| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alina C Stimmell, Zishen Xu, Shawn C Moseley, Sarah D Benthem, Diana M Fernandez, Jessica V Dang, Luis F Santos-Molina, Rosina A Anzalone, Carolina L Garcia-Barbon, Stephany Rodriguez, Jessica R Dixon, Wei Wu, Aaron A Wilbe. Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse. Frontiers in aging. vol 2. 2021-11-11. PMID:34746919. |
tau pathology profile across a parietal-hippocampal brain network is associated with spatial reorientation learning and memory performance in the 3xtg-ad mouse. |
2021-11-11 |
2023-08-13 |
mouse |
| Alina C Stimmell, Zishen Xu, Shawn C Moseley, Sarah D Benthem, Diana M Fernandez, Jessica V Dang, Luis F Santos-Molina, Rosina A Anzalone, Carolina L Garcia-Barbon, Stephany Rodriguez, Jessica R Dixon, Wei Wu, Aaron A Wilbe. Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse. Frontiers in aging. vol 2. 2021-11-11. PMID:34746919. |
surprisingly, despite a lack of impairment relative to controls, 3-month female, as well as 6- and 12- month male mice all had patterns of tau pathology across the parietal-hippocampal brain network that are predictive of spatial learning and memory performance. |
2021-11-11 |
2023-08-13 |
mouse |
| Alina C Stimmell, Zishen Xu, Shawn C Moseley, Sarah D Benthem, Diana M Fernandez, Jessica V Dang, Luis F Santos-Molina, Rosina A Anzalone, Carolina L Garcia-Barbon, Stephany Rodriguez, Jessica R Dixon, Wei Wu, Aaron A Wilbe. Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse. Frontiers in aging. vol 2. 2021-11-11. PMID:34746919. |
thus, the pattern of ptau staining across the parietal-hippocampal network is a strong predictor of spatial learning and memory performance, even for mice with low levels of tau accumulation and intact spatial re-orientation learning and memory. |
2021-11-11 |
2023-08-13 |
mouse |
| Philip L Yates, Ankita Patil, Xiaohuan Sun, Alessia Niceforo, Ramnik Gill, Patrick Callahan, Wayne Beck, Emanuela Piermarini, Alvin V Terry, Kimberly A Sullivan, Peter W Baas, Liang Qian. A cellular approach to understanding and treating Gulf War Illness. Cellular and molecular life sciences : CMLS. vol 78. issue 21-22. 2021-11-08. PMID:34580742. |
wistar rats exposed to a similar toxicant regimen showed a mild learning and memory deficit, as well as cell loss and tau pathology selectively in the ca3 region of the hippocampus. |
2021-11-08 |
2023-08-13 |
human |
| Nibaldo C Inestrosa, Cheril Tapia-Rojas, Waldo Cerpa, Pedro Cisternas, Juan M Zolezz. WNT Signaling Is a Key Player in Alzheimer's Disease. Handbook of experimental pharmacology. vol 269. 2021-11-02. PMID:34486097. |
later, we found that wnt/β-catenin participates in tau phosphorylation and in learning and memory. |
2021-11-02 |
2023-08-13 |
Not clear |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of alzheimer's disease through modulation of brain insulin resistance induced tau pathology. |
2021-10-29 |
2023-08-13 |
rat |
| Bin Wu, Haiqing Cai, Shen Tang, Yilu Xu, Qianqian Shi, Lancheng Wei, Ling Meng, Ning Zhang, Xinhang Wang, Deqiang Xiao, Yunfeng Zou, Xiaobo Yang, Xiyi Li, Cailing L. Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32959271. |
we show that mn-induced neurotoxicity is characterized by pp2ac demethylation accompanied by abnormally decreased lcmt-1 and increased pme-1, which are associated with tau hyperphosphorylation and spatial learning and memory deficits, and that the poor availability of sam in the hippocampus is likely to determine the loss of pp2ac methylation. |
2021-10-28 |
2023-08-13 |
rat |
| Daymara Mercerón-Martínez, Cristobal Ibaceta-González, Claudia Salazar, William Almaguer-Melian, Jorge A Bergado-Rosado, Adrian G Palacio. Alzheimer's Disease, Neural Plasticity, and Functional Recovery. Journal of Alzheimer's disease : JAD. vol 82. issue s1. 2021-09-23. PMID:33459642. |
alzheimer's disease (ad) is the most common and devastating neurodegenerative condition worldwide, characterized by the aggregation of amyloid-β and phosphorylated tau protein, and is accompanied by a progressive loss of learning and memory. |
2021-09-23 |
2023-08-13 |
Not clear |
| Xiao Liu, Kaiyue Wang, Xing Wei, Tian Xie, Bin Lv, Qian Zhou, Xiaoying Wan. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33523396. |
the most important neuropathological features of alzheimer's disease (ad) are extracellular amyloid-β protein (aβ) deposition, tau protein hyperphosphorylation and activation of neurometabolic reaction in the brain accompanied by neuronal and synaptic damage, and impaired learning and memory function. |
2021-09-14 |
2023-08-13 |
Not clear |
| Bin Zhao, Yi Wang, Rui Liu, Xiao-Li Jia, Nan Hu, Xing-Wei An, Chen-Guang Zheng, Chong Chen, Hong-Tao Sun, Feng Chen, Jing-Jing Wang, Xiao-Hong L. Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice. Rejuvenation research. vol 24. issue 3. 2021-09-09. PMID:32892706. |
