| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Shibata, Y Kagami-Ishi, K Tominaga, K Kodama, S Ueki, S Watanab. Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists. European journal of pharmacology. vol 229. issue 1. 1993-02-01. PMID:1473560. |
in the second experiment, we evaluated the neuroprotective effect of the 5-ht1a receptor agonists 8-oh-dpat and buspirone, and the 5-ht2 receptor antagonists cyproheptadine, mianserin and ketanserin on deficits of 2-dg uptake and schaffer-ca1 field potentials induced by ischemia. |
1993-02-01 |
2023-08-11 |
rat |
| E Chojnacka-Wójci. Functional interaction between 5-HT1B and 5-HT1A or 5-HT2 receptors in mice. Polish journal of pharmacology and pharmacy. vol 44. issue 3. 1993-01-22. PMID:1470563. |
to investigate a possible functional interaction between 5-ht1b and 5-ht1a or 5-ht2 receptors we studied the effects of 5-ht1a selective agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and gepirone, of a 5-ht1a/5-ht2 agonist 5-methoxy-n,n-dimethyltryptamine (5-meodmt) and of a putative 5-ht2 agonist (+/-)1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (+/- doi) on the 5-ht1b receptor-mediated hypothermia induced by m-trifluoromethylphenylpiperazine (tfmpp) (25 mg/kg) or m-chlorophenylpiperazine (m-cpp) (20 mg/kg) in mice. |
1993-01-22 |
2023-08-11 |
mouse |
| James Giordano, LaVerne Roger. Putative mechanisms of buspirone-induced antinociception in the rat. Pain. vol 50. issue 3. 1993-01-06. PMID:1454390. |
intraperitoneal administration of the serotonin 5-ht1a agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. |
1993-01-06 |
2023-08-11 |
rat |
| J L Wiley, J H Porte. Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448493. |
the present study examined the effects of haloperidol (d2 dopamine antagonist), ritanserin (5-ht2 antagonist), 1-alpha h,3-alpha,5-alpha h-tropan-3yl-3,5-dichlorobenzoate (mdl 72222) (5-ht3 antagonist), and buspirone (5-ht1a agonist) in stimulus substitution tests with rats trained to discriminate clozapine (5.0 mg/kg, ip) from vehicle in a two-lever drug discrimination procedure under a fixed ratio 30 schedule of food reinforcement. |
1992-12-30 |
2023-08-11 |
rat |
| D Kelder, S B Ros. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 2. 1992-12-24. PMID:1448177. |
the effects of 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-oh-dpat) and some other 5-hydroxytryptamine1a (5-ht1a) receptor agonists (buspirone, ipsapirone and flesinoxan) on corticosterone secretion in rats were studied. |
1992-12-24 |
2023-08-11 |
rat |
| K Takao, T Nagatani, K Kasahara, S Hashimot. Role of the central serotonergic system in the anticonflict effect of d-AP159. Pharmacology, biochemistry, and behavior. vol 43. issue 2. 1992-12-22. PMID:1359579. |
d-ap159 is a d-optical isomer, and in rats it has a high affinity for 5-hydroxytryptamine1a (5-ht1a) receptors and potent anticonflict activity, equal to that of buspirone. |
1992-12-22 |
2023-08-11 |
rat |
| Q Li, P A Rittenhouse, A D Levy, M C Alvarez Sanz, L D Van de Ka. Neuroendocrine responses to the serotonin2 agonist DOI are differentially modified by three 5-HT1A agonists. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1359439. |
rats were pretreated with the 5-ht1a agonists buspirone (0, 0.5, 2.0 mg/kg, i.p. |
1992-12-17 |
2023-08-11 |
rat |
| Q Li, P A Rittenhouse, A D Levy, M C Alvarez Sanz, L D Van de Ka. Neuroendocrine responses to the serotonin2 agonist DOI are differentially modified by three 5-HT1A agonists. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1359439. |
none of the three 5-ht1a agonists influenced the basal levels of renin, acth and prolactin but 8-oh-dpat and buspirone increased the basal level of corticosterone in plasma. |
1992-12-17 |
2023-08-11 |
rat |
| L Uphouse, M Caldarola-Pastuszka, S Montane. Intracerebral actions of the 5-HT1A agonists, 8-OH-DPAT and buspirone and of the 5-HT1A partial agonist/antagonist, NAN-190, on female sexual behavior. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436391. |
intracerebral actions of the 5-ht1a agonists, 8-oh-dpat and buspirone and of the 5-ht1a partial agonist/antagonist, nan-190, on female sexual behavior. |
1992-12-17 |
2023-08-11 |
rat |
| J C Winter, R A Rabi. Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1359109. |
in light of the negligible affinity of flesinoxan and tandospirone for the alpha 2 adrenoceptor (9000 and 8800 nm, respectively), and high affinity for the 5-ht1a receptor (0.3 and 43 nm, respectively), a mechanism mediated by the latter site is suggested. |
1992-12-08 |
2023-08-11 |
rat |
| G C Rigdon, J K Weatherspoo. 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1432685. |
five 5-hydroxytryptamine1a (5-ht1a, serotonin) receptor agonists: 8-hydroxy-2-(di-n-propylamino) tetraline (8-ohdpat), 5-methoxydimethyltryptamine, buspirone, gepirone and ipsapirone, were tested for effects on prepulse inhibition and startle reflex amplitude in rats. |
1992-12-08 |
2023-08-11 |
human |
| N M Barnes, C H Cheng, B Costall, J Ge, R J Naylo. Differential modulation of extracellular levels of 5-hydroxytryptamine in the rat frontal cortex by (R)- and (S)-zacopride. British journal of pharmacology. vol 107. issue 1. 1992-12-04. PMID:1384906. |
), the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat, 0.32 mg kg-1, s.c.) and the 5-ht1a receptor partial agonist buspirone (4.0 mg kg-1, i.p.) |
1992-12-04 |
2023-08-11 |
rat |
| K F Martin, I Phillips, M Hearson, M R Prow, D J Hea. Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. British journal of pharmacology. vol 107. issue 1. 1992-12-04. PMID:1422568. |
the 5-ht1a receptor partial agonists, buspirone, gepirone and ipsapirone, also dose-dependently induced hypothermia. |
1992-12-04 |
2023-08-11 |
mouse |
| P Simon, B Guardiola, J Bizot-Espiard, P Schiavi, J Costenti. 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357709. |
this inhibition appears to result from the stimulation of 5-ht1a receptors since it is an effect shared by both buspirone (from 5 mg/kg) and 8-oh-dpat (from 0.10 mg/kg). |
1992-11-25 |
2023-08-11 |
mouse |
| D J Sanger, H Schoemake. Discriminative stimulus properties of 8-OH-DPAT: relationship to affinity for 5HT1A receptors. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357711. |
substitution tests showed dose-dependent generalisation with the 5ht1a compounds, buspirone, ipsapirone, mdl 72832 and mdl 73005ef, the alpha 2-adrenoceptor antagonists, yohimbine and idazoxan, and bmy 14802, which is usually described as a sigma ligand. |
1992-11-25 |
2023-08-11 |
rat |
| A Z Murphy, R M Murphy, F P Zemla. Role of spinal serotonin1 receptor subtypes in thermally and mechanically elicited nociceptive reflexes. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1410132. |
in the spinal withdrawal reflex test, administration of the selective 5-ht1a agonists ipsapirone, gepirone and papp resulted in significant dose-dependent increases in receptive field (rf) area for withdrawal reflexes when compared to predrug baseline values, indicating an increase in nociceptive sensitivity. |
1992-11-25 |
2023-08-11 |
Not clear |
| P Van den Hooff, M Galva. Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurones in vitro. British journal of pharmacology. vol 106. issue 4. 1992-11-20. PMID:1393288. |
the 5-ht1a receptor ligands, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), n,n-dipropyl-5-carboxamidotryptamine (dp-5-ct) and buspirone but not the non-selective 5-ht1 receptor agonist, 1-m-trifluoromethylphenylpiperazine (tfmpp), also hyperpolarized the neurones. |
1992-11-20 |
2023-08-11 |
rat |
| G D Tollefso. Anxiety and alcoholism: a serotonin link. The British journal of psychiatry. Supplement. issue 12. 1992-11-18. PMID:1840761. |
the 5-ht1a receptor agonist buspirone is an anxiolytic which has been shown to diminish the desire to consume alcohol in anxious alcoholic patients. |
1992-11-18 |
2023-08-11 |
Not clear |
| R J Fanelli, K McMonagle-Struck. Alteration of 5-HT1A receptor binding sites following chronic treatment with ipsapirone measured by quantitative autoradiography. Synapse (New York, N.Y.). vol 12. issue 1. 1992-11-12. PMID:1357765. |
several recent studies have examined the effects of chronic treatment with ipsapirone or other structurally related pyrimidinylpiperazine compounds, including buspirone and gepirone, on 5-ht1a binding sites with mixed results. |
1992-11-12 |
2023-08-11 |
rat |
| R Oishi, Y Itoh, K Saek. Inhibition of histamine turnover by 8-OH-DPAT, buspirone and 5-hydroxytryptophan in the mouse and rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1388247. |
in whole mouse brains, the histamine turnover was significantly inhibited by the 5-ht1a agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (greater than 0.5 mg/kg) and buspirone (greater than 2 mg/kg) injected s.c. 10 min before pargyline treatment. |
1992-10-22 |
2023-08-11 |
mouse |