| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. |
dha suppressed tbi induced jnk and tau hyperphosphorylation, rescued tbi mediated hippocampal ltp deficits and hippocampus dependent learning and memory dysfunction, and improved motor function. |
2021-04-28 |
2023-08-13 |
mouse |
| Haoyu Chen, Lu Liang, Hua Xu, Jia Xu, Leyi Yao, Yanling Li, Yufan Tan, Xiaofen Li, Qingtian Huang, Zhenjun Yang, Jiawen Wu, Jinghong Chen, Hongbiao Huang, Xuejun Wang, Chang-E Zhang, Jinbao Li. Short Term Exposure to Bilirubin Induces Encephalopathy Similar to Alzheimer's Disease in Late Life. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31796680. |
we found that three days exposure to bilirubin in newborn rats could induce ad-like pathological changes in late life, including tau protein hyperphosphorylation at multiple sites, increased aβ production in brain tissues, and spatial learning and memory injury. |
2021-04-19 |
2023-08-13 |
rat |
| Yang Gao, Jie Zheng, Tao Jiang, Guilin Pi, Fei Sun, Rui Xiong, Weijin Wang, Dongqin Wu, Shihong Li, Huiyang Lei, Huiling Yu, Qiuzhi Zhou, Ying Yang, Huaqiu Zhang, Jian-Zhi Wan. Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy. Frontiers in cell and developmental biology. vol 8. 2021-03-10. PMID:33681188. |
simultaneously, the mice showed spatial learning and memory deficits with a prominently elevated total tau and phospho-tau levels in the brain. |
2021-03-10 |
2023-08-13 |
mouse |
| Yang Gao, Jie Zheng, Tao Jiang, Guilin Pi, Fei Sun, Rui Xiong, Weijin Wang, Dongqin Wu, Shihong Li, Huiyang Lei, Huiling Yu, Qiuzhi Zhou, Ying Yang, Huaqiu Zhang, Jian-Zhi Wan. Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy. Frontiers in cell and developmental biology. vol 8. 2021-03-10. PMID:33681188. |
importantly, selective facilitating tau degradation by using a novel designed proteolysis-targeting chimera named c4 could effectively ameliorate the epileptic seizures with remarkable restoration of neuronal firing activities and improvement of spatial learning and memory functions. |
2021-03-10 |
2023-08-13 |
mouse |
| b' Antonio Di Meco, Jaroslav Jelinek, Elisabetta Lauretti, Mary Elizabeth Curtis, Jean-Pierre J Issa, Domenico Pratic\\xc3\\xb. Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology. Molecular psychiatry. 2021-02-27. PMID:31451749.' |
offspring were fed regular chow throughout their life and tested for spatial learning and memory, brain amyloidosis, tau pathology, and synaptic function. |
2021-02-27 |
2023-08-13 |
Not clear |
| Samuel T Peters, Allyssa Fahrenkopf, Jessica M Choquette, Scott C Vermilyea, Michael K Lee, Keith Vosse. Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein. Frontiers in neurology. vol 11. 2021-02-13. PMID:32636798. |
recent work revealed that mice expressing human α-syn with the alanine-53-threonine (a53t) mutation have a similar phenotype to the human condition, exhibiting long-term potentiation deficits, learning and memory deficits, and inhibitory hippocampal remodeling, all of which were reversed by genetic ablation of microtubule-associated protein tau. |
2021-02-13 |
2023-08-13 |
mouse |
| Yuan-Zhu Pu, Can S. [Research progress in pharmacological effects of Erigeron breviscapus and its active ingredients for treatment of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 23. 2021-01-27. PMID:33496103. |
studies in several ad models have shown that erigeron breviscapus and its active ingredients(scutellarin and caffeoylquinic acid) could improve/enhance the learning and memory ability, and the mechanisms are associated with inhibiting amyloid β(aβ) production, aggregation, fibrosis and aβ neurotoxicity toxicity, regulating cholinergic nervous system, inhibiting oxidative stress and inflammation, inhibiting tau hyperphosphorylation, improving mitochondrial function, and resisting neuronal apoptosis. |
2021-01-27 |
2023-08-13 |
Not clear |
| Jinwang Ye, Yaling Yin, Huanhuan Liu, Lin Fang, Xiaoqing Tao, Linyu Wei, Yue Zuo, Ying Yin, Dan Ke, Jian-Zhi Wan. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31668016. |
here, we report that overexpressing full-length wild-type human tau (htau) in mouse hippocampus induces learning and memory deficits with remarkably reduced levels of multiple synapse- and memory-associated proteins. |
2021-01-13 |
2023-08-13 |
mouse |
| Abdalla M Albeely, Olivia O F Williams, Melissa L Perreaul. GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats. Cellular and molecular neurobiology. 2021-01-04. PMID:33392916. |
gsk-3β(s9a)-induced changes in learning and memory were also assessed and the phosphorylation status of tau protein, a substrate of gsk-3β, examined. |
2021-01-04 |
2023-08-13 |
rat |
