| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bart De Cat, Sin-Ya Muyldermans, Christien Coomans, Gisèle Degeest, Bernadette Vanderschueren, John Creemers, Frédéric Biemar, Bernard Peers, Guido Davi. Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. The Journal of cell biology. vol 163. issue 3. 2004-01-12. PMID:14610063. |
the processed gpc3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical wnt signaling additionally require substitution of the core protein with heparan sulfate. |
2004-01-12 |
2023-08-12 |
mouse |
| Hiroaki Shiina, Mikio Igawa, Julia Breault, Leopoldo Ribeiro-Filho, Deepa Pookot, Shinji Urakami, Masaharu Terashima, Masao Deguchi, Masaki Yamanaka, Masato Shirai, Masanori Kaneuchi, Christopher J Kane, Rajvir Dahiy. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 6. 2004-01-06. PMID:12796377. |
the human t-cell factor-4 gene splicing isoforms, wnt signal pathway, and apoptosis in renal cell carcinoma. |
2004-01-06 |
2023-08-12 |
human |
| Hiroaki Shiina, Mikio Igawa, Julia Breault, Leopoldo Ribeiro-Filho, Deepa Pookot, Shinji Urakami, Masaharu Terashima, Masao Deguchi, Masaki Yamanaka, Masato Shirai, Masanori Kaneuchi, Christopher J Kane, Rajvir Dahiy. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 6. 2004-01-06. PMID:12796377. |
we demonstrate for the first time that tcf-4 gene splicing isoforms and the wnt signal pathway can induce progression of rcc by the inhibition of apoptosis and not by the induction of cell proliferation. |
2004-01-06 |
2023-08-12 |
human |
| Gregory H Underhill, David George, Eric G Bremer, Geoffrey S Kansa. Gene expression profiling reveals a highly specialized genetic program of plasma cells. Blood. vol 101. issue 10. 2003-07-18. PMID:12543863. |
furthermore, plasma cells displayed alterations in multiple components of the wnt and notch signaling pathways and showed a unique pattern of apoptosis and proliferation-associated genes. |
2003-07-18 |
2023-08-12 |
Not clear |
| Wang Yanfeng, Jean-Pierre Saint-Jeannet, Peter S Klei. Wnt-frizzled signaling in the induction and differentiation of the neural crest. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 25. issue 4. 2003-07-10. PMID:12655639. |
here we review a number of recent studies supporting a role for wnt signaling in neural crest induction, differentiation, and apoptosis. |
2003-07-10 |
2023-08-12 |
Not clear |
| A E Bonner, W J Lemon, M Yo. Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis. Journal of medical genetics. vol 40. issue 6. 2003-07-07. PMID:12807961. |
using the pathway visualisation tool, genmapp, at least three regulatory pathways were found to contain clusters of differentially expressed genes: wnt signalling, cell cycle, and apoptosis. |
2003-07-07 |
2023-08-12 |
mouse |
| Han Li, Rifat Pamukcu, W Joseph Thompso. beta-Catenin signaling: therapeutic strategies in oncology. Cancer biology & therapy. vol 1. issue 6. 2003-06-16. PMID:12642683. |
exisulind and analogues are inhibitors of cyclic gmp phosphodiesterases (pde) that have been shown to activate and induce protein kinase g. the data show pkg regulation of beta-catenin in wnt signaling, accounting, at least in part, for apoptosis induction in treated colon cancer cells carrying either apc or beta-catenin mutations. |
2003-06-16 |
2023-08-12 |
human |
| Shuhei Kameya, Norman L Hawes, Bo Chang, John R Heckenlively, Jürgen K Naggert, Patsy M Nishin. Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Human molecular genetics. vol 11. issue 16. 2003-02-05. PMID:12140190. |
wnt signaling has been shown to be involved in the control of gene expression, cell adhesion, planar polarity, proliferation and apoptosis. |
2003-02-05 |
2023-08-12 |
mouse |
| Lisette Hari, Véronique Brault, Maurice Kléber, Hye-Youn Lee, Fabian Ille, Rainer Leimeroth, Christian Paratore, Ueli Suter, Rolf Kemler, Lukas Somme. Lineage-specific requirements of beta-catenin in neural crest development. The Journal of cell biology. vol 159. issue 5. 2003-01-23. PMID:12473692. |
moreover, it is a downstream signaling component of wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. |
2003-01-23 |
2023-08-12 |
Not clear |
| Keith A Wharto. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Developmental biology. vol 253. issue 1. 2003-01-16. PMID:12490194. |
