| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoung-Shim Kim, Ko-Woon Lee, In-Sun Baek, Chae-Moon Lim, Vaishnav Krishnan, Ja-Kyeong Lee, Eric J Nestler, Pyung-Lim Ha. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. Journal of neurochemistry. vol 107. issue 1. 2008-11-03. PMID:18673448. |
type 5 adenylyl cyclase (ac5) is highly concentrated in the dorsal striatum and nucleus accumbens (nac), two brain areas which have been implicated in motor function, reward, and emotion. |
2008-11-03 |
2023-08-12 |
mouse |
| Deanna L Wallace, Vincent Vialou, Loretta Rios, Tiffany L Carle-Florence, Sumana Chakravarty, Arvind Kumar, Danielle L Graham, Thomas A Green, Anne Kirk, Sergio D Iñiguez, Linda I Perrotti, Michel Barrot, Ralph J DiLeone, Eric J Nestler, Carlos A Bolaños-Guzmá. The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 41. 2008-11-03. PMID:18842886. |
here, we demonstrate that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of deltafosb in the nac. |
2008-11-03 |
2023-08-12 |
Not clear |
| Brandon J Aragona, Nathan A Cleaveland, Garret D Stuber, Jeremy J Day, Regina M Carelli, R Mark Wightma. Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753384. |
preferential enhancement of dopamine transmission within the nucleus accumbens (nac) shell is a fundamental aspect of the neural regulation of cocaine reward. |
2008-09-18 |
2023-08-12 |
Not clear |
| Thomas F Tropea, Barry E Kosofsky, Anjali M Rajadhyaksh. Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18554320. |
these data suggest that the formation of contextual drug reward associations involves recruitment of the dhc-nac circuit with activation of the darpp-32/creb pathway in the nac and the erk/creb pathway in the dhc. |
2008-09-12 |
2023-08-12 |
mouse |
| Steven R Laviolette, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Ta. Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 32. 2008-09-09. PMID:18685027. |
however, the specific roles of da d(1)-like and d(2)-like receptor subtypes in nicotine reward processing within these nac subregions have not been elucidated. |
2008-09-09 |
2023-08-12 |
Not clear |
| Gabriele Hampp, Jürgen A Ripperger, Thijs Houben, Isabelle Schmutz, Christian Blex, Stéphanie Perreau-Lenz, Irene Brunk, Rainer Spanagel, Gudrun Ahnert-Hilger, Johanna H Meijer, Urs Albrech. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Current biology : CB. vol 18. issue 9. 2008-08-04. PMID:18439826. |
rewards such as food, sex, and drugs influence this system in part by modulating dopamine neurotransmission in the mesolimbic dopamine reward circuit, including the ventral tegmental area (vta) and the ventral striatum (nac). |
2008-08-04 |
2023-08-12 |
mouse |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
piccolo downexpression by antisense technique augmented meth-induced behavioral sensitization, conditioned reward and synaptic dopamine accumulation in nac. |
2008-04-17 |
2023-08-12 |
mouse |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Alexandra Jean, Grégory Conductier, Christine Manrique, Constantin Bouras, Philippe Berta, René Hen, Yves Charnay, Joël Bockaert, Valérie Compa. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 41. 2007-11-28. PMID:17913892. |
we hypothesized that anorexia may involve altered signaling events within the nucleus accumbens (nac), a brain structure involved in reward. |
2007-11-28 |
2023-08-12 |
mouse |
| Matthias E Liechti, Loic Lhuillier, Klemens Kaupmann, Athina Marko. Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 34. 2007-09-11. PMID:17715344. |
metabotropic glutamate (mglu) 2/3 receptors regulate glutamate and dopamine release in the ventral tegmental area (vta) and the nucleus accumbens (nac) shell, two brain areas critically involved in reward and motivational processes. |
2007-09-11 |
2023-08-12 |
rat |
| Graham A Cousens, Jacob T Beckle. Antagonism of nucleus accumbens M(2) muscarinic receptors disrupts operant responding for sucrose under a progressive ratio reinforcement schedule. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17499370. |
