| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nagiua Cuomo-Haymour, Hannes Sigrist, Christian Ineichen, Giancarlo Russo, Ursina Nüesch, Felix Gantenbein, Luka Kulic, Irene Knuesel, Giorgio Bergamini, Christopher Robert Pryc. Evidence for Effects of Extracellular Vesicles on Physical, Inflammatory, Transcriptome and Reward Behaviour Status in Mice. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35162951. |
bodyweight, spleen or nac transcriptome and reward (sucrose) motivation were assessed. |
2022-02-15 |
2023-08-13 |
mouse |
| Kenji Yamaguchi, Yoshitomo Maeda, Takeshi Sawada, Yusuke Iino, Mio Tajiri, Ryosuke Nakazato, Shin Ishii, Haruo Kasai, Sho Yagishit. A behavioural correlate of the synaptic eligibility trace in the nucleus accumbens. Scientific reports. vol 12. issue 1. 2022-02-05. PMID:35121769. |
here we examined a reward-sensitive period to brief pure tones with an accurate measurement of an effective timing of water reward in head-fixed pavlovian conditioning, which depended on the plasticity-related signaling in the nac. |
2022-02-05 |
2023-08-13 |
Not clear |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
microinjections of tfb-tboa into the nac, but not the ventral tegmental area (vta), or dorsal striatum (ds), dose-dependently inhibited cocaine self-administration under fixed-ratio and progressive-ratio reinforcement schedules, shifted the cocaine dose-response curve downward, and inhibited intracranial brain-stimulation reward. |
2022-01-29 |
2023-08-13 |
rat |
| Jianfeng Liu, Ruyan Wu, Robert Seaman, Kevin M Manz, Bernard Johnson, Jimmy Vu, Yufei Huang, Yanan Zhang, Alfred J Robison, Rachael Neve, Brad A Grueter, David Dietz, Jun-Xu L. TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc. Molecular psychiatry. 2022-01-26. PMID:35079125. |
we focused on the shell subregion of nucleus accumbens (nac), a key brain region of the brain reward system. |
2022-01-26 |
2023-08-13 |
rat |
| Maxine K Loh, Nicole C Ferrara, Jocelyn M Torres, J Amiel Rosenkran. Medial orbitofrontal cortex and nucleus accumbens mediation in risk assessment behaviors in adolescents and adults. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-01-18. PMID:35039643. |
namely, the medial orbitofrontal cortex (mo) contributes to behavior guided by reward probability and sends direct projections to the nac (mo→nac), which may permit risk assessment in a mature circuit. |
2022-01-18 |
2023-08-13 |
rat |
| Darius D Becker-Krail, Puja K Parekh, Kyle D Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A Hildebrand, Brandon Dunham, Madhavi K Ganapathiraiu, Ryan W Logan, Colleen A McClun. Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward. The European journal of neuroscience. 2022-01-10. PMID:35001440. |
in the nucleus accumbens (nac), a region important for reward, both sirt1 and the circadian transcription factor neuronal pas domain protein 2 (npas2) are highly enriched, and both are regulated by the metabolic cofactor nad+. |
2022-01-10 |
2023-08-13 |
mouse |
| Darius D Becker-Krail, Puja K Parekh, Kyle D Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A Hildebrand, Brandon Dunham, Madhavi K Ganapathiraiu, Ryan W Logan, Colleen A McClun. Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward. The European journal of neuroscience. 2022-01-10. PMID:35001440. |
interestingly, cocaine also induces nac expression of both npas2 and sirt1, and both have independently been shown to regulate cocaine reward in mice. |
2022-01-10 |
2023-08-13 |
mouse |
| Darius D Becker-Krail, Puja K Parekh, Kyle D Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A Hildebrand, Brandon Dunham, Madhavi K Ganapathiraiu, Ryan W Logan, Colleen A McClun. Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward. The European journal of neuroscience. 2022-01-10. PMID:35001440. |
however, whether npas2 and sirt1 interact in the nac and/or whether together they regulate reward is unknown. |
2022-01-10 |
2023-08-13 |
mouse |
| Darius D Becker-Krail, Puja K Parekh, Kyle D Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A Hildebrand, Brandon Dunham, Madhavi K Ganapathiraiu, Ryan W Logan, Colleen A McClun. Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward. The European journal of neuroscience. 2022-01-10. PMID:35001440. |
together, our data reveal an interaction between npas2 and sirt1 in the nac which may serve to integrate cocaine's effects on circadian and metabolic factors, leading to regulation of drug reward. |
2022-01-10 |
