| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxia Sun, Qiangjun Sui, Cai Zhang, Zhigang Tian, Jian Zhan. Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. Molecular cancer therapeutics. vol 12. issue 12. 2014-08-04. PMID:24107450. |
stat3 is an important transcriptional factor for cell growth, differentiation, and apoptosis. |
2014-08-04 |
2023-08-12 |
human |
| Janakiram Reddy Vangala, Srikanth Dudem, Nishant Jain, Shasi V Kalivend. Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24627483. |
combined treatments with bortezomib and inhibitor of stat3 abrogated proteasome activity and enhanced cellular apoptosis. |
2014-08-02 |
2023-08-12 |
Not clear |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
the results revealed that hela and siha cells treated by 100μm resveratrol showed extensive apoptosis, accompanied with suppression of stat3, notch and wnt activations. |
2014-07-25 |
2023-08-13 |
human |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
our results thus demonstrate that stat3, wnt and notch signaling are frequently co-activated in human cc cells and specimens and resveratrol can concurrently inhibit those signaling activations and meanwhile lead cervical squamous cell carcinoma and adenocarcinoma cells to growth arrest and apoptosis. |
2014-07-25 |
2023-08-13 |
human |
| Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Li. Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes & cancer. vol 5. issue 5-6. 2014-07-25. PMID:25061499. |
stat3 signaling is more critical for cc cells and is the major target of resveratrol because selective inhibition of stat3 rather than wnt or notch activation commits siha and hela cells to apoptosis. |
2014-07-25 |
2023-08-13 |
human |
| Kellie S Rath, Shan K Naidu, Pushpa Lata, Hemant K Bid, Brian K Rivera, Georgia A McCann, Brent J Tierney, Adam C Elnaggar, Veronica Bravo, Gustavo Leone, Peter Houghton, Kálmán Hideg, Periannan Kuppusamy, David E Cohn, Karuppaiyah Selvendira. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer research. vol 74. issue 8. 2014-07-24. PMID:24590057. |
rnai attenuation experiments confirmed the requirement of stat3 for ho-3867-mediated apoptosis in ovarian cancer cells. |
2014-07-24 |
2023-08-12 |
human |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
inactivation of hdac3 and stat3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia k562 cells. |
2014-07-15 |
2023-08-12 |
Not clear |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
consistently, silencing shp-1 and pervanadate, an inhibitor of protein tyrosine phosphatase, reversed inactivation of hdac and stat3, cleavages of caspase 3 and poly (adp-ribose) polymerase in lpc-induced apoptosis. |
2014-07-15 |
2023-08-12 |
Not clear |
| Ji Hoon Jung, Soo-Jin Jeong, Ji-Hyun Kim, Sung-Ki Jung, Deok-Beom Jung, Duckgu Lee, Eun Jung Sohn, Miyong Yun, Hyo-Jung Lee, Hyo-Jeong Lee, Sung-Hoon Ki. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23729004. |
overall, our findings indicate that inactivation of stat3 and hdac mediates lpc-induced apoptosis in cml k562 cells. |
2014-07-15 |
2023-08-12 |
Not clear |
| Wei-Ye Shi, Chang-Yan Che, Li Li. Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal transducers and activators of transcription factor 3 signaling pathways. International journal of molecular sciences. vol 14. issue 12. 2014-07-15. PMID:24351840. |
therefore, our data strongly indicates that il-23r is able to induce cell apoptosis by activating the intrinsic mitochondrial pathways associated with the inhibition in ras/mapk and stat3 activations in mammalian cells. |
2014-07-15 |
2023-08-12 |
human |
| Remi Fagard, Valeri Metelev, Inès Souissi, Fanny Baran-Marsza. STAT3 inhibitors for cancer therapy: Have all roads been explored? JAK-STAT. vol 2. issue 1. 2014-06-24. PMID:24058788. |
