| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Ransom, K B Asarch, J C Shi. Photoaffinity labeling of the 5-hydroxytryptamine 1A receptor in rat hippocampus. Journal of neurochemistry. vol 47. issue 4. 1986-10-15. PMID:3746296. |
1-[2-(4-azidophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (p-azido-papp) inhibits [3h]5-hydroxytryptamine [( 3h]5-ht) binding to 5-ht1a and 5-ht1b sites in rat brain with equilibrium dissociation constants (kd) of 0.9 nm and 230 nm, respectively. |
1986-10-15 |
2023-08-11 |
rat |
| S J Peroutk. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. Journal of neurochemistry. vol 47. issue 2. 1986-09-17. PMID:2942638. |
pharmacological differentiation and characterization of 5-ht1a, 5-ht1b, and 5-ht1c binding sites in rat frontal cortex. |
1986-09-17 |
2023-08-11 |
rat |
| S D Mendelson, B B Gorzalk. 5-HT1A receptors: differential involvement in female and male sexual behavior in the rat. Physiology & behavior. vol 37. issue 2. 1986-09-17. PMID:2942955. |
furthermore, it is proposed that 5-ht1a receptors mediate inhibitory effects, whereas 5-ht1b receptors mediate presynaptic, facilitatory effects of serotonin. |
1986-09-17 |
2023-08-11 |
rat |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
[3h]5-ht was used to label both 5-ht1a and 5-ht1b receptor subtypes. |
1986-08-19 |
2023-08-11 |
human |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
5-ht1a receptors were selectively labeled by [3h]8-hydroxy-2[di-n-propylamino]tetralin, while 5-ht1b receptors were labeled by (-)-[125i]iodocyanopindolol ([125i]cyp) in the presence of 30 microm isoprenaline. |
1986-08-19 |
2023-08-11 |
human |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
in contrast to 5-ht1a receptors, it was not possible to identify 5-ht receptors having the pharmacological properties of 5-ht1b sites in the human brain, using either [3h]5-ht or [125i]cyp as ligands. |
1986-08-19 |
2023-08-11 |
human |
| M L Cohen, W E Colber. Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and rat stomach fundus 5-HT receptors. The Journal of pharmacology and experimental therapeutics. vol 237. issue 3. 1986-07-16. PMID:3712277. |
similarity of the contractile effects of 5-ht in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5-ht-induced contractions in the fundus were not 5-ht1, 5-ht1a, 5-ht1b or 5-ht2 led us to consider the possibility that 5-ht receptors in the canine basilar artery may resemble those in the rat stomach fundus. |
1986-07-16 |
2023-08-11 |
rat |
| H Gozlan, M B Emerit, M D Hall, M Nielsen, M Hamo. In situ molecular sizes of the various types of 5-HT binding sites in the rat brain. Biochemical pharmacology. vol 35. issue 11. 1986-06-27. PMID:3718534. |
using 3h-5-ht or 3h-8-oh-dpat as the ligand, the same molecular weight of 55,000-60,000 daltons was calculated for the postsynaptic 5-ht1a and 5-ht1b sites in the hippocampus and cerebral cortex. |
1986-06-27 |
2023-08-11 |
rat |
| P A Blurton, M D Woo. Identification of multiple binding sites for [3H]5-hydroxytryptamine in the rat CNS. Journal of neurochemistry. vol 46. issue 5. 1986-05-19. PMID:3958711. |
these results suggest the presence of three binding sites for [3h]5-ht, one blocked by low concentrations of spiperone (5-ht1a), one blocked by low concentrations of mianserin (5-ht1c), and one blocked only by high concentrations of both mianserin and spiperone (5-ht1b). |
1986-05-19 |
2023-08-11 |
rat |
| P A Blurton, M D Woo. Identification of multiple binding sites for [3H]5-hydroxytryptamine in the rat CNS. Journal of neurochemistry. vol 46. issue 5. 1986-05-19. PMID:3958711. |
the hippocampus was rich in 5-ht1a sites, whereas the striatum contained mainly 5-ht1b and 5-ht1c sites. |
1986-05-19 |
2023-08-11 |
rat |
| G Engel, M Göthert, D Hoyer, E Schlicker, K Hillenbran. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:2936965. |
