| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Progress in neurobiology. vol 75. issue 3. 2005-07-29. PMID:15882775. |
current work has identified exciting pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and their downstream substrates that include forkhead transcription factors, glycogen synthase kinase-3beta, mitochondrial dysfunction, bad, and bcl-x(l). |
2005-07-29 |
2023-08-12 |
Not clear |
| Diviya Sinha, Zhiyong Wang, Kathleen L Ruchalski, Jerrold S Levine, Selvi Krishnan, Wilfred Lieberthal, John H Schwartz, Steven C Borka. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15572521. |
although wnt signaling antagonizes the effect of proapoptotic triggers, its role in regulating the default pathway of apoptosis is less well defined. |
2005-04-18 |
2023-08-12 |
mouse |
| Diviya Sinha, Zhiyong Wang, Kathleen L Ruchalski, Jerrold S Levine, Selvi Krishnan, Wilfred Lieberthal, John H Schwartz, Steven C Borka. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15572521. |
taken together, these data suggest that li(+) or bio promotes renal epithelial cell survival by inhibiting apoptosis through gsk3beta-dependent activation of the wnt pathway and subsequent release of igf-ii. |
2005-04-18 |
2023-08-12 |
mouse |
| Genevieve M Boland, Geraldine Perkins, David J Hall, Rocky S Tua. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. Journal of cellular biochemistry. vol 93. issue 6. 2005-04-14. PMID:15486964. |
the wnt 3a effect is accompanied by increased cell number, resulting from both increased proliferation and decreased apoptosis, particularly during expansion of undifferentiated mscs. |
2005-04-14 |
2023-08-12 |
human |
| Hui-Chuan Huang, Peter S Klei. Interactions between BMP and Wnt signaling pathways in mammalian cancers. Cancer biology & therapy. vol 3. issue 7. 2005-03-29. PMID:15280667. |
while the importance of wnt signaling in carcinogenesis has been well established, more recent work has also implicated bmp signaling in apoptosis and as a negative regulator of proliferation. |
2005-03-29 |
2023-08-12 |
human |
| Biao He, Amie Y Lee, Sina Dadfarmay, Liang You, Zhidong Xu, Noemi Reguart, Julien Mazieres, Iwao Mikami, Frank McCormick, David M Jablon. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705870. |
restoration of sfrp function attenuates wnt signaling and induces apoptosis in a variety of cancer types. |
2005-03-14 |
2023-08-12 |
human |
| Biao He, Amie Y Lee, Sina Dadfarmay, Liang You, Zhidong Xu, Noemi Reguart, Julien Mazieres, Iwao Mikami, Frank McCormick, David M Jablon. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705870. |
wnt signaling is known to inhibit apoptosis through activation of beta-catenin/tcf-mediated transcription. |
2005-03-14 |
2023-08-12 |
human |
| Biao He, Amie Y Lee, Sina Dadfarmay, Liang You, Zhidong Xu, Noemi Reguart, Julien Mazieres, Iwao Mikami, Frank McCormick, David M Jablon. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705870. |
reexpression of sfrp4 in these beta-catenin-deficient mesothelioma cell lines blocks wnt signaling, induces apoptosis, and suppresses growth. |
2005-03-14 |
2023-08-12 |
human |
| Biao He, Amie Y Lee, Sina Dadfarmay, Liang You, Zhidong Xu, Noemi Reguart, Julien Mazieres, Iwao Mikami, Frank McCormick, David M Jablon. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705870. |
conversely, knocking down sfrp4 by small interfering rna in cell lines expressing both sfrp4 and beta-catenin stimulates wnt signaling, promotes cell growth, and inhibits chemodrug-induced apoptosis. |
2005-03-14 |
2023-08-12 |
human |
| Laurent Meijer, Marc Flajolet, Paul Greengar. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in pharmacological sciences. vol 25. issue 9. 2005-02-10. PMID:15559249. |
three closely related forms of glycogen synthase kinase 3 (gsk-3alpha, gsk-3beta and gsk-3beta2) have a major role in wnt and hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. |
2005-02-10 |
2023-08-12 |
Not clear |
| Annette F Baas, Linda Smit, Hans Clever. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends in cell biology. vol 14. issue 6. 2004-12-13. PMID:15183188. |
mammalian lkb1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, wnt signaling, transforming growth factor (tgf)-beta signaling, ras-induced cell transformation, and energy metabolism. |
