| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ream Al-Hasani, Raajaram Gowrishankar, Gavin P Schmitz, Christian E Pedersen, David J Marcus, Sofia E Shirley, Taylor E Hobbs, Abigail J Elerding, Sophie J Renaud, Miao Jing, Yulong Li, Veronica A Alvarez, Julia C Lemos, Michael R Brucha. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature neuroscience. vol 24. issue 10. 2021-10-08. PMID:34385700. |
the long-range gabaergic input from the ventral tegmental area (vta) to the nucleus accumbens (nac) is relatively understudied, and therefore its role in reward processing has remained unknown. |
2021-10-08 |
2023-08-13 |
mouse |
| Ream Al-Hasani, Raajaram Gowrishankar, Gavin P Schmitz, Christian E Pedersen, David J Marcus, Sofia E Shirley, Taylor E Hobbs, Abigail J Elerding, Sophie J Renaud, Miao Jing, Yulong Li, Veronica A Alvarez, Julia C Lemos, Michael R Brucha. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature neuroscience. vol 24. issue 10. 2021-10-08. PMID:34385700. |
in the present study, we show, in both male and female mice, that long-range gabaergic projections from the vta to the ventral nac shell, but not to the dorsal nac shell or nac core, are engaged in reward and reinforcement behavior. |
2021-10-08 |
2023-08-13 |
mouse |
| Ream Al-Hasani, Raajaram Gowrishankar, Gavin P Schmitz, Christian E Pedersen, David J Marcus, Sofia E Shirley, Taylor E Hobbs, Abigail J Elerding, Sophie J Renaud, Miao Jing, Yulong Li, Veronica A Alvarez, Julia C Lemos, Michael R Brucha. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature neuroscience. vol 24. issue 10. 2021-10-08. PMID:34385700. |
we show that this gabaergic projection exclusively synapses on to cholinergic interneurons (cins) in the ventral nac shell, thereby serving a specialized function in modulating reinforced reward behavior through the inhibition of ventral nac shell cins. |
2021-10-08 |
2023-08-13 |
mouse |
| Yongxiang Li, Lvshuang Chen, Weijie Zhao, Lijuan Sun, Ruixue Zhang, Shuqing Zhu, Kailai Xie, Xiajie Feng, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Lina Wang, Qingyan Jian. Food reward depends on TLR4 activation in dopaminergic neurons. Pharmacological research. vol 169. 2021-10-04. PMID:33971268. |
conditional deletion of tlr4 also decreased the activity of da neurons while suppressing the expression of tyrosine hydroxylase (th) in the vta, which regulates the concentration of da in the nucleus accumbens (nac) to affect food reward. |
2021-10-04 |
2023-08-13 |
mouse |
| Anna Brancato, Valentina Castelli, Gianluca Lavanco, Giuseppe Tringali, Vincenzo Micale, Martin Kuchar, Cesare D'Amico, Giuseppe Pizzolanti, Salvatore Feo, Carla Cannizzar. Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572345. |
binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (nac). |
2021-10-01 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Abbas Haghparas. Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31436887. |
the nucleus accumbens (nac) is a central component of the brain reward system. |
2021-09-28 |
2023-08-13 |
rat |
| Breanne E Pirino, Mary B Spodnick, Andrew T Gargiulo, Genevieve R Curtis, Jessica R Barson, Anushree N Karkhani. Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. Neuropharmacology. vol 181. 2021-09-23. PMID:33011200. |
classically, the dynorphin/kappa opioid receptor (kor) system in the nac was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and kor activation was known to inhibit dopamine release. |
2021-09-23 |
2023-08-13 |
rat |
| Saeedeh Nasrollahi, Sara Karimi, Gholamali Hamidi, Monireh Naderitehrani, Alireza Abe. Blockade of the orexin 1 receptors in the nucleus accumbens' shell reversed the reduction effect of olanzapine on motivation for positive reinforcers. Neuroscience letters. vol 762. 2021-09-14. PMID:34311049. |
the nucleus accumbens (nac) is a region of the neural system that serves effort-related high reward choices andthe orexin 1 receptor (ox1r) is distributed extensively throughout the nucleus accumbens shell (acbs). |
2021-09-14 |
2023-08-13 |
rat |
| Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarih. The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats. Behavioral and brain functions : BBF. vol 17. issue 1. 2021-09-02. PMID:33612106. |
the nucleus accumbens (nac) plays a principal role in drug reward. |
2021-09-02 |
2023-08-13 |
rat |
| Claire E Stelly, Kasey S Girven, Merridee J Lefner, Kaitlyn M Fonzi, Matthew J Wana. Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33452431. |
