| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Wang, Qian Liu, Hai-Tao Yu, Jia-Zhao Xie, Jun-Ning Zhao, Zhi-Ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wan. A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology. Signal transduction and targeted therapy. vol 9. issue 1. 2024-04-28. PMID:38679634. |
as an inhibitory transcription factor of idh3β, the elevated pax6 in turn inhibited the expression of idh3β, leading to tau hyperphosphorylation, synapse impairment, and learning and memory deficits resembling those seen in ad. |
2024-04-28 |
2024-05-01 |
mouse |
| Masen Leigh Boucher, Grace Conley, Nicholas Morriss, Sara Ospina-Mora, Jianhua Qiu, Rebekah Mannix, William Meeha. Time-Dependent Long-Term Effect of Memantine Following Repetitive Mild Traumatic Brain Injury. Journal of neurotrauma. 2024-04-26. PMID:38666723. |
we observed chronic changes in behavior (anxiety-like behavior, motor coordination, spatial learning and memory), as well as neuroinflammation (microglia, astrocytes) and tau phosphorylation (t231). |
2024-04-26 |
2024-04-28 |
Not clear |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
intracerebroventricular injection of msa into the brains of c57bl/6j mice to a similar concentration as in patient brains induced neuronal apoptosis, neuroinflammation, increased tau phosphorylation, and decreased the spatial learning and memory abilities, while elovl1 knockdown significantly prevented the deleterious effect of msa. |
2024-04-23 |
2024-04-26 |
mouse |
| Wu Lun, Guo Xingyu, Gao Yue, Yu Wenting, Qin Wen, Kuang Haixue, Su Yan. Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice. International journal of biological macromolecules. 2024-04-02. PMID:38565361. |
the results demonstrate that wscp exerts significant therapeutic effects on ad mice by enhancing learning and memory abilities, mitigating hippocampal neuronal damage, reducing abnormal amyloid-beta (aβ) deposition, and attenuating hyperphosphorylation of tau. |
2024-04-02 |
2024-04-05 |
mouse |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
this study explored the effects of outer membrane vesicles (omvs) from the gut microbiota of ad patients on learning and memory abilities and tau protein phosphorylation in mice. |
2024-03-14 |
2024-03-17 |
mouse |
| So Yeon Cho, Eun Woo Kim, Soo Jin Park, Benjamin U Phillips, Jihyeon Jeong, Hyunjeong Kim, Christopher J Heath, Daehwan Kim, Yurim Jang, Laura López-Cruz, Lisa M Saksida, Timothy J Bussey, Do Yup Lee, Eosu Ki. Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice. Translational psychiatry. vol 14. issue 1. 2024-01-18. PMID:38238285. |
furthermore, metformin caused learning and memory impairment and increased levels of ampkα1-subunit, β-amyloid oligomers, plaques, phosphorylated tau, and gsk3β expression in ad mice. |
2024-01-18 |
2024-01-21 |
mouse |
| Joshua T Emmerson, Janice C Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C Martinez-Trujillo, A Claudio Cuell. Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy. Neurobiology of disease. 2023-10-06. PMID:37802153. |
heterozygous r955-htau transgenic rats feature a modest, life-long accumulation of mutated human tau that led to tau hyperphosphorylation and produced deficits in learning and memory tasks after 24 months of age. |
2023-10-06 |
2023-10-15 |
human |
| Fanjing Kong, Tianyu Wu, Jingyi Dai, Zhenwei Zhai, Jie Cai, Zhishan Zhu, Ying Xu, Tao Su. Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer's disease models: a systematic review and meta-analysis of preclinical studies. Frontiers in pharmacology. vol 14. 2023-09-29. PMID:37771725. |
the results showed that, in terms of behavioral tests, glp-1 ras could improve the learning and memory abilities of ad rodents; in terms of pathology, glp-1 ras could reduce aβ deposition and phosphorylated tau levels in the brains of ad rodents. |
2023-09-29 |
2023-10-07 |
Not clear |
| Li Gao, Dongqing Wang, Jia Ren, Xue Tan, Jiayuan Chen, Zheng Kong, Yunan Nie, Ming Ya. Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation. Phytotherapy research : PTR. 2023-09-04. PMID:37661763. |
acteoside ameliorates learning and memory impairment in app/ps1 transgenic mice by increasing aβ degradation and inhibiting tau hyperphosphorylation. |
2023-09-04 |
2023-09-07 |
mouse |
| Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. |
two hallmark proteins in ad, amyloid-beta plaques and tau neurofibrillary tangles, accumulate in regions of the brain critical for learning and memory, including the hippocampus. |
2023-08-05 |
2023-08-14 |
mouse |
| Zhengqiang Hu, Guanmin Meng, Lejun Zhang, Meng Zhang, Huashun Cui, Huifang Tan. Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-13. PMID:37442312. |
moreover, mc-lr administration resulted in synaptic damage in mouse neurons, hyperphosphorylation of the microtubule-related protein tau, cognitive impairment, and deficits in learning and memory in c57bl/6 j mice. |
2023-07-13 |
2023-08-14 |
mouse |
| Korey Kam, Kenny Vetter, Rachel A Tejiram, Ward D Pettibone, Kaitlyn Shim, Mickael Audrain, Liping Yu, Ilse S Daehn, Michelle E Ehrlich, Andrew W Varg. Effect of aging and a dual orexin receptor antagonist on sleep architecture and NREM oscillations including a REM Behavior Disorder phenotype in the PS19 mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-25. PMID:37230765. |
the impact of tau pathology on sleep microarchitecture features, including slow oscillations, spindles, and their coupling has been understudied, in spite of the proposed importance of these electrophysiological features toward learning and memory. |
2023-05-25 |
2023-08-14 |
mouse |
| Qian Liu, Xin Wang, Yu Hu, Jun-Ning Zhao, Chun-Hui Huang, Ting Li, Bing-Ge Zhang, Ye He, Yan-Qing Wu, Zai-Jun Zhang, Guo-Ping Wang, Gong-Ping Li. Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis. Redox biology. vol 62. 2023-04-10. PMID:37037158. |
acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis. |
2023-04-10 |
2023-08-14 |
human |
| Longfei Li, Jin Miao, Yanli Jiang, Chun-Ling Dai, Khalid Iqbal, Fei Liu, Dandan Ch. Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice. Experimental neurology. 2023-01-30. PMID:36717015. |
passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xtg-ad mice. |
2023-01-30 |
2023-08-14 |
mouse |
| Longfei Li, Jin Miao, Yanli Jiang, Chun-Ling Dai, Khalid Iqbal, Fei Liu, Dandan Ch. Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice. Experimental neurology. 2023-01-30. PMID:36717015. |
without influencing the levels of detergent-insoluble and aggregated tau, intravenous injection of 77g7 reduced tau hyperphosphorylation in the brain and improved novel object recognition but not spatial learning and memory in 15-18-month-old 3xtg-ad mice. |
2023-01-30 |
2023-08-14 |
mouse |
| Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating "Alzheimer's Disease": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547082. |
insulin plays a pivotal role in learning and memory and is involved in regulating tau phosphorylation though the pi3kakt-gsk3b signaling pathway. |
2022-12-22 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
recent evidence indicates that tau hyperphosphorylation caused by either amyloid-β or long-term depression, a form of synaptic weakening involved in learning and memory, share similar mechanisms. |
2022-12-01 |
2023-08-14 |
Not clear |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
these findings indicate that metformin reduced tau hyperphosphorylation, attenuated tau pathology in tau-seeded ps19 mice, and improved learning and memory deficits. |
2022-11-24 |
2023-08-14 |
mouse |
| Federica Ferrari, Antonio Moretti, Roberto Federico Vill. Incretin-based drugs as potential therapy for neurodegenerative diseases: Current status and perspectives. Pharmacology & therapeutics. 2022-09-05. PMID:36064147. |
for ad, the improvement of learning and memory exerted by incretin-based drugs correlated with reduction of chronic inflammation, brain aβ plaque, tau hyperphosphorylation, protection of mitochondria, enhancement of energy utilisation. |
2022-09-05 |
2023-08-14 |
Not clear |
| Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology. 2022-08-27. PMID:36029808. |
overexpression of mir-702-5p significantly reduced the histopathological damage of the hippocampus, improved the learning and memory function of db/db mice, down-regulated 12/15-lox, app, aβ, tau, bax protein expressions significantly and up-regulated the expression of bcl-2. |
2022-08-27 |
2023-08-14 |
mouse |