since methoctramine has a greater affinity for m(2) receptors compared to pirenzepine, which has a greater relative affinity for m(1) and m(3) receptors, these findings suggest that m(2) machrs within the nac regulate behavioral processes underling the acquisition of reward. |
2007-08-24 |
2023-08-12 |
Not clear |
| Joseph F Cheer, Brandon J Aragona, Michael L A V Heien, Andrew T Seipel, Regina M Carelli, R Mark Wightma. Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron. vol 54. issue 2. 2007-05-31. PMID:17442245. |
intracranial self-stimulation (icss) activates the neural pathways that mediate reward, including dopaminergic terminal areas such as the nucleus accumbens (nac). |
2007-05-31 |
2023-08-12 |
Not clear |
| Jeremy J Day, Regina M Carell. The nucleus accumbens and Pavlovian reward learning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 13. issue 2. 2007-05-25. PMID:17404375. |
the nac is required for a number of reward-related behaviors and processes specific information about reward availability, value, and context. |
2007-05-25 |
2023-08-12 |
human |
| Hiroyuki Mizoguchi, Kiyofumi Yamada, Minae Niwa, Akihiro Mouri, Tomoko Mizuno, Yukihiro Noda, Atsumi Nitta, Shigeyoshi Itohara, Yoshiko Banno, Toshitaka Nabeshim. Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17348864. |
these results suggest that both mmp-2 and mmp-9 play a crucial role in meth-induced behavioural sensitization and reward by regulating meth-induced dopamine release and uptake in the nac. |
2007-05-01 |
2023-08-12 |
mouse |
| Z Dong, J Cao, L X. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17141960. |
subiculum receives output of hippocampal ca1 neurons and projects glutamatergic synapses onto nucleus accumbens (nac), the subicular-nac pathway linking memory and reward system. |
2007-04-11 |
2023-08-12 |
rat |
| Eugenia Shekhtman, Joel C Geerling, Arthur D Loew. Aldosterone-sensitive neurons of the nucleus of the solitary tract: multisynaptic pathway to the nucleus accumbens. The Journal of comparative neurology. vol 501. issue 2. 2007-03-27. PMID:17226797. |
the nucleus accumbens (nac) is part of a forebrain system implicated in reward, motivation, and learning. |
2007-03-27 |
2023-08-12 |
rat |
| Kyle S Smith, Kent C Berridg. Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 7. 2007-03-13. PMID:17301168. |
mu-opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (nac) or the ventral pallidum (vp) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. |
2007-03-13 |
2023-08-12 |
Not clear |
| Yan Zhou, Jacob Bendor, Lauren Hofmann, Matthew Randesi, Ann Ho, Mary Jeanne Kree. Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065397. |
in this study, we investigated the effects of acute morphine administration, chronic intermittent escalating-dose morphine administration and spontaneous withdrawal from chronic morphine on mrna levels of mu opioid receptor (mop-r), and the opioid peptides pro-opiomelanocortin (pomc) and preprodynorphin (ppdyn) in several key brain regions of the rat, associated with drug reward and motivated behaviors: lateral hypothalamus (lat.hyp), nucleus accumbens (nac) core, amygdala, and caudate-putamen (cpu). |
2006-12-29 |
2023-08-12 |
rat |
| Donald C Cooper, William D Klipec, Melissa A Fowler, Emin D Ozka. A role for the subiculum in the brain motivation/reward circuitry. Behavioural brain research. vol 174. issue 2. 2006-12-20. PMID:16870273. |
the ventral subiculum (vsub) is an interface between the hippocampal formation and structures in the brain reward circuitry, such as the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2006-12-20 |
2023-08-12 |
Not clear |
| Arlene C Pak, Charles R Ashby, Christian A Heidbreder, Maria Pilla, Jeremy Gilbert, Zheng-Xiong Xi, Eliot L Gardne. The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. The international journal of neuropsychopharmacology. vol 9. issue 5. 2006-12-11. PMID:16942635. |
increasing evidence suggests that enhanced dopamine (da) neurotransmission in the nucleus accumbens (nac) may play a role in mediating the reward and reinforcement produced by addictive drugs and in the attentional processing of drug-associated environmental cues. |
2006-12-11 |
2023-08-12 |
rat |