| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alain M Gardier, Bruno P Guiard, Jean-Philippe Guilloux, Christelle Repérant, François Coudoré, Denis J Davi. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundamental & clinical pharmacology. vol 23. issue 1. 2009-06-01. PMID:19267769. |
the present review will thus focus on ko mice lacking g protein-coupled monoaminergic receptors (e.g; 5-ht1b, 5-ht1a, and 5-ht4 receptors) and the 5-ht serotonin transporter, which is the main target of antidepressant drugs (or strategies). |
2009-06-01 |
2023-08-12 |
mouse |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
in comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pki) for serotonin receptors (5-ht1a [8.6], 5-ht1b [8.4], 5-ht2a [10.2], 5-ht2b [9.8], 5-ht2c [10.5], 5-ht5 [8.8], 5-ht6 [9.6] and 5-ht7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2a [8.9], alpha2b [9.5] and alpha2c [8.9]), dopamine receptors (d1 [8.9], d2 [8.9], d3 [9.4] and d4 [9.0]) and histamine receptors (h1 [9.0] and h2 [8.2]). |
2009-04-03 |
2023-08-12 |
human |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
asenapine behaved as a potent antagonist (pkb) at 5-ht1a (7.4), 5-ht1b (8.1), 5-ht2a (9.0), 5-ht2b (9.3), 5-ht2c (9.0), 5-ht6 (8.0), 5-ht7 (8.5), d2 (9.1), d3 (9.1), alpha2a (7.3), alpha2b (8.3), alpha2c (6.8) and h1 (8.4) receptors. |
2009-04-03 |
2023-08-12 |
human |
| Lígia Aline Centenaro, Karin Vieira, Nicolle Zimmermann, Klaus A Miczek, Aldo Bolten Lucion, Rosa Maria Martins de Almeid. Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex. Psychopharmacology. vol 201. issue 2. 2009-03-24. PMID:18688602. |
social instigation and aggressive behavior in mice: role of 5-ht1a and 5-ht1b receptors in the prefrontal cortex. |
2009-03-24 |
2023-08-12 |
mouse |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Ana Muñoz, Qin Li, Fabrizio Gardoni, Elena Marcello, Chuan Qin, Thomas Carlsson, Deniz Kirik, Monica Di Luca, Anders Björklund, Erwan Bezard, Manolo Cart. Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:18952677. |
combined 5-ht1a and 5-ht1b receptor agonists for the treatment of l-dopa-induced dyskinesia. |
2009-02-02 |
2023-08-12 |
rat |
| Moshe Rav-Acha, Hagai Bergman, Yosef Yaro. Pre- and postsynaptic serotoninergic excitation of globus pallidus neurons. Journal of neurophysiology. vol 100. issue 2. 2008-11-05. PMID:18550726. |
analyzing the effects of specific 5-ht agonists and antagonists on the firing rate of gp neurons showed that the increase in firing rate is due to the activation of 5-ht1b and 5-ht1a receptors. |
2008-11-05 |
2023-08-12 |
rat |
| Kyu Seung Lee, Tae Hee Han, Ji Yoon Jo, Gun Kang, So Yeong Lee, Pan Dong Ryu, Jae Hyeng Im, Byeong Hwa Jeon, Jin Bong Par. Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons. Neuroscience letters. vol 439. issue 2. 2008-10-14. PMID:18524490. |
the sipsc inhibition of 5-ht was mimicked by 5-ht1a agonist, 8-oh-dpat (8-hydroxy-2(di-n-propylamino)tetralin, 10 microm), and blocked by 5-ht1a antagonist way-100635 but not by 5-ht1b antagonist sb224289. |
2008-10-14 |
2023-08-12 |
Not clear |
| Nigus Dessale. QSAR study on dual 5-HT1A and 5-HT1B antagonists: an insight into the structural requirement for antidepressant activity. Archiv der Pharmazie. vol 341. issue 5. 2008-07-08. PMID:18389517. |
with the purpose of designing new chemical entities with enhanced antagonist potencies against 5-ht1a and 5-ht1b, a qsar study carried out on thienopyrimidinone derivatives as antagonists of serotonin autoreceptors is presented. |
2008-07-08 |
2023-08-12 |
Not clear |
| Kayo Nakamura, Takefumi Kikusui, Yukari Takeuchi, Yuji Mor. Changes in social instigation- and food restriction-induced aggressive behaviors and hippocampal 5HT1B mRNA receptor expression in male mice from early weaning. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18022705. |
we also measured 5ht1a and 5ht1b receptor mrna expression in the hippocampus which involved in aggression using real-time pcr. |
2008-04-07 |
2023-08-12 |
mouse |