the affinities of the compounds for 5-ht1b and 5-ht2 binding sites in rat brain cortex membranes (labelled by [125i]cyanopindolol = [125i]-cyp in the presence of 30 mumol/l isoprenaline and [3h]ketanserin, respectively), for 5-ht1a binding sites in pig and rat brain cortex membranes (labelled by [3h]8-hydroxy-2-(di-n-propylamino)tetralin = [3h]8-oh-dpat) and for 5-ht1c binding sites in pig choroid plexus membranes (labelled by [3h]mesulergine) were also determined. |
1986-04-22 |
2023-08-11 |
rat |
| K G Charlton, R A Bond, D E Clark. An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:3951568. |
it is concluded that the receptor to 5-ht conforms to general criteria defining 5-ht1-like receptors but at the present time the receptor site cannot be fitted to the designated 5-ht1a, 5-ht1b or 5-ht1c subtypes. |
1986-04-22 |
2023-08-11 |
rat |
| D Hoyer, G Engel, H O Kalkma. Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935410. |
finally, the beta-adrenoceptor antagonist (-)21-009 which has different affinities for 5-ht1a, 5-ht1b and 5-ht1c recognition sites, yielded triphasic competition curves for [3h]5-ht binding in rat cortex membranes providing evidence that [3h]5-ht labels three distinct 5-ht1 sites in these membranes. |
1986-03-05 |
2023-08-11 |
rat |
| E W Taylor, S P Duckles, D L Nelso. Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site. The Journal of pharmacology and experimental therapeutics. vol 236. issue 1. 1986-02-20. PMID:2934545. |
logs of these ka values did not correlate with log ki values for the inhibition of binding of the 5-ht2 ligand [3h] ketanserin (r = 0.2253, p greater than .05) or log ic50 values for inhibition of [3h]5-ht binding (r = 0.5732, p greater than 0.05), which labels both 5-ht1a and 5-ht1b sites. |
1986-02-20 |
2023-08-11 |
Not clear |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
meta chlorophenylpiperazine (cpp) and meta trifluoromethylphenylpiperazine (tfmpp), selective ligands for the 5ht1b receptor and ly165163, a selective ligand for the 5ht1a receptor, have been evaluated for their agonist and antagonist activity at serotonin receptors in the rat stomach fundus. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
the affinity for serotonin receptors in the rat fundus was similar for all three phenylpiperazines in spite of the reported selectivity of mcpp and tfmpp for 5ht1b and of ly165163 for 5ht1a receptors. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
furthermore, the affinity of these agents for serotonin receptors in the rat stomach fundus did not agree with their reported affinity for either 5ht1a or 5ht1b binding sites in rat cortical membranes. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
thus, the similarity in affinities of these phenylpiperazine derivatives for serotonin receptors mediating contraction in the rat fundus along with their different affinities for 5ht1a and 5ht1b binding sites argues against the possibility that the serotonin receptor in the rat fundus is of the 5ht1a or 5ht1b subtype of serotonin receptor. |
1986-02-18 |
2023-08-11 |
rat |
| K A Yagaloff, P R Harti. 125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 5. issue 12. 1986-02-07. PMID:4078623. |
the choroid plexus site exhibits a novel pharmacology that does not match the properties of 5-hydroxytryptamine-1a (5-ht1a), 5-ht1b, or 5-ht2 serotonergic sites. |
1986-02-07 |
2023-08-11 |
rat |
| A B Norman, G Battaglia, I Crees. [3H]WB4101 labels the 5-HT1A serotonin receptor subtype in rat brain. Guanine nucleotide and divalent cation sensitivity. Molecular pharmacology. vol 28. issue 6. 1986-01-29. PMID:2867462. |
these data indicate that [3h]wb4101 selectively labels the 5-ht1a serotonin receptor, whereas [3h] lsd appears to label both the 5-ht1a and the 5-ht1b serotonin receptor subtypes. |
1986-01-29 |
2023-08-11 |
rat |