| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B F King, C Dacquet, A U Ziganshin, D F Weetman, G Burnstock, P M Vanhoutte, M Speddin. Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882604. |
in radioligand binding assays, pit showed a low affinity (pki < 5) for a range of membrane receptors, including: alpha 1, alpha 2-adrenoceptors, 5-ht1a, 5-ht1b, 5-ht2, 5-ht3, d1, d2, muscarinic, central benzodiazepine, h1, mu-opioid, dihydropyridine and batrachotoxin receptors. |
1996-12-11 |
2023-08-12 |
chicken |
| Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882632. |
these findings suggest that 5-ht elicits vasoconstriction in rat basilar arteries by stimulation of a mixed receptor population of 5-ht2 and 5-ht1-like receptors (similar to the 5-ht1b receptor subtype), and that the contraction mediated by 5-ht1-like receptors is enhanced in the basilar artery from shrsp. |
1996-12-11 |
2023-08-12 |
rat |
| M A Geye. Serotonergic functions in arousal and motor activity. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788473. |
thus, studies of locomotor and investigatory responses can be used to demonstrate and differentiate the effects of direct agonists at 5-ht1a, 5-ht1b, and 5-ht2 receptors as well as indirect serotonin agonists. |
1996-12-04 |
2023-08-12 |
rat |
| C Comoy, C Marot, T Podona, M L Baudin, L Morin-Allory, G Guillaumet, B Pfeiffer, D H Caignard, P Renard, M C Rettori, G Adam, B Guardiola-Lemaitr. 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]. Journal of medicinal chemistry. vol 39. issue 21. 1996-11-25. PMID:8863806. |
affinities for the 5-ht1a receptors were in the nanomolar range for the best compounds ((+)-11a,23) with a high selectivity versus other 5-ht (5-ht1b, 5-ht2, 5-ht3) or dopamine (d1, d2) receptor subtypes. |
1996-11-25 |
2023-08-12 |
Not clear |
| P D Feldma. Effects of serotonin-1 and serotonin-2 receptor agonists on neuronal activity in the nucleus tractus solitarius. Journal of the autonomic nervous system. vol 56. issue 1-2. 1996-09-26. PMID:8786274. |
these data provide electrophysiological evidence for the presence of 5-ht1 receptors in the nts, presumably of the 5-ht1b subclass, but cast further doubt on the contribution of 5-ht2 and 5-ht1a receptors to the actions of serotonin in the nucleus. |
1996-09-26 |
2023-08-12 |
Not clear |
| R B Raffa, E E Cod. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699917. |
in the present study, we measured the affinity of acetaminophen at 5-ht3, as well as 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2, 5-ht2c, 5-ht4, 5-ht6, 5-ht7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites. |
1996-08-30 |
2023-08-12 |
Not clear |
| K Uvnäs-Moberg, S Ahlenius, P Alster, V Hillegaar. Effects of selective serotonin and dopamine agonists on plasma levels of glucose, insulin and glucagon in the rat. Neuroendocrinology. vol 63. issue 3. 1996-08-12. PMID:8677015. |
no significant effects on plasma insulin, glucagon or glucose were seen after treatment with the 5-ht1b, 5-ht2 or 5-ht3 agonists. |
1996-08-12 |
2023-08-12 |
rat |
| R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. |
in contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-oh-dpat, 5-ht1a agonist), buspirone hydrochloride (5-ht1a agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (cgs 12066b, 5-ht1b agonist), ketanserin tartrate (5-ht2 antagonist), methysergide maleate (5-ht2 antagonist), fluoxetine (5-ht uptake blocker), and saline (vehicle). |
1996-02-20 |
2023-08-12 |
rat |
| B K Koe, L A Lebe. Effects of serotoninergic agents on downregulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 2. 1996-02-06. PMID:8540763. |
the 5-ht1b agonist, 3-trifluoromethylphenylpiperazine, and the 5-ht2 antagonist, ritanserin, showed neither facilitation nor antagonism of sertraline, but the 5-ht3 antagonist, ondansetron, attenuated the decrease of bmax of [3h]dihydroalprenolol binding elicited by sertraline. |
1996-02-06 |
2023-08-12 |
rat |
