| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukihiko Shirayama, Shigeyuki Chak. Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. Current neuropharmacology. vol 4. issue 4. 2010-06-10. PMID:18654637. |
given that clinical depression is marked by anhedonia (diminished interest or pleasure), dysfunction of the brain reward pathway has been suggested as contributing to the pathophysiology of depression.since the nac is the center of reward and learning, it is hypothesized that anhedonia might be produced by hampering the function of the nac. |
2010-06-10 |
2023-08-12 |
Not clear |
| Sonia Y Bernal, Khalid Touzani, Meri Gerges, Yana Abayev, Anthony Sclafani, Richard J Bodna. Opioid receptor antagonism in the nucleus accumbens fails to block the expression of sugar-conditioned flavor preferences in rats. Pharmacology, biochemistry, and behavior. vol 95. issue 1. 2010-06-01. PMID:20006967. |
because opioid signaling in the nucleus accumbens (nac) is implicated in food reward, this study determined if ntx administered into the nac would block the expression of sugar-conditioned preferences. |
2010-06-01 |
2023-08-12 |
rat |
| Paul M Forlano, Catherine S Woolle. Quantitative analysis of pre- and postsynaptic sex differences in the nucleus accumbens. The Journal of comparative neurology. vol 518. issue 8. 2010-06-01. PMID:20151363. |
the nucleus accumbens (nac) plays a central role in motivation and reward. |
2010-06-01 |
2023-08-12 |
rat |
| Paul M Forlano, Catherine S Woolle. Quantitative analysis of pre- and postsynaptic sex differences in the nucleus accumbens. The Journal of comparative neurology. vol 518. issue 8. 2010-06-01. PMID:20151363. |
this study is the first demonstration of neuroanatomical sex differences in the nac and provides evidence that structural differences in synaptic connectivity and glutamatergic input may contribute to behavioral sex differences in reward and addiction. |
2010-06-01 |
2023-08-12 |
rat |
| Meg Waraczynski, Jennifer Salemme, Benjamin Farra. Brain stimulation reward is affected by D2 dopamine receptor manipulations in the extended amygdala but not the nucleus accumbens. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20085789. |
this work examines the effects on brain stimulation reward (bsr) of d1 and d2 dopamine receptor manipulations in the sublenticular central extended amygdala (sleac) and the nucleus accumbens shell (nac). |
2010-05-25 |
2023-08-12 |
rat |
| Meg Waraczynski, Jennifer Salemme, Benjamin Farra. Brain stimulation reward is affected by D2 dopamine receptor manipulations in the extended amygdala but not the nucleus accumbens. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20085789. |
these results suggest that dopaminergic neurotransmission in the sleac is more important to reward processes than is dopamine in the nac. |
2010-05-25 |
2023-08-12 |
rat |
| Meg Waraczynski, Jennifer Salemme, Benjamin Farra. Brain stimulation reward is affected by D2 dopamine receptor manipulations in the extended amygdala but not the nucleus accumbens. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20085789. |
we align our findings with past work by considering methodological details and a currently hypothesized role for nac dopamine in learning behaviors that lead to reward capture. |
2010-05-25 |
2023-08-12 |
rat |
| Kenneth Blum, Thomas J H Chen, Amanda L H Chen, Margaret Madigan, B William Downs, Roger L Waite, Eric R Braverman, Mallory Kerner, Abdalla Bowirrat, John Giordano, Harry Henshaw, Mark S Gol. Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS). Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19914781. |
using fmri, menon and levitin [9] clearly found for the first time that listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the nucleus accumbens (nac) and the ventral tegmental area (vta), as well as the hypothalamus, and insula, which are thought to be involved in regulating autonomic and physiological responses to rewarding and emotional stimuli. |
2010-05-07 |
2023-08-12 |
human |
| Kenneth Blum, Thomas J H Chen, Amanda L H Chen, Margaret Madigan, B William Downs, Roger L Waite, Eric R Braverman, Mallory Kerner, Abdalla Bowirrat, John Giordano, Harry Henshaw, Mark S Gol. Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS). Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19914781. |
thus it is conjectured that similar mechanisms in terms of adequate dopamine release and subsequent activation of reward circuitry by listening to music might also be affected by an individual's d2 density in the vta mediated interaction of the nac. |
2010-05-07 |
2023-08-12 |
human |
| Kenneth Blum, Thomas J H Chen, Amanda L H Chen, Margaret Madigan, B William Downs, Roger L Waite, Eric R Braverman, Mallory Kerner, Abdalla Bowirrat, John Giordano, Harry Henshaw, Mark S Gol. Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS). Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19914781. |
