| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2975354. |
in contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-ht1a (8-oh-dpat, buspirone), 5-ht1b (21-009, ru 24969), 5-ht1c (mesulergine, mianserin) and 5-ht2 sites (ketanserin, cinanserin). |
1989-03-02 |
2023-08-11 |
human |
| J C Winter, R A Rabi. Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:3211970. |
drugs purported to have selective affinities for 5-ht1a, 5-ht1b, and 5-ht2 receptors were tested in rats trained with 0.1 mg lsd versus saline. |
1989-02-23 |
2023-08-11 |
rat |
| K J Simansky, L E Schechte. Properties of some 1-arylpiperazines as antagonists of stereotyped behaviors mediated by central serotonergic receptors in rodents. The Journal of pharmacology and experimental therapeutics. vol 247. issue 3. 1989-01-31. PMID:3144595. |
this investigation evaluated the effects of the 1-arylpiperazines (1-(1-naphthyl)piperazine (1-np), 1-(2-[4-aminophenylethyl]-4-[3-trifluoromethylphenyl]piperazine (papp), 1-(3-trifluoromethylphenyl)piperazine (tfmpp) and 1-(3-chlorophenyl)piperazine (mcpp) on head-twitching elicited by central 5-hydroxytryptamine2, (5-ht2) agonists and on the 5-ht motor syndrome associated with stimulating 5-ht1a receptors in rodents. |
1989-01-31 |
2023-08-11 |
mouse |
| T Mizuta, T Segaw. Chronic effects of imipramine and lithium on postsynaptic 5-HT1A and 5-HT1B sites and on presynaptic 5-HT3 sites in rat brain. Japanese journal of pharmacology. vol 47. issue 2. 1989-01-26. PMID:3199589. |
it is concluded that enhanced 5-ht neurotransmission which develops during chronic treatment with imipramine or lithium seems tob e related to the down-regulation of postsynaptic 5-ht1a receptors in addition to postsynaptic 5-ht2 receptors, which may also have an important role in the antidepressant effects of these drugs. |
1989-01-26 |
2023-08-11 |
rat |
| A Dumuis, R Bouhelal, M Sebben, R Cory, J Bockaer. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849052. |
the action of antagonists acting on 5-ht1 or 5-ht2 receptors, such as methiothepin (5-ht1 and 5-ht2), metergoline (5-ht1 and 5-ht2), spiperone (5-ht1a and 5-ht2), (-)-pindolol (5-ht1b), mesulergine (5-ht1c), and ketanserin (5-ht2), were almost inactive in reversing the 5-ht stimulating effect. |
1989-01-23 |
2023-08-11 |
mouse |
| R Bouhelal, L Smounya, J Bockaer. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. European journal of pharmacology. vol 151. issue 2. 1988-11-23. PMID:2971554. |
spiroperidol, mesulergine and ketanserin, which are potent 5-ht1a, 5-ht1c and 5-ht2 antagonists respectively, were unable to reverse the 5-ht-mediated inhibition of forskolin-stimulated adenylate cyclase whereas the beta-adrenoceptor antagonists, (+/-)-cyanopindolol and (+/-)-propranolol or metergoline, fully reversed the 5-ht effect with calculated ki of 34 +/- 18, 82 +/- 19 and 248 +/- 47 nm, respectively. |
1988-11-23 |
2023-08-11 |
rat |
| I I Abramets, I V Komissarov, I M Samoĭlovic. [Spinal ganglion neurons of rats--a model for the study of the central serotonin receptors]. Biulleten' eksperimental'noi biologii i meditsiny. vol 106. issue 8. 1988-10-21. PMID:3416053. |
5-ht depolarizing responses of rdg neurons were mediated by 5-ht2 receptors activation and decreased membrane potassium conductivity; 5-ht hyperpolarizing responses were mediated by 5-ht1a receptor activation and increased potassium conductivity. |
1988-10-21 |
2023-08-11 |
rat |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
development of 5ht agonists and antagonists selective for different 5ht receptor sub-types (5ht1a, 5ht1b, 5ht2, 5ht3) has opened a new avenue for investigation of the potential role of 5ht in anxiety. |
1988-10-20 |
2023-08-11 |
Not clear |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
a selective 5ht2 antagonist, ritanserin, has anxiolytic effects in clinical studies but, like the 5ht1a agonists, does not show a similar profile to benzodiazepines in models of anxiety. |
1988-10-20 |
2023-08-11 |
Not clear |
| C L Kirstein, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in neonatal rat pups. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2970973. |
