| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fawzia Bardag-Gorce, Barbara A French, Jennifer Dedes, Jun Li, Samuel W Frenc. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Experimental and molecular pathology. vol 80. issue 3. 2006-07-05. PMID:16770850. |
these included the insulin signaling pathway, tgfbeta signaling pathway, apoptosis, mapk signaling pathway, wnt signaling pathway and apoptosis. |
2006-07-05 |
2023-08-12 |
Not clear |
| Alastair J M Watso. An overview of apoptosis and the prevention of colorectal cancer. Critical reviews in oncology/hematology. vol 57. issue 2. 2006-05-10. PMID:16326109. |
depending on the cellular context, loss of apc activates the wnt signalling pathway causing immediate widespread apoptosis of colorectal epithelial cells and defects in differentiation and cell migration. |
2006-05-10 |
2023-08-12 |
Not clear |
| Alastair J M Watso. An overview of apoptosis and the prevention of colorectal cancer. Critical reviews in oncology/hematology. vol 57. issue 2. 2006-05-10. PMID:16326109. |
two gene targets of the wnt signalling pathway are of particular relevance to apoptosis. |
2006-05-10 |
2023-08-12 |
Not clear |
| Craig C Malbon, Hsien-Yu Wan. Dishevelled: a mobile scaffold catalyzing development. Current topics in developmental biology. vol 72. 2006-05-08. PMID:16564334. |
wnt proteins are secreted glycoprotein ligands that regulate critical aspects of development, including cell proliferation, apoptosis, and cell fate. |
2006-05-08 |
2023-08-12 |
Not clear |
| Mattias Ormestad, Jeanette Astorga, Henrik Landgren, Tao Wang, Bengt R Johansson, Naoyuki Miura, Peter Carlsso. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development (Cambridge, England). vol 133. issue 5. 2006-04-27. PMID:16439479. |
activation of the canonical wnt pathway -- with nuclear localization of beta-catenin in epithelial cells -- is associated with over-proliferation and resistance to apoptosis. |
2006-04-27 |
2023-08-12 |
Not clear |
| James Adjaye, John Huntriss, Ralf Herwig, Alia BenKahla, Thore C Brink, Christoph Wierling, Claus Hultschig, Detlef Groth, Marie-Laure Yaspo, Helen M Picton, Roger G Gosden, Hans Lehrac. Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells. Stem cells (Dayton, Ohio). vol 23. issue 10. 2006-03-17. PMID:16081659. |
the expression patterns suggest that the emergence of pluripotent icm and te cell lineages from the morula is controlled by metabolic and signaling pathways, which include inter alia, wnt, mitogen-activated protein kinase, transforming growth factor-beta, notch, integrin-mediated cell adhesion, phosphatidylinositol 3-kinase, and apoptosis. |
2006-03-17 |
2023-08-12 |
human |
| Sanja Kapitanović, Tamara Cacev, Mariastefania Antica, Marijeta Kralj, Gordana Cavrić, Kresimir Pavelić, Radan Spavent. Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells. Experimental and molecular pathology. vol 80. issue 1. 2006-02-28. PMID:15963497. |
in this paper, we present the effect of indomethacin on growth inhibition, induction of apoptosis, and alterations in the expression of several genes involved in wnt signaling in ht-29 colon cancer cells. |
2006-02-28 |
2023-08-12 |
Not clear |
| Maria Almeida, Li Han, Teresita Bellido, Stavros C Manolagas, Stavroula Kousten. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. The Journal of biological chemistry. vol 280. issue 50. 2006-02-07. PMID:16251184. |
wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving src/erk and phosphatidylinositol 3-kinase/akt. |
2006-02-07 |
2023-08-12 |
mouse |
| Maria Almeida, Li Han, Teresita Bellido, Stavros C Manolagas, Stavroula Kousten. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. The Journal of biological chemistry. vol 280. issue 50. 2006-02-07. PMID:16251184. |
genetic studies in humans and mice have revealed an important role of the wnt signaling pathway in the regulation of bone mass, resulting from potent effects on the control of osteoblast progenitor proliferation, commitment, differentiation, and perhaps osteoblast apoptosis. |
2006-02-07 |
2023-08-12 |
mouse |
| Caroline A Hanson, Jeffrey R Mille. Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. Gene. vol 361. 2006-01-12. PMID:16185824. |
however, a body of evidence is growing to support the idea that apc plays non-traditional functions outside of the wnt pathway with roles in cell migration, adhesion, chromosome segregation, spindle assembly, apoptosis, and neuronal differentiation. |
2006-01-12 |
2023-08-12 |
Not clear |
| Shiho Nakagiri, Akira Murakami, Shinji Takada, Tetsu Akiyama, Shin Yonehar. Viral FLIP enhances Wnt signaling downstream of stabilized beta-catenin, leading to control of cell growth. Molecular and cellular biology. vol 25. issue 21. 2005-12-20. PMID:16227577. |
