| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Marie Wissman, Renee M May, Catherine S Woolle. Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21987050. |
despite robust sex differences in behavioral responses to drugs of abuse, relatively little is known about structural sex differences in synaptic connectivity of reward circuits such as in the nucleus accumbens (nac). |
2012-09-04 |
2023-08-12 |
rat |
| Anne Marie Wissman, Renee M May, Catherine S Woolle. Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21987050. |
these findings underscore the importance of including both males and females in studies of reward circuitry, and of considering variation along the rostro-caudal axis of the nac in future studies. |
2012-09-04 |
2023-08-12 |
rat |
| Vincent Vialou, Jian Feng, Alfred J Robison, Stacy M Ku, Deveroux Ferguson, Kimberly N Scobie, Michelle S Mazei-Robison, Ezekiell Mouzon, Eric J Nestle. Serum response factor and cAMP response element binding protein are both required for cocaine induction of ΔFosB. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 22. 2012-08-06. PMID:22649236. |
here, we demonstrate a necessary role for two transcription factors, camp response element binding protein (creb) and serum response factor (srf), in mediating this induction within the mouse nucleus accumbens (nac), a key brain reward region. |
2012-08-06 |
2023-08-12 |
mouse |
| Thorfinn T Riday, Barry E Kosofsky, C J Malang. The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22197517. |
these data suggest that the effects of repeated cocaine exposure on reward and motor processes are dissociable in mice, and that reduction of excitatory neurotransmission in the nac may predict altered motor function independently from changes in reward perception. |
2012-07-27 |
2023-08-12 |
mouse |
| Dani Dumitriu, Quincey Laplant, Yael S Grossman, Caroline Dias, William G Janssen, Scott J Russo, John H Morrison, Eric J Nestle. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593064. |
the divergence in regulation of proximal spine density in nac core versus shell by cocaine correlates with recently reported electrophysiological data from a similar drug administration regimen and might represent a key mediator of changes in the reward circuit that drive aspects of addiction. |
2012-07-27 |
2023-08-12 |
mouse |
| Tünde Molnár, Arpád Dobolyi, Gabriella Nyitrai, Péter Barabás, László Héja, Zsuzsa Emri, Miklós Palkovits, Julianna Kardo. Calcium signals in the nucleus accumbens: activation of astrocytes by ATP and succinate. BMC neuroscience. vol 12. 2012-07-26. PMID:21967230. |
the purpose of the present study is to identify the characteristics of atp-evoked glial signalling in the brain reward area, the nucleus accumbens (nac), and thereby to explore the action of citric acid cycle intermediate succinate (suc). |
2012-07-26 |
2023-08-12 |
Not clear |
| Fabio Cacciapaglia, Michael P Saddoris, R Mark Wightman, Regina M Carell. Differential dopamine release dynamics in the nucleus accumbens core and shell track distinct aspects of goal-directed behavior for sucrose. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22261383. |
the aim of the present study was to characterize rapid dopamine transmission across the two nac sub-regions during cue-signaled operant behavior for a natural (sucrose) reward in rats. |
2012-07-23 |
2023-08-12 |
rat |
| Fabio Cacciapaglia, Michael P Saddoris, R Mark Wightman, Regina M Carell. Differential dopamine release dynamics in the nucleus accumbens core and shell track distinct aspects of goal-directed behavior for sucrose. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22261383. |
these findings demonstrate that the nac displays regional specificity in dopamine transmission patterns during cued operant behavior for natural reward. |
2012-07-23 |
2023-08-12 |
rat |
| Darlene H Brunzell, J Michael McIntos. Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169946. |
before pr, rats received local infusions of 0, 10, or 20 pmol of a selective α7 nachr antagonist, α-conotoxin arib [v11l,v16d] (arib) into the nucleus accumbens (nac) shell or the anterior cingulate cortex, brain areas that contribute to motivation for drug reward. |
2012-07-20 |
2023-08-12 |
rat |
| Erik B Oleson, Michael V Beckert, Joshua T Morra, Carien S Lansink, Roger Cachope, Rehab A Abdullah, Amy L Loriaux, Dustin Schetters, Tommy Pattij, Mitchell F Roitman, Aron H Lichtman, Joseph F Chee. Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. Neuron. vol 73. issue 2. 2012-07-19. PMID:22284189. |
transient increases in nucleus accumbens (nac) dopamine concentration are observed when animals are presented with motivationally salient stimuli and are theorized to energize reward seeking. |
