| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Qu, Xiaowei Xiong, Gulibaha Hujie, Jun Ren, Lihui Yan, Liqun M. MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1. Cell cycle (Georgetown, Tex.). vol 20. issue 21. 2021-11-12. PMID:34585626. |
microrna-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in alzheimer's disease by downregulation of hnrnpu stabilized bace1. |
2021-11-12 |
2023-08-13 |
Not clear |
| Chang-Hai Fu, Xue-Yan Han, Lei Tong, Peng-Yin Nie, Yue-Dong Hu, Li-Li J. miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice. Behavioural brain research. vol 414. 2021-11-04. PMID:34302879. |
mir-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pcamkii and bai3 in the hippocampus of app/ps1 transgenic mice. |
2021-11-04 |
2023-08-13 |
mouse |
| Retraction. Journal of cellular biochemistry. vol 122 Suppl 1. 2021-11-01. PMID:34288079. |
retraction: "down-regulated long non-coding rna anril restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin-induced diabetic rats via the nf-κb signaling pathway," by xin wen, xin-rui han, yong-jian wang, shan wang, min shen, zi-feng zhang, shao-hua fan, qun shan, liang wang, meng-qiu li, bin hu, chun-hui sun, dong-mei wu, jun lu, yuan-lin zheng, j cell biochem. |
2021-11-01 |
2023-08-13 |
rat |
| Weiye Zhu, Jiasheng Ding, Liang Sun, Jiang Wu, Xiang Xu, Wenjie Wang, Haiying Li, Haitao Shen, Xiang Li, Zhengquan Yu, Gang Che. Heterogeneous nuclear ribonucleoprotein A1 exerts protective role in intracerebral hemorrhage-induced secondary brain injury in rats. Brain research bulletin. vol 165. 2021-10-26. PMID:33053433. |
however, downregulated hnrnpa1 damages neurological function and learning and memory abilities and aggravates neuronal cell degeneration and apoptosis. |
2021-10-26 |
2023-08-13 |
rat |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. issue 1. 2021-10-13. PMID:34535636. |
here, we report that the serine protease inhibitor serpina3n is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (hsi), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after hsi. |
2021-10-13 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
our findings showed that the qjd-treated groups, especially the m-qjd group, mitigated learning and memory impairments of the model of brain aging as well as the improvement of neurodegenerative changes and hippocampal neuron apoptosis. |
2021-10-12 |
2023-08-13 |
mouse |
| Mingliang Xu, Jianguo Feng, Mingxi Tang, Qingxi Guo, Jian Zhan, Fuzu Zhu, Hong Lei, Qingmei Kan. Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. Acta neurologica Belgica. vol 121. issue 5. 2021-10-02. PMID:32385796. |
morris water maze experiment was used to test the learning and memory abilities of mice, flow cytometry was conducted to detect apoptosis and mitochondrial membrane potential of brain cells in mice, transmission electron microscopy was used to observe the number of autophagosomes at the axon in mice, and western blot was carried out to detect the expression of bax, bcl-2, lc3ii, p62, kif3b and dic proteins of brain cells in mice. |
2021-10-02 |
2023-08-13 |
mouse |
| Mingliang Xu, Jianguo Feng, Mingxi Tang, Qingxi Guo, Jian Zhan, Fuzu Zhu, Hong Lei, Qingmei Kan. Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. Acta neurologica Belgica. vol 121. issue 5. 2021-10-02. PMID:32385796. |
sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in appswe/ps1Δe9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons. |
2021-10-02 |
2023-08-13 |
mouse |
| Emily M Pitzer, Michael T Williams, Charles V Vorhee. Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicology and teratology. vol 87. 2021-09-21. PMID:33848594. |
but existing data clearly show there are lasting effects on locomotor activity, acoustic startle, learning and memory, apoptosis, and dopamine in mice and rats after early exposure. |
2021-09-21 |
2023-08-13 |
mouse |
| Peng Song, Biao Yan, Fan Lei, Zhuonan Qiu, Chi Zhang, Yang Wu, Shaohui Chen, Xu Yang, Dingwen Shen, Ping M. Continuous artificial light at night exacerbates diisononyl phthalate-induced learning and memory impairment in mice: Toxicological evidence. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 151. 2021-09-14. PMID:33711377. |
the results showed that oxidative stress levels increased with increasing dinp exposure concentrations, which triggered apoptosis (bcl-2 levels decreased, bax levels increased), resulting in nerve cell damage and a decline in the learning and memory abilities of mice. |
2021-09-14 |
2023-08-13 |
mouse |
| Wei Chen, Jianwu Zhang, Jing Wang, Yunxiang Li, Wenhu Liu, Jun Xi. Lycopene supplementation protects vascular dementia gerbils against the impairment of learning and memory. Folia neuropathologica. vol 59. issue 2. 2021-07-21. PMID:34284544. |
