| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J David, L Tritschler, J-P Guilloux, A M Gardier, C Sanchez, R Gaillar. [Pharmacological properties of vortioxetine and its pre-clinical consequences]. L'Encephale. vol 42. issue 1 Suppl 1. 2016-12-13. PMID:26879252. |
compared to the ssris, vortioxetine is defined as a multimodal antidepressant drug since it is not only a serotonin reuptake inhibitor, but also a 5-ht1d, 5-ht3, 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist and 5-ht1a receptor agonist. |
2016-12-13 |
2023-08-13 |
Not clear |
| R Colle, E Corrubl. [Vortioxetine: a new antidepressant to treat depressive episodes]. L'Encephale. vol 42. issue 1. 2016-10-31. PMID:26358483. |
vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin transporter (5-htt). |
2016-10-31 |
2023-08-13 |
Not clear |
| Giovanna Paolone, Alberto Brugnoli, Ludovico Arcuri, Daniela Mercatelli, Michele Morar. Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 13. 2016-10-12. PMID:26207892. |
selective serotonin (5-hydroxytryptamine; 5-ht) 5-ht1a or 5-ht1b receptor agonists, and, very recently, the mixed 5-ht1a /5-ht1b receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. |
2016-10-12 |
2023-08-13 |
Not clear |
| Gitte M Knudsen, Peter S Jensen, David Erritzoe, William F C Baaré, Anders Ettrup, Patrick M Fisher, Nic Gillings, Hanne D Hansen, Lars Kai Hansen, Steen G Hasselbalch, Susanne Henningsson, Matthias M Herth, Klaus K Holst, Pernille Iversen, Lars V Kessing, Julian Macoveanu, Kathrine Skak Madsen, Erik L Mortensen, Finn Årup Nielsen, Olaf B Paulson, Hartwig R Siebner, Dea S Stenbæk, Claus Svarer, Terry L Jernigan, Stephen C Strother, Vibe G Frokjae. The Center for Integrated Molecular Brain Imaging (Cimbi) database. NeuroImage. vol 124. issue Pt B. 2016-09-06. PMID:25891375. |
the data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht4 and the 5-ht transporter (5-htt), but can easily serve other purposes. |
2016-09-06 |
2023-08-13 |
human |
| Víctor Rovira, Emilio Geijo-Barriento. Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice. PloS one. vol 11. issue 3. 2016-08-02. PMID:26930051. |
these actions of serotonin were mimicked by the activation of either 5-ht1b or 5-ht2a receptors, but not by the activation of the 5-ht1a subtype. |
2016-08-02 |
2023-08-13 |
mouse |
| Martin Reznitsky, Per Plenge, Anders Hay-Schmid. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study. Neuroscience letters. vol 612. 2016-06-28. PMID:26683905. |
autoradiography showed that serotonin receptors 5-ht1b and 5-ht2c and the serotonin transporter were present in stn, whereas the 5-ht1a and 5-ht2a not were present. |
2016-06-28 |
2023-08-13 |
rat |
| Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanche. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26174134. |
vortioxetine, a multimodal antidepressant acting through serotonin (5-ht) transporter (sert) inhibition, 5-ht3, 5-ht7 and 5-ht1d receptor antagonism, 5-ht1b receptor partial agonism, and 5-ht1a receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. |
2016-06-23 |
2023-08-13 |
human |
| Michael S Virk, Yotam Sagi, Lucian Medrihan, Jenny Leung, Michael G Kaplitt, Paul Greengar. Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 3. 2016-06-14. PMID:26733685. |
the inhibitory modulation by 5-ht1b, but not that by 5-ht1a, is mediated by p11, a protein associated with major depressive disorder. |
2016-06-14 |
2023-08-13 |
mouse |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascular pharmacology. vol 72. 2016-05-19. PMID:26003124. |
bolus of agonists α-methyl-5-ht (5-ht2), 1-pbg (5-ht3), cisapride (5-ht4), as-19 (5-ht7), cgs-12066b (5-ht1b) or 8-oh-dpat (5-ht1a) (0.0125μg/kg each). |
2016-05-19 |
2023-08-13 |
rat |
| Laura A Stanquini, Leonardo B M Resstel, Fernando M A Corrêa, Sâmia R L Joca, América A Scopinh. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26143050. |
