| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuikui Zhou, Hua Xu, Shanshan Lu, Shaolei Jiang, Guoqiang Hou, Xiaofei Deng, Miao He, Yingjie Zh. Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice. Nature communications. vol 13. issue 1. 2022-10-21. PMID:36271048. |
the nucleus accumbens (nac) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. |
2022-10-21 |
2023-08-14 |
mouse |
| Bowen Tan, Tobias Nöbauer, Caleb J Browne, Eric J Nestler, Alipasha Vaziri, Jeffrey M Friedma. Dynamic processing of hunger and thirst by common mesolimbic neural ensembles. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 43. 2022-10-17. PMID:36252036. |
the nucleus accumbens (nac) is a canonical reward center that regulates feeding and drinking but it is not known whether these behaviors are mediated by same or different neurons. |
2022-10-17 |
2023-08-14 |
mouse |
| Bowen Tan, Tobias Nöbauer, Caleb J Browne, Eric J Nestler, Alipasha Vaziri, Jeffrey M Friedma. Dynamic processing of hunger and thirst by common mesolimbic neural ensembles. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 43. 2022-10-17. PMID:36252036. |
in aggregate, these data show that a highly overlapping set of d1 and d2 neurons in nac detect food and water reward and elicit concordant responses to hunger and thirst. |
2022-10-17 |
2023-08-14 |
mouse |
| Tong-Yu Liang, Hua Zhou, Yan-Gang Su. Distinct roles of dopamine receptor subtypes in the nucleus accumbens during itch signal processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-14. PMID:36241382. |
ventral tegmental area (vta) dopaminergic neurons, which are well known for their central roles in reward and motivation-related behaviors, have been shown to participate in itch processing via their projection to the nucleus accumbens (nac). |
2022-10-14 |
2023-08-14 |
mouse |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Anibal Araya, Scarlet Gallegos, Adolfo Maldonado, Mario Rivera-Meza, Ramesh Chandra, Mary Kay Lobo, Luis G Aguay. Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-29. PMID:36175550. |
the nucleus accumbens (nac) is a critical region in the brain reward system since it integrates abundant synaptic inputs contributing to the control of neuronal excitability in the circuit. |
2022-09-29 |
2023-08-14 |
mouse |
| Jia-Ying Li, Yang-Jung Yu, Chun-Lin Su, Yu-Qi Shen, Chih-Hua Chang, Po-Wu Gea. Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-15. PMID:36109595. |
the basolateral amygdala (bla) involves the association of conditioned cues with reward and aversive valences and projects the information to the nucleus accumbens (nac) that mediates reward-seeking. |
2022-09-15 |
2023-08-14 |
mouse |
| Daisuke Tsuboi, Takeshi Otsuka, Takushi Shimomura, Md Omar Faruk, Yukie Yamahashi, Mutsuki Amano, Yasuhiro Funahashi, Keisuke Kuroda, Tomoki Nishioka, Kenta Kobayashi, Hiromi Sano, Taku Nagai, Kiyofumi Yamada, Anastasios V Tzingounis, Atsushi Nambu, Yoshihiro Kubo, Yasuo Kawaguchi, Kozo Kaibuch. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior. Cell reports. vol 40. issue 10. 2022-09-07. PMID:36070693. |
previously, we reported that dopamine increases d1 receptor (d1r)-expressing medium spiny neuron (msn) excitability and firing rates in the nucleus accumbens (nac) via the pka/rap1/erk pathway to promote reward behavior. |
2022-09-07 |
2023-08-14 |
Not clear |
| Wooyoung Kang, Younbin Kang, Aram Kim, Woo-Suk Tae, Kyeong Jin Kim, Sin Gon Kim, Byung-Joo Ham, Kyu-Man Ha. Shape analysis of the subcortical structures in North Korean refugees with post-traumatic stress disorder and major depressive disorder. Psychiatry research. Neuroimaging. vol 326. 2022-09-01. PMID:36049318. |
