| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N el-Yassir, S M Fleetwood-Walker, R Mitchel. Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes. Brain research. vol 456. issue 1. 1988-10-13. PMID:2970278. |
the use of agonists, shown to discriminate between subtypes of 5-ht1 receptor revealed that a 5-ht1a receptor agonist mimicked the non-selective effects of 5-ht, whereas a 5-ht1b receptor agonist mimicked the selective antinociceptive effects of 5-ht. |
1988-10-13 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-ht1 subtype different from 5-ht1a, 5-ht1b, and 5-ht1c. |
1988-09-15 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-ht binding sites of the 5-ht1 type are heterogeneous and appear to comprise several subtypes (5-ht1a, 5-ht1b and 5-ht1c); their physiological role is as yet unclear. |
1988-09-15 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
on the other hand, the high-affinity activation of the enzyme induced by 5-ht, 5-methoxytryptamine, bufotenin, lsd, and the activation induced by tfmpp were not inhibited by spiperone (1 microm), by propranolol (3 microm), or by mesulergine (0.1 microm), which selectively block 5-ht1a, 5-ht1b, and 5-ht1c sites. |
1988-09-15 |
2023-08-11 |
rat |
| C Waeber, M M Dietl, D Hoyer, A Probst, J M Palacio. Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography. Neuroscience letters. vol 88. issue 1. 1988-08-26. PMID:3399126. |
8-oh-dpat (8-hydroxy-2-[n,n-di-n-propyl-amino]tetralin) was used to block [3h]5-ht binding to 5-ht1a, the beta-blocker (-)-21 009 (4-[3-ter-butyl-amino-2-hydroxy-propoxy]indol-2-carbonic acid isopropyl ester) to 5-ht1b and the ergoline mesulergine to 5-ht1c recognition sites. |
1988-08-26 |
2023-08-11 |
human |
| S Bischoff, M Heinrich, J Krauss, M A Sills, M Williams, A Vassou. Interaction of the D1 receptor antagonist SCH 23390 with the central 5-HT system: radioligand binding studies, measurements of biochemical parameters and effects on L-5-HTP syndrome. Journal of receptor research. vol 8. issue 1-4. 1988-08-08. PMID:3290470. |
sch 23390 had weak affinity for 5-ht1b (ic50 = 0.5 microm), 5-ht1a (ic50 = 2.6 microm) and alpha 1-adrenergic receptors (ic50 = 4.4 microm). |
1988-08-08 |
2023-08-11 |
rat |
| R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455040. |
the 5-ht1a agonist 8-hydroxy-n,n-dipropyl-2-aminotetralin and the 5ht1b agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole (ru-24969) also produced depressor effects but, in contrast to 5-ht, facilitated the tail-flick reflex, whereas the 5-ht2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, 6-chloro-2-(1-piperazinyl)-pyrazine (mk-212) and quipazine produced dose-dependent antinociception and had little or no effect on blood pressure. |
1988-07-29 |
2023-08-11 |
rat |
| H Shimizu, N Karai, A Hirose, T Tatsuno, H Tanaka, Y Kumasaka, M Nakamur. Interaction of SM-3997 with serotonin receptors in rat brain. Japanese journal of pharmacology. vol 46. issue 3. 1988-07-25. PMID:2898033. |
sm-3997 possessed a high affinity towards 5-ht1a receptors, low affinity towards dopamine (d2) and 5-ht2 receptors, and no affinity towards benzodiazepine (bz), gaba, 5-ht1b and adrenergic receptors. |
1988-07-25 |
2023-08-11 |
rat |
| P Wang, C S Aulakh, J L Hill, D L Murph. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists. Psychopharmacology. vol 94. issue 4. 1988-07-14. PMID:2967518. |
the food intake suppressant effects of three serotonin agonists, m-cpp (a selective 5-ht1b agonist), 8-ohdpat (a selective 5-ht1a agonist) and fenfluramine (a 5-ht releasing agent) were compared in three different rat strains: wistar, sprague-dawley (sd) and fawn-hooded (fh) rats. |
1988-07-14 |
2023-08-11 |
