Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
R H McAllister-Williams, A E Masse. EEG effects of buspirone and pindolol: a method of examining 5-HT1A receptor function in humans. Psychopharmacology. vol 166. issue 3. 2003-05-07. PMID:12589521. |
eeg effects of buspirone and pindolol: a method of examining 5-ht1a receptor function in humans. |
2003-05-07 |
2023-08-12 |
Not clear |
Bernadette Astier, Laura Lambás Señas, Fabienne Soulière, Patricia Schmitt, Nadia Urbain, Nicolas Rentero, Lionel Bert, Luc Denoroy, Bernard Renaud, Monique Lesourd, Carmen Muñoz, Guy Chouve. In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. European journal of pharmacology. vol 459. issue 1. 2003-04-30. PMID:12505530. |
in vivo comparison of two 5-ht1a receptors agonists alnespirone (s-20499) and buspirone on locus coeruleus neuronal activity. |
2003-04-30 |
2023-08-12 |
rat |
Eugene M Cassidy, Esther Tomkins, Neda Sharifi, Timothy Dinan, Orla Hardiman, Veronica O'Kean. Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone. Pain. vol 101. issue 3. 2003-04-10. PMID:12583871. |
prolactin (prl) responses to the 5ht1a receptor agonist drug buspirone were compared in 30 female subjects with migraine (ten migraine with aura, ma; ten migraine without aura, mo and ten chronic/transformed migraine, cm), and ten healthy controls matched for age, gender and menstrual status. |
2003-04-10 |
2023-08-12 |
human |
Takashi Nakayama, Tetsuya Suhara, Yoshiro Okubo, Tetsuya Ichimiya, Fumihiko Yasuno, Jun Maeda, Akihiro Takano, Tomoyuki Saijo, Kazutoshi Suzuk. In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response. Psychopharmacology. vol 165. issue 1. 2003-03-20. PMID:12474116. |
in vivo drug action of tandospirone at 5-ht1a receptor examined using positron emission tomography and neuroendocrine response. |
2003-03-20 |
2023-08-12 |
human |
Rita M Condren, Timothy G Dinan, Jogin H Thakor. A preliminary study of buspirone stimulated prolactin release in generalised social phobia: evidence for enhanced serotonergic responsivity? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 4. 2002-11-15. PMID:12126875. |
buspirone, which is a partial agonist at 5ht1a receptors, increases prolactin release and may be used as a probe to examine serotonergic responses, dysfunction of which may be relevant to the pathophysiology of social phobia. |
2002-11-15 |
2023-08-12 |
human |
Yasuhiro Fujino, Masashi Nakajima, Yoshio Tsuboi, Yasuhiko Baba, Tatsuo Yamad. [Clinical effectiveness of tandospirone citrate (5-HT1A agonist) on patients with progressive supranuclear palsy]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 1. 2002-10-28. PMID:12355852. |
[clinical effectiveness of tandospirone citrate (5-ht1a agonist) on patients with progressive supranuclear palsy]. |
2002-10-28 |
2023-08-12 |
Not clear |
M Sasa, S Takeshita, T Amano, K Kuris. Primary neurotransmitters and regulatory substances onto vestibular nucleus neurons. Uchu Seibutsu Kagaku. vol 15. issue 4. 2002-09-27. PMID:12101361. |
as such, the 5-ht1a agonist, tandospirone, may be effective in preventing and/or treating motion sickness and/or space sickness. |
2002-09-27 |
2023-08-12 |
Not clear |
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. |
gepirone, a pyridinyl piperazine 5-ht1a receptor agonist, has been developed by fabre-kramer as an antidepressant. |
2002-09-11 |
2023-08-12 |
Not clear |
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. |
mechanism of action studies have demonstrated that gepirone, compared to buspirone, possesses a much greater selectivity for 5-ht1a receptors over dopamine d2 receptors. |
2002-09-11 |
2023-08-12 |
Not clear |
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. |
long-term studies have shown that gepirone has a differential action at presynaptic (agonist) and post-synaptic (partial agonist) 5-ht1a receptors. |
2002-09-11 |
2023-08-12 |
Not clear |
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. |
however, further studies are still required to determine the relative contribution of pre- and post-synaptic 5-ht1a receptors to the therapeutic action of gepirone and related compounds. |
2002-09-11 |
2023-08-12 |
Not clear |
Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in order to address this issue in humans, 12 healthy volunteers underwent a dietary tryptophan depletion paradigm to decrease 5-ht availability, under double-blind conditions, during which body temperature was monitored following oral administration of the 5-ht1a agonist buspirone (30 mg). |
2002-08-07 |
2023-08-12 |
human |
Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in conclusion, these results strongly suggest that the hypothermia and the increases in prolactin and growth hormone produced by buspirone are attributable to the enhanced activation of postsynaptic 5-ht1a receptors, and not to a decrease in 5-ht transmission resulting from the activation of the 5-ht1a cell body autoreceptors on 5-ht neurons. |
2002-08-07 |
2023-08-12 |
human |
Antoni Sastre-Coll, Susana Esteban, Jesús A García-Sevill. Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 3. 2002-07-22. PMID:11882917. |
in morphine-dependent rats (tolerant and withdrawn states) the inhibitory effects of the 5-ht1a agonists 8-oh-dpat and buspirone (0.1 mg/kg, 1 h), and that of the alpha2-adrenoceptor agonist clonidine (0.1 mg/kg, 1 h), on the synthesis of 5-htp/5-ht were potentiated (25%-50%). |
2002-07-22 |
2023-08-12 |
rat |
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. |
molecular dynamics of 5-ht1a and 5-ht2a serotonin receptors with methylated buspirone analogues. |
2002-06-10 |
2023-08-12 |
Not clear |
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. |
in the present study experimentally determined ligand selectivity of three methylated buspirone analogues (denoted as mm2, mm5 and p55) towards 5-ht1a and 5-ht2a serotonin receptors was theoretically investigated on a molecular level. |
2002-06-10 |
2023-08-12 |
Not clear |
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. |
moreover, both location and topography of putative binding sites for buspirone analogues are different at 5-ht1a and 5-ht2a receptors. |
2002-06-10 |
2023-08-12 |
Not clear |
Vera Targino Moreira Lima, Danielle Silveira Macedo, Carlos Renato Alves Nogueira, Silvânia Maria Mendes Vasconcelos, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sous. [Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum]. Arquivos de neuro-psiquiatria. vol 60. issue 1. 2002-05-23. PMID:11965407. |
buspirone (busp) a piperazinyl derivative with anxiolytic properties is a partial agonist on 5-ht1a with affinity for d2-like dopaminergic receptors (rd2). |
2002-05-23 |
2023-08-12 |
rat |
David L Walker, Michael Davi. Light-enhanced startle: further pharmacological and behavioral characterization. Psychopharmacology. vol 159. issue 3. 2002-05-07. PMID:11862363. |
the phenomenon is disrupted by the 5ht1a partial agonist and the d2 receptor antagonist buspirone, a compound that also blocks the effect on startle of conditioned fear, and it was suggested that light-enhanced startle reflects an anxious state produced by bright light. |
2002-05-07 |
2023-08-12 |
rat |
Asako Takei, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashir. Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease. Psychiatry and clinical neurosciences. vol 56. issue 2. 2002-04-30. PMID:11952922. |
tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 a [5-ht1a]). |
2002-04-30 |
2023-08-12 |
Not clear |