the nucleus accumbens (nac) and ventral pallidum (vp) are the major sites in subcortical structures that play key roles in reward and motivation. |
2022-09-01 |
2023-08-14 |
Not clear |
| M I Airapetov, S O Eresko, D A Skabelkin, A R Iskalieva, A A Lebedev, E R Bychkov, P D Shabano. [The effect of rifampicin on the system of Toll-like receptors in the nucleus accumbens of the brain of long-term alcoholized rats during alcohol withdrawal]. Biomeditsinskaia khimiia. vol 68. issue 4. 2022-08-25. PMID:36005846. |
nucleus accumbens (nac) is the ventral part of the striatum of the brain; it is an important part of the mesolimbic pathway involved in the reward system that mediates the formation of various forms of addiction, in particular alcohol addiction. |
2022-08-25 |
2023-08-14 |
rat |
| Haleh Amirteymori, Saeideh Karimi-Haghighi, Mahboobeh Mirmohammadi, Maryam Majidinezhad, Elahe Khosrowabadi, Abbas Haghparas. Hypocretin/orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP. Progress in neuro-psychopharmacology & biological psychiatry. 2022-08-21. PMID:35988849. |
based on the current data, the ox system in the nac is extensively implicated in the reward properties of meth; therefore, modulation of this system has therapeutic potential in treating psychostimulant use disorders. |
2022-08-21 |
2023-08-14 |
rat |
| Benfu Wang, Xiaowei Yang, Wenhua Zhou, Huaqiang Zhu, Qingquan Lian, Jianping Yan. Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats. Pharmacology, biochemistry, and behavior. 2022-08-15. PMID:35970339. |
in the previous study, we demonstrated that the erk signaling pathways in the nucleus accumbens (nac) were involved in propofol reward. |
2022-08-15 |
2023-08-14 |
rat |
| Xuhong Li, Yuqian Zheng, Xiaoxuan Zhao, Ruisi Cui, Xinwang L. Relationship between the role of muscarinic M Neuroscience letters. 2022-07-09. PMID:35809878. |
relationship between the role of muscarinic m opioid use disorder mainly results from functional defects in the brain reward loop, which includs the ventral tegmental area (vta) and nucleus accumbens (nac; consisting of shell and core, nacs and nacc). |
2022-07-09 |
2023-08-14 |
Not clear |
| Ling-Ling Xie, Chen Rui, Zhuang-Zhuang Li, Shan-Shan Li, Yong-Jian Fan, Man-Man Q. Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats. Neuroscience letters. 2022-06-26. PMID:35753614. |
moreover, the activity of creb in the nucleus accumbens (nac) participates in reward and motivation, further contributing to depression induced by tbi. |
2022-06-26 |
2023-08-14 |
rat |
| Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L K Goh, Yingjie Zhu, Fanglin Guan, Teng Che. A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. Molecular psychiatry. 2022-06-17. PMID:35715487. |
increasing novel-m009c levels in the nac attenuated meth-induced conditioned place preference (cpp) and hyperlocomotion, whereas inhibiting novel-m009c expression in the nac enhanced these effects but did not change the preference of mice for a natural reward, i.e., sucrose. |
2022-06-17 |
2023-08-14 |
mouse |
| Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L K Goh, Yingjie Zhu, Fanglin Guan, Teng Che. A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. Molecular psychiatry. 2022-06-17. PMID:35715487. |
our findings demonstrate an important role for nac novel-m009c in regulating meth reward, reveal a novel molecular regulator of the actions of meth on brain reward circuitries and provide a new strategy for treating meth addiction based on the modulation of small non-coding rnas. |
2022-06-17 |