2012-07-19 |
2023-08-12 |
Not clear |
| Erik B Oleson, Michael V Beckert, Joshua T Morra, Carien S Lansink, Roger Cachope, Rehab A Abdullah, Amy L Loriaux, Dustin Schetters, Tommy Pattij, Mitchell F Roitman, Aron H Lichtman, Joseph F Chee. Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. Neuron. vol 73. issue 2. 2012-07-19. PMID:22284189. |
to test this, we pharmacologically manipulated endocannabinoid neurotransmission in the vta while measuring transient changes in dopamine concentration in the nac during reward seeking. |
2012-07-19 |
2023-08-12 |
Not clear |
| Courtney M Cameron, Regina M Carell. Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. The European journal of neuroscience. vol 35. issue 6. 2012-07-18. PMID:22356698. |
here, electrophysiological recording procedures were used to determine if the selective encoding of natural vs. cocaine reward by nac neurons is: (i) maintained when the natural reinforcer is a highly palatable sweet tastant and (ii) altered by cocaine abstinence. |
2012-07-18 |
2023-08-12 |
rat |
| Saïd Kourrich, Jason R Klug, Mark Mayford, Mark J Thoma. AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573680. |
this study identifies camkii regulation of ia in nac shell neurons as a novel cellular contributor to the sensitization of cocaine reward. |
2012-07-06 |
2023-08-12 |
mouse |
| Amy L Loriaux, Jamie D Roitman, Mitchell F Roitma. Nucleus accumbens shell, but not core, tracks motivational value of salt. Journal of neurophysiology. vol 106. issue 3. 2012-06-26. PMID:21697439. |
the nucleus accumbens (nac) is a critical component of reward circuitry, but recent work suggests that the nac encodes aversion as well as reward. |
2012-06-26 |
2023-08-12 |
rat |
| Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M Reye. Epigenetic dysregulation of the dopamine system in diet-induced obesity. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22220805. |
dopamine (da) system changes in response to hf diet have been observed in the hypothalamus, important in the homeostatic control of food intake, as well as within the central reward circuitry [ventral tegmental area (vta), nucleus accumbens (nac), and pre-frontal cortex (pfc)], critical for coding the rewarding properties of palatable food and important in hedonically driven feeding behavior. |
2012-06-01 |
2023-08-12 |
mouse |
| Kenneth Blum, Eliot Gardner, Marlene Oscar-Berman, Mark Gol. "Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22236117. |
addictive drugs have in common that they are voluntarily selfadministered, they enhance (directly or indirectly) dopaminergic synaptic function in the nucleus accumbens (nac), and they stimulate the functioning of brain reward circuitry (producing the "high" that drug users seek). |
2012-05-31 |
2023-08-12 |
Not clear |
| Xing-Xiang Peng, Edward B Ziff, Kenneth D Car. Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425350. |
considering the parallels between drug addiction and compulsive eating, plus the supranormal reward properties of sucrose, and the role of dieting as a risk factor in development of binge pathology, the present study used a biochemical subcellular fractionation approach to determine whether brief intake of a 10% sucrose solution increases synaptic delivery of ampa receptors in nac of chronically food-restricted (fr) relative to ad libitum fed (al) rats. |
2012-05-30 |
2023-08-12 |
human |
| Xing-Xiang Peng, Edward B Ziff, Kenneth D Car. Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425350. |
this may contribute to nac integrative mechanisms that mediate the enhanced behavioral responsiveness of fr subjects to phasic reward stimuli, including food and drugs. |
2012-05-30 |
2023-08-12 |
human |
| Ruud van Zessen, Jana L Phillips, Evgeny A Budygin, Garret D Stube. Activation of VTA GABA neurons disrupts reward consumption. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445345. |
in addition, direct activation of vta gaba projections to the nucleus accumbens (nac) resulted in detectable gaba release but did not alter reward consumption. |
2012-05-15 |
2023-08-12 |
Not clear |
| Alessandra Lintas, Ning Chi, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Tan, Steven R Laviolett. Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. The European journal of neuroscience. vol 35. issue 2. 2012-05-08. PMID:22236063. |
the basolateral amygdala (bla), ventral tegmental area and nucleus accumbens (nac) form a functionally connected neural circuit involved in the processing of opiate-related reward and memory. |
2012-05-08 |
2023-08-12 |
rat |