thus, viral flip e8 not only inhibits death receptor-mediated apoptosis but also enhances wnt signaling pathways that are closely related to those of both ontogenesis and oncogenesis. |
2005-12-20 |
2023-08-12 |
Not clear |
| K Kashfi, B Riga. Molecular targets of nitric-oxide-donating aspirin in cancer. Biochemical Society transactions. vol 33. issue Pt 4. 2005-12-14. PMID:16042578. |
this effect is owing to cell kinetics [inhibition of proliferation, induction of apoptosis (multiple criteria) and blocking the g1 to s cell-cycle transition] and cell signalling [inhibition of wnt signalling (ic50=0.2 microm), inhibition of nf-kappab (nuclear factor kappab) activation (ic50=7.5 microm), inhibition of nitric oxide synthase-2 expression (ic50=48 microm), inhibition of mapk (mitogen-activated protein kinase) signalling (ic50=10 microm) and induction of cyclo-oxygenase-2 at approx. |
2005-12-14 |
2023-08-12 |
mouse |
| Minoru Narita, Kazuya Miyagawa, Michiko Narita, Keisuke Mizuo, Mayumi Miyatake, Suzuki Tsutom. [The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 25. issue 2. 2005-12-07. PMID:16220659. |
it has been accepted that gsk3beta in the wnt signal pathway plays an important role in various neuronal functions including apoptosis, clustering of synapsin i and early growth and axonal remodeling. |
2005-12-07 |
2023-08-12 |
mouse |
| Z Ju, M Kapoor, K Newton, K Cheon, A Ramaswamy, R Lotan, L C Strong, J S Ko. Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells. Molecular genetics and genomics : MGG. vol 274. issue 2. 2005-11-08. PMID:16049682. |
further analysis of the differentially expressed genes indicated that wnt responses, apoptosis, cell cycle regulation and cell proliferation were significantly altered in the h292 cells. |
2005-11-08 |
2023-08-12 |
human |
| Z Ju, M Kapoor, K Newton, K Cheon, A Ramaswamy, R Lotan, L C Strong, J S Ko. Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells. Molecular genetics and genomics : MGG. vol 274. issue 2. 2005-11-08. PMID:16049682. |
these findings show that (1) nsclc cells display deregulation of the wnt, apoptosis, proliferation and cell cycle pathways, as has been found in many other types of cancer cells, and (2) that organotypically cultured nhtbe cells can be used as a reference to identify genes and pathways that are differentially expressed in tumor cells derived from bronchogenic epithelium. |
2005-11-08 |
2023-08-12 |
human |
| Eun-Jin Lee, Hye-Young Min, Hwa-Jin Chung, Eun-Jung Park, Dae-Hong Shin, Lak Shin Jeong, Sang Kook Le. A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Biochemical pharmacology. vol 70. issue 6. 2005-10-03. PMID:16051194. |
these results suggest that a novel a3ar agonist, thio-cl-ib-meca can down-regulate wnt signaling, inhibit proliferation and induce apoptosis in hl-60 leukemia cells, and thus provide the possibility of this compound in the potential therapeutic value of the treatment of leukemia. |
2005-10-03 |
2023-08-12 |
human |
| Jennifer A Kennell, Ormond A MacDougal. Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. The Journal of biological chemistry. vol 280. issue 25. 2005-09-29. PMID:15849360. |
wnt signaling has been reported to block apoptosis and regulate differentiation of mesenchymal progenitors through inhibition of glycogen synthase kinase 3 and stabilization of beta-catenin. |
2005-09-29 |
2023-08-12 |
Not clear |
| Edgar Gil Rizzatti, Roberto Passetto Falcão, Rodrigo Alexandre Panepucci, Rodrigo Proto-Siqueira, Wilma Terezinha Anselmo-Lima, Oswaldo Keith Okamoto, Marco Antonio Zag. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. British journal of haematology. vol 130. issue 4. 2005-09-22. PMID:16098065. |
several genes related to apoptosis and to the pi3k/akt, wnt and tumour growth factor beta signalling pathways were altered in mcl cells when compared with naive b cells. |
2005-09-22 |
2023-08-12 |
Not clear |
| Fumiyuki Uematsu, Masakazu Takahashi, Midori Yoshida, Maki Igarashi, Naoto Watanabe, Noriko Suzuki, Masayoshi Abe, Ivan Rusyn, Robert A Floyd, Dai Naka. Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet. Cancer science. vol 96. issue 7. 2005-09-21. PMID:16053513. |
a total of 146 genes were identified as differentially expressed; the affected functions including metabolism, apoptosis, cell cycling, rna splicing, wnt signaling, reactive oxygen species-induced stress, and fibro/cirrhogenesis. |
2005-09-21 |
2023-08-12 |
rat |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain research. Brain research reviews. vol 49. issue 1. 2005-08-17. PMID:15960984. |
recent work has identified novel pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and the formation of neurofibrillary tangles through their downstream substrates that include glycogen synthase kinase-3beta, bad, and bcl-xl. |
2005-08-17 |
2023-08-12 |
Not clear |