2023-08-14 |
mouse |
| Sophia C Levis, Matthew T Birnie, Jessica L Bolton, Christina R Perrone, Johanna S Montesinos, Tallie Z Baram, Stephen V Mahle. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Translational psychiatry. vol 12. issue 1. 2022-06-15. PMID:35705547. |
we probe potential circuit mechanisms in males by assessing opioid-associated neuronal activation in stress and reward circuit nodes including nucleus accumbens (nac), amygdala, medial prefrontal cortex (mpfc), and paraventricular thalamus. |
2022-06-15 |
2023-08-14 |
rat |
| Yu-Dan Ding, Xiao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li, Francisco Xavier Castellanos, Tong-Jian Bai, Qi-Jing Bo, Jun Cao, Zhi-Kai Chang, Guan-Mao Chen, Ning-Xuan Chen, Wei Chen, Chang Cheng, Yu-Qi Cheng, Xi-Long Cui, Jia Duan, Yi-Ru Fang, Qi-Yong Gong, Zheng-Hua Hou, Lan Hu, Li Kuang, Feng Li, Hui-Xian Li, Kai-Ming Li, Tao Li, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Bin Lu, Qing-Hua Luo, Hua-Qing Meng, Dai-Hui Peng, Hai-Tang Qiu, Jiang Qiu, Yue-Di Shen, Yu-Shu Shi, Tian-Mei Si, Yan-Qing Tang, Chuan-Yue Wang, Fei Wang, Kai Wang, Li Wang, Xiang Wang, Ying Wang, Yu-Wei Wang, Xiao-Ping Wu, Xin-Ran Wu, Chun-Ming Xie, Guang-Rong Xie, Hai-Yan Xie, Peng Xie, Xiu-Feng Xu, Hong Yang, Jian Yang, Jia-Shu Yao, Shu-Qiao Yao, Ying-Ying Yin, Yong-Gui Yuan, Yu-Feng Zang, Ai-Xia Zhang, Hong Zhang, Ke-Rang Zhang, Lei Zhang, Zhi-Jun Zhang, Jing-Ping Zhao, Ru-Bai Zhou, Yi-Ting Zhou, Jun-Juan Zhu, Zhi-Chen Zhu, Chao-Jie Zou, Xi-Nian Zuo, Chao-Gan Yan, Wen-Bin Gu. Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Translational psychiatry. vol 12. issue 1. 2022-06-06. PMID:35668086. |
the nucleus accumbens (nac) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (mdd). |
2022-06-06 |
2023-08-14 |
Not clear |
| Yu-Dan Ding, Xiao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li, Francisco Xavier Castellanos, Tong-Jian Bai, Qi-Jing Bo, Jun Cao, Zhi-Kai Chang, Guan-Mao Chen, Ning-Xuan Chen, Wei Chen, Chang Cheng, Yu-Qi Cheng, Xi-Long Cui, Jia Duan, Yi-Ru Fang, Qi-Yong Gong, Zheng-Hua Hou, Lan Hu, Li Kuang, Feng Li, Hui-Xian Li, Kai-Ming Li, Tao Li, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Bin Lu, Qing-Hua Luo, Hua-Qing Meng, Dai-Hui Peng, Hai-Tang Qiu, Jiang Qiu, Yue-Di Shen, Yu-Shu Shi, Tian-Mei Si, Yan-Qing Tang, Chuan-Yue Wang, Fei Wang, Kai Wang, Li Wang, Xiang Wang, Ying Wang, Yu-Wei Wang, Xiao-Ping Wu, Xin-Ran Wu, Chun-Ming Xie, Guang-Rong Xie, Hai-Yan Xie, Peng Xie, Xiu-Feng Xu, Hong Yang, Jian Yang, Jia-Shu Yao, Shu-Qiao Yao, Ying-Ying Yin, Yong-Gui Yuan, Yu-Feng Zang, Ai-Xia Zhang, Hong Zhang, Ke-Rang Zhang, Lei Zhang, Zhi-Jun Zhang, Jing-Ping Zhao, Ru-Bai Zhou, Yi-Ting Zhou, Jun-Juan Zhu, Zhi-Chen Zhu, Chao-Jie Zou, Xi-Nian Zuo, Chao-Gan Yan, Wen-Bin Gu. Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Translational psychiatry. vol 12. issue 1. 2022-06-06. PMID:35668086. |
specifically, the combination of disrupted nac fcs within the reward network could discriminate patients with recurrent mdd from healthy controls with an optimal accuracy of 74.7%. |
2022-06-06 |
2023-08-14 |
Not clear |
| Xin Wang, Fei Li, Jun Zhu, Dayun Feng, Yingwu Shi, Liang Qu, Yang Li, Kang Guo, Yue Zhang, Qiang Wang, Naigeng Wang, Xuelian Wang, Shunnan G. Upregulation of Cell Division Cycle 20 Expression Alters the Morphology of Neuronal Dendritic Spines in the Nucleus Accumbens by Promoting FMRP Ubiquitination. Journal of neurochemistry. 2022-05-27. PMID:35621027. |
the nucleus accumbens (nac) is the key area of the reward circuit, but its heterogeneity has been poorly studied. |
2022-05-27 |
2023-08-13 |
rat |