| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Dong He, Chang-Mei Liu, Zhao-Qian Ten. A Mouse Model of Neurodegeneration Induced by Blade Penetrating Stab Wound to the Hippocampus. Biology. vol 11. issue 9. 2022-09-23. PMID:36138848. |
mice with a hippocampal blade stab injury (hbsi) displayed the activation of microglia and astrocytes, inflammation, neuronal apoptosis, and deficits in spatial learning and memory. |
2022-09-23 |
2023-08-14 |
mouse |
| Zhao-Cong Li, Lei-Lei Wang, Yue-Song Zhao, Dong-Jie Peng, Jing Chen, Si-Yang Jiang, Lin Zhao, Michael Aschner, Shao-Jun Li, Yue-Ming Jian. Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP Ecotoxicology and environmental safety. vol 241. 2022-09-07. PMID:36068756. |
sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the ip lead (pb) is a naturally occurring heavy metal, which can damage the brain and affect learning and memory. |
2022-09-07 |
2023-08-14 |
rat |
| Mingqi Shen, Rongxiu Zheng, Xuan Ka. Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage. Neurochemical research. 2022-08-26. PMID:36028735. |
treatment with mir-410-containing bmsc-evs improved learning and memory abilities of hibd mice while attenuating apoptosis by inactivating the wnt pathway via targeting hdac4. |
2022-08-26 |
2023-08-14 |
mouse |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. |
2022-08-07 |
2023-08-14 |
mouse |
| Z Junde, L Tingting, Z Lu, C Shan, Y Da. Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation. Folia morphologica. 2022-08-02. PMID:35916382. |
current experimental results showed that licl treatment significantly improved the impaired spatial learning and memory ability, suppressed oxidative stress, inflammatory reaction, and neuron apoptosis accompanied by attenuating neuronal damage, which subsequently decreased the brain edema, infarct volume and neurological deficit. |
2022-08-02 |
2023-08-14 |
human |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
this study evaluates the neuroprotective effect of achillea millefolium (ach) on chronic morphine‑induced learning and memory impairment, oxidative stress, and neuronal apoptosis in the ca1 region of the rat hippocampus. |
2022-07-14 |
2023-08-14 |
human |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
based on the present study, ach improved spatial learning and memory defects, and reduced oxidative stress and apoptosis in the hippocampus ca1 region, in chronic morphine‑treated animals. |
2022-07-14 |
2023-08-14 |
human |
| Chongqi Wei, Ziqiang Zhu, Jia-Ni Zheng, Yunqing Lu, Cheng Cao, Suchen Qu, Mengqiu Liu, Xue-Er Meng, Qianyin Lou, Qingqing Wang, Jin-Ao Duan, Er-Xin Shang, Zhenxiang Han, Yue Zh. Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784758. |
it was found that ethyl acetate extracts of succinum significantly improved the learning and memory abilities of model rats and inhibited neuronal apoptosis in the hippocampus. |
2022-07-05 |
2023-08-14 |
mouse |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
we found that sqw treatment significantly alleviated learning and memory impairment, pathological damage, and apoptosis in rats, as evidenced by an increased level of neun and bcl-2, and decreased phosphorylation of tau, bax, and caspase-3 protein expression. |
2022-06-24 |
2023-08-14 |
rat |
| Yin Xu, Yun Liu, Xi Chen, Qia Xu, Liwei Liu, Hui Liu, Ruowen Guo, Yide Qi. OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy. Translational psychiatry. vol 12. issue 1. 2022-06-06. PMID:35662233. |
functionally, optn suppresses apoptosis and enhances cellular viability in tau-p301l expressing ht22 cells, and increases learning and memory in tau-p301l expressing mice, respectively. |
2022-06-06 |
2023-08-14 |
mouse |
| Xiaojing Wang, Linchuan Ma, Jingmin Li, Fanzhen Kon. Activated cell-cycle CDK4/CyclinD1-pRB-E2F1 signaling pathway is involved in the apoptosis of dorsal raphe nucleus in the rat model of PTSD. Biochemical and biophysical research communications. vol 602. 2022-03-10. PMID:35272144. |
treatment with cdk4 inhibitor abemaciclib successfully attenuated the drn apoptosis and rescued decreased spatial learning and memory abilities in sps rats, indicating that activation of cdk4/cyclind1-prb-e2f1 pathway was involved in drn apoptosis, which may be one of the pathogenesis for ptsd. |
