| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
we also inhibited 5-ht1a or 5-ht1b receptors in ca1 during conditioned place preference (cpp) for cocaine, to examine mechanisms involved in persistent effects of ed1 manipulations. |
2024-03-21 |
2024-03-24 |
rat |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
in addition, 5-ht1b antagonism alone transiently decreased drug-associated memory performance when given prior to a conditioned place preference (cpp) test, whereas similar antagonism of 5-ht1a alone had no such effect but blocked cpp retrieval on a test 24h later. |
2024-03-21 |
2024-03-24 |
rat |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
these cpp findings are consistent with prior work showing that dr inputs to ca1 augments recall of the drug-associated context and drug-seeking via 5-ht1b receptors and prevents consolidation of the updated non-drug context via 5-ht1a receptors. |
2024-03-21 |
2024-03-24 |
rat |
| Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys. PLoS biology. vol 22. issue 1. 2024-01-01. PMID:38163325. |
reduced serotonergic transmission alters sensitivity to cost and reward via 5-ht1a and 5-ht1b receptors in monkeys. |
2024-01-01 |
2024-01-05 |
monkey |
| Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys. PLoS biology. vol 22. issue 1. 2024-01-01. PMID:38163325. |
these results suggest that 5-ht deficiency disrupts 2 processes, the subjective valuation of costs and rewards, via 5-ht1a and 5-ht1b receptors, thus leading to reduced motivation. |
2024-01-01 |
2024-01-05 |
monkey |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-08-14 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2023-08-14 |
rat |
| M Angela Cenci, Katrine Skovgård, Per Odi. Non-dopaminergic approaches to the treatment of motor complications in Parkinson's disease. Neuropharmacology. 2022-03-16. PMID:35292330. |
in particular, we discuss both the experimental rationale and the clinical experience thus far gained from studying 5-ht1a and 5-ht1b receptor agonists, nmda and ampa receptor antagonists, mglur5 negative allosteric modulators, mglur4 positive allosteric modulators, and adenosine a2a receptor antagonists. |
2022-03-16 |
2023-08-13 |
Not clear |
| Lonne Heijmans, Martijn R Mons, Elbert A Jooste. A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation. Molecular pain. vol 17. 2021-11-10. PMID:34662215. |
descending serotonergic modulation of nociceptive signaling in spinal dorsal horn in normal adult rat is mainly inhibitory and mediated by 5-ht1a, 5-ht1b, 5-ht2c, 5-ht3 and 5-ht4 receptors. |
2021-11-10 |
2023-08-13 |
rat |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
serotonin type 1a receptor (5ht1a) is primarily expressed on glutamatergic nerve terminals, and 5ht1b is expressed on gabaergic medium spiny neurons (msns). |
2021-10-14 |
2023-08-13 |
rat |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
continuously levodopa-infused rats or intermittently zns-injected rats did not develop aims, and no differences in the expression of brain-derived neurotrophic factor, 5-ht transporter, 5ht1a, and 5ht1b mrna between the lesioned striatum and normal side were observed. |
2021-10-14 |
2023-08-13 |
rat |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
the severity of aims was correlated with the ratio of 5ht1b to 5ht1a mrna expression in the lesioned striatum, indicating that the anti-lid effect of zns is based on inhibition via 5ht1b receptors to direct pathway msns sensitized by intermittent levodopa treatment. |
2021-10-14 |
2023-08-13 |
rat |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
selectively acting serotonergic drugs, especially those that lower the 5ht1b to 5ht1a ratio, are promising new therapeutic agents to attenuate lid development. |
2021-10-14 |
2023-08-13 |
rat |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Anoosha Attaran, Arash Salahinejad, Mohammad Naderi, Adam L Crane, Douglas P Chivers, Som Niyog. Transgenerational effects of selenomethionine on behaviour, social cognition, and the expression of genes in the serotonergic pathway in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 286. 2021-08-25. PMID:33971468. |
maternal exposure to high levels of se-met also led to dysregulation of the serotonergic system via changes in mrna expression of serotonin receptors, including the 5-ht1a, 5-ht1b, and 5-ht1d subtypes, the serotonin transporter, and monoamine oxidase (mao). |
2021-08-25 |
2023-08-13 |
human |
| Minxuan Cai, Liangliang Zhou, Jun Liao, Qiaoling Huang, Zhenjiang Xia, Jing Shan. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro. Journal of pharmacological sciences. vol 141. issue 1. 2020-03-11. PMID:31519333. |
in addition, we found that ifn-γ decreased serum serotonin levels as well as the cutaneous expression of tryptophan hydroxylase 1 (tph1), 5-ht1a receptor (5-ht1ar) and 5-ht1b receptor (5-ht1br) in c57bl/6 mice. |
2020-03-11 |
2023-08-13 |
mouse |
| Jan Gommans, Theo H. Hijzen, Robert A. Maes, Berend Olivie. Two-lever drug-drug discrimination with the 5-HT1 receptor agonists flesinoxan and eltoprazine. The international journal of neuropsychopharmacology. vol 3. issue 3. 2019-11-20. PMID:11343599. |
previous drug discrimination studies with the 5-ht1 receptor agonists flesinoxan and eltoprazine showed a clear 5-ht1a receptor-mediated effect for flesinoxan and the involvement of both 5-ht1a and 5-ht1b receptors in eltoprazine. |
2019-11-20 |
2023-08-12 |
rat |
| Jan Gommans, Theo H. Hijzen, Robert A. Maes, Berend Olivie. Two-lever drug-drug discrimination with the 5-HT1 receptor agonists flesinoxan and eltoprazine. The international journal of neuropsychopharmacology. vol 3. issue 3. 2019-11-20. PMID:11343599. |
in the present experiments, in order to create a specific 5-ht1a vs. 5-ht1b receptor-mediated discrimination, rats were trained to discriminate between flesinoxan and eltoprazine. |
2019-11-20 |
2023-08-12 |
rat |
| Jan Gommans, Theo H. Hijzen, Robert A. Maes, Berend Olivie. Two-lever drug-drug discrimination with the 5-HT1 receptor agonists flesinoxan and eltoprazine. The international journal of neuropsychopharmacology. vol 3. issue 3. 2019-11-20. PMID:11343599. |
we conclude that rats can learn to discriminate between two serotonergic drugs with overlapping stimulus properties and that the flesinoxan stimulus is mediated by 5-ht1a receptors and the eltoprazine stimulus, under these particular training conditions, by 5-ht1b receptors. |
2019-11-20 |
2023-08-12 |
rat |