sprague-dawley rat pups at 3-4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-ohdpat), the 5-ht1b agonist 1-(3-chlorophenyl)piperazine (mcpp), or the 5-ht2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi). |
1988-10-18 |
2023-08-11 |
rat |
| P H Hutson, C T Dourish, G Curzo. Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A receptors. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2970974. |
8-oh-dpat-induced feeding was blocked by metergoline which has comparable affinity for 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors. |
1988-10-18 |
2023-08-11 |
rat |
| J Maj, E Chojnacka-Wójcik, A Kłodzińska, A Dereń, E Mory. Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors? Journal of neural transmission. vol 73. issue 1. 1988-09-22. PMID:2969949. |
neither hypothermia is antagonized by 5-ht1a antagonists (ipsapirone, spiperone), a 5-ht1c antagonist (mesulergine), 5-ht2 antagonists (cyproheptadine, mianserin, methysergide), 5-ht3 antagonists (ics 205930, metoclopramide). |
1988-09-22 |
2023-08-11 |
mouse |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
the neuroleptic spiperone, which binds to 5-ht1a, 5-ht2 and dopamine (da) receptors, was studied for its effects on serotonin (5-ht) and da neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. |
1988-08-31 |
2023-08-11 |
Not clear |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
spiperone, but not ly53837 (a 5-ht2 antagonist), antagonized the inhibition induced by 5-ht1a agonists 8-hydroxy-dipropylaminotetralin (8-oh-dpat) and buspirone in the dorsal raphe nucleus. |
1988-08-31 |
2023-08-11 |
Not clear |
| M R Pranzatell. Effect of antiepileptic and antimyoclonic drugs on serotonin receptors in vitro. Epilepsia. vol 29. issue 4. 1988-08-17. PMID:2839332. |
adrenocorticotropic hormone (acth1-39) noncompetitively inhibited specific binding at 5-ht1, 5-ht1a, and 5-ht2 sites in brainstem and neocortex [concentrations required to displace 50% of ligand binding (ic50s) 4-8 x 10(-5) m]. |
1988-08-17 |
2023-08-11 |
rat |
| R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455040. |
the 5-ht1a agonist 8-hydroxy-n,n-dipropyl-2-aminotetralin and the 5ht1b agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole (ru-24969) also produced depressor effects but, in contrast to 5-ht, facilitated the tail-flick reflex, whereas the 5-ht2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, 6-chloro-2-(1-piperazinyl)-pyrazine (mk-212) and quipazine produced dose-dependent antinociception and had little or no effect on blood pressure. |
1988-07-29 |
2023-08-11 |
rat |
| H Shimizu, N Karai, A Hirose, T Tatsuno, H Tanaka, Y Kumasaka, M Nakamur. Interaction of SM-3997 with serotonin receptors in rat brain. Japanese journal of pharmacology. vol 46. issue 3. 1988-07-25. PMID:2898033. |
sm-3997 possessed a high affinity towards 5-ht1a receptors, low affinity towards dopamine (d2) and 5-ht2 receptors, and no affinity towards benzodiazepine (bz), gaba, 5-ht1b and adrenergic receptors. |
1988-07-25 |
2023-08-11 |
rat |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
in contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-ht1a (8-oh-dpat, buspirone), 5-ht1b (21-009, ru 24969), 5-ht1c (mesulergine, mianserin) and 5-ht2 sites (ketanserin, cinanserin). |
1988-06-02 |
2023-08-11 |
human |
| M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2895033. |
a 5-ht1a agonist (8-oh-dpat) blocked wds, but like putative 5-ht1b (ru 24969) and 5-ht2 (doi) agonists and the 5-ht antagonists methysergide (non-selective), ritanserin (5-ht2 selective), and l-propranolol (5-ht1 selective), it did not block other antagonists behavioural effects of mk-771. |
1988-05-12 |
2023-08-11 |
rat |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
in the present study, the affinities of these urapidil derivatives (5-acetyl, 5-formyl- and 5-methyl-urapidil) for 5-ht receptors were investigated using 3h-8-hydroxy-2-(di-n-propyl-amino)tetralin (3h-8-oh-dpat), 125i-iodocyanopindolol (125i-icyp) and 3h-ketanserin for labelling 5-ht1a, 5-ht1b and 5-ht2 binding sites, respectively. |
1988-05-03 |
2023-08-11 |
Not clear |