| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A T Kilpatrick, C M Brown, A C MacKinnon, M Speddin. The alpha 2-adrenoceptor antagonist SK&F 104078 has high affinity for 5-HT1A and 5-HT2 receptors. European journal of pharmacology. vol 166. issue 2. 1989-11-06. PMID:2571511. |
if sk&f 104078 is used in functional studies to define heterogeneity within of alpha 2-adrenoceptors, care must be taken to define the role of 5-ht1a and 5-ht2 receptors in the response being measured. |
1989-11-06 |
2023-08-11 |
rat |
| S Gleeson, S T Ahlers, R S Mansbach, J M Foust, J E Barret. Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2476547. |
ru 24969, with high affinity for both 5-ht1a and 5-ht1b receptors, and 1-(2-methoxyphenyl)piperazine, a 5-ht1 compound, increased punished responding to a lesser extent, as did the 5-ht2 antagonists ketanserin and ritanserin. |
1989-10-17 |
2023-08-11 |
Not clear |
| G A Kennett, P Whitton, K Shah, G Curzo. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. European journal of pharmacology. vol 164. issue 3. 1989-10-05. PMID:2767117. |
the effect of mcpp on social interaction was blocked by three antagonists which share a high affinity for 5-ht1c and 5-ht2 receptors: mianserin, cyproheptadine and metergoline but not by the 5-ht2 antagonists ketanserin or ritanserin or the 5-ht1a and 5-ht1b antagonists cyanopindolol and (-)-propranolol. |
1989-10-05 |
2023-08-11 |
rat |
| N S Buckholtz, D F Zhou, B Tabakof. Ethanol does not affect serotonin receptor binding in rodent brain. Alcohol (Fayetteville, N.Y.). vol 6. issue 4. 1989-10-03. PMID:2527520. |
in no case did ethanol (100 mm) significantly affect 5-ht1a or 5-ht2 receptor-binding characteristics. |
1989-10-03 |
2023-08-11 |
mouse |
| N S Buckholtz, D F Zhou, B Tabakof. Ethanol does not affect serotonin receptor binding in rodent brain. Alcohol (Fayetteville, N.Y.). vol 6. issue 4. 1989-10-03. PMID:2527520. |
when 5-ht receptor characteristics were measured after mice consumed ethanol for seven days, there was no change in either 5-ht1a or 5-ht2 receptor-binding properties in any of the brain areas examined. |
1989-10-03 |
2023-08-11 |
mouse |
| T Mizuta, T Segaw. Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: quantitative receptor autoradiographic analysis. Japanese journal of pharmacology. vol 50. issue 3. 1989-09-20. PMID:2761132. |
administration of imipramine (20 mg/kg/day for 21 days) decreased the densities of 5-ht1, 5-ht1a, 5-ht1c and 5-ht2 sites in the frontal cortex, hippocampus and choroid plexus. |
1989-09-20 |
2023-08-11 |
rat |
| T Mizuta, T Segaw. Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: quantitative receptor autoradiographic analysis. Japanese journal of pharmacology. vol 50. issue 3. 1989-09-20. PMID:2761132. |
lithium (2 meq/kg/day for 21 days) also decreased the densities of 5-ht1, 5-ht1c and 5-ht2 sites in the frontal cortex, and the densities of those including 5-ht1a sites in the hippocampus and choroid plexus. |
1989-09-20 |
2023-08-11 |
rat |
| H C Jackson, I Kitche. Behavioural profiles of putative 5-hydroxytryptamine receptor agonists and antagonists in developing rats. Neuropharmacology. vol 28. issue 6. 1989-08-29. PMID:2526930. |
in contrast, locomotion was not affected by buspirone (5-ht1a); mcpp (1-(3-chlorophenyl)piperazine; 5-ht1b/5-ht1c) and doi (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; 5-ht2) though buspirone produced a small increase in head-weaving at 5- and 20-days. |
1989-08-29 |
2023-08-11 |
rat |
| H Koda, T Hashimoto, M Katsura, K Kuriyam. Effect of (+/-)-methyl 3-ethyl-2,3,3a,4-tetrahydro-1H-indolo-[3,2,1-de] [1,5] naphthyridine-6-carboxylate hydrochloride (OM-853), a new vincamine analogue, on the metabolism and function of cerebral serotonergic neurons. Japanese journal of pharmacology. vol 49. issue 3. 1989-08-25. PMID:2526270. |
om-853 had more potent inhibitory effect on the binding of [3h]8-hydroxy-2-(di-n-propylamino)tetralin (8-hydroxy dpat) to 5-ht1a receptors and/or 5-ht autoreceptors than that of [3h]-ketanserin to 5-ht2 receptors. |
1989-08-25 |
2023-08-11 |
rat |
| G J Marek, A A Li, L S Seide. Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2746511. |