if music causes a powerful activation in spite of the drd2 a1 allele due to a strong da neuronal release which subsequently impinges on existing d2 receptors, then it is reasonable to assume that music is a strong indirect d2 agonist (by virtue of da neuronal release in the nac) and may have important therapeutic applicability in reward deficiency syndrome (rds) related behaviors including substance use disorder (sud). |
2010-05-07 |
2023-08-12 |
human |
| Marwan N Baliki, Paul Y Geha, Howard L Fields, A Vania Apkaria. Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron. vol 66. issue 1. 2010-05-03. PMID:20399736. |
positive phasic nac activations at stimulus onset and offset tracked stimulus salience and, in normal subjects, predicted reward (pain relief) magnitude at stimulus offset. |
2010-05-03 |
2023-08-12 |
human |
| Francesca M Filbey, Joseph P Schacht, Ursula S Myers, Robert S Chavez, Kent E Hutchiso. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 4. 2010-04-28. PMID:20010552. |
the faah group contrasts showed that faah rs324420 c homozygotes also had greater activation in widespread areas within the reward circuit, specifically in the ofc, acg, and nucleus accumbens (nac), as compared with the faah a-allele carriers. |
2010-04-28 |
2023-08-12 |
human |
| Helga Höifödt Lidö, Rosita Stomberg, Anne Fagerberg, Mia Ericson, Bo Söderpal. The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism, clinical and experimental research. vol 33. issue 7. 2010-03-26. PMID:19389199. |
the mesolimbic dopamine (da) projection from the ventral tegmental area to nucleus accumbens (nac), a central part of the reward system, is activated by ethanol (etoh) and other drugs of abuse. |
2010-03-26 |
2023-08-12 |
rat |
| K D Carr, L S Chau, S Cabeza de Vaca, K Gustafson, M Stouffer, D S Tukey, S Restituito, E B Zif. AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19931598. |
previous findings suggest that neuroadaptations downstream of d-1 dopamine (da) receptor stimulation in nucleus accumbens (nac) are involved in the enhancement of drug reward by chronic food restriction (fr). |
2010-03-12 |
2023-08-12 |
rat |
| K D Carr, L S Chau, S Cabeza de Vaca, K Gustafson, M Stouffer, D S Tukey, S Restituito, E B Zif. AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19931598. |
given the high co-expression of d-1 and glur1 ampa receptors in nac, and the regulation of glur1 channel conductance and trafficking by d-1-linked intracellular signaling cascades, the present study examined effects of the d-1 agonist, skf-82958, on nac glur1 phosphorylation, intracranial electrical self-stimulation reward (icss), and reversibility of reward effects by a polyamine glur1 antagonist, 1-na-spermine, in ad libitum fed (al) and fr rats. |
2010-03-12 |
2023-08-12 |
rat |
| Brandon J Aragona, Jeremy J Day, Mitchell F Roitman, Nathan A Cleaveland, R Mark Wightman, Regina M Carell. Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. The European journal of neuroscience. vol 30. issue 10. 2010-02-26. PMID:19912327. |
drug seeking is significantly regulated by drug-associated cues and associative learning between environmental cues and cocaine reward is mediated by dopamine transmission within the nucleus accumbens (nac). |
2010-02-26 |
2023-08-12 |
rat |
| Wolfgang Hauber, Susanne Somme. Prefrontostriatal circuitry regulates effort-related decision making. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 10. 2009-12-14. PMID:19131436. |
experiment 1 revealed that bilateral excitotoxic lesions of the core subregion of the nac impaired effort-based decision making, that is, reduced the preference for the high effort-lr option when having the choice to obtain a low reward with little effort. |
2009-12-14 |
2023-08-12 |
rat |
| Sondra T Bland, Mark R Hutchinson, Steven F Maier, Linda R Watkins, Kirk W Johnso. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, behavior, and immunity. vol 23. issue 4. 2009-12-09. PMID:19486648. |
the present studies extend this line of investigation by exploring whether glial activation may also affect extracellular levels of dopamine (da) in the nucleus accumbens (nac) shell, a neurochemical corollary of morphine-induced drug reward, during a challenge dose of morphine in experiments both with and without precipitated withdrawal. |
2009-12-09 |
2023-08-12 |
rat |
| Yao-Ying Ma, Li Meng, Chang-Yong Guo, Ji-Sheng Han, David Yue-Wei Lee, Cai-Lian Cu. Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19539657. |
the dopamine (da) projections from the ventral tegmental area to the nucleus accumbens (nac) are the key component of the brain reward circuitry. |
2009-12-01 |
2023-08-12 |
rat |
| Su-Mi Park, Ron P A Gaykema, Lisa E Goehle. How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry. Brain, behavior, and immunity. vol 22. issue 8. 2009-11-17. PMID:18562160. |
the findings from this study point to a network of brain regions (lh, pvt, nac, and bla) previously implicated in the modulation of feeding behavior, reward, and arousal that may also contribute to neural substrates involved in the reorganization of behavioral priorities that occurs during sickness. |
2009-11-17 |
2023-08-12 |
Not clear |