| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyang Zhang, Mian Wei, Qinghong Sun, Tianyuan Yang, Xiangyu Lu, Xiujing Feng, Miao Song, Lin Cui, Honggang Fa. Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-13. PMID:32810585. |
furthermore, the jnk inhibitor sp600125 relieved crs-induced hippocampal mitochondrial dysfunction, apoptosis via the mitochondrial apoptotic pathway, and learning and memory dysfunction. |
2021-05-13 |
2023-08-13 |
rat |
| Haiyang Zhang, Mian Wei, Qinghong Sun, Tianyuan Yang, Xiangyu Lu, Xiujing Feng, Miao Song, Lin Cui, Honggang Fa. Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-13. PMID:32810585. |
together, these results suggest that lyc alleviates hippocampal oxidative stress, mitochondrial dysfunction, and apoptosis by inhibiting the ros/jnk signaling pathway, thereby improving crs-induced hippocampal injury and learning and memory dysfunction. |
2021-05-13 |
2023-08-13 |
rat |
| Jun-Jie Tang, Shuang Feng, Xing-Dong Chen, Hua Huang, Min Mao, Hai-Yan Wang, Sen Li, Xiu-Min Lu, Yong-Tang Wan. The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity. Current pharmaceutical design. vol 27. issue 4. 2021-04-26. PMID:32938344. |
it can be inferred that p75ntr mediates apoptosis in the hippocampus and amygdale, which may affect learning and memory behavior. |
2021-04-26 |
2023-08-13 |
Not clear |
| Lili Xu, Qi Xu, Fang Xu, Wenxin Zhang, Qing Chen, Hui Wu, Xinzhong Che. MicroRNA-325-3p prevents sevoflurane-induced learning and memory impairment by inhibiting Nupr1 and C/EBPβ/IGFBP5 signaling in rats. Aging. vol 12. issue 6. 2021-03-08. PMID:32191629. |
moreover, nupr1 knockdown and mir-325-3p overexpression improved the rats' performance in learning and memory tests and reduced sevoflurane-induced apoptosis |
2021-03-08 |
2023-08-13 |
human |
| Tae-Woon Kim, Sang-Seo Park, Joon-Young Park, Hye-Sang Par. Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32384696. |
we then analyzed spatial learning and memory, long-term memory, hippocampal gsk3β/tau proteins, synaptic proteins, mitochondrial function, apoptosis, and neurogenesis. |
2021-02-01 |
2023-08-13 |
mouse |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
the findings of the present study may imply that normobaric hyperoxia preconditioning attenuates sevoflurane-induced spatial learning and memory impairment, and this effect may be partly related to apoptosis inhibition in the hippocampus. |
2021-01-29 |
2023-08-13 |
rat |
| Yuan-Zhu Pu, Can S. [Research progress in pharmacological effects of Erigeron breviscapus and its active ingredients for treatment of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 23. 2021-01-27. PMID:33496103. |
studies in several ad models have shown that erigeron breviscapus and its active ingredients(scutellarin and caffeoylquinic acid) could improve/enhance the learning and memory ability, and the mechanisms are associated with inhibiting amyloid β(aβ) production, aggregation, fibrosis and aβ neurotoxicity toxicity, regulating cholinergic nervous system, inhibiting oxidative stress and inflammation, inhibiting tau hyperphosphorylation, improving mitochondrial function, and resisting neuronal apoptosis. |
2021-01-27 |
2023-08-13 |
Not clear |
| Zhenjie Zhu, Min Ge, Chunlei Li, Liqiang Yu, Yudan Gu, Yuming Hu, Zhilong Ca. Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 78. 2020-11-17. PMID:32360159. |
inhibition of p38 mapk signaling pathway can effectively improve the learning and memory ability and motor function of newborn rats with hibi, and reduce neuronal apoptosis in the hippocampal tissues, thereby promoting neuronal recovery. |
2020-11-17 |
2023-08-13 |
rat |
| Hongna Sun, Yanmei Yang, Hanwen Shao, Weiwei Sun, Muyu Gu, Hui Wang, Lixin Jiang, Lisha Qu, Dianjun Sun, Yanhui Ga. Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28936164. |
sodium arsenite-induced learning and memory impairment is associated with endoplasmic reticulum stress-mediated apoptosis in rat hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yuan Gao, Ming-Yang Zhang, Tao Wang, Yan-Yan Fan, Lin-Sheng Yu, Guang-Hua Ye, Zu-Feng Wang, Cheng Gao, Hao-Chen Wang, Cheng-Liang Luo, Lu-Yang Ta. IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29922130. |
together, these data demonstrate that il-33/st2 signaling mitigates tbi-induced brain edema, motor function outcome, spatial learning and memory deficits, at least in part, by a mechanism involving suppressing autophagy, er stress, apoptosis and neuroinflammation. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu-Min Xu, Xin-Chen Wang, Ting-Ting Xu, Hong-Ying Li, Shang-Yan Hei, Na-Chuan Luo, Hong Wang, Wei Zhao, Shu-Huan Fang, Yun-Bo Chen, Li Guan, Yong-Qi Fang, Shi-Jie Zhang, Qi Wang, Wei-Xiong Lian. Neural regeneration research. vol 14. issue 5. 2020-10-01. PMID:30688265. |
