| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Ransom, K B Asarch, J C Shi. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. Journal of neurochemistry. vol 46. issue 1. 1986-01-21. PMID:2933490. |
1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (papp) inhibits [3h]5-hydroxytryptamine (5-ht, serotonin) binding to 5-ht1a and 5-ht1b sites in rat brain with apparent equilibrium dissociation constants (kd) of 2.9 and 328 nm, respectively. |
1986-01-21 |
2023-08-11 |
rat |
| R W Ransom, K B Asarch, J C Shi. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. Journal of neurochemistry. vol 46. issue 1. 1986-01-21. PMID:2933490. |
spiperone and 8-hydroxy-2-(di-n-propylamino)tetralin, two compounds that discriminate [3h]5-ht binding to 5-ht1a and 5-ht1b sites, inhibited [3h]papp binding in accordance with their much higher affinities for the 5-ht1a receptor subtype. |
1986-01-21 |
2023-08-11 |
rat |
| A Pazos, J M Palacio. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain research. vol 346. issue 2. 1985-12-20. PMID:4052776. |
from the areas strongly enriched in 5-ht1 sites, dentate gyrus and septal nucleus contained 5-ht1a sites, while globus pallidus, dorsal subiculum, substantia nigra and olivary pretectal nucleus were enriched in 5-ht1b. |
1985-12-20 |
2023-08-11 |
rat |
| S J Peroutk. Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain. Brain research. vol 344. issue 1. 1985-11-12. PMID:4041865. |
drug interactions with serotonin(1a) 5-ht1a and serotonin(1b) (5-ht1b) binding sites were analyzed in bovine brain membranes. |
1985-11-12 |
2023-08-11 |
cattle |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-ht) binding subtypes: 5-ht2, 5-ht1a and 5-ht1b. |
1985-06-20 |
2023-08-11 |
mouse |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
these techniques have also indicated that certain drugs appear to show sub-type specificity: 8-hydroxy-2-(di-n-propylamino)tetralin(8-oh-dpat), a 5-ht1a agonist; 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1-h indole (ru 24969), a 5-ht1b agonist; and ritanserin, a 5-ht2 antagonist. |
1985-06-20 |
2023-08-11 |
mouse |
| M B Emerit, H Gozlan, M D Hall, M Hamon, A Marque. Irreversible blockade of central 5-HT binding sites by 8-methoxy-2'-chloro-PAT. Biochemical pharmacology. vol 34. issue 6. 1985-04-17. PMID:3156602. |
although 8-methoxy-2'-chloro-pat bound irreversibly to different classes of 5-ht binding sites (5-ht1a, 5-ht1b, presynaptic sites), it can be considered a selective alkylating agent, since it exerted no action on 3h-spiperone binding to 5-ht2 sites, 3h-muscimol binding to gaba sites, or 3h-flunitrazepam binding to benzodiazepine sites. |
1985-04-17 |
2023-08-11 |
rat |
| A Pazos, R Cortés, J M Palacio. Quantitative receptor autoradiography: application to the characterization of multiple receptor subtypes. Journal of receptor research. vol 4. issue 1-6. 1985-04-04. PMID:6241253. |
in vitro autoradiographic techniques combined with computer assisted microdensitometry were used to analyze the characteristics and distribution of multiple recognition sites for the neurotransmitters acetylcholine (m1 and m2) and serotonin (5-ht1a and 5-ht1b). |
1985-04-04 |
2023-08-12 |
Not clear |
| R D Todd, R D Ciaranell. Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child. Proceedings of the National Academy of Sciences of the United States of America. vol 82. issue 2. 1985-03-01. PMID:2578670. |
human 5-ht1a sites can be distinguished from human 5-ht1b, 5-ht2, and 5-ht3 sites and from equivalent sites in rat and bovine cortex. |
1985-03-01 |
2023-08-11 |
human |