| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen M Stah. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors). CNS spectrums. vol 20. issue 2. 2015-09-15. PMID:25831967. |
modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (mma): enhancing serotonin release by combining serotonin (5ht) transporter inhibition with actions at 5ht receptors (5ht1a, 5ht1b, 5ht1d, 5ht7 receptors). |
2015-09-15 |
2023-08-13 |
Not clear |
| Asres Berhan, Alex Barke. Vortioxetine in the treatment of adult patients with major depressive disorder: a meta-analysis of randomized double-blind controlled trials. BMC psychiatry. vol 14. 2015-09-02. PMID:25260373. |
it is a selective serotonin (5-ht) 3a and 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of serotonin transporters. |
2015-09-02 |
2023-08-13 |
Not clear |
| Ashish Dhir, Jayrajsinh Sarvaiy. The efficacy of vortioxetine for the treatment of major depressive disorder. Expert review of neurotherapeutics. vol 14. issue 12. 2015-09-01. PMID:25418918. |
vortioxetine is an agonist of 5-ht1a, a partial agonist of 5-ht1b and an antagonist of 5-ht1d, 5-ht3 and 5-ht7 serotoninergic receptors. |
2015-09-01 |
2023-08-13 |
Not clear |
| Connie Sanchez, Karen E Asin, Francesc Artiga. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacology & therapeutics. vol 145. 2015-08-31. PMID:25016186. |
vortioxetine, a novel antidepressant for the treatment of major depressive disorder (mdd), is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and serotonin (5-ht) transporter (sert) inhibitor. |
2015-08-31 |
2023-08-13 |
Not clear |
| Ligia Westrich, Nasser Haddjeri, Ouria Dkhissi-Benyahya, Connie Sánche. Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents. Neuropharmacology. vol 89. 2015-07-15. PMID:25446573. |
vortioxetine is a multimodal antidepressant that inhibits 5-ht1d, 5-ht3, 5-ht7 receptor activity, 5-ht reuptake, and enhances the activity of 5-ht1a and 5-ht1b receptors. |
2015-07-15 |
2023-08-13 |
mouse |
| Per Svenningsson, Carl Rosenblad, Karolina Af Edholm Arvidsson, Klas Wictorin, Charlotte Keywood, Bavani Shankar, David A Lowe, Anders Björklund, Håkan Widne. Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25669730. |
simultaneous activation of 5-ht1a and 5-ht1b receptors effectively blocks l-dopa-induced dyskinesias in animal models of dopamine depletion, justifying a clinical study with eltoprazine, a 5-ht1a/b receptor agonist, against l-dopa-induced dyskinesias in patients with parkinson's disease. |
2015-06-16 |
2023-08-13 |
Not clear |
| Laurent Tritschler, Daniela Felice, Romain Colle, Jean-Philippe Guilloux, Emmanuelle Corruble, Alain Michel Gardier, Denis Joseph Davi. Vortioxetine for the treatment of major depressive disorder. Expert review of clinical pharmacology. vol 7. issue 6. 2015-06-15. PMID:25166025. |
vortioxetine (brintellix(®), 1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine) is a multimodal antidepressant targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin (5-ht) transporter (5-htt). |
2015-06-15 |
2023-08-13 |
Not clear |
| Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu, Charles R Yang, Niels Plath, Connie Sanche. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. Journal of psychopharmacology (Oxford, England). vol 28. issue 10. 2015-06-09. PMID:25122043. |
vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-ht)3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (sert) inhibitor. |
2015-06-09 |
2023-08-13 |
rat |
| Ashley Wallace, Alan L Pehrson, Connie Sánchez, David A Morila. Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. The international journal of neuropsychopharmacology. vol 17. issue 10. 2015-06-02. PMID:24852131. |
vortioxetine, a novel, multimodal-acting antidepressant, is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, and inhibits the 5-ht transporter. |
2015-06-02 |
2023-08-13 |
rat |
| S C Leiser, A L Pehrson, P J Robichaud, C Sanche. Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats. British journal of pharmacology. vol 171. issue 18. 2015-05-26. PMID:24846338. |