| Leila Mohammadzadeh, Khalil Abnous, Bibi Marjan Razavi, Hossein Hosseinzade. Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects. Nutritional neuroscience. vol 23. issue 3. 2020-12-11. PMID:30789100. |
malathion exposure induced spatial learning and memory deficits with a simultaneous decrease of psd93 and tau hyperphosphorylation at multiple ad-related phosphorylation sites with activation of glycogen synthase kinase-3β (gsk-3β) and inhibition of protein phosphatase-2a (pp2a). |
2020-12-11 |
2023-08-13 |
rat |
| Darryll M A Oliver, P Hemachandra Redd. Molecular Basis of Alzheimer's Disease: Focus on Mitochondria. Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:30932888. |
morphological and pathological studies revealed that ad is associated with the loss of synapses, defective mitochondria, and the proliferation of reactive astrocytes and microglia, in addition to the presence amyloid-β and phosphorylated tau in learning and memory regions of the brain in ad patients. |
2020-11-30 |
2023-08-13 |
Not clear |
| Iason Keramidis, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios M C Skoulaki. Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192295. |
expression of human tau protein in drosophila cns results in increased toxicity, premature mortality and learning and memory deficits. |
2020-11-17 |
2023-08-13 |
human |
| Tao Liang, Feixiao Xue, Weijian Hang, Bin Wen, Qianying Zhang, Jiehui Chen, Xiaofeng Liu, Juan Che. Neuron-Specific Apolipoprotein E4 (1-272) Fragment Induces Tau Hyperphosphorylation and Axonopathy via Triggering Endoplasmic Reticulum Stress. Journal of Alzheimer's disease : JAD. vol 71. issue 2. 2020-11-04. PMID:31424401. |
meanwhile, the apoe4(1-272) transgenic mice presented obviously ad-like neuropathological changes, including the impairment of spatial learning and memory, prominent axonal morphological changes, and hyperphosphorylation of tau. |
2020-11-04 |
2023-08-13 |
mouse |
| Yang Yang, Xingxing Jia, Jianchao Feng, Zhiyong Wang, Yu Cao, Jiangang Liu, Hao L. Fuzheng Quxie Decoction Ameliorates Learning and Memory Impairment in SAMP8 Mice by Decreasing Tau Hyperphosphorylation. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:29422936. |
fuzheng quxie decoction ameliorates learning and memory impairment in samp8 mice by decreasing tau hyperphosphorylation. |
2020-10-01 |
2023-08-13 |
mouse |
| Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu L. Neural regeneration research. vol 13. issue 5. 2020-10-01. PMID:29863023. |
our results demonstrated that homocysteine produced learning and memory deficits and increased levels of tau phosphorylation, and diminished the activity of catalytic protein phosphatase 2a. |
2020-10-01 |
2023-08-13 |
rat |
| Kee-Hong Choi, Eunju Jaekal, Ga-Young Le. Motivational and Behavioral Activation as an Adjunct to Psychiatric Rehabilitation for Mild to Moderate Negative Symptoms in Individuals with Schizophrenia: A Proof-of-Concept Pilot Study. Frontiers in psychology. vol 7. 2020-09-30. PMID:27895602. |
in addition, participants in the mba group showed improved verbal learning and memory compared with those in the tau group. |
2020-09-30 |
2023-08-13 |
human |
| Cheril Tapia-Rojas, Nibaldo C Inestros. Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease. Neural regeneration research. vol 13. issue 10. 2020-09-30. PMID:30136680. |
later, it was reported that it participates in tau phosphorylation and processes of learning and memory. |
2020-09-30 |
2023-08-13 |
mouse |
| Yang Tan, Shuke Nie, Wende Zhu, Fang Liu, Hailong Guo, Jiewen Chu, Xue B Cao, Xingjun Jiang, Yunjian Zhang, Yuzhen L. 7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice. Frontiers in aging neuroscience. vol 8. 2020-09-29. PMID:27965573. |
spatial learning and memory deficits were observed in apoe-ko mice, which were consistent with higher expression of active-asparaginyl endopeptidase (active-aep) as well as aep-derived truncated tau n368 compared with normal group. |
2020-09-29 |
2023-08-13 |
mouse |
| Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiz. Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural regeneration research. vol 12. issue 4. 2020-09-29. PMID:28553339. |
through the regulation of tau and gsk3β/akt/pi3k pathway, and cdk5/p35/p25 complexes, tib may modulate neuronal plasticity and regulate learning and memory processes. |
2020-09-29 |
2023-08-13 |
mouse |
| Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Su. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542451. |
ellagic acid ameliorates learning and memory impairment in app/ps1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. |
2020-09-29 |
2023-08-13 |
mouse |