| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hélio Zangrossi, Frederico G Graef. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24657635. |
the evidence so far reported with the etm supports the above hypothesis and indicates that: (1) whereas 5-ht neurons located at the dorsal raphe nucleus are involved in the regulation of both inhibitory avoidance and escape, those of the median raphe nucleus are primarily implicated in the former task; (2) facilitation of 5-ht1a- and 5-ht2a-mediated neurotransmission in the dorsal periaqueductal gray (dpag) is likely to mediate the panicolytic drug action; (3) stimulation of 5-ht2c receptors in the basolateral amygdala increases anxiety and is implicated in the anxiogenesis caused by short-term administration of antidepressant drugs, and (4) 5-ht1a and the μ-opioid receptors work together in the dpag to modulate escape or panic attacks. |
2015-07-17 |
2023-08-12 |
rat |
| Ligia Westrich, Nasser Haddjeri, Ouria Dkhissi-Benyahya, Connie Sánche. Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents. Neuropharmacology. vol 89. 2015-07-15. PMID:25446573. |
vortioxetine is a multimodal antidepressant that inhibits 5-ht1d, 5-ht3, 5-ht7 receptor activity, 5-ht reuptake, and enhances the activity of 5-ht1a and 5-ht1b receptors. |
2015-07-15 |
2023-08-13 |
mouse |
| Taro Kato, Yuji Matsumoto, Masanori Yamamoto, Kenji Matsumoto, Satoko Baba, Keiko Nakamichi, Harumi Matsuda, Haruka Nishimuta, Kazuki Yabuuch. DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171224. |
dsp-1053, a novel serotonin reuptake inhibitor with 5-ht1a partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. |
2015-07-14 |
2023-08-13 |
human |
| Taro Kato, Yuji Matsumoto, Masanori Yamamoto, Kenji Matsumoto, Satoko Baba, Keiko Nakamichi, Harumi Matsuda, Haruka Nishimuta, Kazuki Yabuuch. DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171224. |
here, we show that dsp-1053, a novel serotonin reuptake inhibitor with 5-ht1a partial agonistic activity, displays fast antidepressant efficacy with minimal undesirable effects, especially nausea and emesis in animal models. |
2015-07-14 |
2023-08-13 |
human |
| Taro Kato, Yuji Matsumoto, Masanori Yamamoto, Kenji Matsumoto, Satoko Baba, Keiko Nakamichi, Harumi Matsuda, Haruka Nishimuta, Kazuki Yabuuch. DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171224. |
dsp-1053 bound human serotonin transporter and 5-ht1a receptor with the k i values of 1.02 ± 0.06 and 5.05 ± 1.07 nmol/l, respectively. |
2015-07-14 |
2023-08-13 |
human |
| Taro Kato, Yuji Matsumoto, Masanori Yamamoto, Kenji Matsumoto, Satoko Baba, Keiko Nakamichi, Harumi Matsuda, Haruka Nishimuta, Kazuki Yabuuch. DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171224. |
this compound inhibited the serotonin transporter with an ic50 value of 2.74 ± 0.41 nmol/l and had an intrinsic activity for 5-ht1a receptors of 70.0 ± 6.3%. |
2015-07-14 |
2023-08-13 |
human |
| Isabel M Quadros, Lara S Hwa, Akiko Shimamoto, Julia Carlson, Joseph F DeBold, Klaus A Micze. Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 12. 2015-07-10. PMID:24917195. |
next, a 5-ht1a agonist, 8-oh-dpat, was coadministered with cp-154,526 into the drn to temporarily disrupt 5-ht activity. |
2015-07-10 |
2023-08-13 |
mouse |
| P Sowa, M Adamczyk-Sowa, K Zwirska-Korczala, K Pierzchala, D Adamczyk, Z Paluch, M Misiole. Proopiomelanocortin but not vasopressin or renin-angiotensin system induces resuscitative effects of central 5-HT1A activation in haemorrhagic shock in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 65. issue 5. 2015-06-30. PMID:25371525. |
the aim of this study was to determine the effectory mechanisms: vasopressin, renin-angiotensin system and proopiomelanocortin-derived peptides (pomc), partaking in the effects of serotonin through central serotonin 1a receptor (5-ht1a) receptors in haemorrhagic shock in rats. |
2015-06-30 |
2023-08-13 |
rat |
| Karunakaran Vijayakaran, Manickam Kesavan, Kandasamy Kannan, Palanisamy Sankar, Surendra Kumar Tandan, Souvendra Nath Sarka. Arsenic decreases antinociceptive activity of paracetamol: possible involvement of serotonergic and endocannabinoid receptors. Environmental toxicology and pharmacology. vol 38. issue 2. 2015-06-23. PMID:25128769. |
serotonin content and gene expression of 5-ht1a, 5-ht2a and cb1 receptors were evaluated in brainstem and frontal cortex. |
2015-06-23 |
2023-08-13 |
rat |
| Anderson Manoel Herculano, Caio Maximin. Serotonergic modulation of zebrafish behavior: towards a paradox. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24681196. |
for example, in both zebrafish and rodents acute serotonin reuptake inhibitors (ssris) seem to increase anxiety-like behavior, while chronic ssris decrease it; drugs which act at the 5-ht1a receptor seem to decrease anxiety-like behavior in both zebrafish and rodents. |
2015-06-16 |
2023-08-12 |