vortioxetine is a 5-ht3 , 5-ht7 , and 5-ht1d receptor antagonist, 5-ht1b partial agonist, 5-ht1a agonist, and 5-ht transporter inhibitor. |
2015-05-26 |
2023-08-13 |
rat |
| Mauro Giovanni Carta, Andrea Norcini Pala, Gabriele Finco, Mario Musu, Maria Francesca Mor. Depression and cerebrovascular disease: could vortioxetine represent a valid treatment option? Clinical practice and epidemiology in mental health : CP & EMH. vol 11. 2015-04-20. PMID:25893002. |
mechanism of action : vortioxetine has 5-ht3, 5-ht7 and 5-ht1d antagonists, 5-ht1b partial agonist and a 5-ht1a agonist and serotonin transporter inhibitor property. |
2015-04-20 |
2023-08-13 |
Not clear |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25225185. |
using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-ht) receptor subtypes 5-ht1a, 5-ht1b, and 5-ht2a; dopamine (da) d2 autoreceptors, and α1- and α2-adrenergic receptors. |
2015-02-17 |
2023-08-13 |
Not clear |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
also, the local administration of a drug using the intracranial microinjection technique has shown that activation of specific subtypes of 5-ht receptors (5-ht1a and 5-ht1b) in mesocorticolimbic areas can reduce species-typical and other aggressive behaviors, but the same receptors in the medial prefrontal cortex or septal area promote escalated forms of aggression. |
2015-01-20 |
2023-08-12 |
mouse |
| Rachel Lynn Dennis, Heng-Wei Chen. Differential serotonergic mediation of aggression in roosters bred for resistance and susceptibility to Marek's disease. British poultry science. vol 55. issue 1. 2014-12-18. PMID:24697575. |
levels of the serotonin metabolite 5-hiaa, but not absolute central 5-ht levels, were altered in both strains following 5-ht1b antagonism, but only in strain 72 cocks following 5-ht1a antagonism. |
2014-12-18 |
2023-08-13 |
Not clear |
| Stal Saurav Shrestha, Daniel S Pine, David A Luckenbaugh, Katarina Varnäs, Ioline D Henter, Robert B Innis, Aleksander A Mathé, Per Svenningsso. Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model. Neuroscience letters. vol 559. 2014-09-28. PMID:24287374. |
quantitative in vitro autoradiography was performed using [(125)i]mppi (5-ht1a) and [(125)i]cyp (5-ht1b) in prefrontal cortex (pfc) and hippocampus. |
2014-09-28 |
2023-08-12 |
rat |
| Stal Saurav Shrestha, Daniel S Pine, David A Luckenbaugh, Katarina Varnäs, Ioline D Henter, Robert B Innis, Aleksander A Mathé, Per Svenningsso. Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model. Neuroscience letters. vol 559. 2014-09-28. PMID:24287374. |
stringent, bonferroni-corrected statistical analyses showed significant strain-by-rearing-by-treatment (three-way) interactions in pfc 5-ht1a and hippocampal 5-ht1b receptors. |
2014-09-28 |
2023-08-12 |
rat |
| Stal Saurav Shrestha, Daniel S Pine, David A Luckenbaugh, Katarina Varnäs, Ioline D Henter, Robert B Innis, Aleksander A Mathé, Per Svenningsso. Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model. Neuroscience letters. vol 559. 2014-09-28. PMID:24287374. |
both antidepressants increased hippocampal 5-ht1b receptor binding; however, only nortriptyline selectively increased pfc 5-ht1a receptor binding. |
2014-09-28 |
2023-08-12 |
rat |
| Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. |
vortioxetine reversed pcpa-induced memory deficits dose-dependently with a minimal effective dose (med) ≤0.1mg/kg (∼80% 5-ht3 receptor occupancy; or) and ≤3.0mg/kg (5-ht1a, 5-ht1b, 5-ht3 receptor occupancy: ∼15%, 60%, 95%) in sa. |
2014-09-12 |
2023-08-12 |
rat |
| Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. |
vortioxetine administration significantly improved memory performance in or and occupied 95%, 66%, and 9.5% of 5-ht3, 5-ht1b, and 5-ht1a receptors, respectively. |
2014-09-12 |
2023-08-12 |
rat |
| Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. |
the investigational multimodal acting antidepressant vortioxetine is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and 5-ht transporter (sert) inhibitor that enhances memory in normal rats in novel object recognition (nor) and conditioned fear (mørk et al., 2013). |
2014-09-12 |
2023-08-12 |
rat |