| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Titeler, R A Lyon, R A Glenno. Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology. vol 94. issue 2. 1988-05-03. PMID:3127847. |
in order to test the hypothesis that the mechanism of action of lsd and phenylisopropylamine hallucinogens is through stimulation of a specific brain serotonin receptor sub-type, the affinities of these compounds for radiolabelled 5-ht2, 5-ht1a, 5-ht1b, and 5-ht1c receptors have been determined using recently developed in vitro radioligand binding methodologies. |
1988-05-03 |
2023-08-11 |
Not clear |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |
| D G Spencer, T Glaser, J Trabe. Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:3122248. |
these data indicate that the 5-ht1a receptor subtype is strongly involved in the transduction of the interoceptive discriminative stimuli induced by 5-ome-dmt, with 5-ht2 agonism also playing a possible role. |
1988-02-03 |
2023-08-11 |
rat |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2891550. |
antagonism by neuroleptics of serotonin 5-ht1a and 5-ht2 receptors of normal human brain in vitro. |
1988-02-02 |
2023-08-11 |
human |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:2891550. |
using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (kds) of 17 neuroleptics at the serotonin 5-ht1a and serotonin 5-ht2 receptors with [3h]wb4101 and [3h]ketanserin, respectively. |
1988-02-02 |
2023-08-11 |
human |
| W J Brunken, N W Da. The actions of serotonergic agonists and antagonists on the activity of brisk ganglion cells in the rabbit retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:2961853. |
selective antagonists or agonists of serotonin at the 5-ht2 or 5-ht1a receptors were applied, and the changes in light-evoked and spontaneous activity were studied. |
1988-01-28 |
2023-08-11 |
rabbit |
| W J Brunken, N W Da. The actions of serotonergic agonists and antagonists on the activity of brisk ganglion cells in the rabbit retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:2961853. |
both 5-ht1a agonists and 5-ht2 antagonists reduced the on-components of the light-evoked responses of all classes of brisk ganglion cell; spontaneous activity was reduced in these cells as well. |
1988-01-28 |
2023-08-11 |
rabbit |
| G J Molderings, K Fink, E Schlicker, M Göther. Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:3683595. |
ketanserin, a 5-ht2 receptor antagonist, and spiperone, which blocks 5-ht2 and 5-ht1a but not 5-ht1b or 5-ht1c receptors, failed to antagonize the effect of 5-ht. |
1988-01-11 |
2023-08-11 |
rat |
| J Maj, E Chojnacka-Wójcik, E Tatarczyńska, A Kłodzińsk. Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. Journal of neural transmission. vol 70. issue 1-2. 1987-11-24. PMID:2889795. |
the obtained results indicate that ipsapirone exhibits 5-ht1a antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-ht2 and the alpha 1-adrenergic function. |
1987-11-24 |
2023-08-11 |
mouse |
| E W Taylor, S Nikam, B Weck, A Martin, D Nelso. Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites. Life sciences. vol 41. issue 16. 1987-11-13. PMID:3657392. |
in an attempt to define pharmacophoric differences between 5-ht1, 5-ht1a and 5-ht2 recognition sites, a number of rigid analogs were studied and compared to analogous free chain tryptamines. |
1987-11-13 |
2023-08-11 |
Not clear |
| M Titeler, R A Lyon, K H Davis, R A Glenno. Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand. Biochemical pharmacology. vol 36. issue 19. 1987-11-04. PMID:3663239. |
quipazine, a putative specific 5-ht2 agonist, appeared to be only 3-fold more potent at 5-ht2 than at 5-ht1a receptors when [3h]ketanserin was used as the 5-ht2 radioligand. |
1987-11-04 |
2023-08-11 |
Not clear |
| M Titeler, R A Lyon, K H Davis, R A Glenno. Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand. Biochemical pharmacology. vol 36. issue 19. 1987-11-04. PMID:3663239. |
when [3h]dob was used as the 5-ht2 radioligand, quipazine was determined to be 100-fold more potent at 5-ht2 receptors than at 5-ht1a receptors. |
1987-11-04 |
2023-08-11 |
Not clear |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
the interaction of the enantiomers of mianserin and propranolol with the binding of [3h]5-hydroxytryptamine ([3h]5-ht) to the 5-ht1a, 5-ht1b and 5-ht1c sites, and with the binding of [3h]ketanserin to the 5-ht2 site, has been evaluated in rat brain membranes. |
1987-10-26 |
2023-08-11 |
rat |
| B L Roth, D M Chuan. Multiple mechanisms of serotonergic signal transduction. Life sciences. vol 41. issue 9. 1987-09-23. PMID:2441225. |
recent findings suggest that the distinct types of pharmacologically defined serotonergic receptors (5ht1a, 5ht1b, 5ht1c, 5ht2) may be coupled to one or more signal transduction systems. |
1987-09-23 |
2023-08-11 |
Not clear |
| M B Emerit, S el Mestikawy, H Gozlan, J M Cossery, R Besselievre, A Marquet, M Hamo. Identification of the 5-HT1A receptor binding subunit in rat brain membranes using the photoaffinity probe [3H]8-methoxy-2-[N-n-propyl, N-3-(2-nitro-4-azidophenyl)aminopropyl]aminotetralin. Journal of neurochemistry. vol 49. issue 2. 1987-08-12. PMID:3598578. |
as expected of a possible correspondence between pi and 5-ht1a receptor binding sites, 3h labeling by the photoaffinity probe could be prevented by selective 5-ht1a ligands such as 8-hydroxy-2-(di-n-propylamino)tetralin, ipsapirone, buspirone, and gepirone and by n-ethylmaleimide, but not by the 5-ht2 antagonist ketanserin, noradrenaline- and dopamine-related drugs, monoamine oxidase inhibitors, and chlorimipramine. |
1987-08-12 |
2023-08-11 |
rat |
| H H Berendsen, C L Broekkam. Drug-induced penile erections in rats: indications of serotonin1B receptor mediation. European journal of pharmacology. vol 135. issue 3. 1987-07-17. PMID:3495447. |
spiperone and pirenperone in doses selective for 5ht1a and 5ht2 receptors respectively were also inactive. |
1987-07-17 |
2023-08-11 |
rat |
| S A Lorens, L D Van de Ka. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. vol 45. issue 4. 1987-06-01. PMID:2952898. |
differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. |
1987-06-01 |
2023-08-11 |
Not clear |
| S A Lorens, L D Van de Ka. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. vol 45. issue 4. 1987-06-01. PMID:2952898. |
the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. |
1987-06-01 |
2023-08-11 |
Not clear |
| G A Kennett, C T Dourish, G Curzo. Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:2883013. |
evidence suggests that the above action of 8-oh-dpat is mediated by 5-ht1a receptors since it was antagonised by the 5-ht1a antagonist spiperone but not by the 5-ht2 antagonist ketanserin and was not mimicked by the 5-ht1b agonist ru 24969. |
1987-05-28 |
2023-08-11 |
rat |
| R E Heuring, S J Peroutk. Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 3. 1987-04-29. PMID:2951504. |
these data therefore demonstrate the presence of a homogeneous class of 5-ht1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5-ht1a, 5-ht1b, 5-ht1c, 5-ht2, and 5-ht3 receptor subtypes. |
1987-04-29 |
2023-08-11 |
rat |