these results provide evidence that stimulation of 5-ht1a receptors and antagonism of 5-ht2 receptors lead to an antidepressant-like effect on the drl 72-s schedule and implies that these two receptors may be important in mediating clinical drug effects in depression. |
1989-08-11 |
2023-08-11 |
rat |
| M A Geyer, G S Tapso. Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 1. issue 2. 1989-08-03. PMID:3150805. |
the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin, ipsapirone, and 5-methoxy-n,n-dimethyltryptamine, the 5-ht1b agonist m-trifluoromethylphenylpiperazine, and the 5-ht2 agonist quipazine affected startle reactivity rather than having specific effects on habituation. |
1989-08-03 |
2023-08-11 |
rat |
| J Arnt, J Hytte. Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. European journal of pharmacology. vol 161. issue 1. 1989-07-12. PMID:2524390. |
the potency of the serotonin 1a (5-ht1a) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-ohdpat), to induce forepaw treading was increased 20-fold after co-treatment with the 5-ht2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi). |
1989-07-12 |
2023-08-11 |
rat |
| J Arnt, J Hytte. Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. European journal of pharmacology. vol 161. issue 1. 1989-07-12. PMID:2524390. |
these results indicate a complex and different interaction between 5-ht1a and 5-ht2 receptors in the expression of two behavioural responses mediated by 5-ht. |
1989-07-12 |
2023-08-11 |
rat |
| J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. |
effects of 5-ht1a agonists and 5-ht2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-ht-dopamine interaction. |
1989-06-27 |
2023-08-11 |
monkey |
| J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. |
in view of previous suggestions that brain serotonergic systems may tonically inhibit dopamine neurons, the effects of several new and selective 5-ht2 receptor antagonists and 5-ht1a receptor agonists were investigated in this model. |
1989-06-27 |
2023-08-11 |
monkey |
| K P Nanry, H A Tilso. The role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524858. |
8-hydroxy-2-(di-n-propylamino) tetralin (8-ohdpat) (1,2 and 4 mg/kg, sc) and 5-methoxy-n,n-dimethyltryptamine (5-meodmt) (1,2 and 4 mg/kg, ip), putative 5-ht1a receptor agonists, increased the magnitude of the startle reflex, while quipazine (5, 10 and 20 mg/kg, sc), an agonist with mixed 5-ht2 and 5-ht1b receptor activity, decreased startle responsiveness. |
1989-06-27 |
2023-08-11 |
rat |
| P R Harti. Molecular biology of 5-HT receptors. Trends in pharmacological sciences. vol 10. issue 2. 1989-06-19. PMID:2655240. |
within the past six months, isolation of cdna or genomic clones has been reported for three 5-ht receptors, the 5-ht1c, 5-ht1a and 5-ht2 subtypes. |
1989-06-19 |
2023-08-11 |
Not clear |
| D Scherman, M Hamon, H Gozlan, J P Henry, A Lesage, M Masson, J F Rumign. Molecular pharmacology of niaprazine. Progress in neuro-psychopharmacology & biological psychiatry. vol 12. issue 6. 1989-05-16. PMID:2853885. |
niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (ki = 77 nm) and 5-ht2 (ki = 25 nm) binding sites, but is poorly recognized by 5-ht1a and 5-ht1b binding sites (ki sigma mcirom). |
1989-05-16 |
2023-08-11 |
Not clear |
| G E Martin, R J Elgin, J M Kesslick, W J Baldy, J R Mathiasen, R P Shank, M K Scot. Block of conditioned avoidance responding in the rat by substituted phenylpiperazines. European journal of pharmacology. vol 156. issue 2. 1989-05-15. PMID:3240768. |
mcpp, on the other hand, displaced ligands for 5-ht1, 5-ht1a and 5-ht2 binding sites with similar potencies (ki values = 25 (3, 67), 23 (14, 40) and 40 (33, 48) nm, respectively). |
1989-05-15 |
2023-08-11 |
rat |
| C M Brown, A T Kilpatrick, A Martin, M Speddin. Cerebral ischaemia reduces the density of 5-HT2 binding sites in the frontal cortex of the gerbil. Neuropharmacology. vol 27. issue 8. 1989-03-03. PMID:3216962. |
specific binding of [3h]ketanserin was displaced by a number of 5-ht2a antagonists ritanserin, cyproheptadine and methysergide) but not by the 5-ht1a agonist, 8-hydroxy-2-(di-n- propylamino)tetralin (8-oh-dpat) or the 5-ht1a/1b agonists 5-carboxyamidotryptamine (5-ct) or ru 24969, indicating that the labelled site probably represents the 5-ht2 receptor. |
1989-03-03 |
2023-08-11 |
Not clear |