| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingli Liu, Nana O Wilson, Jacqueline M Hibbert, Jonathan K Stile. STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967200. |
in the present study, we further tested the hypothesis that heme reduces blood-brain barrier integrity during ecm by induction of apoptosis of brain vascular endothelial cells through stat3 and its target gene matrix metalloproteinase three (mmp3) signaling. |
2014-05-14 |
2023-08-12 |
mouse |
| Yang Wang, Xuequn Ren, Chaoyang Deng, Lu Yang, Erfu Yan, Tao Guo, Yanmin Li, Marvin Xuejun X. Mechanism of the inhibition of the STAT3 signaling pathway by EGCG. Oncology reports. vol 30. issue 6. 2014-05-13. PMID:24065300. |
following treatment of the hepatocellular carcinoma cell lines bel-7402 and qgy-7703 with egcg, in vitro, egcg significantly suppressed cell proliferation as detected by mtt assay, induced apoptosis as detected by flow cytometry, dramatically lowered the expression levels of phosphorylated stat3 proteins (p-stat3) as determined by immunoblot detection, and inhibited the expression of multiple genes including bcl-xl, c-myc, vegf and cyclin d1 as demonstrated by rt-pcr analysis. |
2014-05-13 |
2023-08-12 |
Not clear |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
inhibition of stat3 expression induces apoptosis and suppresses proliferation in human leukemia hl-60 cells. |
2014-05-12 |
2023-08-12 |
human |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
the results indicated that constitutively expressed stat3 is present in human leukemia hl-60 cells, and the down-regulation of stat3 expression caused significant induction of apoptosis as well as inhibition of proliferation in hl-60 cells. |
2014-05-12 |
2023-08-12 |
human |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
these data further demonstrated that stat3 plays a critical role in human leukemia hl-60 cell apoptosis and proliferation. |
2014-05-12 |
2023-08-12 |
human |
| Xiaolei Zhang, Peishu Liu, Bo Zhang, Hongluan Mao, Liang Shen, Yanhui M. Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo. International journal of molecular medicine. vol 32. issue 3. 2014-05-12. PMID:23828376. |
the results revealed that the stat3 decoy odn inhibited ovarian cancer cell growth and promoted ovarian cancer cell apoptosis in vivo. |
2014-05-12 |
2023-08-12 |
mouse |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
inhibition of flipl by rna interference resulted, as expected, not only in enhanced hepatocyte apoptosis in response to fas signals, but also in decreased levels of il-6, stat3, and hamp. |
2014-05-09 |
2023-08-12 |
Not clear |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
in contrast, overexpression of flipl protected hepatocytes against agonistic anti-fas antibody-mediated apoptosis and increased the levels of il-6 and stat3, thereby maintaining the expression of hamp in an nf-κb-dependent fashion. |
2014-05-09 |
2023-08-12 |
Not clear |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
in vivo overexpression of flipl in the liver via hydrodynamic transfection, similarly, interfered with fas-initiated apoptosis and prevented down-regulation of il-6, stat3, and hamp. |
2014-05-09 |
2023-08-12 |
Not clear |
| Braden C McFarland, G Kenneth Gray, Susan E Nozell, Suk W Hong, Etty N Benvenist. Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells. Molecular cancer research : MCR. vol 11. issue 5. 2014-05-02. PMID:23386688. |
in this study, we confirmed that jsi-124 inhibits both constitutive and stimulus-induced janus kinase 2 (jak2) and stat3 phosphorylation, and decreases cell proliferation while inducing apoptosis in cultured gbm cells. |
2014-05-02 |
2023-08-12 |
human |
| Lei Lv, Jiwei Zhang, Lan Zhang, Guanhua Xue, Peng Wang, Qiurong Meng, Wei Lian. Essential role of Pin1 via STAT3 signalling and mitochondria-dependent pathways in restenosis in type 2 diabetes. Journal of cellular and molecular medicine. vol 17. issue 8. 2014-05-01. PMID:23750710. |