2022-03-10 |
2023-08-13 |
rat |
| Yolanda Diz-Chaves, Salvador Herrera-Pérez, Lucas C González-Matías, Federico Mall. Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus. Vitamins and hormones. vol 118. 2022-02-19. PMID:35180937. |
glp-1 enhances learning and memory in the hippocampus, promotes neurogenesis, decreases inflammation and apoptosis, modulates reward behavior, and reduces food intake. |
2022-02-19 |
2023-08-13 |
Not clear |
| Liwei Gao, Xin Guo, Shan Liu, Qiang Sun, Xuejiao Qin, Peiyuan Lv, Ming Hu, Jing Xu, Yanhong Don. Neuroprotective role of DL-3-n-butylphthalide via the Nrf2/SIRT3 pathway in a mouse model of vascular dementia. Brain research. 2022-01-15. PMID:35032442. |
the results indicated that nbp treatment ameliorated learning and memory deficits, attenuated pathological damage in the ca1 regions, and reduced autophagy and apoptosis via the nrf2/sirt3 pathway after repeated cerebral i/r. |
2022-01-15 |
2023-08-13 |
mouse |
| Bagher Pourheydar, Mojgan Abar, Gholamhossein Farjah, Maryam Pourheydar, Leila Derafshpou. Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus. Behavioral neuroscience. 2022-01-13. PMID:35025528. |
curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus. |
2022-01-13 |
2023-08-13 |
rat |
| Bagher Pourheydar, Mojgan Abar, Gholamhossein Farjah, Maryam Pourheydar, Leila Derafshpou. Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus. Behavioral neuroscience. 2022-01-13. PMID:35025528. |
the present study is designed to investigate the effects of curcumin on learning and memory, activity, biochemical, morphology changes, and apoptosis in the hippocampus and prefrontal cortex of restraint stress rats. |
2022-01-13 |
2023-08-13 |
rat |
| Tianpeng Li, Shuyan Dong, Jiancheng He, Jing Yang, Weiyun Li, Shanshan Li, Jing Li, Xiaoxue Du, Zhaoxia Hou, Luping Li, Songtao Li, Zhihui Huang, Tingting Su. Apoptosis, rather than neurogenesis, induces significant hippocampal-dependent learning and memory impairment in chronic low Cd Environmental toxicology. 2022-01-06. PMID:34989457. |
apoptosis, rather than neurogenesis, induces significant hippocampal-dependent learning and memory impairment in chronic low cd cadmium (cd), a ubiquitous toxic heavy metal, with the intractable trait of low degradation, can induce multiple organ damage. |
2022-01-06 |
2023-08-13 |
Not clear |
| Jialu Wang, Xiaoxue Xu, Wanying Jia, Dongyi Zhao, Tomasz Boczek, Qinghua Gao, Qianhui Wang, Yu Fu, Miao He, Ruixue Shi, Xin Tong, Meixuan Li, Yu Tong, Dongyu Min, Wuyang Wang, Feng Gu. Calcium-/Calmodulin-Dependent Protein Kinase II (CaMKII) Inhibition Induces Learning and Memory Impairment and Apoptosis. Oxidative medicine and cellular longevity. vol 2021. 2022-01-03. PMID:34976299. |
calcium-/calmodulin-dependent protein kinase ii (camkii) inhibition induces learning and memory impairment and apoptosis. |
2022-01-03 |
2023-08-13 |
Not clear |
| Weifeng Shan, Yini Wu, Xin Han, Qin Chen, Jimin W. The mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in rats. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34672892. |
after sf post-treatment, the neurons in cerebral cortex, the learning and memory skills and the contents of ngf/bdnf were increased, while the apoptosis and g9a/h3k9me2 levels were reduced. |
2021-12-08 |
2023-08-13 |
rat |
| Wenyue Wei, Yuyin Wang, Jing Zhang, Qingfang Gu, Xiaoqin Liu, Lijuan Song, Zhi Chai, Minfang Guo, Jiezhong Yu, Cungen M. Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969676. |
the results showed that the administration of fasudil improved learning and memory ability, elevated the concentration of antioxidative substances and decreased lipid peroxides, as well as inhibited neuronal apoptosis by increasing the expression of b-cell lymphoma-2 (bcl-2) (p < 0.05), reducing bcl-2 associated x (bax) (p < 0.05) and cleaved caspase-3 (p < 0.05) of app/ps1 mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. 2021-11-17. PMID:33014432. |
here, we report that the serine protease inhibitor serpina3n is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (hsi), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after hsi. |
2021-11-17 |
2023-08-13 |
mouse |