| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
intracerebroventricular injection of msa into the brains of c57bl/6j mice to a similar concentration as in patient brains induced neuronal apoptosis, neuroinflammation, increased tau phosphorylation, and decreased the spatial learning and memory abilities, while elovl1 knockdown significantly prevented the deleterious effect of msa. |
2024-04-23 |
2024-04-26 |
mouse |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Charlene P Poore, Nurul A M N Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Lia. TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia. Neurobiology of disease. 2024-01-10. PMID:38199274. |
using a rat model of chronic hypoxia with both common carotid arteries occluded, we found that m4p treatment could reduce apoptosis in the neurons within the hippocampus, attenuate long-term potentiation impairment and improve the functions of learning and memory in this rat model. |
2024-01-10 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Jingjing Ge, Xiaoling Jiao, Hui L. MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063094. |
injection of mir-126-3p mimic raised the learning and memory abilities through down-regulating the cerebral ischemic area, improving pathological damage of the cortex, reducing the neurons apoptosis of the cortex and down-regulating the autophagy-related and apoptosis-related proteins. |
2023-12-08 |
2023-12-17 |
rat |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the rats fed with copper-laden diet for 12 weeks, and the effect of chr on the copper content in liver and 24-h urine, the learning and memory ability, the morphological changes and the apoptosis level of neurons in hippocampal ca1 region, the expression level of bax, bcl-2, cleaved caspase-3, p-pi3k, pi3k, p-akt, and akt proteins were detected. |
2023-11-24 |
2023-11-29 |
human |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the experiments showed that chr could reduce the copper content in liver, increase the copper content in 24-h urine, improve the ability of the learning and memory, alleviate the damage and apoptosis level of hippocampal neurons, down-regulate the expression of bax, cleaved caspase-3, and up-regulate the expressions of bcl-2, p-pi3k/pi3k, p-akt/akt. |
2023-11-24 |
2023-11-29 |
human |
| Meng-Nan Zeng, Bing Cao, Ao-Zi Feng, Peng-Li Guo, Meng Liu, Yu-Han Zhang, Meng Li, Xiao-Ke Zhen. [Platycladi Semen oil ameliorates Aβ_(25-35)-induced brain injury in mice based on network pharmacology and gut microbiota]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 15. 2023-10-06. PMID:37802772. |
learning and memory ability, neuronal damage, levels of aβ_(1-42)/aβ_(1-40), p-tau, related indicators of apoptosis and oxidative stress, and immune cells, and protein and mrna expression related to the sphingosine kinase 1(sphk1)/sphingosine-1-phosphate(s1p)/sphingosine-1-phosphate receptor 5(s1pr5) signaling pathway of mice in each group were determined. |
2023-10-06 |
2023-10-15 |
mouse |
| Meng-Nan Zeng, Bing Cao, Ao-Zi Feng, Peng-Li Guo, Meng Liu, Yu-Han Zhang, Meng Li, Xiao-Ke Zhen. [Platycladi Semen oil ameliorates Aβ_(25-35)-induced brain injury in mice based on network pharmacology and gut microbiota]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 15. 2023-10-06. PMID:37802772. |
the results showed that sp could improve the learning and memory function of aβ_(25-35)-induced mice, reduce hippocampal neuronal damage, decrease the levels of aβ_(1-42)/aβ_(1-40), p-tau, and indicators related to apoptosis and oxidative stress in the brain, and maintain the homeostasis of immune cells and gm. |
2023-10-06 |
2023-10-15 |
mouse |
| Haojie Ni, Yanfang Liao, Yifan Zhang, Huinian Lu, Zhiju Huang, Fengming Huang, Zhende Zhang, Yan Dong, Zihao Wang, Yujie Huan. Levistilide A ameliorates neuroinflammation via inhibiting JAK2/STAT3 signaling for neuroprotection and cognitive improvement in scopolamine-induced Alzheimer's disease mouse model. International immunopharmacology. vol 124. issue Pt A. 2023-08-24. PMID:37619415. |