2023-08-13 |
mouse |
| Salar Vaseghi, Shahram Zarrabian, Abbas Haghparas. Reviewing the role of the orexinergic system and stressors in modulating mood and reward-related behaviors. Neuroscience and biobehavioral reviews. 2022-01-01. PMID:34973302. |
cross-talk between the reward system and orexinergic signaling was also investigated, especially orexinergic signaling in the ventral tegmental area (vta), the nucleus accumbens (nac), and the hippocampus. |
2022-01-01 |
2023-08-13 |
Not clear |
| Hidenari Nomura, Cheol Son, Daisuke Aotani, Yoshiyuki Shimizu, Goro Katsuura, Michio Noguchi, Toru Kusakabe, Tomohiro Tanaka, Takashi Miyazawa, Kiminori Hosoda, Kazuwa Naka. Impaired leptin responsiveness in the nucleus accumbens of leptin-overexpressing transgenic mice with dysregulated sucrose and lipid preference independent of obesity. Neuroscience research. 2021-12-31. PMID:34971637. |
however, compared to wt-cd1w mice, leptg-hfd1w mice exhibited attenuated leptin-induced anorexia, decreased leptin-induced c-fos immunostaining in nucleus accumbens (nac), one of important site of reward system, decreased leptin-stimulated pstat3 immunostaining in hypothalamus. |
2021-12-31 |
2023-08-13 |
mouse |
| Isao Nagata, Mika Sasaki, Tomoyuki Miyazaki, Kensuke Saeki, Ken-Ichi Ogawa, Yoshinori Kamiy. Subanesthetic Dose of Propofol Activates the Reward System in Rats. Anesthesia and analgesia. 2021-12-27. PMID:34958308. |
activation of the dopaminergic circuits of the midbrain reward system, including the ventral tegmental area (vta) and nac, plays a crucial role in addiction. |
2021-12-27 |
2023-08-13 |
rat |
| Inês M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944702. |
altogether, these results suggest that social interaction reward engages camkii in the nac. |
2021-12-24 |
2023-08-13 |
rat |
| Katrina Y Choe, Richard A I Bethlehem, Martin Safrin, Hongmei Dong, Elena Salman, Ying Li, Valery Grinevich, Peyman Golshani, Laura A DeNardo, Olga Peñagarikano, Neil G Harris, Daniel H Geschwin. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. Neuron. 2021-12-21. PMID:34932941. |
notably, chemogenetically triggered release of endogenous oxytocin strongly stimulated the nucleus accumbens (nac), a forebrain nucleus implicated in social reward. |
2021-12-21 |
2023-08-13 |
mouse |
| Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin W. The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats. Frontiers in behavioral neuroscience. vol 15. 2021-12-20. PMID:34924971. |
this study supports the role of crf1r in the brain in mediating the central reward processing through d1r in the nac and provided a possibility that crf1r antagonist may be a new therapeutic approach for the treatment of propofol addiction. |
2021-12-20 |
2023-08-13 |
rat |
| Brandon J Polzin, Sarah A Heimovics, Lauren V Riter. Immunolabeling provides evidence for subregions in the songbird nucleus accumbens and suggests a context-dependent role in song in male European starlings (Sturnus vulgaris). Brain, behavior and evolution. 2021-12-08. PMID:34879382. |
the nucleus accumbens (nac) is a brain region well-known to mediate reward and motivation, which suggests it is an ideal candidate to regulate reward associated with gregarious song. |
2021-12-08 |
2023-08-13 |
Not clear |
| Collin D Teague, Eric J Nestle. Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens. Molecular psychiatry. 2021-12-06. PMID:34079067. |
repeated cocaine use induces coordinated changes in gene expression that drive plasticity in the nucleus accumbens (nac), an important component of the brain's reward circuitry, and promote the development of maladaptive, addiction-like behaviors. |
2021-12-06 |
2023-08-13 |
Not clear |
| Asrin Sharifi, Saeideh Karimi-Haghighi, Ronak Shabani, Hamid Reza Asgari, Reza Ahadi, Abbas Haghparas. Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 113. 2021-12-06. PMID:34662693. |
moreover, the nucleus accumbens (nac), as a key area in the reward circuit, extensively receives dopaminergic projections from the ventral tegmentum area. |
2021-12-06 |
2023-08-13 |
rat |
| Zhiyuan Liu, Qiumin Le, Yanbo Lv, Xi Chen, Jian Cui, Yiming Zhou, Deqin Cheng, Chaonan Ma, Xiujuan Su, Lei Xiao, Ruyi Yang, Jiayi Zhang, Lan Ma, Xing Li. A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state. Cell research. 2021-12-01. PMID:34848869. |
dopamine (da) level in the nucleus accumbens (nac) is critical for reward and aversion encoding. |
2021-12-01 |
2023-08-13 |
Not clear |