| S Besnard, F Massé, M Verdaguer, B Cappelin, J C Meurice, C Gestrea. Time- and dose-related effects of three 5-HT receptor ligands on the genioglossus activity in anesthetized and conscious rats. Sleep & breathing = Schlaf & Atmung. vol 11. issue 4. 2008-03-14. PMID:17457631. |
the purpose of this study was to investigate time- and dose-related effects of central and systemic injections of 8-ohdpat (5-ht1a agonist), sb224289 (5-ht1b antagonist), and doi (5-ht2a/2c agonist) on the gg activity in anesthetized and conscious rats. |
2008-03-14 |
2023-08-12 |
rat |
| Henrik Stig Jørgense. Studies on the neuroendocrine role of serotonin. Danish medical bulletin. vol 54. issue 4. 2008-02-14. PMID:18208678. |
the acth response to 5-ht is mediated via 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors and an involvement of the 5-ht4, 5-ht5 and 5-ht7 receptors is proposed. |
2008-02-14 |
2023-08-12 |
rat |
| Alfredo Menese. Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory. Behavioural brain research. vol 184. issue 1. 2008-01-09. PMID:17692935. |
stimulation of 5-ht1a, 5-ht1b, 5-ht2a/2c, 5-ht3 and 5-ht4 receptors or 5-ht uptake inhibition: short- and long-term memory. |
2008-01-09 |
2023-08-12 |
Not clear |
| M S Clark, R A McDevitt, B J Hoplight, J F Neumaie. Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467184. |
following behavioral testing, 5-ht1a, 5-ht1b, 5-ht transporter (sert), and tryptophan hydroxylase-2 (tph2) expression was examined through the drn by in situ hybridization. |
2007-10-25 |
2023-08-12 |
human |
| Jeannette M Watson, Lee A Dawso. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS drug reviews. vol 13. issue 2. 2007-09-21. PMID:17627673. |
it has been proven that selective serotonin reuptake inhibitors are effective antidepressants, but the delay to therapeutic onset of these agents is thought to be due to the time required for 5-ht1a, and possibly 5-ht1b, autoreceptors to desensitize. |
2007-09-21 |
2023-08-12 |
human |
| Jeannette M Watson, Lee A Dawso. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS drug reviews. vol 13. issue 2. 2007-09-21. PMID:17627673. |
therefore, an agent incorporating 5-ht reuptake inhibition coupled with 5-ht1a and/or 5-ht1b autoreceptor antagonism may provide a fast-acting clinical agent. |
2007-09-21 |
2023-08-12 |
human |
| Jeannette M Watson, Lee A Dawso. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS drug reviews. vol 13. issue 2. 2007-09-21. PMID:17627673. |
the current studies review the profile of sb-649915 (6-[(1-{2-[(2-methylquinolin-5-yl)oxy]ethyl}piperidin-4-yl)methyl]-2h-1,4-benzoxazin-3(4h)-one), a novel compound with high affinity for human (h) 5-ht1a and 5-ht1b receptors (pki values of 8.6 and 8.0, respectively) as well as the (h) 5-ht transporter (sert) (pki value of 9.3). |
2007-09-21 |
2023-08-12 |
human |
| Jeannette M Watson, Lee A Dawso. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS drug reviews. vol 13. issue 2. 2007-09-21. PMID:17627673. |
sb-649915 behaved as an antagonist at both 5-ht1a and 5-ht1b receptors in vitro and in vivo, reversing 5-ht, (+)8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) and skf99101-induced functional/behavioral responses. |
2007-09-21 |
2023-08-12 |
human |
| Valérie Kayser, Iskander Elfihri Elfassi, Bertrand Aubel, Maxette Melfort, David Julius, Jay A Gingrich, Michel Hamon, Sylvie Bourgoi. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain. vol 130. issue 3. 2007-08-09. PMID:17250964. |
pain behaviors of mutants which do not express 5-ht1a, 5-ht1b, 5-ht2a or 5-ht3a receptors, or lacking the 5-ht transporter, compared to paired wild-type mice of the same genetic background, were examined using validated tests based on different sensory modalities. |
2007-08-09 |
2023-08-12 |
mouse |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
removal of the serotonin afferents, or dampening of serotonin neuron activity by 5-ht1a and 5-ht1b agonist drugs, resulted in a near-complete block of the l-dopa-induced dyskinesias, suggesting that dysregulated dopamine release from serotonin terminals is the prime trigger of dyskinesia in the rat parkinson's disease model. |
2007-07-24 |
2023-08-12 |
rat |