| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph A Kim, Kelly A Pollak, Gregory O Hjelmstad, Howard L Field. A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 15. 2004-05-19. PMID:15064402. |
thus, through a circuit involving the ventral tegmental area, a single cocaine exposure enhanced both micro-opioid receptor reward and kappa-opioid receptor aversion. |
2004-05-19 |
2023-08-12 |
rat |
| Vasile Hefco, Kiyofumi Yamada, Andreea Hefco, Lucian Hritcu, Adrian Tiron, Toshitaka Nabeshim. Role of the mesotelencephalic dopamine system in learning and memory processes in the rat. European journal of pharmacology. vol 475. issue 1-3. 2004-05-03. PMID:12954359. |
our findings suggest that ventral tegmental area and substantia nigra dopaminergic neurons play an important role in retention of both short-term memory, tested in the y-maze task and long-term memory evaluated with the multi-trial passive avoidance test, without affecting memory acquisition. |
2004-05-03 |
2023-08-12 |
rat |
| Mark A Ungless, Peter J Magill, J Paul Bola. Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science (New York, N.Y.). vol 303. issue 5666. 2004-04-22. PMID:15044807. |
uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
2004-04-22 |
2023-08-12 |
rat |
| Marzia Foddai, Gabriella Dosia, Saturnino Spiga, Marco Dian. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14973432. |
these results also suggest that acetaldehyde, by increasing da neuronal activity in the vta, may significantly contribute to the centrally mediated positive motivational properties of ethanol, which would oppose the well-known peripherally originating aversive properties. |
2004-04-14 |
2023-08-12 |
rat |
| Sondra T Bland, David Hargrave, Julie L Pepin, Jose Amat, Linda R Watkins, Steven F Maie. Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784102. |
the mpfc also contains dopaminergic afferents from the ventral tegmental area, which has been the focus of many studies exploring both the rewarding properties of drugs and the aversive properties of stress. |
2003-10-06 |
2023-08-12 |
rat |
| Carlos A Bolaños, Linda I Perrotti, Scott Edwards, Amelia J Eisch, Michel Barrot, Valerie G Olson, David S Russell, Rachael L Neve, Eric J Nestle. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 20. 2003-09-23. PMID:12930795. |
using viral-mediated gene transfer to locally alter the activity of plcgamma1, we show that overexpression of plcgamma1 in rostral portions of the vta (r-vta) results in increased morphine place preference, whereas plcgamma1 overexpression in the caudal vta (c-vta) results in avoidance of morphine-paired compartments. |
2003-09-23 |
2023-08-12 |
Not clear |
| Carlos A Bolaños, Linda I Perrotti, Scott Edwards, Amelia J Eisch, Michel Barrot, Valerie G Olson, David S Russell, Rachael L Neve, Eric J Nestle. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 20. 2003-09-23. PMID:12930795. |
these results show that levels of plcgamma1 in the vta regulate responsiveness to drugs of abuse, natural rewards, and aversive stimuli and point to the possibility that distinct topographical regions within the vta mediate generally positive versus negative responses to emotional stimuli. |
2003-09-23 |
2023-08-12 |
Not clear |
| Carlos A Bolaños, Linda I Perrotti, Scott Edwards, Amelia J Eisch, Michel Barrot, Valerie G Olson, David S Russell, Rachael L Neve, Eric J Nestle. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 20. 2003-09-23. PMID:12930795. |
moreover, these data also support a role for drug-induced elevations in plcgamma1 expression in the vta in mediating long-term adaptations to drugs of abuse and aversive stimuli. |
2003-09-23 |
2023-08-12 |
Not clear |
| Catherine Bielajew, Magali Diotte, Eleftherios Milairessi. Effects of naloxone on rewarding and aversive brain sites. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842298. |
the effects of naloxone on the rewarding and aversive properties of brain stimulation derived from the ventral tegmental area and the nucleus reticularis gigantocellularis, respectively, were assessed in rats, based on the following measures-the current threshold for latency to escape aversive nucleus reticularis gigantocellularis stimulation, the frequency threshold for rewarding ventral tegmental area stimulation, and the frequency threshold for self-stimulation obtained from delivery of concurrent ventral tegmental area and nucleus reticularis gigantocellularis stimulation, before and after three systemic doses of naloxone (0, 10, and 20mg/kg); in the latter case, the stimulation trains were interdigitated with an interpulse interval of 2 ms. |