zebrafish |
| Matthew O Parker, Leonette V Annan, Alexandros H Kanellopoulos, Alistair J Brock, Fraser J Combe, Matteo Baiamonte, Muy-Teck Teh, Caroline H Brenna. The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24690524. |
furthermore, it proposes a putative developmental mechanism characterized by ethanol-induced ot inhibition leading to suppression of 5-ht and up-regulation of 5-ht1a, which leads, in turn, to possible homeostatic up-regulation of 5-htt at 72hpf and subsequent imbalance of the 5-ht system. |
2015-06-16 |
2023-08-13 |
zebrafish |
| Laurent Tritschler, Daniela Felice, Romain Colle, Jean-Philippe Guilloux, Emmanuelle Corruble, Alain Michel Gardier, Denis Joseph Davi. Vortioxetine for the treatment of major depressive disorder. Expert review of clinical pharmacology. vol 7. issue 6. 2015-06-15. PMID:25166025. |
vortioxetine (brintellix(®), 1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine) is a multimodal antidepressant targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin (5-ht) transporter (5-htt). |
2015-06-15 |
2023-08-13 |
Not clear |
| April Johnston, Chris J McBain, André Fisah. 5-Hydroxytryptamine1A receptor-activation hyperpolarizes pyramidal cells and suppresses hippocampal gamma oscillations via Kir3 channel activation. The Journal of physiology. vol 592. issue 19. 2015-06-10. PMID:25107925. |
we found that 5-ht decreases the power of kainate-induced hippocampal gamma oscillations in both species via the 5-ht1a receptor subtype. |
2015-06-10 |
2023-08-13 |
mouse |
| Rakesh Jain, Dalei Chen, John Edwards, Maju Mathew. Early and sustained improvement with vilazodone in adult patients with major depressive disorder: post hoc analyses of two phase III trials. Current medical research and opinion. vol 30. issue 2. 2015-06-09. PMID:24127687. |
to retrospectively examine the timing of depressive symptom improvement in patients treated with vilazodone, a selective serotonin reuptake inhibitor (ssri) and 5-ht1a partial agonist. |
2015-06-09 |
2023-08-12 |
Not clear |
| Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu, Charles R Yang, Niels Plath, Connie Sanche. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. Journal of psychopharmacology (Oxford, England). vol 28. issue 10. 2015-06-09. PMID:25122043. |
vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-ht)3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (sert) inhibitor. |
2015-06-09 |
2023-08-13 |
rat |
| F Tirgar, A Rezayof, M-R Zarrindas. Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. Neuroscience. vol 277. 2015-06-08. PMID:25050820. |
the present study was designed to investigate possible involvement of the central amygdala (cea) nicotinic acetylcholine (nach) and 5-hydroxytryptamine 1a (5-ht1a) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-n-methylamphetamine (mdma or ecstasy) on morphine-induced amnesia. |
2015-06-08 |
2023-08-13 |
rat |
| Ashley Wallace, Alan L Pehrson, Connie Sánchez, David A Morila. Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. The international journal of neuropsychopharmacology. vol 17. issue 10. 2015-06-02. PMID:24852131. |
vortioxetine, a novel, multimodal-acting antidepressant, is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, and inhibits the 5-ht transporter. |
2015-06-02 |
2023-08-13 |
rat |
| D Toufexis, M A Rivarola, H Lara, V Via. Stress and the reproductive axis. Journal of neuroendocrinology. vol 26. issue 9. 2015-06-01. PMID:25040027. |
for example, although serotonin (5-ht) has a stimulatory effect on the hpa axis in humans and rodents that is mediated by the 5-ht1a receptor, only male rodents respond to 5-ht1a antagonism to show increased corticosterone responses to stress. |
2015-06-01 |
2023-08-13 |
human |
| Ferdinando Fiorino, Elisa Magli, Beatrice Severino, Angela Corvino, Antonio Ciano, Elisa Perissutti, Francesco Frecentese, Paola Massarelli, Cristina Nencini, Vincenzo Santagada, Giuseppe Caliend. Synthesis and in vitro pharmacological evaluation of novel 2-hydroxypropyl-4-arylpiperazine derivatives as serotoninergic ligands. Archiv der Pharmazie. vol 347. issue 10. 2015-06-01. PMID:25113046. |
this paper reports the synthesis of new norbornene and exo-n-hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivatives and their binding to the 5-ht1a , 5-ht2a , and 5-ht2c receptors, in order to identify selective ligands for these 5-hydroxytryptamine (5-ht, serotonine) receptor subtypes. |
2015-06-01 |
2023-08-13 |
Not clear |
| Shengyuan Ding, Fu-Ming Zho. Serotonin regulation of subthalamic neurons. Reviews in the neurosciences. vol 25. issue 4. 2015-05-26. PMID:24717335. |
first, 5-ht may affect stn neuron excitability directly by either inhibiting a subpopulation of stn neurons via activation of 5-ht1a receptors or exciting stn neurons through activation of 5-ht2c and 5-ht4 receptors. |
2015-05-26 |
2023-08-13 |
Not clear |