rat |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
in human caudate and cortex membranes, [3h]serotonin ([3h]5-ht) labels 5-ht1a and 5-ht1c recognition sites which show nanomolar affinity for 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-ht1b binding could be identified. |
1988-06-02 |
2023-08-11 |
human |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
however, the majority of the sites labelled by [3h]5-ht (greater than or equal to 60% in cortex, 90% in caudate) are different from 5-ht1a, 5-ht1b and 5-ht1c sites. |
1988-06-02 |
2023-08-11 |
human |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
in contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-ht1a (8-oh-dpat, buspirone), 5-ht1b (21-009, ru 24969), 5-ht1c (mesulergine, mianserin) and 5-ht2 sites (ketanserin, cinanserin). |
1988-06-02 |
2023-08-11 |
human |
| M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2895033. |
a 5-ht1a agonist (8-oh-dpat) blocked wds, but like putative 5-ht1b (ru 24969) and 5-ht2 (doi) agonists and the 5-ht antagonists methysergide (non-selective), ritanserin (5-ht2 selective), and l-propranolol (5-ht1 selective), it did not block other antagonists behavioural effects of mk-771. |
1988-05-12 |
2023-08-11 |
rat |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the 5-ht receptor agonists serotonin (1-100 nm), lysergic acid diethylamide (10 nm-1 microm) and the 5-ht1b receptor agonists 1-(m-trifluoromethylphenyl)piperazine (100 nm-1 microm) and 1-(m-chlorophenyl) piperazine (100 nm-3 microm) concentration dependently decreased [3h]5-ht release, while 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a receptor agonist, was inactive. |
1988-05-06 |
2023-08-11 |
rat |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the actions of the effective agonists were reversed by quipazine, an antagonist with high affinity for 5-ht1b binding sites, but not by spiperone, a 5-ht1a receptor antagonist. |
1988-05-06 |
2023-08-11 |
rat |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
in the present study, the affinities of these urapidil derivatives (5-acetyl, 5-formyl- and 5-methyl-urapidil) for 5-ht receptors were investigated using 3h-8-hydroxy-2-(di-n-propyl-amino)tetralin (3h-8-oh-dpat), 125i-iodocyanopindolol (125i-icyp) and 3h-ketanserin for labelling 5-ht1a, 5-ht1b and 5-ht2 binding sites, respectively. |
1988-05-03 |
2023-08-11 |
Not clear |
| M Titeler, R A Lyon, R A Glenno. Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology. vol 94. issue 2. 1988-05-03. PMID:3127847. |
in order to test the hypothesis that the mechanism of action of lsd and phenylisopropylamine hallucinogens is through stimulation of a specific brain serotonin receptor sub-type, the affinities of these compounds for radiolabelled 5-ht2, 5-ht1a, 5-ht1b, and 5-ht1c receptors have been determined using recently developed in vitro radioligand binding methodologies. |
1988-05-03 |
2023-08-11 |
Not clear |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
the effect of selective 5-ht1a and 5-ht1b agonists on k+-evoked release of [3h]5-ht and the binding of [3h]5-ht were examined. |
1988-04-22 |
2023-08-11 |
rat |
| B A McMillen, J K Chamberlain, J P DaVanz. Effects of housing and muricidal behavior on serotonergic receptors and interactions with novel anxiolytic drugs. Journal of neural transmission. vol 71. issue 2. 1988-04-18. PMID:2894404. |
binding of [3h]-5-hydroxytryptamine (5ht) to 5ht1a receptors decreased in septum of both groups of isolated rats and binding to 5ht1b receptors decreased 50% in hippocampus of isolated and aggregated muricidal rats. |
1988-04-18 |
2023-08-11 |
mouse |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |