anti-glioma target. |
2014-01-23 |
2023-08-12 |
Not clear |
| Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi, Yasuto Akiyam. Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. International journal of oncology. vol 43. issue 1. 2014-01-07. PMID:23612755. |
notably, stx-0119 demonstrated strong inhibition of the expression of stat3 target genes (c-myc, survivin, cyclin d1, hif-1α and vegf) and stem cell-associated genes (cd44, nanog, nestin and cd133) as well as the induction of apoptosis in one stem-like cell line. |
2014-01-07 |
2023-08-12 |
Not clear |
| Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jov. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23206899. |
dual inhibition of janus and src family kinases by novel indirubin derivative blocks constitutively-activated stat3 signaling associated with apoptosis of human pancreatic cancer cells. |
2013-12-23 |
2023-08-12 |
human |
| Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jov. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23206899. |
e738 down-regulated expression of the stat3 target proteins mcl-1 and survivin, associated with induction of apoptosis. |
2013-12-23 |
2023-08-12 |
human |
| Chun-Sheng Han, Yan Chen, Xue-Qiang W. [Role of signal transducer and activator of transcription 3 in the development of tumors]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 2. 2013-12-16. PMID:23628067. |
signal transducer and activator of transcription 3 (stat3) take part in cell proliferation, differentiation, survival, apoptosis, transformation, cellular immunity and some other important physiological and pathological processes. |
2013-12-16 |
2023-08-12 |
Not clear |
| R Kerek, A Geoffroy, A Bison, N Martin, N Akchiche, G Pourié, D Helle, J-L Guéant, C Bossenmeyer-Pourié, J-L Dava. Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124. Cell death & disease. vol 4. 2013-12-13. PMID:23928694. |
vitamin shortage also affected upstream kinases of stat3 signaling pathway (phospho-erk1/2, phospho-src, phospho-jnk, and phospho-p38) as well as downstream target gene products (bcl-2 and bcl-xl), thus promoting apoptosis. |
2013-12-13 |
2023-08-12 |
rat |
| Futoshi Matsui, Audrey Rhee, Karen L Hile, Hongji Zhang, Kirstan K Meldru. IL-18 induces profibrotic renal tubular cell injury via STAT3 activation. American journal of physiology. Renal physiology. vol 305. issue 7. 2013-12-11. PMID:23904224. |
in vitro results similarly demonstrate increased p-stat3, socs3, α-sma, and collagen iii expression, and increased collagen production and tec apoptosis in response to il-18 stimulation, but the response was significantly diminished in the presence of stat3 inhibition. |
2013-12-11 |
2023-08-12 |
mouse |
| Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Pen. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. International journal of molecular medicine. vol 32. issue 1. 2013-12-10. PMID:23613111. |
the analysis of the effects of nc on apoptosis in hcc tumor xenografts in mice was carried out by terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay; the expression of bcl-2, bax, cyclin-dependent kinase (cdk)4, cyclin d1, p21 and proliferating cell nuclear antigen (pcna) was analyzed by immunohistochemistry; and the protein expression of jak1 and stat3 was examined by western blot analysis. |
2013-12-10 |
2023-08-12 |
mouse |
| Philipp Stahl, Volker Ruppert, Thomas Meyer, Jörg Schmidt, Marco A Campos, Ricardo T Gazzinelli, Bernhard Maisch, Ralph T Schwarz, Françoise Debierre-Grockieg. Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23435997. |
trypomastigotes and amastigotes of trypanosoma cruzi induce apoptosis and stat3 activation in cardiomyocytes in vitro. |
2013-11-26 |
2023-08-12 |
rat |
| Gerardo G Mackenzie, Liqun Huang, Ninche Alston, Nengtai Ouyang, Kvetoslava Vrankova, George Mattheolabakis, Panayiotis P Constantinides, Basil Riga. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PloS one. vol 8. issue 5. 2013-11-26. PMID:23650499. |
p-v also reduced stat3 levels in the mitochondria by preventing its translocation from the cytosol, and enhanced the mitochondrial levels of reactive oxygen species, which triggered apoptosis. |
2013-11-26 |
2023-08-12 |
mouse |
| Brent D G Page, Danielle C Croucher, Zhi Hua Li, Sina Haftchenary, Victor H Jimenez-Zepeda, Jennifer Atkinson, Paul A Spagnuolo, Yoong Lim Wong, Robert Colaguori, Andrew M Lewis, Aaron D Schimmer, Suzanne Trudel, Patrick T Gunnin. Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. Journal of medicinal chemistry. vol 56. issue 18. 2013-11-26. PMID:23968501. |
these compounds showed high-affinity binding to stat3's sh2 domain, inhibited intracellular stat3 phosphorylation, and induced apoptosis in mm cell lines at low micromolar concentrations. |
2013-11-26 |
2023-08-12 |
Not clear |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
platelet factor 4 induces cell apoptosis by inhibition of stat3 via up-regulation of socs3 expression in multiple myeloma. |
2013-11-25 |
2023-08-12 |
mouse |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
knockdown of lrp1, a putative pf4 receptor, could also abolish pf4-induced apoptosis and stat3 inhibition. |
2013-11-25 |
2023-08-12 |
mouse |
| Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y D Chow, Natalie P H Chan, Rosalina K L Ip, Raymond S M Wong, Margaret H L N. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica. vol 98. issue 2. 2013-11-25. PMID:22929979. |
immunostaining of rabbit bone xenografts from pf4-treated mice showed induction of apoptosis of myeloma cells and inhibition of angiogenesis, which was associated with suppression of stat3 activity. |
2013-11-25 |
2023-08-12 |
mouse |
| Huizhen Nie, Qingzhen Cao, Lei Zhu, Yuehua Gong, Jianren Gu, Zuping H. Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620780. |
collectively, these data suggest that ach activates stat3 and akt pathways and acts on ar to promote the migration and invasion but inhibit the apoptosis of hcc cells. |
2013-11-11 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
trichosanthes kirilowii ethanol extract and cucurbitacin d inhibit cell growth and induce apoptosis through inhibition of stat3 activity in breast cancer cells. |
2013-11-06 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
in the present study, we tested whether trichosanthes kirilowii ethanol extract (tke) or cud suppresses cell growth and induces apoptosis through inhibition of stat3 activity in breast cancer cells. |
2013-11-06 |
2023-08-12 |
human |
| Soon Re Kim, Hye Sook Seo, Han-Seok Choi, Sung-Gook Cho, Yong Kuk Kim, Eun Hee Hong, Yong Cheol Shin, Seong-Gyu K. Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-06. PMID:24194785. |
we found that both tke and cud suppressed proliferation and induced apoptosis and g2/m cell cycle arrest in mda-mb-231 breast cancer cells by inhibiting stat3 phosphorylation. |
2013-11-06 |
2023-08-12 |
human |