yet, there is still only a small number of stat3 direct inhibitors; in addition, the high similarity of stat3 with stat1, another stat family member mostly oriented toward apoptosis, cell death and defense against pathogens, requires that stat3-inhibitors have no effect on stat1. |
2014-06-24 |
2023-08-12 |
Not clear |
| Qian-Rong Qi, Zeng-Ming Yan. Regulation and function of signal transducer and activator of transcription 3. World journal of biological chemistry. vol 5. issue 2. 2014-06-24. PMID:24921012. |
recent studies have shown that stat3 can also translocate into mitochondria, participating in aerobic respiration and apoptosis. |
2014-06-24 |
2023-08-13 |
mouse |
| Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick, Devasis Chatterje. RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. BMC cancer. vol 13. 2014-06-23. PMID:24098947. |
in contrast, activated signal transducer and activator of transcription 3 (stat3) is a protein that promotes tumor cell survival by inhibiting apoptosis and has an important role in cancer progression in many of cancer types. |
2014-06-23 |
2023-08-12 |
Not clear |
| Kodappully Sivaraman Siveen, Sakshi Sikka, Rohit Surana, Xiaoyun Dai, Jingwen Zhang, Alan Prem Kumar, Benny K H Tan, Gautam Sethi, Anupam Bishaye. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica et biophysica acta. vol 1845. issue 2. 2014-06-13. PMID:24388873. |
there is strong evidence to suggest that aberrant stat3 signaling promotes initiation and progression of human cancers by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. |
2014-06-13 |
2023-08-12 |
human |
| Kodappully Sivaraman Siveen, Sakshi Sikka, Rohit Surana, Xiaoyun Dai, Jingwen Zhang, Alan Prem Kumar, Benny K H Tan, Gautam Sethi, Anupam Bishaye. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica et biophysica acta. vol 1845. issue 2. 2014-06-13. PMID:24388873. |
suppression of stat3 activation results in the induction of apoptosis in tumor cells, and accordingly its pharmacological modulation by tyrosine kinase inhibitors, antisense oligonucleotides, decoy nucleotides, dominant negative proteins, rna interference and chemopreventive agents have been employed to suppress the proliferation of various human cancer cells in culture and tumorigenicity in vivo. |
2014-06-13 |
2023-08-12 |
human |
| Xiaomei Ren, Lei Duan, Qiang He, Zhang Zhang, Yi Zhou, Donghai Wu, Jingxuan Pan, Duanqing Pei, Ke Din. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS medicinal chemistry letters. vol 1. issue 9. 2014-06-05. PMID:24900231. |
this compound potently inhibited the activation and transcriptional function of stat3 and consequently induced cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active stat3. |
2014-06-05 |
2023-08-13 |
human |
| Dae-Seop Shin, Seung Nam Jung, Jieun Yun, Chang Woo Lee, Dong Cho Han, Bumtae Kim, Yong Ki Min, Nam Sook Kang, Byoung-Mog Kwo. Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3. Biochemical pharmacology. vol 89. issue 1. 2014-05-29. PMID:24607275. |
the inhibition of stat3 phosphorylation led to the apoptosis of mda-mb-468 cells. |
2014-05-29 |
2023-08-12 |
human |
| Mon-Yuan Yang, Chau-Jong Wang, Nai-Fang Chen, Wen-Hsin Ho, Fung-Jou Lu, Tsui-Hwa Tsen. Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24525192. |
luteolin enhances paclitaxel-induced apoptosis in human breast cancer mda-mb-231 cells by blocking stat3. |
2014-05-27 |
2023-08-12 |
mouse |
| Rui Li, Shuo You, Zhongliang Hu, Zhuo G Chen, Gabriel L Sica, Fadlo R Khuri, Walter J Curran, Dong M Shin, Xingming Den. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PloS one. vol 8. issue 9. 2014-05-16. PMID:24019973. |
combined inhibition of egfr and stat3 by erlotinib and niclosamide more effectively induced apoptosis in tumor tissues without toxicity for normal tissues. |
2014-05-16 |
2023-08-12 |
Not clear |
| Mingli Liu, Nana O Wilson, Jacqueline M Hibbert, Jonathan K Stile. STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967200. |
stat3 regulates mmp3 in heme-induced endothelial cell apoptosis. |
2014-05-14 |
2023-08-12 |
mouse |