specifically, a cue that always follows the previous reward by a short delay (high reward rate) evokes a larger dopamine response in the nucleus accumbens (nac) core relative to a distinct cue that always follows the prior reward by a long delay (low reward rate). |
2021-08-27 |
2023-08-13 |
rat |
| Sohini Dutta, Jasmin Beaver, Carly J Halcomb, Aaron M Jasno. Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear. Neurobiology of stress. vol 15. 2021-08-27. PMID:34355048. |
the nucleus accumbens (nac), consisting of core (nacc) and shell (nacs) sub-regions, has primarily been studied as a locus mediating the effects of drug reward and addiction. |
2021-08-27 |
2023-08-13 |
mouse |
| Diana Sketriene, Damien Battista, Christina J Perry, Priya Sumithran, Andrew J Lawrence, Robyn M Brow. N-acetylcysteine reduces addiction-like behaviour towards high-fat high-sugar food in diet-induced obese rats. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34028895. |
this persistent responding in the absence of reward displayed by dio rats was ameliorated by daily injections of nac (100 mg/kg, i.p.) |
2021-08-20 |
2023-08-13 |
rat |
| Linshan Sun, Jingjing You, Fengjiao Sun, Minghu Cui, Jiangong Wang, Wentao Wang, Dan Wang, Dunjiang Liu, Zhicheng Xu, Changyun Qiu, Bin Liu, Haijing Ya. Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress. Neurobiology of stress. vol 15. 2021-08-13. PMID:34381852. |
blocking the projections from the bla to the nac associated with sex reward increases the excitability of vta gabaergic neurons and decreases the excitability of vta dopaminergic neurons, while activating this pathway decreases the excitability of vta gabaergic neurons and increases the excitability of vta dopaminergic neurons, which may be the cellular mechanism by which the vta-bla-nac circuit associated with sex reward ameliorates the attenuated reward sensitivity induced by chronic stress. |
2021-08-13 |
2023-08-13 |
Not clear |
| Hassan Jorjani, Marzieh Joneidi, Abbas Ali Vafaei, Ali Rashidy-Pour, Hamidreza Sameni, Ahmad Reza Bandegi, Behpour Yousefi, Hossein Miladi-Gorj. Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats. Pharmacology, biochemistry, and behavior. vol 201. 2021-08-10. PMID:33444602. |
we conclude that blocking trkb with ana-12 showed therapeutic effects on morphine-associated reward memory and neuronal death in the nac and mpfc induced by morphine cpp. |
2021-08-10 |
2023-08-13 |
rat |
| Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kaliva. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemporary clinical trials. vol 91. 2021-08-04. PMID:32087337. |
nac is a cysteine pro-drug that stimulates the cystine-glutamate exchanger, normalizes glial glutamate transporters, and restores glutamatergic tone on presynaptic receptors in reward regions of the brain. |
2021-08-04 |
2023-08-13 |
Not clear |
| Yasaman Razavi, Sara Karimi, Saeideh Karimi-Haghighi, Soghra Hesam, Abbas Haghparas. Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Canadian journal of physiology and pharmacology. vol 98. issue 11. 2021-08-02. PMID:32574519. |
neural circuitry comprising the nucleus accumbens (nac), prefrontal cortex (pfc), amygdala (amy), and hippocampus (hip) are the main components of the reward circuit. |
2021-08-02 |
2023-08-13 |
rat |
| Rui Liu, Yun Wang, Xiongying Chen, Zhifang Zhang, Le Xiao, Yuan Zho. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33662708. |
the nucleus accumbens (nac) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (mdd). |
2021-07-30 |
2023-08-13 |
Not clear |
| Marcos Brandão Contó, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Tania Marcourakis, Vânia D'Almeida, Rosana Camarin. Exposure to Running Wheels Prevents Ethanol Rewarding Effects: The Role of CREB and Deacetylases SIRT-1 and SIRT-2 in the Nucleus Accumbens and Prefrontal Cortex. Neuroscience. vol 469. 2021-07-27. PMID:34175423. |
vpa, ethanol and the combination of both inhibited pcreb and pcreb/creb ratio in the nac, suggesting that both reward stimuli can share similar patterns of creb activation. |
2021-07-27 |
2023-08-13 |
mouse |
| Hee-Dae Kim, Jing Wei, Tanessa Call, Nicole Teru Quintus, Alexander J Summers, Samantha Carotenuto, Ross Johnson, Xiaokuang Ma, Chenxi Xu, Jin G Park, Shenfeng Qiu, Deveroux Ferguso. Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens. Molecular psychiatry. 2021-07-13. PMID:34253865. |
in the reward circuitry, the nucleus accumbens (nac) is a key brain region of depression pathophysiology, possibly based on differential activity of d1- or d2- medium spiny neurons (msns). |
2021-07-13 |
2023-08-13 |
mouse |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |