| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kara A Clissold, Eugene Choi, Wayne E Prat. Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activity. Pharmacology, biochemistry, and behavior. vol 112. 2014-07-16. PMID:24125784. |
food-deprived rats were given 2-h access to rat chow after stimulation of nucleus accumbens 5-ht1a, 5-ht1b, or 5-ht7 receptors, or blockade of the 5-ht1a or 5-ht1b receptors. |
2014-07-16 |
2023-08-12 |
rat |
| C Cervantes-Durán, H I Rocha-González, V Granados-Sot. Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats. Neuroscience. vol 252. 2014-06-11. PMID:23994595. |
the peripheral pronociceptive effect of fluoxetine was prevented by the 5-ht2a (ketanserin, 3-10 pmol/paw), 5-ht2b (3-(2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1h,3h)-quinazolinedione(+) tartrate, rs-127445, 3-10 pmol/paw), 5-ht2c (8-[5-(2,4-dimethoxy-5-(4-trifluoromethylphenylsulphonamido) phenyl-5-oxopentyl]1,3,8-triazaspiro[4.5] decane-2,4-dione hydrochloride, rs-102221, 3-10 pmol/paw), 5-ht3 (ondansetron, 3-10 nmol/paw), 5-ht4 ([1-[2-methylsulphonylamino ethyl]-4-piperidinyl]methyl 1-methyl-1h-indole-3-carboxylate, gr-113808, 3-100 fmol/paw), 5-ht6 (4-iodo-n-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzene-sulfonamide hydrochloride, sb-258585, 3-10 pmol/paw) and 5-ht7 ((r)-3-(2-(2-(4-methylpiperidin-1-yl) ethyl) pyrrolidine-1-sulfonyl) phenol hydrochloride, sb-269970, 0.3-1 nmol/paw), but not by the 5-ht1a (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate, way-100635, 0.3-1 nmol/paw), 5-ht1b/1d (n-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride hydrate, gr-127935, 0.3-1 nmol/paw), 5-ht1b (1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride, sb-224289, 0.3-1 nmol/paw), 5-ht1d (4-(3-chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride, brl-15572, 0.3-1nmol/paw) nor 5-ht5a ((n-[2-(dimethylamino)ethyl]-n-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride, sb-699551, 1-3 nmol/paw), receptor antagonists. |
2014-06-11 |
2023-08-12 |
rat |
| C Cervantes-Durán, H I Rocha-González, V Granados-Sot. Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats. Neuroscience. vol 252. 2014-06-11. PMID:23994595. |
in marked contrast, the spinal antinociceptive effect of fluoxetine was prevented by the 5-ht1a (way-100635, 0.3-1 nmol/rat), 5-ht1b/1d (gr-127935, 0.3-1 nmol/rat), 5-ht1b (sb-224289, 0.3-1 nmol/rat), 5-ht1d (brl-15572, 0.3-1 nmol/rat) and 5-ht5a (sb-699551, 1-3 nmol/rat), but not by the 5-ht2a (ketanserin, 3-10 pmol/rat), 5-ht2b (rs-127445, 3-10 pmol/rat), 5-ht2c (rs-102221, 3-10 pmol/rat), 5-ht3 (ondansetron, 3-10 nmol/rat), 5-ht4 (gr-113808, 3-100 fmol/rat), 5-ht6 (sb-258585, 3-10 pmol/rat) nor 5-ht7 (sb-269970, 0.3-1 nmol/rat), receptor antagonists. |
2014-06-11 |
2023-08-12 |
rat |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
based on localization and function, 5-ht can modulate glutamate neurotransmission at least through the 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors, which presents a rational pharmacological opportunity for modulating glutamatergic transmission without the direct use of glutamatergic compounds. |
2014-06-03 |
2023-08-12 |
Not clear |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
preclinical research suggests that 5-ht receptor subtypes, including 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors as well as the 5-ht transporter (sert), may have important roles in treating depression. |
2014-04-21 |
2023-08-12 |
rat |
| Colin P Leslie, Matteo Biagetti, Silvia Bison, Steven M Bromidge, Romano Di Fabio, Daniele Donati, Alessandro Falchi, Martine J Garnier, Albert Jaxa-Chamiec, Gary Manchee, Giancarlo Merlo, Domenica A Pizzi, Luigi P Stasi, Jessica Tibasco, Antonio Vong, Simon E Ward, Laura Zonzin. Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. Journal of medicinal chemistry. vol 53. issue 23. 2014-04-15. PMID:21053897. |
a novel series of compounds was identified showing low intrinsic activities and potent affinities across the 5-ht1a, 5-ht1b, and 5-ht1d receptors as well as high selectivity against the serotonin transporter. |
2014-04-15 |
2023-08-12 |
Not clear |
| A Dhi. Vortioxetine for the treatment of major depression. Drugs of today (Barcelona, Spain : 1998). vol 49. issue 12. 2014-03-10. PMID:24524096. |
it inhibits the activity of serotonin transporters and is an agonist of serotonin 5-ht1a receptor, partial agonist of 5-ht1b and antagonist of 5-ht3a, 5-ht7 and 5-ht1d receptors. |
2014-03-10 |
2023-08-12 |
Not clear |
| Jean-François Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen, Anders Victor Peterse. Modulation of the intrinsic properties of motoneurons by serotonin. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360270. |
the somato-dendritic compartments of motoneurons are densely innervated by serotonergic synaptic boutons and several receptors are expressed in the membrane of motoneurons including 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht2c and 5-ht5a. |
2014-01-27 |
2023-08-12 |
Not clear |
| Omer Ates, Nevin Karakus, Saime Sezer, Nihan Bozkur. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population. Journal of the neurological sciences. vol 326. issue 1-2. 2013-12-03. PMID:23375453. |
the present study was designed to explore the associations of polymorphisms of 5-hydroxytryptamine (serotonin) receptor 1a (5-ht1a) and 5-hydroxytryptamine receptor 1b (5-ht1b) genes in turkish migraine patients. |
2013-12-03 |
2023-08-12 |
human |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
novel drugs in development include those that combine multiple simultaneous pharmacologic mechanisms in addition to sert inhibition within the same molecule, such as vilazodone (combining 5ht1a partial agonism with sert inhibition), triple reuptake inhibitors (combining norepinephrine and dopamine reuptake inhibition with sert inhibition), and vortioxetine, a multimodal antidepressant combining actions at the g protein receptor mode (5ht1a and 5ht1b partial agonism and 5ht7 antagonism), at the ion channel mode (5ht3 antagonism) as well as the neurotransmitter transporter mode (sert inhibition). |
2013-10-29 |
2023-08-12 |
Not clear |
| Arne Mørk, Liliana P Montezinho, Silke Miller, Crista Trippodi-Murphy, Niels Plath, Yan Li, Maria Gulinello, Connie Sanche. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23380522. |
vortioxetine (lu aa21004) in development as a novel multimodal antidepressant is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (5-htt) inhibitor in vitro. |
2013-10-23 |
2023-08-12 |
rat |
| Wenjun Zhou, Ligong Chen, Jodi Paul, Sufen Yang, Fuzeng Li, Karen Sampson, Jim R Woodgett, Jean Martin Beaulieu, Karen L Gamble, Xiaohua L. The effects of glycogen synthase kinase-3beta in serotonin neurons. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912839. |
compared to littermate wild type mice, sngsk3β-ko mice had a reduced response to the 5-ht1b receptor agonist anpirtoline in the regulation of serotonergic neuron firing, camp production, and serotonin release, whereas these animals displayed a normal response to the 5-ht1a receptor agonist 8-oh-dpat. |
2013-05-01 |
2023-08-12 |
mouse |
| Pau Celada, M Victoria Puig, Francesc Artiga. Serotonin modulation of cortical neurons and networks. Frontiers in integrative neuroscience. vol 7. 2013-04-30. PMID:23626526. |
5-ht and selective receptor agonists modulate the excitability of cortical neurons and their discharge rate through the activation of several receptor subtypes, of which the 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht3 subtypes play a major role. |
2013-04-30 |
2023-08-12 |
Not clear |
| Gyorgy Bagdy, Gabriella Juhasz, Xenia Gond. A new clinical evidence-based gene-environment interaction model of depression. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 14. issue 4. 2013-04-12. PMID:23269207. |
in the newmood cohort polymorphisms of the genes of the serotonin transporter, 5-ht1a, 5-ht1b and 5-ht2a and endocannabinoid cb1 receptors, tryptophan hydroxylase, creb1, bdnf and girk provide evidence for the involvement of these genes in the development of depression. |
2013-04-12 |
2023-08-12 |
human |
| Tzuri Lifschytz, Esther Channah Broner, Polina Zozulinsky, Alexandra Slonimsky, Renana Eitan, Lior Greenbaum, Bernard Lere. Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22040681. |
we sought to study the relationship of rgs2 expression level to depression and anxiety-like behavioural features, sociability and brain 5-ht1a and 5-ht1b receptor expression. |
2013-01-17 |
2023-08-12 |
mouse |
| Tzuri Lifschytz, Esther Channah Broner, Polina Zozulinsky, Alexandra Slonimsky, Renana Eitan, Lior Greenbaum, Bernard Lere. Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22040681. |
expression levels of 5-ht1a and 5-ht1b receptors in the cortex, raphe nucleus and hypothalamus were compared among mice of the different rgs2 genotype groups. |
2013-01-17 |
2023-08-12 |
mouse |
| Jorge J Pérez-Maceira, María J Mancebo, Manuel Aldegund. Serotonin-induced brain glycogenolysis in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. vol 215. issue Pt 17. 2012-12-12. PMID:22875766. |
5-ht1a, 5-ht1b, 5ht2b and 5-ht2c-like receptors appeared to be involved in the glycogenolytic action of 5-ht, although the effect mediated by 5-ht1a or 5-ht1b was apparently stronger. |
2012-12-12 |
2023-08-12 |
Not clear |
| T Watanabe, H Aonum. Identification and expression analyses of a novel serotonin receptor gene, 5-HT2β, in the field cricket, Gryllus bimaculatus. Acta biologica Hungarica. vol 63 Suppl 2. 2012-09-17. PMID:22776473. |
in our previous report, in order to elucidate the molecular basis of the cricket 5-ht system, we identified three genes involved in 5-ht biosynthesis, as well as four 5-ht receptor genes (5-ht1a, 5-ht1b, 5-ht2α, and 5-ht7) expressed in the brain of the field cricket gryllus bimaculatus degeer [7]. |
2012-09-17 |
2023-08-12 |
cricket |
| Enric Alvarez, Victor Perez, Marianne Dragheim, Henrik Loft, Francesc Artiga. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. The international journal of neuropsychopharmacology. vol 15. issue 5. 2012-09-06. PMID:21767441. |
lu aa21004 is a novel antidepressant that is a 5-ht3 and 5-ht7 receptor antagonist, 5-ht1a receptor agonist, 5-ht1b receptor partial agonist and inhibitor of the 5-ht transporter in recombinant cell lines. |
2012-09-06 |
2023-08-12 |
Not clear |
| Sarah M Clinton, Ilan A Kerman, Hailey R Orr, Tracy A Bedrosian, Antony D Abraham, Danielle N Simpson, Stanley J Watson, Huda Aki. Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter. Brain research. vol 1422. 2012-07-31. PMID:21974861. |
we also found divergent 5-ht1a receptor mrna expression within some of these same areas, with blrs having greater 5-ht1a, but not 5-ht1b, receptor mrna levels in the septum, hippocampus and cingulate cortex. |
2012-07-31 |
2023-08-12 |
rat |