independent groups of rats were pretreated with intra-pl antagonists of 5-ht receptors: 5-ht1a (way100635), 5-ht2c (sb242084) or 5-ht1b (sb216641). |
2016-05-17 |
2023-08-13 |
rat |
| Zdzisław Chilmonczyk, Andrzej Jacek Bojarski, Andrzej Pilc, Ingebrigt Sylt. Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands. International journal of molecular sciences. vol 16. issue 8. 2016-05-09. PMID:26262615. |
it should also be noted that the 5-ht1a receptor cooperates with other signal transduction systems (like the 5-ht1b or 5-ht2a/2b/2c receptors, the gabaergic and the glutaminergic systems), which also contribute to its antidepressant and/or anxiolytic activity. |
2016-05-09 |
2023-08-13 |
Not clear |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
the serotonin transporter (sert), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1a (5-ht1a) and -1b (5-ht1b) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
this finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the sert and 5-ht1b receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-ht1a receptors. |
2016-04-07 |
2023-08-13 |
human |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 6. 2016-02-29. PMID:25854421. |
administration (0.00000125 to 0.1 μg/kg) of 5-ct or l-694,247 (5-ht1d agonist) mimicked 5-ht vasodilator effect, while other agonists (1-pbg, α-methyl-5-ht, as-19 (5-ht₇), 8-oh-dpat (5-ht1a) or cgs-12066b (5-ht1b)) did not alter baseline haemodynamic variables. |
2016-02-29 |
2023-08-13 |
rat |
| Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. |
vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. |
2016-02-02 |
2023-08-13 |
rat |
| Vijeta Bobade, Subhash L Bodhankar, Urmila Aswar, Mohan Vishwaraman, Prasad Thakurdesa. Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908624. |
the interaction of indca with selective 5-ht1a, 5-ht1b, and 5-ht1d receptor antagonists (nan-190, isamoltane hemifumarate, and brl-15572 respectively) against ntg-induced hyperalgesia was also evaluated. |
2016-01-12 |
2023-08-13 |
rat |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Asenapine alters the activity of monoaminergic systems following its subacute and long-term administration: an in vivo electrophysiological characterization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25656272. |
in the hippocampus, 21-day asenapine administration increased serotonergic tone by partial agonistic action on postsynaptic 5-ht1a and terminal 5-ht1b receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Cécile Bétry, Adeline Etiévant, Alan Pehrson, Connie Sánchez, Nasser Haddjer. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25524057. |
vortioxetine is a multimodal acting antidepressant that functions as a 5-ht3 and 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of the 5-ht transporter. |
2016-01-05 |
2023-08-13 |
human |
| Joung Min Kim, Seong Wook Jeong, Jihoon Yang, Seong Heon Lee, Woon Mo Kim, Seongtae Jeong, Hong Beom Bae, Myung Ha Yoon, Jeong Il Cho. Spinal 5-HT1A, not the 5-HT1B or 5-HT3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation. Neuroscience letters. vol 600. 2015-10-19. PMID:26037417. |
spinal 5-ht1a, not the 5-ht1b or 5-ht3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation. |
2015-10-19 |
2023-08-13 |
Not clear |
| Joung Min Kim, Seong Wook Jeong, Jihoon Yang, Seong Heon Lee, Woon Mo Kim, Seongtae Jeong, Hong Beom Bae, Myung Ha Yoon, Jeong Il Cho. Spinal 5-HT1A, not the 5-HT1B or 5-HT3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation. Neuroscience letters. vol 600. 2015-10-19. PMID:26037417. |
these results suggest that spinal 5-ht1a, but not 5-ht1b or 5-ht3 receptors mediate descending serotonergic inhibition on nociceptive processing of late-phase mechanical allodynia in carrageenan-induced inflammation. |
2015-10-19 |
2023-08-13 |
Not clear |