we demonstrated that stat3 signalling and mitochondria-dependent pathways played critical roles in the involvement of pin1 in cell cycle regulation and apoptosis of vsmcs in t2d. |
2014-05-01 |
2023-08-12 |
mouse |
| Pengyi Deng, Chen Wang, Liulin Chen, Cheng Wang, Yuhan Du, Xu Yan, Mingjie Chen, Guangxiao Yang, Guangyuan H. Sesamin induces cell cycle arrest and apoptosis through the inhibition of signal transducer and activator of transcription 3 signalling in human hepatocellular carcinoma cell line HepG2. Biological & pharmaceutical bulletin. vol 36. issue 10. 2014-04-28. PMID:24088253. |
our studies showed that stat3 signalling played a key role in sesamin-induced g2/m phase arrest and apoptosis in hepg2 cells. |
2014-04-28 |
2023-08-12 |
human |
| Chunjuan Jiang, Qian Xu, Kai Xu, Haiyang Dai, Zhuiyang Zhang, Wenjuan Wu, Jianming N. Effects of erythropoietin on STAT1 and STAT3 levels following cerebral ischemia-reperfusion in rats. The International journal of neuroscience. vol 123. issue 10. 2014-04-24. PMID:23786492. |
stat1 initiates neuronal apoptosis following cerebral ischemia-reperfusion, while stat3 is neuroprotective. |
2014-04-24 |
2023-08-12 |
rat |
| Qingyuan Jiang, Lei Dai, Lin Cheng, Xiaolei Chen, Yiming Li, Shuang Zhang, Xiaolan Su, Xia Zhao, Yuquan Wei, Hongxin Den. Efficient inhibition of intraperitoneal ovarian cancer growth in nude mice by liposomal delivery of short hairpin RNA against STAT3. The journal of obstetrics and gynaecology research. vol 39. issue 3. 2014-04-22. PMID:23003327. |
our goal was to investigate the effect of silencing stat3 on ovarian cancer cell apoptosis, proliferation, angiogenesis and expression of key targets in vitro and in vivo. |
2014-04-22 |
2023-08-12 |
mouse |
| Robert H Lee, Guillermo Vazque. Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages. Physiological reports. vol 1. issue 7. 2014-04-18. PMID:24744866. |
our findings show that stimulation of α7nachr results in activation of the stat3 prosurvival pathway and protection of macrophages from endoplasmic reticulum (er) stress-induced apoptosis. |
2014-04-18 |
2023-08-13 |
mouse |
| Haitao Xu, Songyan Zhan. Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway. Phytotherapy research : PTR. vol 27. issue 10. 2014-04-14. PMID:23192830. |
scutellarin-induced apoptosis in hepg2 hepatocellular carcinoma cells via a stat3 pathway. |
2014-04-14 |
2023-08-12 |
Not clear |
| Haitao Xu, Songyan Zhan. Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway. Phytotherapy research : PTR. vol 27. issue 10. 2014-04-14. PMID:23192830. |
in summary, we found that scutellarin was able to inhibit the proliferation and induce the apoptosis of hepg2 cells via a stat3 signal pathway, which provided evident support for developing scutellarin as an alternative treatment for liver cancer. |
2014-04-14 |
2023-08-12 |
Not clear |
| Pingping Xue, Yang Zhao, Yang Liu, Qianying Yuan, Chaomei Xiong, Jinlan Rua. A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells. Chemico-biological interactions. vol 209. 2014-04-14. PMID:24300195. |
a novel compound ry10-4 induces apoptosis and inhibits invasion via inhibiting stat3 through erk-, p38-dependent pathways in human lung adenocarcinoma a549 cells. |
2014-04-14 |
2023-08-12 |
human |
| K H Koo, H Kim, Y-K Bae, K Kim, B-K Park, C-H Lee, Y-N Ki. Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell death & disease. vol 4. 2014-02-25. PMID:23807222. |
taken together, our data indicate that salinomycin induces cell cycle arrest and apoptosis via downregulation or inactivation of cell cycle-associated oncogenes, such as stat3, cyclin d1, and skp2, regardless of multidrug resistance. |
2014-02-25 |
2023-08-12 |
Not clear |
| Ming Liu, Fei Wang, Zeqing Wen, Min Shi, Hui Zhan. Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells. Cancer investigation. vol 32. issue 1. 2014-02-20. PMID:24328557. |
the stat3 decoy odn treatment specifically blocked stat3 signaling, and inhibited cell proliferation by inducing apoptosis and cell cycle arrest. |
2014-02-20 |
2023-08-12 |
human |