| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
in an effort to assess the role of 5-ht in drug-mediated reward, this study analyzed the serotonergic innervation of nac using immunocytochemistry for 5-ht and the 5-ht transporter (sert). |
2000-03-09 |
2023-08-12 |
rat |
| V Bassareo, G Di Chiar. Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594666. |
these results show that the phasic responsiveness of nac da transmission to an unfamiliar palatable food is under strong modulatory control by primary (consummatory) and secondary (appetitive) stimuli, and that the sign and extent of this control depends on the nature of the appetitive stimulus, delay of reward and motivational state (deprivation). |
2000-02-10 |
2023-08-12 |
rat |
| W J McBride, J M Murphy, S Ikemot. Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behavioural brain research. vol 101. issue 2. 1999-08-23. PMID:10372570. |
the nac also appears to have a major role in brain reward mechanisms, whereas most data from icsa and icpc studies do not support an involvement of the caudate-putamen in reinforcement processes. |
1999-08-23 |
2023-08-12 |
rat |
| W J McBride, J M Murphy, S Ikemot. Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behavioural brain research. vol 101. issue 2. 1999-08-23. PMID:10372570. |
activation of the da system within the shell subregion of the nac appears to play a key role in brain reward mechanisms. |
1999-08-23 |
2023-08-12 |
rat |
| P H Janak, J Y Chang, D J Woodwar. Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889360. |
thus different but overlapping populations of neurons in the nac represent each event that occurs along the temporal dimension of a single trial performed to obtain ethanol reward. |
1999-03-12 |
2023-08-12 |
rat |
| T H Park, K D Car. Neuroanatomical patterns of fos-like immunoreactivity induced by a palatable meal and meal-paired environment in saline- and naltrexone-treated rats. Brain research. vol 805. issue 1-2. 1998-11-25. PMID:9733960. |
since naltrexone, alone, increased fli in vta, nac shell, central amygdala (cea) and laterodorsal bed nucleus of the stria terminalis (bstld), the blunting of ingestion reward by naltrexone may result from direct or transsynaptic activating effects on opponent neuronal activity within this highly interconnected set of structures that mediate and modulate reward. |
1998-11-25 |
2023-08-12 |
rat |
| A Her. Endogenous opioid systems and alcohol addiction. Psychopharmacology. vol 129. issue 2. 1997-06-16. PMID:9040115. |
one hypothetical model proposes that reward results from activation of mu-opioid receptors in the vta and/or delta-receptor in the nac; both these nuclei are targets of endogenous beta-endorphin. |
1997-06-16 |
2023-08-12 |
Not clear |
| S A Josselyn, F J Vaccarin. Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-140548, a CCKA receptor antagonist. Pharmacology, biochemistry, and behavior. vol 55. issue 3. 1997-05-08. PMID:8951986. |
thus, the present experiment examined the role of endogenous ccka mechanisms in the nac in the development of conditioned reward. |
1997-05-08 |
2023-08-12 |
Not clear |
| S A Josselyn, F J Vaccarin. Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-140548, a CCKA receptor antagonist. Pharmacology, biochemistry, and behavior. vol 55. issue 3. 1997-05-08. PMID:8951986. |
the ccka receptor-selective antagonist pd-140548 was microinjected into the nac during the cs-food pairing phase of a conditioned reward experiment. |
1997-05-08 |
2023-08-12 |
Not clear |
| S A Josselyn, F J Vaccarin. Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-140548, a CCKA receptor antagonist. Pharmacology, biochemistry, and behavior. vol 55. issue 3. 1997-05-08. PMID:8951986. |
results suggest that blockade of ccka receptors in the nac impairs the development of conditioned reward. |
1997-05-08 |
2023-08-12 |
Not clear |
| M Koch, A Schmid, H U Schnitzle. Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens. Neuroreport. vol 7. issue 8. 1997-01-07. PMID:8856694. |
these findings suggest that the catecholaminergic innervation of the nac is important for behavioural control by conditioned reward. |
1997-01-07 |
2023-08-12 |
rat |
| P I Johnson, M A Parente, J R Stella. NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813355. |
the role of the nucleus accumbens (nac) and ventral pallidum (vp) in food reward modulation was investigated using heyman's [24] curve fitting approach in food deprived rats. |
1996-12-18 |
2023-08-12 |
rat |
| P I Johnson, M A Parente, J R Stella. NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813355. |
these data are surprising, given the extensive literature on the relationship between damage in the nac and loss of reward efficacy. |
1996-12-18 |
2023-08-12 |
rat |
| P I Johnson, M A Parente, J R Stella. NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813355. |
the results from the present study suggest that (1) both the nac and vp are involved in the modulation of food reward, (2) that lateral subregions in each structure may function to dampen food reward efficacy, and (3) that medial subregions may enhance food reward. |
1996-12-18 |
2023-08-12 |
rat |
| S A Josselyn, V P Franco, F J Vaccarin. PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. Neuroscience letters. vol 209. issue 2. 1996-12-04. PMID:8761988. |
the present experiment examines whether the blockade of cckb receptors in the nac with microinjection of pd-135158 (10 micrograms in 0.5 microliter) potentiates bar-pressing for stimuli previously associated with food reward. |
1996-12-04 |
2023-08-12 |
Not clear |
| M A Gerrits, N F Ramsey, G Wolterink, J M van Re. Lack of evidence for an involvement of nucleus accumbens dopamine D1 receptors in the initiation of heroin self-administration in the rat. Psychopharmacology. vol 114. issue 3. 1995-03-16. PMID:7855207. |
the dopamine d1 receptors present in the nac are probably not involved in opiate reward. |
1995-03-16 |
2023-08-12 |
rat |
| P I Johnson, J R Stella. N-methyl-D-aspartic acid-induced lesions of the nucleus accumbens and/or ventral pallidum fail to attenuate lateral hypothalamic self-stimulation reward. Brain research. vol 646. issue 1. 1994-09-15. PMID:8055342. |
contrary to motor effects, reward efficacy was relatively unaffected for the nac and vp groups. |
1994-09-15 |
2023-08-12 |
Not clear |
| P I Johnson, J R Stella. N-methyl-D-aspartic acid-induced lesions of the nucleus accumbens and/or ventral pallidum fail to attenuate lateral hypothalamic self-stimulation reward. Brain research. vol 646. issue 1. 1994-09-15. PMID:8055342. |
however, this explanation is questionable given the fact that nmda lesions which encompassed both the nac and vp had little effect on reward efficacy. |
1994-09-15 |
2023-08-12 |
Not clear |
| A Agmo, M Góme. Sexual reinforcement is blocked by infusion of naloxone into the medial preoptic area. Behavioral neuroscience. vol 107. issue 5. 1994-02-15. PMID:8280390. |
the nac appears to be a critical structure for drug-induced reward. |
1994-02-15 |
2023-08-12 |
rat |
| C H West, A N Clancy, R P Michae. Enhanced responses of nucleus accumbens neurons in male rats to novel odors associated with sexually receptive females. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1511333. |
findings demonstrated that pairing odors with the presentation of sexually receptive females enhanced the responsiveness of nac neurons to those odors and indicated a role for nac in associating environmental stimuli with natural reward processes. |
1992-09-29 |
2023-08-11 |
rat |