2003-09-09 |
2023-08-12 |
rat |
| S R Laviolette, D van der Koo. Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area. Molecular psychiatry. vol 8. issue 1. 2003-07-29. PMID:12556908. |
here, we report that the mammalian ventral tegmental area (vta) represents a critical neural substrate for the mediation of both the rewarding and aversive properties of nicotine. |
2003-07-29 |
2023-08-12 |
Not clear |
| S R Laviolette, D van der Koo. Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area. Molecular psychiatry. vol 8. issue 1. 2003-07-29. PMID:12556908. |
we demonstrate that direct infusions of nicotine into the vta can produce both rewarding and aversive motivational effects. |
2003-07-29 |
2023-08-12 |
Not clear |
| Steven R Laviolette, Derek van der Koo. The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor. Psychopharmacology. vol 166. issue 3. 2003-05-07. PMID:12569428. |
the motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor. |
2003-05-07 |
2023-08-12 |
rat |
| Steven R Laviolette, Derek van der Koo. The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor. Psychopharmacology. vol 166. issue 3. 2003-05-07. PMID:12569428. |
within the mammalian ventral tegmental area (vta), nicotine produces both aversive and rewarding motivational effects. |
2003-05-07 |
2023-08-12 |
rat |
| Steven R Laviolette, Tania O Alexson, Derek van der Koo. Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 19. 2002-10-24. PMID:12351739. |
lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. |
2002-10-24 |
2023-08-12 |
Not clear |
| Steven R Laviolette, Tania O Alexson, Derek van der Koo. Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 19. 2002-10-24. PMID:12351739. |
however, the neural outputs from the vta that may be involved in the transmission of the rewarding and aversive motivational effects of nicotine are not well understood. |
2002-10-24 |
2023-08-12 |
Not clear |
| M Diotte, C Bielajew, M Miguelez, E Miliaressi. Factors that influence the persistence of stimulation-induced aversion. Physiology & behavior. vol 72. issue 5. 2001-07-05. PMID:11336997. |
unlike our previous experience with gi aversion that required either pairing with rewarding lateral hypothalamic (lh) or ventral tegmental area (vta) pulses in order to increase the threshold for latency to escape gi aversion, in this study, simply brief experience with rewarding dr stimulation in unpaired trials was sufficient to entirely suppress gi-induced aversion. |
2001-07-05 |
2023-08-12 |
Not clear |
| W A Carlezon, C N Haile, R Coppersmith, Y Hayashi, R Malinow, R L Neve, E J Nestle. Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-06-02. PMID:10684909. |
we now report that in rats given hsv-glur1 directly into the vta, morphine is most rewarding when maximal transgene expression is in the rostral vta, whereas morphine is aversive when maximal transgene expression is in the caudal vta. |
2000-06-02 |
2023-08-12 |
rat |
| W A Carlezon, C N Haile, R Coppersmith, Y Hayashi, R Malinow, R L Neve, E J Nestle. Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-06-02. PMID:10684909. |
these results suggest that distinct substrates within the vta itself differentially contribute to the rewarding and aversive properties of opiates. |
2000-06-02 |
2023-08-12 |
rat |
| F A Guarraci, B S Kap. An electrophysiological characterization of ventral tegmental area dopaminergic neurons during differential pavlovian fear conditioning in the awake rabbit. Behavioural brain research. vol 99. issue 2. 1999-10-27. PMID:10512583. |
while this research suggests that da neurons in the vta are activated by aversive events, there has been a paucity of electrophysiological research designed to examine the sensory response characteristics of these da neurons, and in particular their response to stimuli which predict aversive events. |
1999-10-27 |
2023-08-12 |
rat |
| F A Guarraci, B S Kap. An electrophysiological characterization of ventral tegmental area dopaminergic neurons during differential pavlovian fear conditioning in the awake rabbit. Behavioural brain research. vol 99. issue 2. 1999-10-27. PMID:10512583. |
these overall results suggest that conditioned aversive stimuli can affect the firing of vta da neurons and that these neurons comprise a heterogenous population with respect to their response profiles. |
1999-10-27 |
2023-08-12 |
rat |