| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:3027734. |
lithium decreases 5-ht1a and 5-ht2 receptor and alpha 2-adrenoceptor mediated function in mice. |
1987-03-20 |
2023-08-11 |
mouse |
| G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:3027734. |
by contrast with this reduction of 5-hydroxytryptamine (5-ht) function mediated by the 5-ht1a and 5-ht2 receptor sub-types, repeated lithium administration had no effect on the motor response to a putative 5-ht1b receptor agonist 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1h indole (ru 24969, 3 mg/kg ip). |
1987-03-20 |
2023-08-11 |
mouse |
| G A Gudelsky, J I Koenig, H Jackman, H Y Meltze. Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors. Psychopharmacology. vol 90. issue 3. 1987-01-16. PMID:2947256. |
in view of the concept that the hypo- and hyperthermic responses to 5-ht agonists are mediated by 5-ht1a and 5-ht2 receptor subtypes, respectively, it is concluded that the responsiveness of these 5-ht receptor subtypes involved in thermoregulatory responses is decreased following chronic treatment of rats with monoamine oxidase inhibitors. |
1987-01-16 |
2023-08-11 |
rat |
| M G Palfreyman, A K Mir, M Kubina, D N Middlemiss, M Richards, M D Tricklebank, J R Fozar. Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase. European journal of pharmacology. vol 130. issue 1-2. 1987-01-06. PMID:3780861. |
the effect of chronic mao inhibitor treatment on 5-ht1a receptors was associated with a decrease in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin and the decrease in 5-ht2 binding was related to a small reduction in the sensitivity of the inositol phosphate system to stimulation by 5-ht. |
1987-01-06 |
2023-08-11 |
rat |
| H O Kalkman, G Engel, D Hoye. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125I]LSD binding. European journal of pharmacology. vol 129. issue 1-2. 1986-12-11. PMID:3770071. |
the results suggest that the 5-ht receptor-mediating relaxation in the guinea-pig ileum can be labelled with [125i]lsd and that this receptor does not belong to the 5-ht2, 5-ht1a, 5-ht1b or 5-ht1c receptor subtypes. |
1986-12-11 |
2023-08-11 |
Not clear |
| M B Emerit, H Gozlan, A Marquet, M Hamo. Irreversible blockade of central 5-HT1A receptor binding sites by the photoaffinity probe 8-methoxy-3'-NAP-amino-PAT. European journal of pharmacology. vol 127. issue 1-2. 1986-11-10. PMID:2944752. |
the apparent affinity of 8-methoxy-3'-nap-amino-pat for the 5-ht1a binding sites was at least 20 times higher than for the other 5-ht receptor sites (5-ht2 and 5-ht3) or the dopamine-related [3h]spiperone and [3h]7-oh-dpat binding sites. |
1986-11-10 |
2023-08-11 |
rat |
| M L Cohen, W E Colber. Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and rat stomach fundus 5-HT receptors. The Journal of pharmacology and experimental therapeutics. vol 237. issue 3. 1986-07-16. PMID:3712277. |
similarity of the contractile effects of 5-ht in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5-ht-induced contractions in the fundus were not 5-ht1, 5-ht1a, 5-ht1b or 5-ht2 led us to consider the possibility that 5-ht receptors in the canine basilar artery may resemble those in the rat stomach fundus. |
1986-07-16 |
2023-08-11 |
rat |
| G Engel, M Göthert, D Hoyer, E Schlicker, K Hillenbran. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:2936965. |
the affinities of the compounds for 5-ht1b and 5-ht2 binding sites in rat brain cortex membranes (labelled by [125i]cyanopindolol = [125i]-cyp in the presence of 30 mumol/l isoprenaline and [3h]ketanserin, respectively), for 5-ht1a binding sites in pig and rat brain cortex membranes (labelled by [3h]8-hydroxy-2-(di-n-propylamino)tetralin = [3h]8-oh-dpat) and for 5-ht1c binding sites in pig choroid plexus membranes (labelled by [3h]mesulergine) were also determined. |
1986-04-22 |
2023-08-11 |
rat |
| E W Taylor, S P Duckles, D L Nelso. Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site. The Journal of pharmacology and experimental therapeutics. vol 236. issue 1. 1986-02-20. PMID:2934545. |
logs of these ka values did not correlate with log ki values for the inhibition of binding of the 5-ht2 ligand [3h] ketanserin (r = 0.2253, p greater than .05) or log ic50 values for inhibition of [3h]5-ht binding (r = 0.5732, p greater than 0.05), which labels both 5-ht1a and 5-ht1b sites. |
1986-02-20 |
2023-08-11 |
Not clear |
| K A Yagaloff, P R Harti. 125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 5. issue 12. 1986-02-07. PMID:4078623. |
the choroid plexus site exhibits a novel pharmacology that does not match the properties of 5-hydroxytryptamine-1a (5-ht1a), 5-ht1b, or 5-ht2 serotonergic sites. |
1986-02-07 |
2023-08-11 |
rat |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-ht) binding subtypes: 5-ht2, 5-ht1a and 5-ht1b. |
1985-06-20 |
2023-08-11 |
mouse |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
these techniques have also indicated that certain drugs appear to show sub-type specificity: 8-hydroxy-2-(di-n-propylamino)tetralin(8-oh-dpat), a 5-ht1a agonist; 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1-h indole (ru 24969), a 5-ht1b agonist; and ritanserin, a 5-ht2 antagonist. |
1985-06-20 |
2023-08-11 |
mouse |
| M B Emerit, H Gozlan, M D Hall, M Hamon, A Marque. Irreversible blockade of central 5-HT binding sites by 8-methoxy-2'-chloro-PAT. Biochemical pharmacology. vol 34. issue 6. 1985-04-17. PMID:3156602. |
although 8-methoxy-2'-chloro-pat bound irreversibly to different classes of 5-ht binding sites (5-ht1a, 5-ht1b, presynaptic sites), it can be considered a selective alkylating agent, since it exerted no action on 3h-spiperone binding to 5-ht2 sites, 3h-muscimol binding to gaba sites, or 3h-flunitrazepam binding to benzodiazepine sites. |
1985-04-17 |
2023-08-11 |
rat |
| A Pazos, D Hoyer, J M Palacio. The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site. European journal of pharmacology. vol 106. issue 3. 1985-03-05. PMID:6519175. |
the binding of these ligands to frontal cortex and hippocampus demonstrated the presence of 5-ht1 and 5-ht2 sites in both tissues, although hippocampus was richer in 5-ht1 (subtype 5-ht1a) sites. |
1985-03-05 |
2023-08-12 |
Not clear |
| R D Todd, R D Ciaranell. Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child. Proceedings of the National Academy of Sciences of the United States of America. vol 82. issue 2. 1985-03-01. PMID:2578670. |
human 5-ht1a sites can be distinguished from human 5-ht1b, 5-ht2, and 5-ht3 sites and from equivalent sites in rat and bovine cortex. |
1985-03-01 |
2023-08-11 |
human |