| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew M J Young, Paula M Moran, Michael H Josep. The role of dopamine in conditioning and latent inhibition: what, when, where and how? Neuroscience and biobehavioral reviews. vol 29. issue 6. 2005-10-27. PMID:16045987. |
it is well established that dopamine is released in the nucleus accumbens (nac) in animals in rewarding or reinforcing situations, and widely believed that this release is the substrate of, or at least closely related to, the experience of reward. |
2005-10-27 |
2023-08-12 |
Not clear |
| Anna Molander, Bo Söderpal. Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcoholism, clinical and experimental research. vol 29. issue 1. 2005-05-25. PMID:15654288. |
ethanol (etoh), like other drugs of abuse, increases extracellular dopamine (da) levels in the nucleus accumbens (nac) of the brain reward system, an effect that may be of importance for alcohol addiction. |
2005-05-25 |
2023-08-12 |
Not clear |
| David W Self, Kwang-Ho Cho. Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. Stress (Amsterdam, Netherlands). vol 7. issue 3. 2005-04-28. PMID:15764012. |
we previously reported that extinction training, a form of inhibitory learning that progressively reduces cocaine-seeking behaviour when reward is withheld, reverses this deficit by up-regulating glur1 and glur2/3 subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) glutamate receptors in the nac. |
2005-04-28 |
2023-08-12 |
Not clear |
| David W Self, Kwang-Ho Cho. Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. Stress (Amsterdam, Netherlands). vol 7. issue 3. 2005-04-28. PMID:15764012. |
recent studies indicate that both environmental stress and the frustrative stress of withholding reward during extinction of drug self-administration induce similar neurochemical events in the nac. |
2005-04-28 |
2023-08-12 |
Not clear |
| Mitchell F Roitman, Robert A Wheeler, Regina M Carell. Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output. Neuron. vol 45. issue 4. 2005-04-25. PMID:15721244. |
the nucleus accumbens (nac) is a key component of the brain's reward pathway, yet little is known of how nac cells respond to primary rewarding or aversive stimuli. |
2005-04-25 |
2023-08-12 |
rat |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
here we describe the cellular circuitry of the vta and the nac, define the sites within these areas at which cannabinoids alter synaptic processes, and discuss the relevance of these actions to the regulation of reinforcement and reward. |
2005-04-22 |
2023-08-12 |
Not clear |
| Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Taketoshi On. Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 6. 2005-04-22. PMID:15684065. |
the present study investigated the specific contribution of dopamine d1 receptor (d1r) in mediating reward, locomotor activity, and spatial associative processes and in regulating nac neural responses. |
2005-04-22 |
2023-08-12 |
mouse |
| Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Taketoshi On. Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 6. 2005-04-22. PMID:15684065. |
thus, the present results suggest that d1r may be an important determinant in brain stimulation reward (icss) and participates in coding for a type of reward prediction of nac neurons and in spatial learning. |
2005-04-22 |
2023-08-12 |
mouse |
| Gaetano Di Chiara, Valentina Bassareo, Sandro Fenu, Maria Antonietta De Luca, Liliana Spina, Cristina Cadoni, Elio Acquas, Ezio Carboni, Valentina Valentini, Daniele Lecc. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464140. |
intracranial self-administration studies with mixtures of d1 and d2 receptor agonists point to the nac shell as the critical site of da reward. |
2004-12-20 |
2023-08-12 |
Not clear |
| Gaetano Di Chiara, Valentina Bassareo, Sandro Fenu, Maria Antonietta De Luca, Liliana Spina, Cristina Cadoni, Elio Acquas, Ezio Carboni, Valentina Valentini, Daniele Lecc. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464140. |
stimulation of nac shell da transmission by addictive drugs is shared by a natural reward like food but lacks its adaptive properties (habituation and inhibition by predictive stimuli). |
2004-12-20 |
2023-08-12 |
Not clear |
| Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward. Behavioural brain research. vol 154. issue 1. 2004-12-08. PMID:15302107. |
microinjection of d1 or d2 dopamine receptor antagonists into the nac did not affect the length of time animals were willing to wait for reward (fail point), but did reduce the proportion of cues to which the animal responded. |
2004-12-08 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward. Behavioural brain research. vol 154. issue 1. 2004-12-08. PMID:15302107. |
these results suggest that waiting for reward without increased caloric energy expenditure does not require nac dopamine. |
2004-12-08 |
2023-08-12 |
rat |
| Olivera Pluzarev, Subhash C Pande. Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal. Journal of neuroscience research. vol 77. issue 6. 2004-11-06. PMID:15334606. |
these results suggest the possibility that decreased creb activity in the shell of nac may be associated with abnormal reward mechanisms during nicotine withdrawal after chronic exposure. |
2004-11-06 |
2023-08-12 |
rat |
| Remigijus Lape, John A Dan. Complex response to afferent excitatory bursts by nucleus accumbens medium spiny projection neurons. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15331641. |
the nucleus accumbens (nac) of the ventral striatum is involved in attention, motivation, movement, learning, reward, and addiction. |
2004-11-04 |
2023-08-12 |
mouse |
| Rachel F Genn, Soyon Ahn, Anthony G Phillip. Attenuated dopamine efflux in the rat nucleus accumbens during successive negative contrast. Behavioral neuroscience. vol 118. issue 4. 2004-09-20. PMID:15301614. |
these data are consistent with the hypothesis that da efflux in the nac reflects the current incentive valence of sucrose reward and its influence on initiation of individual bouts of sucrose consumption. |
2004-09-20 |
2023-08-12 |
rat |
| Robert T Matthews, Olusegun Coker, Danny G Winde. A novel mouse brain slice preparation of the hippocampo-accumbens pathway. Journal of neuroscience methods. vol 137. issue 1. 2004-09-16. PMID:15196826. |
the nucleus accumbens (nac) is an important component of circuitry that underlies reward related behaviors and the rewarding properties of drugs of abuse. |
2004-09-16 |
2023-08-12 |
mouse |
| C Giertler, I Bohn, W Haube. Transient inactivation of the rat nucleus accumbens does not impair guidance of instrumental behaviour by stimuli predicting reward magnitude. Behavioural pharmacology. vol 15. issue 1. 2004-08-02. PMID:15075627. |
the involvement of the nucleus accumbens (nac) in the determination of reaction times (rts) of instrumental responses by the expectancy of future reward was investigated. |
2004-08-02 |
2023-08-12 |
rat |
| C Giertler, I Bohn, W Haube. Transient inactivation of the rat nucleus accumbens does not impair guidance of instrumental behaviour by stimuli predicting reward magnitude. Behavioural pharmacology. vol 15. issue 1. 2004-08-02. PMID:15075627. |
inactivation of the nac by lidocaine had no effect on rts and their determination by cue-associated reward magnitudes, and did not affect the rate of correct responses. |
2004-08-02 |
2023-08-12 |
rat |
| Irene A Yun, Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 12. 2004-06-10. PMID:15044531. |
rats trained to perform an operant response to a cue to obtain a sucrose reward were implanted with both multiunit recording electrodes in the nac and microinjection cannulas in the vta. |
2004-06-10 |
2023-08-12 |
rat |
| Irene A Yun, Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 12. 2004-06-10. PMID:15044531. |
like vta baclofen injection, injection of dopamine receptor antagonists into the nac profoundly reduced cue-elicited reward seeking. |
2004-06-10 |
2023-08-12 |
rat |