the effects of kxs on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. |
2020-10-01 |
2023-08-13 |
mouse |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
compared with the control group, the rats in the model group presented significantly decreased learning and memory abilities, poor neuronal morphology of the brain, significantly higher neuronal apoptosis rate in the brain, decreased level of serum bcl-2, increased level of serum bax, and significantly decreased protein levels of notch1 and hes1 in brain tissues. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
compared with the model group, the rats in mir-9 inhibitor group showed obviously improved learning and memory abilities, improved neuronal morphology of the brain, an obviously lower neuronal apoptosis rate in the brain, increased level of serum bcl-2, decreased level of serum bax, and obviously increased protein levels of notch1 and hes1 in brain tissues. |
2020-10-01 |
2023-08-13 |
rat |
| Xinwu Huang, Guozhou Lu, Guochun Li, Hua Li, Beihua Li, Jiazhen Yin, Shousong Ca. Dynamic Changes in the Renin-Angiotensin-Aldosterone System and the Beneficial Effects of Renin-Angiotensin-Aldosterone Inhibitors on Spatial Learning and Memory in a Rat Model of Chronic Cerebral Ischemia. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:28690496. |
therefore, we studied the dynamic changes in the raas in the blood, cerebral cortex, and hippocampus and the effects of raas inhibitors on spatial learning and memory and hippocampal apoptosis in a rat model of chronic cerebral ischemia (cci) established by bilateral ligation of the common carotid arteries of rats. |
2020-09-30 |
2023-08-13 |
rat |
| Xinwu Huang, Guozhou Lu, Guochun Li, Hua Li, Beihua Li, Jiazhen Yin, Shousong Ca. Dynamic Changes in the Renin-Angiotensin-Aldosterone System and the Beneficial Effects of Renin-Angiotensin-Aldosterone Inhibitors on Spatial Learning and Memory in a Rat Model of Chronic Cerebral Ischemia. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:28690496. |
spatial learning and memory and hippocampal apoptosis were evaluated on day 30 by morris water maze test (navigation and space exploration tests) and terminal dexynucleotidyl transferase (tdt)-mediated dutp nick end labeling (tunel) assay, respectively, after rats were orally administered with distilled water (dw), renin inhibitor aliskiren (30 mg/kg), ang converting enzyme inhibitor enalapril (4 mg/kg), or ang ii receptor antagonist candesartan (2 mg/kg) daily for 30 days. |
2020-09-30 |
2023-08-13 |
rat |
| Zhi-Yuan Su, Qing Ye, Xian-Bao Liu, Yu-Zhong Chen, Hong Zhan, Shi-Yuan X. Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy. Neural regeneration research. vol 12. issue 8. 2020-09-30. PMID:28966649. |
our results demonstrate that 4 hours after inhaling isoflurane, 20 μg/kg dexmedetomidine visibly mitigated isoflurane-induced neuronal apoptosis, reversed downregulation of brain-derived neurotrophic factor expression, and lessened decreased spatial learning and memory ability in adulthood in the fetal rats. |
2020-09-30 |
2023-08-13 |
rat |
| Xingyue Li, Ziyi Wu, Yi Zhang, Ying Xu, Guang Han, Ping Zha. Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29311820. |
changes in neural stem cell (nsc) apoptosis, neurogenesis, neuron quantity and learning and memory function were examined after administration of an autophagy or pten inhibitor. |
2020-09-30 |
2023-08-13 |
rat |
| Xiao Li, Rui-Zhen Liu, Qi Zeng, Zhi-Hua Huang, Jian-Dong Zhang, Zong-Liang Liu, Jing Zeng, Hai Xia. 3'-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127116. |
results showed that dss treatment greatly improved the learning and memory deficits of rats with cch, reduced apoptosis of neurons in the hippocampal ca1, ca3 regions and dentate gyrus, and increased the phosphorylation of pka, erk1/2, and creb in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Su. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542451. |
the results demonstrated that ea treatment ameliorated spatial learning and memory impairment in app/ps1 mice and significantly reduced neuronal apoptosis and aβ deposition in the hippocampus (p<0.05 and p<0.01). |
2020-09-29 |
2023-08-13 |
mouse |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
type 2 diabetes causes learning and memory deficits that might be mediated by hippocampus neuron apoptosis. |
2020-09-24 |
2023-08-13 |
rat |