| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Huang, S J Peroutk. Identification of 5-hydroxytryptamine binding site subtypes in rat spinal cord. Brain research. vol 436. issue 1. 1988-02-16. PMID:2961414. |
the results demonstrate that 5-ht1a, 5-ht1b and 5-ht1c binding sites are present in rat spinal cord. |
1988-02-16 |
2023-08-11 |
rat |
| M W Hamblin, K Ariani, P I Adriaenssens, R D Ciaranell. [3H]dihydroergotamine as a high-affinity, slowly dissociating radioligand for 5-HT1B binding sites in rat brain membranes: evidence for guanine nucleotide regulation of agonist affinity states. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2826763. |
competition studies with selective drugs reveal alpha adrenergic, 5-ht1a and 5-ht1b components of [3h]de specific binding. |
1988-02-02 |
2023-08-11 |
human |
| M W Hamblin, K Ariani, P I Adriaenssens, R D Ciaranell. [3H]dihydroergotamine as a high-affinity, slowly dissociating radioligand for 5-HT1B binding sites in rat brain membranes: evidence for guanine nucleotide regulation of agonist affinity states. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2826763. |
when phentolamine (500 nm) is included to block alpha receptors and dpat (100 nm) or spiroxatrine (500 nm) is included to block 5-ht1a receptors, specific binding is exclusively to sites with drug affinities characteristic of 5-ht1b receptors. |
1988-02-02 |
2023-08-11 |
human |
| G J Molderings, K Fink, E Schlicker, M Göther. Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:3683595. |
ketanserin, a 5-ht2 receptor antagonist, and spiperone, which blocks 5-ht2 and 5-ht1a but not 5-ht1b or 5-ht1c receptors, failed to antagonize the effect of 5-ht. |
1988-01-11 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
stereoselective blockade of central [3h]5-hydroxytryptamine binding to multiple sites (5-ht1a, 5-ht1b and 5-ht1c) by mianserin and propranolol. |
1987-10-26 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
the interaction of the enantiomers of mianserin and propranolol with the binding of [3h]5-hydroxytryptamine ([3h]5-ht) to the 5-ht1a, 5-ht1b and 5-ht1c sites, and with the binding of [3h]ketanserin to the 5-ht2 site, has been evaluated in rat brain membranes. |
1987-10-26 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
the stereoselective association of mianserin and propranolol with the 5-ht1a, 5-ht1b and 5-ht1c sites may prove useful in the characterization of these sites. |
1987-10-26 |
2023-08-11 |
rat |
| G A Kennett, M Marcou, C T Dourish, G Curzo. Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like action. European journal of pharmacology. vol 138. issue 1. 1987-10-16. PMID:2442002. |
the 5-ht1a agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), buspirone or tvxq 7821 (ipsapirone) but not the 5-ht1b agonist ru 24969, attenuated the hyperphagic response to 8-oh-dpat administered on the next day. |
1987-10-16 |
2023-08-11 |
Not clear |
| B L Roth, D M Chuan. Multiple mechanisms of serotonergic signal transduction. Life sciences. vol 41. issue 9. 1987-09-23. PMID:2441225. |
recent findings suggest that the distinct types of pharmacologically defined serotonergic receptors (5ht1a, 5ht1b, 5ht1c, 5ht2) may be coupled to one or more signal transduction systems. |
1987-09-23 |
2023-08-11 |
Not clear |
| C Bendotti, R Samani. The role of putative 5-HT1A and 5-HT1B receptors in the control of feeding in rats. Life sciences. vol 41. issue 5. 1987-08-20. PMID:2955189. |
the role of putative 5-ht1a and 5-ht1b receptors in the control of feeding in rats. |
1987-08-20 |
2023-08-11 |
rat |
| G A Kennett, C T Dourish, G Curzo. Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:2883013. |
