| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aimilia Lydia Kalafateli, Cajsa Aranäs, Elisabet Jerlha. Activation of the amylin pathway modulates cocaine-induced activation of the mesolimbic dopamine system in male mice. Hormones and behavior. vol 127. 2021-06-25. PMID:33166561. |
we therefore explored in male mice, the effects of systemic administration of sct on cocaine-induced locomotor stimulation, dopamine release in the nac and cocaine reward, as well as reward-dependent memory of cocaine, in the conditioned place preference (cpp) paradigm. |
2021-06-25 |
2023-08-13 |
mouse |
| Daniel Vallöf, Aimilia Lydia Kalafateli, Elisabet Jerlha. Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31069918. |
we demonstrated here, that nmu into the nac shell, but not avta or ldtg, blocked the ability of acute alcohol to cause locomotor stimulation and to induce memory retrieval of alcohol reward, as well as reduced peanut butter in mice. |
2021-06-24 |
2023-08-13 |
mouse |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine is transferred through milk and alters the dopaminergic reward system of adult male rats, reducing dopamine action in the nucleus accumbens (nac) and hypothalamic arcuate nucleus. |
2021-06-24 |
2023-08-13 |
rat |
| S Gallegos, L San Martin, A Araya, D M Lovinger, G E Homanics, L G Aguay. Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:32357359. |
previous studies have shown the presence of several subunits of the inhibitory glycine receptor (glyr) in the reward system, specifically in medium spiny neurons (msns) of the nucleus accumbens (nac). |
2021-06-23 |
2023-08-13 |
mouse |
| Adina S Fischer, Bailey Holt-Gosselin, Scott L Fleming, Laura M Hack, Tali M Ball, Alan F Schatzberg, Leanne M William. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33230268. |
we quantified functional connectivity (fc) of reward neurocircuitry using nucleus accumbens (nac) seed regions of interest, and then characterized how changes in fc relate to symptom response (primary outcome) and qol response (secondary outcome). |
2021-06-23 |
2023-08-13 |
Not clear |
| Kenneth D Car. Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens. Physiology & behavior. vol 219. 2021-06-21. PMID:32092445. |
an encompassing, though speculative, hypothesis is that nac synaptic incorporation of cp-ampars in response to food scarcity and other forms of sustained reward loss adaptively increases incentive effects of reward stimuli and, at the same time, diminishes responsiveness to aversive stimuli that have potential to interfere with goal pursuit. |
2021-06-21 |
2023-08-13 |
human |
| Deepak Chouhan, Ankit Uniyal, Anagha Gadepalli, Akhilesh, Vineeta Tiwari, Somesh Agrawal, Tapas Kumar Roy, Sneha Shaw, Narendra Purohit, Vinod Tiwar. Probing the Manipulated Neurochemical Drive in Alcohol Addiction and Novel Therapeutic Advancements. ACS chemical neuroscience. vol 11. issue 9. 2021-06-18. PMID:32243128. |
these changes occur in various regions of the brain including reward circuit such as the ventral tegmental area (vta), nucleus accumbens (nac), and prefrontal cortex. |
2021-06-18 |
2023-08-13 |
Not clear |
| Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Abdolrahman Sarih. The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats. BMC neuroscience. vol 22. issue 1. 2021-06-17. PMID:33743609. |
in addition, metabotropic glutamate receptors (mglurs) in nac play important roles in the reward pathways. |
2021-06-17 |
2023-08-13 |
rat |
| Chun-Yu Yin, Shu-Ying Huang, Ling Gao, Yu-Hui Lin, Lei Chang, Hai-Yin Wu, Dong-Ya Zhu, Chun-Xia Lu. Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 11. 2021-06-11. PMID:33500273. |
nac, a "reward" center, is recently reported to be critical to confer the susceptibility to chronic social defeat stress (csds) and the depression-related outcome. |
2021-06-11 |
2023-08-13 |
mouse |
| Tracy L Fetterly, Max F Oginsky, Allison M Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R Ferrari. Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 11. 2021-06-11. PMID:33514676. |
human fmri studies show that insulin influences brain activity in regions that mediate reward and motivation, including the nucleus accumbens (nac). |
2021-06-11 |
2023-08-13 |
human |
| Elahe Khosrowabadi, Saeideh Karimi-Haghighi, Shole Jamali, Abbas Haghparas. Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32643036. |
a large amount of document has revealed that the orexin system in the reward circuity, including the nucleus accumbens (nac), contributes to the modification of drug reinforcement. |
