| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. |
2022-08-07 |
2023-08-14 |
mouse |
| Laura Martínez-Drudis, Razan Sheta, Rémi Pellegrinato, Salma Loukili, Cyntia Tremblay, Frédéric Calon, Serge Rivest, Abid Oueslat. Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease. Neurobiology of disease. 2022-07-29. PMID:35905928. |
in 3xtg-ad males, treatment with plk2i #37 led to lower tau burden, higher synaptic protein content, and prevented learning and memory deficits. |
2022-07-29 |
2023-08-14 |
mouse |
| Kizhakke Purayil Anupama, Anet Antony, Olakkaran Shilpa, Shamprasad Varija Raghu, Hunasanahally Puttaswamygowda Gurushankar. Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model. Molecular neurobiology. 2022-07-21. PMID:35864434. |
lifespan, locomotor activity, learning and memory, tau protein expression level, eye degeneration, oxidative stress level, and cholinesterase activities were analyzed in 10, 20, and 30-day-old control (wild type), and tauopathy flies reared on jatamansinol supplemented food or regular food without jatamansinol supplementation. |
2022-07-21 |
2023-08-14 |
drosophila_melanogaster |
| Kizhakke Purayil Anupama, Anet Antony, Olakkaran Shilpa, Shamprasad Varija Raghu, Hunasanahally Puttaswamygowda Gurushankar. Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model. Molecular neurobiology. 2022-07-21. PMID:35864434. |
jatamansinol treatment significantly extends the lifespan, improves locomotor activity, enhances learning and memory, and reduces tau protein levels in tauopathy flies. |
2022-07-21 |
2023-08-14 |
drosophila_melanogaster |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
we found that sqw treatment significantly alleviated learning and memory impairment, pathological damage, and apoptosis in rats, as evidenced by an increased level of neun and bcl-2, and decreased phosphorylation of tau, bax, and caspase-3 protein expression. |
2022-06-24 |
2023-08-14 |
rat |
| Ran Li, Jia-Kai He, Yu-Hang Jiang, Bao-Hui Ji. [Progress of experimental researches on acupuncture intervention for Alzheimer's disease based on SAMP8 mice model]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 5. 2022-05-26. PMID:35616423. |
results showed that acupuncture therapy can intervene the central pathological process of ad in multiple approaches, including reducing formation of cerebral β amyloid protein and promoting its removal, intervening the phosphorylation process of tau protein, improving mitochondrial and synaptic structure, enhancing autophagy activity, accelerating cerebral blood flow, and increasing the levels of estrogen content, and improving the learning and memory ability, etc. |
2022-05-26 |
2023-08-13 |
mouse |
| Tao Wang, Xiaona Zhang, Yushan Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xia. High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice. The Journal of nutritional biochemistry. 2022-04-21. PMID:35447319. |
high cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in c57bl/6j mice. |
2022-04-21 |
2023-08-13 |
mouse |
| Tao Wang, Xiaona Zhang, Yushan Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xia. High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice. The Journal of nutritional biochemistry. 2022-04-21. PMID:35447319. |
to investigate whether cholesterol and 27-ohc affected learning and memory through autophagy-mediated phosphorylation of tau, male c57bl/6j mice were administrated with 2% cholesterol diet, cyp27a1-short-hairpin rna (cyp27a1-shrna) and 3-methyladenine (3-ma). |
2022-04-21 |
2023-08-13 |
mouse |
| Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. vol 13. issue 1. 2022-04-13. PMID:35413950. |
inhibition of microglial nf-κb in aged ps19 mice rescued tau-mediated learning and memory deficits, restored overall transcriptomic changes while increasing neuronal tau inclusions. |
2022-04-13 |
2023-08-13 |
mouse |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. |
2022-04-12 |
2023-08-13 |
rat |
| Dai-Ting Lin, Ning-Juo Kao, Tzu-Wen Liu Cross, Wei-Ju Lee, Shyh-Hsiang Li. Effects of ketogenic diet on cognitive functions of mice fed high-fat-high-cholesterol diet. The Journal of nutritional biochemistry. vol 104. 2022-03-28. PMID:35196576. |