evidence suggests that the above action of 8-oh-dpat is mediated by 5-ht1a receptors since it was antagonised by the 5-ht1a antagonist spiperone but not by the 5-ht2 antagonist ketanserin and was not mimicked by the 5-ht1b agonist ru 24969. |
1987-05-28 |
2023-08-11 |
rat |
| K B Asarch, J C Shi. Solubilization of serotonin1a and serotonin1b binding sites from bovine brain. Journal of neurochemistry. vol 48. issue 5. 1987-05-20. PMID:2951498. |
the density of [3h]dpat binding sites relative to the [3h]5-ht sites in the solubilized cortical membranes (35%) corresponds well with the proportion of 5-ht1a sites in the crude membranes determined by spiperone displacement (33%), suggesting that both the 5-ht1a and 5-ht1b binding sites have been cosolubilized. |
1987-05-20 |
2023-08-11 |
cattle |
| R E Heuring, S J Peroutk. Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 3. 1987-04-29. PMID:2951504. |
these data therefore demonstrate the presence of a homogeneous class of 5-ht1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5-ht1a, 5-ht1b, 5-ht1c, 5-ht2, and 5-ht3 receptor subtypes. |
1987-04-29 |
2023-08-11 |
rat |
| R D Todd, R D Ciaranell. Multiple high-affinity [3H]serotonin binding sites in human frontal cortex. Brain research. vol 400. issue 2. 1987-04-02. PMID:3815073. |
high-affinity [3h]serotonin (5-hydroxytryptamine, 5-ht) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-ht1a, 5-ht1b and 5-ht3) based on affinity for [3h]serotonin and spiperone. |
1987-04-02 |
2023-08-11 |
human |
| G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:3027734. |
by contrast with this reduction of 5-hydroxytryptamine (5-ht) function mediated by the 5-ht1a and 5-ht2 receptor sub-types, repeated lithium administration had no effect on the motor response to a putative 5-ht1b receptor agonist 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1h indole (ru 24969, 3 mg/kg ip). |
1987-03-20 |
2023-08-11 |
mouse |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
5-ht1a binding was notably high in limbic regions (dentate gyrus, ca1 and ca3 hippocampal regions, lateral septum, frontal cortex), whereas 5-ht1b binding was particularly concentrated in extrapyramidal areas (caudate nucleus, globus pallidus, substantia nigra). |
1987-02-10 |
2023-08-11 |
rat |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
the selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5,7-dihydroxytryptamine was associated only with a significant loss of 5-ht1a binding to the dorsal raphe nucleus (-60%) and of 5-ht1b binding to the substantia nigra (-37%). |
1987-02-10 |
2023-08-11 |
rat |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
these results are discussed in relation to the possible identity of 5-ht1a and/or 5-ht1b sites with the presynaptic 5-ht autoreceptors controlling nerve impulse flow and neurotransmitter release in serotoninergic neurons. |
1987-02-10 |
2023-08-11 |
rat |
| R Markstein, D Hoyer, G Enge. 5-HT1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 4. 1986-12-12. PMID:2945992. |
5-ht1a, 5-ht1b and 5-ht1c recognition sites were labelled with [3h]8-oh-dpat([3h]8-hydroxy-2-(di-n-propylamino)-tetralin) in pig cortex membranes, [125i]cyp([125i]iodocyanopindolol) in rat cortex and [3h]mesulergine in pig choroid plexus membranes, respectively. |
1986-12-12 |
2023-08-11 |
rat |
| H O Kalkman, G Engel, D Hoye. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125I]LSD binding. European journal of pharmacology. vol 129. issue 1-2. 1986-12-11. PMID:3770071. |
the results suggest that the 5-ht receptor-mediating relaxation in the guinea-pig ileum can be labelled with [125i]lsd and that this receptor does not belong to the 5-ht2, 5-ht1a, 5-ht1b or 5-ht1c receptor subtypes. |
1986-12-11 |
2023-08-11 |
Not clear |