our results showed that rutaecarpine significantly attenuated high sucrose diet-induced spatial memory impairment and enhanced synaptic plasticity; rutaecarpine prevented high sucrose diet-induced tau hyperphosphorylation by decreasing glycogen synthase kinase-3β (gsk-3β) activity; activation of gsk-3β reversed the protective effect of rutaecarpine on learning and memory deficits, synaptic plasticity, and tau hyperphosphorylation induced by high-glucose diet significantly, suggesting that gsk-3β activation is required for high glucose-induced tau hyperphosphorylation. |
2021-09-09 |
2023-08-13 |
mouse |
| Zhen Liu, Kai-Min Hao, Hao-Yu Wang, Wen-Xiu Q. Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B. Neuroreport. vol 31. issue 10. 2021-08-18. PMID:32453021. |
our results showed that hdac6 may not only lead to the deterioration of learning and memory abilities but also elevate the levels of aβo and tau phosphorylation in aβ-induced cognitive dysfunction rats via upregulating ptk2b. |
2021-08-18 |
2023-08-13 |
rat |
| Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Siva. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein. Neuroscience letters. vol 759. 2021-08-06. PMID:34023407. |
dietary supplementation of oxy-cd together with akg improved the learning and memory abilities during the climbing assay in tau flies. |
2021-08-06 |
2023-08-13 |
drosophila_melanogaster |
| Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Che. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-17. PMID:33939165. |
importantly, tau transgenic mice treated with jzl184 displayed improvements in spatial learning and memory retention. |
2021-07-17 |
2023-08-13 |
mouse |
| Yanmin Chang, Yi Yao, Rong Ma, Zemin Wang, Junjie Hu, Yanqing Wu, Xingjun Jiang, Lulu Li, Gang L. Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice. Frontiers in neuroscience. vol 15. 2021-07-12. PMID:33642981. |
in this study, we examined the effects of dl-nbp on learning and memory in p301s transgenic mice, which carry the human tau gene with the p301s mutation. |
2021-07-12 |
2023-08-13 |
mouse |
| Sarah A Kent, Tara L Spires-Jones, Claire S Durran. The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32728795. |
tau has been revealed to be more than a simple stabiliser of microtubules, reported to play a role in a range of biological processes including myelination, glucose metabolism, axonal transport, microtubule dynamics, iron homeostasis, neurogenesis, motor function, learning and memory, neuronal excitability, and dna protection. |
2021-05-31 |
2023-08-13 |
Not clear |
| Huiming Zhang, Xiaojuan Wang, Pu Xu, Xuefei Ji, Tianyan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models. The journal of physiological sciences : JPS. vol 70. issue 1. 2021-05-18. PMID:32517647. |
tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 (sp1)-mediated cyclin-dependent kinase-5 (cdk5), a major protein kinase that regulates hyperphosphorylated tau, in alzheimer's disease (ad) transgenic mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Xiaoliang Wang, Lihai Chen, Yajie Xu, Wanling Wang, Youran Wang, Zhiyuan Zhang, Jing Zheng, Hongguang Ba. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. European journal of pharmacology. vol 892. 2021-05-18. PMID:33220272. |
the improvement of learning and memory, the reduction of inflammation and microglia activation, and the suppression of gsk-3β and tau phosphorylation by gas were prevented when gsk-3β was overexpressed in aged mice subjected to surgery. |
2021-05-18 |
2023-08-13 |
mouse |
| b' Jian-Guo Li, Jin Chu, Domenico Pratic\\xc3\\xb. Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer\'s disease mouse model with plaques, tangles, and memory impairments. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:30279460.' |
compared with controls, mice over-expressing 12/15lo manifested an exacerbation of spatial learning and memory impairments, which was associated with significant increase in aβ formation and deposition, and accumulation of hyper-phosphorylated insoluble tau secondary to a down-regulation of autophagy. |
2021-05-14 |
2023-08-13 |
mouse |
| Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-An Wei, Jie Li. Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials. vol 237. 2021-05-14. PMID:32035322. |
due to its excellent photothermal effect, under the near-infrared (nir) irradiation, the nanocomposite could effectively penetrate the blood-brain barrier (bbb) and respond to phase changes in the lesion area, releasing ngf, which inhibited tau hyperphosphorylation, reduced oxidative stress, and more importantly restored nerve damage and maintained neuronal morphology, thereby significantly improving learning and memory in ad mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. |
we treated tbi and sham operated mice with dha, and investigated the effects of dha on jnk and tau phosphorylation, hippocampal long term potentiation (ltp), learning and memory, and motor function by western blot analysis, electrophysiology recording and behavioral assessments including morris water maze test, beam-balance test, beam-walk test and rotarod test. |
2021-04-28 |
2023-08-13 |
mouse |