after consuming the hfhc diet for 16 weeks and subsequently receiving the mct diet for 8 weeks, results showed that the mice fed a mct diet had significantly better spatial learning and memory performance, lower expression of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), tumor necrosis factor-α (tnf-α), glial fibrillary acidic protein (gfap), amyloid protein precursor (app) and phosphate tau, and higher expression of brain-derived neurotrophic factor (bdnf) than the mice fed the hfhc diet. |
2022-03-28 |
2023-08-16 |
mouse |
| Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985). 2022-02-24. PMID:35201933. |
spatial learning and memory, long-term memory, hippocampal aβ, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. |
2022-02-24 |
2023-08-13 |
mouse |
| Meng-Shan Tan, Yi Liu, Hao Hu, Chen-Chen Tan, Lan Ta. Inhibition of caspase-1 ameliorates tauopathy and rescues cognitive impairment in SAMP8 mice. Metabolic brain disease. 2022-02-10. PMID:35143023. |
more importantly, we provided the evidence that vx-765, a selective inhibitor of caspase-1, significantly rescued spatial learning and memory impairments and reduced tau hyperphosphorylation in brains of samp8 mice at early stages of the disease. |
2022-02-10 |
2023-08-13 |
mouse |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
we observed that ica treatment improved the learning and memory of 3 × tg-ad mice and reduced aβ deposition and tau protein phosphorylation in the hippocampus. |
2022-01-17 |
2023-08-13 |
mouse |
| Chanting He, Xiaoyan Zhao, Yang Lei, Jisheng Nie, Xiaoting Lu, Jing Song, Linping Wang, Huan Li, Fangqu Liu, Yidan Zhang, Qiao Ni. Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al. Molecular therapy. Nucleic acids. vol 26. 2021-12-13. PMID:34900398. |
aluminum is a known neurotoxin that can induce aβ deposition and abnormal phosphorylation of tau protein, leading to alzheimer disease (ad)-like damages such as neuronal damage and decreased learning and memory functions. |
2021-12-13 |
2023-08-13 |
rat |
| Lei Xia, Yayan Pang, Junjie Li, Bin Wu, Yehong Du, Yuxin Chen, Man Luo, Yan Wang, Zhifang Don. Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-10. PMID:34511503. |
hyperphosphorylation modification promotes tau protein misfolding and aggregation into neurofibrillary tangles, leading to impairments of synaptic plasticity and learning and memory. |
2021-12-10 |
2023-08-13 |
mouse |
| Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Y. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. The EMBO journal. vol 40. issue 17. 2021-11-29. PMID:34260075. |
vagotomy selectively blunts this signaling, attenuates aβ and tau pathologies, and restores learning and memory. |
2021-11-29 |
2023-08-13 |
mouse |
| Bo-Wen Chen, Kai-Wen Zhang, Si-Jia Chen, Chun Yang, Peng-Gao L. Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice. Frontiers in aging neuroscience. vol 13. 2021-11-19. PMID:34790112. |
our results show that vad aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin a (va)-related receptors and va-related enzymes in the cortex, increased amyloid-β peptides (aβ40 and aβ42) in the brain and gut, upregulate the translation of beta-site app-cleaving enzyme 1 (bace1) and phosphorylated tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) receptors in the cortex. |
2021-11-19 |
2023-08-13 |
mouse |
| Liang Chen, Yi-Ping Zhou, Hua-Yi Liu, Juan-Hua Gu, Xin-Fu Zhou, Zeng Yue-Qi. Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice. Neurochemistry international. vol 151. 2021-11-18. PMID:34601013. |
after 9 months of treatment, we found that hyperoside can improve spatial learning and memory in app/ps1 transgenic mice, reduce amyloid plaque deposition and tau phosphorylation, decrease the number of activated microglia and astrocytes, and attenuate neuroinflammation and oxidative stress in the brain of app/ps1 mice. |
2021-11-18 |
2023-08-13 |
mouse |
| Jie Zheng, Na Tian, Fei Liu, Yidian Zhang, Jingfen Su, Yang Gao, Mingmin Deng, Linyu Wei, Jingwang Ye, Honglian Li, Jian-Zhi Wan. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:34262014. |
further studies revealed that deptac significantly improved microtubule assembly, neurite plasticity, and hippocampus-dependent learning and memory in transgenic mice with inducible overexpression of truncated and neurotoxic human tau n368. |
2021-11-15 |
2023-08-13 |
mouse |