we therefore conclude that lyc can improve the learning and memory ability of vad gerbils, the mechanism of which may be related to reduced oxidative stress and apoptosis in vad hippocampus neurons. |
2021-07-21 |
2023-08-13 |
Not clear |
| Xiujun Qin, Liang Li, Xiaohan Nie, Qiao Ni. Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31845204. |
long-term exposure to aluminum could induce the apoptosis of hippocampal neurons, damage the synaptic plasticity, and impair the learning and memory functions in rats. |
2021-06-18 |
2023-08-13 |
rat |
| Jie Chen, Haochen Wang, Chengliang Luo, Cheng Gao, Yalai Zhang, Guang Chen, Wei Chen, Xiping Chen, Luyang Ta. Chd8 Rescued TBI-Induced Neurological Deficits by Suppressing Apoptosis and Autophagy Via Wnt Signaling Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32034634. |
chd8 knockdown inhibited wnt pathway, promoted the activation of apoptosis and autophagy, and caused learning and memory impairments both at normal and tbi condition. |
2021-06-11 |
2023-08-13 |
Not clear |
| Muhammad M Hossain, Jason R Richardso. Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31841155. |
collectively, these results demonstrate that the loss of ngf following er stress may contribute to deltamethrin-induced apoptosis in the hippocampus through the akt signaling pathway, and that this may provide a plausible mechanism for impaired learning and memory observed following exposure of mice to deltamethrin. |
2021-06-09 |
2023-08-13 |
mouse |
| Xi Chen, Hansen Chen, Yachong He, Shuping Fu, Haosheng Liu, Qi Wang, Jiangang She. Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades. Molecular neurobiology. vol 57. issue 10. 2021-06-09. PMID:32700252. |
in the present study, we investigated the effects of bhd on inhibiting neuronal apoptosis, promoting proliferation and differentiation of neural stem cells (nscs) and neurite formation and enhancing learning and memory functional recovery in an experimental rat ischemic stroke model. |
2021-06-09 |
2023-08-13 |
rat |
| Lulu An, Yi Shen, Michael Chopp, Alex Zacharek, Poornima Venkat, Zhili Chen, Wei Li, Yu Qian, Julie Landschoot-Ward, Jieli Che. Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094639. |
compared to corresponding sham mice, bcas in wild-type (wt) and enos-/- mice significantly: 1) induces short term, long term memory loss, spatial learning and memory deficits; 2) decreases cbf, increases ischemic cell damage, including apoptosis, white matter (wm) and axonal damage; 3) increases blood brain barrier (bbb) leakage, decreases aquaporin-4 (aqp4) expression and vessel density; 4) increases microglial, astrocyte activation and oxidative stress in the brain; 5) increases inflammatory factor interleukin-1 receptor-associated kinase-1(irak-1) and amyloid beta (aβ) expression in brain; 6) increases il-6 and irak4 expression in brain. |
2021-06-08 |
2023-08-13 |
mouse |
| Wen Niu, Lei Ma, Tianqi Tao, Fangfang Tian, Tao He, Min Qiao, Haimeng He, Xiuhua Liu, Xiayong Zha. Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32381365. |
meanwhile, up-regulated trem2 expression in the brain of mice, induced by selective trem2 agonist hsp60, significantly improved the learning and memory, alleviated the neuroinflammation, and decreased the neuronal cell apoptosis in mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Maryam Moosavi, Etrat Hooshmandi, Pegah Javadpour, Nader Maghsoudi, Hermann Katinger, Rasoul Ghasem. Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats. Behavioural brain research. vol 384. 2021-05-20. PMID:32057828. |
effect of carbamylated erythropoietin fc fusion protein (cepo-fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats. |
2021-05-20 |
2023-08-13 |
rat |
| Maryam Moosavi, Etrat Hooshmandi, Pegah Javadpour, Nader Maghsoudi, Hermann Katinger, Rasoul Ghasem. Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats. Behavioural brain research. vol 384. 2021-05-20. PMID:32057828. |
collectively, our findings suggest that cepo-fc could restore stz-induced learning and memory impairment as well as apoptosis in the hippocampal region in a rat model of sporadic ad induced by icv-stz. |
2021-05-20 |
2023-08-13 |
rat |
| Honghe Xiao, Yuying Wang, Yutong Wu, Hongyan Li, Xicai Liang, Yin Lin, Liang Kong, Yingnan Ni, Yan Deng, Yan Li, Wanyi Li, Jingxian Yan. Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice. Neuroscience research. vol 164. 2021-05-14. PMID:32302734. |
in this study, by using morris water maze (mwm) test, hematoxylin-eosin (he) staining, nissl staining, immunofluorescence analysis and western blot, we demonstrated that oral administration of ost could improve the learning and memory function, inhibit neuronal apoptosis, elevate the expression of glial cell line derived neurotrophic factor (gdnf), synaptophysin (syp) and postsynaptic density protein 95 (psd95). |
2021-05-14 |
2023-08-13 |
mouse |