we show that la suppresses neuronal apoptosis, restores cholinergic system function, and lowers neuroinflammation in vivo to improve scopolamine (scop)-induced learning and memory deficits. |
2023-08-24 |
2023-09-07 |
mouse |
| Jiawei Zhang, Yining Xiao, Hongna Liu, Lili Xu, Xing Guo, Yaran Gao, Meixi Li, Jing Xu, Qianqian Qi, Peiyuan L. Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats. Neurochemical research. 2023-06-20. PMID:37338792. |
the results indicated that edb ameliorates learning and memory in rats subjected to the vd model, alleviates neuroinflammatory response by reducing the proliferation of the neuroglial cell and inhibits apoptosis and autophagy, which may be mediated by the pi3k/akt/mtor signaling pathway. |
2023-06-20 |
2023-08-14 |
rat |
| Xiao-Bo Bi, Xia Zhang, Ji-Peng Wen, Wei Ding, Jin L. [Effects of repeated sevoflurane exposure on hippocampal cell apoptosis and long-term learning and memory ability in neonatal rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 6. 2023-06-12. PMID:37308440. |
[effects of repeated sevoflurane exposure on hippocampal cell apoptosis and long-term learning and memory ability in neonatal rats]. |
2023-06-12 |
2023-08-14 |
rat |
| Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemat. Neuroprotective Effect of Wharton's Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neuroinflammation, and Apoptosis. Stem cells international. vol 2023. 2023-04-21. PMID:37081849. |
in the current study, we aimed to examine the effects of wharton's jelly-derived mesenchymal stem cell-conditioned medium (wjmsc-cm) on learning and memory, oxidative stress, apoptosis, and histological changes in the hippocampus of diabetic rats. |
2023-04-21 |
2023-08-14 |
rat |
| Guiping Xu, Yang Wang, Zhe Chen, Yuxuan Zhang, Xuexue Zhang, Guichao Zhan. Esketamine improves propofol-induced brain injury and cognitive impairment in rats. Translational neuroscience. vol 13. issue 1. 2022-12-23. PMID:36561289. |
the results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. |
2022-12-23 |
2023-08-14 |
human |
| Zhihong Zhuo, Huimin Kong, Peina Jin, Youhong Re. The ubiquitin-editing enzyme TNFAIP3 exerts neuroprotective roles in epilepsy rats through repressing inflammation. General physiology and biophysics. vol 41. issue 6. 2022-12-01. PMID:36454111. |
besides, tnfaip3 overexpression relieved the spatial learning and memory, reduced the hot plate latency, as well as inhibited neuronal apoptosis in ka-treated mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Weijie Xie, Yanqin Zeng, Yunqiu Zheng, Bin Ca. Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice. Cellular and molecular neurobiology. 2022-11-28. PMID:36441266. |
three months after bcas, we measured the ampk protein expression, spatial learning and memory, nissl bodies, cell apoptosis, astrocyte activation, and oligodendrocyte maturation. |
2022-11-28 |
2023-08-14 |
mouse |
| Seyed Hamidreza Rastegar-Moghaddam, Fatemeh Alipour, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats during the growth period. Life sciences. 2022-11-21. PMID:36410409. |
the current study was designed to investigate the protective effects of vitamin d (vd) on hippocampal neurogenesis, apoptosis, and subsequent hippocampal-dependent learning and memory performance in hypothyroid juvenile rats. |
2022-11-21 |
2023-08-14 |
rat |
| Seyed Hamidreza Rastegar-Moghaddam, Fatemeh Alipour, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats during the growth period. Life sciences. 2022-11-21. PMID:36410409. |
in conclusion, these results support a role for vd in the restoring hippocampal neurogenesis impairment, reducing neuronal apoptosis, and dns in hypothyroid rats as well as raise the possibility that vd may contribute as a therapeutic approach to improve the learning and memory deficits associated with hypothyroidism. |
2022-11-21 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
learning and memory abilities were assessed by morris water maze (mwm) trainings; pathological alterations in hippocampal region were assessed by he staining; neuronal apoptosis was assessed by tunel; related protein expression was analyzed by immunofluorescence, immunohistochemistry, and western blotting. |
2022-11-02 |
2023-08-14 |
rat |