| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asako Takei, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashir. Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease. Psychiatry and clinical neurosciences. vol 56. issue 2. 2002-04-30. PMID:11952922. |
in addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-ht1a receptors, were also remarkably alleviated by treatment with tandospirone. |
2002-04-30 |
2023-08-12 |
Not clear |
| G S Sonavane, V P Sarveiya, V S Kasture, S B Kastur. Anxiogenic activity of Myristica fragrans seeds. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812528. |
), and 5-ht1a receptor agonist, buspirone (1 mg/kg i.p. |
2002-04-05 |
2023-08-12 |
mouse |
| G S Sonavane, V P Sarveiya, V S Kasture, S B Kastur. Anxiogenic activity of Myristica fragrans seeds. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812528. |
inhibition of anxiolytic activity of ondansetron (5-ht3 receptor antagonist), buspirone (5-ht1a receptor agonist), and diazepam [acting on gamma-aminobutyric acid (gabaa) receptor] suggests a nonspecific anxiogenic activity of tm and also a link between 5-ht and gaba systems in the anxiogenic activity of tm. |
2002-04-05 |
2023-08-12 |
mouse |
| Kazuya Kannari, Kozo Kurahashi, Masahiko Tomiyama, Tetsuya Maeda, Akira Arai, Masayuki Baba, Toshihiro Suda, Muneo Matsunag. [Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease]. No to shinkei = Brain and nerve. vol 54. issue 2. 2002-04-02. PMID:11889759. |
[tandospirone citrate, a selective 5-ht1a agonist, alleviates l-dopa-induced dyskinesia in patients with parkinson's disease]. |
2002-04-02 |
2023-08-12 |
rat |
| Kazuya Kannari, Kozo Kurahashi, Masahiko Tomiyama, Tetsuya Maeda, Akira Arai, Masayuki Baba, Toshihiro Suda, Muneo Matsunag. [Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease]. No to shinkei = Brain and nerve. vol 54. issue 2. 2002-04-02. PMID:11889759. |
in the present study, we administered tandospirone citrate, a selective 5-ht1a agonist, to patients with parkinson's disease suffering from l-dopa-induced dyskinesia. |
2002-04-02 |
2023-08-12 |
rat |
| Kazuya Kannari, Kozo Kurahashi, Masahiko Tomiyama, Tetsuya Maeda, Akira Arai, Masayuki Baba, Toshihiro Suda, Muneo Matsunag. [Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease]. No to shinkei = Brain and nerve. vol 54. issue 2. 2002-04-02. PMID:11889759. |
both the anti-dyskinetic effect and the worsening of parkinsonian features are thought to be induced by tandospirone's potent 5-ht1a agonistic activity. |
2002-04-02 |
2023-08-12 |
rat |
| Kazuya Kannari, Kozo Kurahashi, Masahiko Tomiyama, Tetsuya Maeda, Akira Arai, Masayuki Baba, Toshihiro Suda, Muneo Matsunag. [Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease]. No to shinkei = Brain and nerve. vol 54. issue 2. 2002-04-02. PMID:11889759. |
diverse effect of tandospirone may be caused by its partial agonist activity on 5-ht1a receptors, or may indicate that other causes for the expression of dyskinesia exist apart from excessive rise in brain da levels. |
2002-04-02 |
2023-08-12 |
rat |
| M W Bridge, G Marvin, C E Thompson, A Sharma, D A Jones, M J Kendal. Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology. vol 158. issue 3. 2002-02-12. PMID:11713611. |
quantifying the 5-ht1a agonist action of buspirone in man. |
2002-02-12 |
2023-08-12 |
Not clear |
| C Belzung, A M Le Guisquet, S Barreau, F Calatayu. An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology. vol 12. issue 3. 2002-01-25. PMID:11485052. |
the drugs used included the benzodiazepine diazepam, the 5-ht1a receptor partial agonist buspirone, the 5-ht1a receptor antagonists pindolol and way-100635, the non-selective 5-ht2 receptor antagonists methiothepin, mianserin and ritanserin, the non-selective dopamine (da) receptor antagonist haloperidol, the d1 antagonist sch23390, the selective d2 antagonist raclopride, the d2/3 agonist quinelorane, the cholecystokininb (cck(b)) receptor antagonist ly 288513, and the corticotropin-releasing factor1 (crf1) receptor antagonist cp-154,526. |