depending on the context, a given wnt signal may denote: cell proliferation or apoptosis; cell fate determination, differentiation, or stem cell maintenance; a variety of changes in cell behavior; and/or coordinated interactions with its neighbors. |
2003-01-16 |
2023-08-12 |
human |
| Aruna S Jaiswal, Benjamin P Marlow, Nirupama Gupta, Satya Naraya. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466962. |
our results suggest that curcumin treatment impairs both wnt signaling and cell-cell adhesion pathways, resulting in g(2)/m phase arrest and apoptosis in hct-116 cells. |
2003-01-06 |
2023-08-12 |
Not clear |
| Kenneth A Longo, Jennifer A Kennell, Margaret J Ochocinska, Sarah E Ross, Wendy S Wright, Ormond A MacDougal. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12154096. |
wnt signaling protects 3t3-l1 preadipocytes from apoptosis through induction of insulin-like growth factors. |
2002-11-25 |
2023-08-12 |
Not clear |
| Kenneth A Longo, Jennifer A Kennell, Margaret J Ochocinska, Sarah E Ross, Wendy S Wright, Ormond A MacDougal. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12154096. |
although activation of wnt signaling by inhibition of gsk-3 activity or ectopic expression of dominant stable beta-catenin blocks apoptosis, inhibition of wnt signaling through expression of dominant negative tcf-4 increases apoptosis. |
2002-11-25 |
2023-08-12 |
Not clear |
| Steve E Jones, Catherine Jomar. Secreted Frizzled-related proteins: searching for relationships and patterns. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 24. issue 9. 2002-10-30. PMID:12210517. |
the wnt networks influence biological processes ranging from developmental cell fate, cell polarity and adhesion to tumorigenesis and apoptosis. |
2002-10-30 |
2023-08-12 |
Not clear |
| Janet Y Leung, Frank T Kolligs, Rong Wu, Yali Zhai, Rork Kuick, Samir Hanash, Kathleen R Cho, Eric R Fearo. Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. The Journal of biological chemistry. vol 277. issue 24. 2002-07-25. PMID:11940574. |
the wnt pathway regulates cell fate, proliferation, and apoptosis, and defects in the pathway play a key role in many cancers. |
2002-07-25 |
2023-08-12 |
human |
| Lillian Shum, Glen Nuckoll. The life cycle of chondrocytes in the developing skeleton. Arthritis research. vol 4. issue 2. 2002-06-20. PMID:11879545. |
extracellular growth and differentiation factors including bone morphogenetic proteins, fibroblast growth factors, parathyroid hormone-related peptide, extracellular matrix components, and members of the hedgehog and wnt families provide important signals for the regulation of cell proliferation, differentiation and apoptosis. |
2002-06-20 |
2023-08-12 |
Not clear |
| Zongbing You, Daniel Saims, Shaoqiong Chen, Zhaocheng Zhang, Denis C Guttridge, Kun-Liang Guan, Ormond A MacDougald, Anthony M C Brown, Gerard Evan, Jan Kitajewski, Cun-Yu Wan. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of cell biology. vol 157. issue 3. 2002-05-22. PMID:11980918. |
wnt signaling promotes oncogenic transformation by inhibiting c-myc-induced apoptosis. |
2002-05-22 |
2023-08-12 |
mouse |
| Zongbing You, Daniel Saims, Shaoqiong Chen, Zhaocheng Zhang, Denis C Guttridge, Kun-Liang Guan, Ormond A MacDougald, Anthony M C Brown, Gerard Evan, Jan Kitajewski, Cun-Yu Wan. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of cell biology. vol 157. issue 3. 2002-05-22. PMID:11980918. |
these results elucidate the molecular mechanisms by which wnt/beta-catenin inhibits apoptosis and provide new insight into wnt signaling-mediated oncogenesis. |
2002-05-22 |
2023-08-12 |
mouse |
| Nicholas A Shackel, Peter H McGuinness, Catherine A Abbott, Mark D Gorrell, Geoffrey W McCaugha. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. The American journal of pathology. vol 160. issue 2. 2002-03-19. PMID:11839585. |
novel observations of differential gene expression included increased expression of secreted apoptosis-related protein 3, a wnt pathway gene possibly involved in cellular apoptosis. |
2002-03-19 |
2023-08-12 |
Not clear |
| Jiang Shou, Francis Ali-Osman, Asha S Multani, Sen Pathak, Paolo Fedi, Kalkunte S Srivenugopa. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene. vol 21. issue 6. 2002-03-05. PMID:11840333. |
human dkk-1, a gene encoding a wnt antagonist, responds to dna damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of dna. |
2002-03-05 |
2023-08-12 |
human |