2004-12-13 |
2023-08-12 |
caenorhabditis_elegans |
| Eun Ok Lee, Yoo Jung Shin, Young Hae Chon. Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor. Journal of neuroimmunology. vol 155. issue 1-2. 2004-10-27. PMID:15342193. |
pge2 did not promote neurotoxicity, but rather had a strong protective effect against tnf-alpha by ameliorating tnf-alpha-induced apoptosis and also by rescuing the intracellular level of beta-catenin, a key transducer of the wnt signaling pathway. |
2004-10-27 |
2023-08-12 |
human |
| Desheng Lu, Yandong Zhao, Rommel Tawatao, Howard B Cottam, Malini Sen, Lorenzo M Leoni, Thomas J Kipps, Maripat Corr, Dennis A Carso. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14973184. |
uncontrolled wnt signaling may contribute to the defect in apoptosis that characterizes this malignancy. |
2004-06-17 |
2023-08-12 |
Not clear |
| Darina L Lazarova, Michael Bordonaro, Rocco Carbone, Alan C Sartorell. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International journal of cancer. vol 110. issue 4. 2004-06-15. PMID:15122584. |
linear relationship between wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. |
2004-06-15 |
2023-08-12 |
human |
| Darina L Lazarova, Michael Bordonaro, Rocco Carbone, Alan C Sartorell. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International journal of cancer. vol 110. issue 4. 2004-06-15. PMID:15122584. |
we have reported that butyrate, a fatty acid produced by dietary fiber that induces cell cycle arrest, differentiation and/or apoptosis in colorectal carcinoma (crc) cells in vitro, modulates wnt activity in 2 crc cell lines (bordonaro et al., int. |
2004-06-15 |
2023-08-12 |
human |
| Darina L Lazarova, Michael Bordonaro, Rocco Carbone, Alan C Sartorell. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International journal of cancer. vol 110. issue 4. 2004-06-15. PMID:15122584. |
our study determines how changes in the levels of wnt activity induced by butyrate relate to the effects of butyrate on apoptosis, cell cycle arrest and differentiation of crc cells. |
2004-06-15 |
2023-08-12 |
human |
| Darina L Lazarova, Michael Bordonaro, Rocco Carbone, Alan C Sartorell. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International journal of cancer. vol 110. issue 4. 2004-06-15. PMID:15122584. |
in 10 human crc cell lines a direct relationship was shown between apoptosis and butyrate-induced increase in wnt activity, as well as between suppressed clonal growth and increased wnt activity. |
2004-06-15 |
2023-08-12 |
human |
| Darina L Lazarova, Michael Bordonaro, Rocco Carbone, Alan C Sartorell. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International journal of cancer. vol 110. issue 4. 2004-06-15. PMID:15122584. |
the direct relationship between apoptosis and wnt activity was supported by analyses of dld-1 and hct-116 cells expressing a dominant negative form of tcf4, and therefore, with repressed wnt activity, as well as by measuring the ratio of apoptotic to live cells in flow cytometry-sorted cell fractions with high and low wnt activity. |
2004-06-15 |
2023-08-12 |
human |
| Allan S Wagman, Kirk W Johnson, Dirksen E Bussier. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Current pharmaceutical design. vol 10. issue 10. 2004-04-30. PMID:15078145. |
originally identified as a modulator of glycogen metabolism, glycogen synthase kinase-3 (gsk3) is now understood to play an important regulatory role in a variety of pathways including initiation of protein synthesis, cell proliferation, cell differentiation, apoptosis, and is essential for embryonic development as a component of the wnt signaling cascade. |
2004-04-30 |
2023-08-12 |
Not clear |
| Alexandre de la Taille, Mark A Rubin, Min-Wei Chen, Francis Vacherot, Sixtina Gil-Diez de Medina, Martin Burchardt, Ralph Buttyan, Dominique Chopi. Beta-catenin-related anomalies in apoptosis-resistant and hormone-refractory prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 5. 2004-01-12. PMID:12738737. |
beta-catenin is a critical end component of the wnt signaling pathway that regulates cell growth, apoptosis, and migratory behavior in response to intercellular adhesion molecules. |
2004-01-12 |
2023-08-12 |
human |