2002-01-25 |
2023-08-12 |
mouse |
| A Boido, C C Boido, F Sparator. Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes. Farmaco (Societa chimica italiana : 1989). vol 56. issue 4. 2001-12-04. PMID:11421254. |
the synthesized compounds displayed from moderate to good affinity to the serotonin 5-ht1a receptor and only modest or poor affinity to the dopamine d2 receptor, similar to buspirone. |
2001-12-04 |
2023-08-12 |
mouse |
| Y Masuda, S Ohnuma, T Sugiyam. Alpha 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse forced swimming. Methods and findings in experimental and clinical pharmacology. vol 23. issue 1. 2001-10-25. PMID:11413859. |
in order to detect the mechanisms of the neuron receptor activities on the effect, the glycolipid reactivities in the serum induced by tandospirone, a specific 5-ht1a receptor agonist, and clonidine, a specific alpha 2-adrenoceptor agonist, were investigated. |
2001-10-25 |
2023-08-12 |
mouse |
| T Amano, M Akbar, H Matsubayashi, M Sas. Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats. Brain research. vol 910. issue 1-2. 2001-10-25. PMID:11489272. |
inhibitory effects of tandospirone, a 5-ht1a agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats. |
2001-10-25 |
2023-08-12 |
rat |
| T Amano, M Akbar, H Matsubayashi, M Sas. Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats. Brain research. vol 910. issue 1-2. 2001-10-25. PMID:11489272. |
an electrophysiological study was performed using chloral hydrate-anesthetized rats to determine whether tandospirone, a 5-ht1a agonist, affects neuronal activities of the medial vestibular nucleus (mvn), since serotonergic innervation and 5-ht1a receptors are present in this nucleus. |
2001-10-25 |
2023-08-12 |
rat |
| T Amano, M Akbar, H Matsubayashi, M Sas. Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats. Brain research. vol 910. issue 1-2. 2001-10-25. PMID:11489272. |
these results suggest that tandospirone acts on a 5-ht1a receptor to inhibit transmission of otolith information to alpha- and beta-type mvn neurons. |
2001-10-25 |
2023-08-12 |
rat |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
molecular dynamics of buspirone analogues interacting with the 5-ht1a and 5-ht2a serotonin receptors. |
2001-10-11 |
2023-08-12 |
human |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
three-dimensional (3-d) models of the human serotonin 5-ht1a and 5-ht2a receptors were constructed, energy refined, and used to study the interactions with a series of buspirone analogues. |
2001-10-11 |
2023-08-12 |
human |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
differences in binding site architecture in the region of highly conserved serine and tyrosine residues in tmh7 gave slightly different binding modes of the buspirone analogues at the 5-ht1a and 5-ht2a receptors. |
2001-10-11 |
2023-08-12 |
human |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
molecular dynamics simulations of receptor-ligand interactions indicated that the buspirone analogues did not alter the interhelical hydrogen bonding patterns upon binding to the 5-ht2a receptor, while interhelical hydrogen bonds were broken and others were formed upon ligand binding to the 5-ht1a receptor. |
2001-10-11 |
2023-08-12 |
human |
| M Iijima, H Terashi, M Iwat. [A case of progressive supranuclear palsy improved with tandospirone citrate]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 2-3. 2001-09-06. PMID:11481861. |
we reported a 74-year-old male case of progressive supranuclear palsy (psp) who responded to tandospirone citrate, a serotonin receptor (5-ht1a) agonist. |
2001-09-06 |
2023-08-12 |
Not clear |
| W Koek, B Vacher, C Cosi, M B Assié, J F Patoiseau, P J Pauwels, F C Colpaer. 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential. European journal of pharmacology. vol 420. issue 2-3. 2001-08-09. PMID:11408031. |
in addition, novel compounds with intermediate intrinsic activity, like buspirone, but with high selectivity for 5-ht1a receptors, unlike buspirone, were identified. |
2001-08-09 |
2023-08-12 |
rat |