2021-06-08 |
2023-08-13 |
rat |
| Atefeh Bakhtazad, Nasim Vousooghi, Mohammad Nasehi, Nima Sanadgol, Behzad Garmabi, Mohammad Reza Zarrindas. The effect of microinjection of CART 55-102 into the nucleus accumbens shell on morphine-induced conditioned place preference in rats: Involvement of the NMDA receptor. Peptides. vol 129. 2021-06-07. PMID:32335205. |
here, we evaluated whether intra-nucleus accumbens (nac) shell infusions of cart induces conditioned place preference (cpp) or conditioned place aversion (cpa) and affects morphine reward. |
2021-06-07 |
2023-08-13 |
rat |
| Atefeh Bakhtazad, Nasim Vousooghi, Mohammad Nasehi, Nima Sanadgol, Behzad Garmabi, Mohammad Reza Zarrindas. The effect of microinjection of CART 55-102 into the nucleus accumbens shell on morphine-induced conditioned place preference in rats: Involvement of the NMDA receptor. Peptides. vol 129. 2021-06-07. PMID:32335205. |
we also measured nr1 subunit expressions of the n-methyl-d-aspartate (nmda) receptor in various parts of the reward pathway (nac, prefrontal cortex and hippocampus) after conditioning tests. |
2021-06-07 |
2023-08-13 |
rat |
| Deirdre A Sackett, Travis M Moschak, Regina M Carell. Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task. The European journal of neuroscience. vol 51. issue 7. 2021-05-26. PMID:31863510. |
we previously reported that rapid dopamine release in the nac shell preferentially tracks the "preferred" (i.e., large reward) option during cues that predict the ability to respond for rewards of different sizes, as well as during reward delivery itself. |
2021-05-26 |
2023-08-13 |
Not clear |
| Carina Soares-Cunha, Nivaldo A P de Vasconcelos, Bárbara Coimbra, Ana Verónica Domingues, Joana M Silva, Eduardo Loureiro-Campos, Rita Gaspar, Ioannis Sotiropoulos, Nuno Sousa, Ana João Rodrigue. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31462765. |
one of the key regions of the reward circuit is the nucleus accumbens (nac). |
2021-05-14 |
2023-08-13 |
Not clear |
| Carina Soares-Cunha, Nivaldo A P de Vasconcelos, Bárbara Coimbra, Ana Verónica Domingues, Joana M Silva, Eduardo Loureiro-Campos, Rita Gaspar, Ioannis Sotiropoulos, Nuno Sousa, Ana João Rodrigue. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31462765. |
the classical view on the field postulates that nac dopamine receptor d1-expressing medium spiny neurons (d1-msns) convey reward signals, while dopamine receptor d2-expressing msns (d2-msns) encode aversion. |
2021-05-14 |
2023-08-13 |
Not clear |
| M J Castelhano-Carlos, S Aslani, N Sous. The Impact of Physical Enrichment in the Structure of the Medial Prefrontal Cortex and Nucleus Accumbens of the Adult Male Rat Brain. Neuroscience. vol 454. 2021-05-14. PMID:32058067. |
herein, we assessed neuronal plasticity as a consequence of living in the phw, by comparing the structure of the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac), two brain areas involved in the circuitry regulating motivation and reward. |
2021-05-14 |
2023-08-13 |
rat |
| Erin W Noye Tuplin, Faye Chleilat, Erna Alukic, Raylene A Reime. The Effects of Human Milk Oligosaccharide Supplementation During Critical Periods of Development on the Mesolimbic Dopamine System. Neuroscience. vol 459. 2021-05-14. PMID:33588004. |
the brain reward system, specifically the mesolimbic dopamine (da) projections from the ventral tegmental area (vta) to nucleus accumbens (nac) is involved in the motivation and preference for food. |
2021-05-14 |
2023-08-13 |
human |
| Daniel J Christoffel, Jessica J Walsh, Boris D Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K Ravikumar, Hemmings Wu, Casey H Halpern, Robert C Malenk. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33837200. |
here, we show that modulation of prefrontal cortex (pfc) and anterior paraventricular thalamus (apvt) excitatory inputs to the nucleus accumbens (nac), a key node of reward circuitry, has opposing effects on high fat intake in mice. |
2021-05-03 |
2023-08-13 |
mouse |
| Daniel J Christoffel, Jessica J Walsh, Boris D Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K Ravikumar, Hemmings Wu, Casey H Halpern, Robert C Malenk. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33837200. |
these results demonstrate that input-specific nac circuit adaptations occur with repeated exposure to a potent natural reward and suggest that neuromodulatory interventions may be therapeutically useful for individuals with pathologic hedonic feeding. |
2021-05-03 |
2023-08-13 |
mouse |