| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Silvia Vincentiis, Juliana Alcantara, Patricia Rzezak, Daniel S Kerr, Wagner F Gattaz, Helio van der Linden, Bernardo Dos Santos, Sebastiao E Melo-Souza, Francisco Arruda, Paulo Ragazzo, Tiffany Chaim-Avancini, Mauricio H Serpa, Fernando Fernandes, Ricardo A Moreno, Geraldo Busatto, Ruda Alessi, Renata Demarque, Kette D Valent. Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & behavior : E&B. vol 83. 2019-02-25. PMID:29709878. |
the primary goal of this study was to determine the possible association between polymorphisms of genes encoding the serotonin receptors 5ht1a (rs6295), 5ht1b (rs6296), and 5ht2c (rs6318) and the presence of mood disorders in patients with tle-hs. |
2019-02-25 |
2023-08-13 |
Not clear |
| Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicolett. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Molecular pain. vol 14. 2019-02-20. PMID:30289053. |
vortioxetine is a multimodal antidepressant that potently antagonizes 5-ht3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-ht1a and 5-ht1b receptors, and antagonizes 5-ht1d and 5-ht7 receptors. |
2019-02-20 |
2023-08-13 |
mouse |
| Elske N de Haas, Jerine A J van der Eij. Where in the serotonergic system does it go wrong? Unravelling the route by which the serotonergic system affects feather pecking in chickens. Neuroscience and biobehavioral reviews. vol 95. 2019-02-11. PMID:30055196. |
genetic associations exist between fp, 5-ht1a and 5-ht1b receptor functioning and metabolism of 5-ht and da. |
2019-02-11 |
2023-08-13 |
Not clear |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| Rebecca L Brindley, Mary Beth Bauer, Randy D Blakely, Kevin P M Curri. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27544824. |
the 5-ht1a receptor antagonist way100635 blocked the inhibition by 5-ht which was mimicked by the 5-ht1a agonist 8-oh-dpat but not the 5-ht1b agonist cp93129. |
2018-02-22 |
2023-08-13 |
mouse |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Michele Fornaro, Annastasia L C Fiengo, Giovanni Martinotti, Federica Vellante, Ilaria Matarazzo, Roberta Vecchiotti, Giampaolo Perna, Marco Di Nicola, Alessandro Carano, Andrea Di Bartolomeis, Massimo De Giannantonio, Domenico De Berardi. Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine. CNS & neurological disorders drug targets. vol 16. issue 1. 2018-02-09. PMID:27781949. |
vortioxetine (vrx) is a multimodal antidepressant that acts as serotonin (5ht) transporter inhibitor as well as 5ht3a and 5ht7 receptors antagonist, 5ht1a and 5ht1b receptors partial agonist. |
2018-02-09 |
2023-08-13 |
Not clear |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Main. [Vortioxetine in the treatment of major depression]. Rivista di psichiatria. vol 51. issue 6. 2017-11-20. PMID:27996982. |
vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (sert) inhibitor and as 5-ht3, 5-ht7 and 5-ht1d receptors antagonist, 5-ht1a receptor agonist and 5-ht1b receptor partial agonist. |
2017-11-20 |
2023-08-13 |
Not clear |
| Annina Huser, Melanie Eschment, Nazli Güllü, Katharina A N Collins, Kathrin Böpple, Lyubov Pankevych, Emilia Rolsing, Andreas S Thu. Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777821. |
our data suggest that 5-ht1a, 5-ht1b, and 5-ht7 are dispensable for larval naïve olfactory and gustatory choice behaviors as well as for appetitive and aversive associative olfactory learning and memory. |
2017-10-10 |
2023-08-13 |
drosophila_melanogaster |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
serotonin's homeostasis involves serotoninergic autoreceptor such as 5-ht1a, 5-ht1b, 5-ht1d, the enzymatic degradation of serotonin by monoamine oxidase a (mao-a), and a transporter (serotoninergic transporter [sert]). |
2017-09-20 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
among all the 5-ht receptors, 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2b and 5-ht4 receptors activation would mediate antidepressant effects. |
2017-09-20 |
2023-08-13 |
Not clear |
| Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Betina Elfving, Elena Dale, Gregers Wegener, Connie Sanche. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27262695. |
recent imaging and behavioral data predominantly support a role for 5-ht1a or 5-ht1b receptors, but the full range of 5-ht receptors has currently not been systematically investigated in this context. |
2017-08-30 |
2023-08-13 |
rat |
| Wayne E Pratt, Kara A Clissold, Peagan Lin, Amanda E Cain, Alexa F Ciesinski, Thomas R Hopkins, Adeolu O Ilesanmi, Erin A Kelly, Zachary Pierce-Messick, Daniel S Powell, Ian A Rosne. A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat. Brain research. vol 1648. issue Pt A. 2017-08-28. PMID:27431937. |
feeding and locomotor activity were monitored following ventral tegmentum stimulation or blockade of 5-ht1a, 5-ht1b, 5-ht2a, 5-ht2b, or 5-ht2c receptors. |
2017-08-28 |
2023-08-13 |
rat |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Federica Vellante, Michele Fornaro, Annastasia Fiengo, Monica Mazza, Roberta Vecchiotti, Giampaolo Perna, Andrea de Bartolomeis, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardi. New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. Expert review of neurotherapeutics. vol 16. issue 5. 2017-06-27. PMID:27050932. |
vortioxetine (vrx) is a multimodal antidepressant with a unique mechanism of action, by acting as 5-ht3a, 5-ht1d and 5-ht7 receptor antagonist, partial agonist at the 5-ht1a and 5-ht1b receptors and inhibitor at the 5-ht transporter. |
2017-06-27 |
2023-08-13 |
Not clear |
| Przemysław Nowa. Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment. Current topics in behavioral neurosciences. vol 29. 2017-06-19. PMID:26427851. |
however, as a consequence of altering the functional efficacy of 5-ht1a, 5-ht1b, da, and gaba receptors, these neurotransmitter systems are profoundly affected in adulthood. |
2017-06-19 |
2023-08-13 |
rat |
| Katarina Varnäs, Anders Juréus, Peter Johnström, Charlotte Ahlgren, Pär Schött, Magnus Schou, Susanne Gruber, Eva Jerning, Jonas Malmborg, Christer Halldin, Lovisa Afzelius, Lars Fard. Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27402278. |
azd3676 [n,n-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl) benzofuran-2-carboxamide] is a novel combined serotonin (5-hydroxytryptamine) 5-ht1a and 5-ht1b receptor antagonist that was developed for the treatment of cognitive impairment in alzheimer's disease. |
2017-05-26 |
2023-08-13 |
monkey |
| Gennady N Smagin, Dekun Song, David P Budac, Jessica A Waller, Yan Li, Alan L Pehrson, Connie Sánche. Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:26945513. |
vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-ht)3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b receptor partial agonist; 5-ht1a receptor agonist; and 5-ht transporter inhibitor in vitro. |
2017-01-02 |
2023-08-13 |
rat |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| Dane Aronsen, Natasha Bukholt, Susan Schen. Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Psychopharmacology. vol 233. issue 8. 2016-12-13. PMID:26856853. |
the 5-ht1a and 5-ht1b receptors are both well localized to regulate dopamine (da) release, and have been implicated in modulating the reinforcing effects of many drugs of abuse, but a role in acquisition of self-administration has not been determined. |
2016-12-13 |
2023-08-13 |
Not clear |