| F J Miranda, G Torregrosa, J B Salom, J A Alabadí, T Jover, M D Barberá, E Alborc. Characterization of 5-hydroxytryptamine receptors in goat cerebral arteries. General pharmacology. vol 26. issue 6. 1995-12-07. PMID:7590117. |
pretreatment with the antagonist of 5-ht1a and 5-ht1b receptors cyanopindolol (10(-8), 10(-6) m), the antagonist of 5-ht1/5-ht2 receptors methysergide (10(-11), 10(-9) m) and the antagonist of 5-ht2 receptors ketanserin (10(-11), 10(-9) m) induced non-competitive inhibition of the concentration-response curve to 5-ht. |
1995-12-07 |
2023-08-12 |
Not clear |
| F Muehlenkamp, A Lucion, W H Voge. Effects of selective serotonergic agonists on aggressive behavior in rats. Pharmacology, biochemistry, and behavior. vol 50. issue 4. 1995-08-24. PMID:7617717. |
the effects of the relatively specific serotonergic agonists 8-oh-dpat (5-ht1a), tfmpp (5-ht1b), and dob (5-ht2) were studied on defensive aggressive behavior in rats using the water competition test, 8-oh-dpat (up to 0.25 mg/kg) and tfmpp (up to 1 mg/kg) were found to be ineffective, whereas dob (up to 0.4 mg/kg) significantly reduced aggressive behavior in this test as well as in the offensive aggression test of the resident-intruder model. |
1995-08-24 |
2023-08-12 |
rat |
| W J McBride, J M Murphy, G J Gatto, A D Levy, K Yoshimoto, L Lumeng, T K L. CNS mechanisms of alcohol self-administration. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748340. |
this is indicated by (a) lower contents of da and 5-ht; (b) fewer 5-ht immunostained fibers; (c) lower densities of 5-ht1b, 5-ht2 and d2 receptors; and (d) higher densities of 5-ht1a receptors in the cns of p rats compared to the alcohol-nonpreferring np line of rats. |
1995-06-22 |
2023-08-12 |
rat |
| T A Sipes, M A Geye. 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology. vol 117. issue 1. 1995-05-25. PMID:7724701. |
both serotonin (5-ht) releasers and agonists at 5-ht1a, 5-ht1b, and 5-ht2 receptors reduce ppi in the rat. |
1995-05-25 |
2023-08-12 |
rat |
| R Perrone, F Berardi, N A Colabufo, M Leopoldo, V Tortorella, F Fiorentini, V Olgiati, A Ghiglieri, S Govon. High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2. Journal of medicinal chemistry. vol 38. issue 6. 1995-04-28. PMID:7699710. |
final compounds were evaluated for in vitro activity on dopamine d-1 and d-2, serotonin 5-ht1a, 5-ht1b, 5-ht1c, and 5-ht2, alpha 1 adrenergic, and sigma receptors by radioreceptor binding assay. |
1995-04-28 |
2023-08-12 |
Not clear |
| S J Kitchener, C T Douris. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology. vol 113. issue 3-4. 1995-03-20. PMID:7862847. |
previous studies have shown that administration of 5-ht1b, 5-ht1c or 5-ht2 agonists decreases food intake in rats. |
1995-03-20 |
2023-08-12 |
rat |
| S J Kitchener, C T Douris. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology. vol 113. issue 3-4. 1995-03-20. PMID:7862847. |
in the present study the post-prandial satiety sequence was used to characterise the actions of the 5-ht2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), the 5-ht1b/5-ht1c receptor agonists, 1-(3-chorophenyl) piperazine (mcpp) and 1-[3-(trifluoromethyl)phenyl] piperazine (tfmpp), and the 5-ht1b agonist, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)h-indole (ru 24969), on feeding in rats. |
1995-03-20 |
2023-08-12 |
rat |
| M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology. vol 261. issue 1-2. 1995-01-23. PMID:8001641. |
neonatal destruction of the nigrostriatal dopamine projection by intraventricular 6-hydroxydopamine leads to a serotonin (5-hydroxytryptamine, 5-ht) hyperinnervation of the adult neostriatum accompanied by increased radioligand binding to 5-ht1b, 5-ht1nonab and 5-ht2 receptors. |
1995-01-23 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, R Pluchino, W Gonzales, S Simmen. p,p'-DDT myoclonic/epileptic model: serotonin receptor binding and behavioral studies in the rat. Neurotoxicology. vol 15. issue 2. 1995-01-12. PMID:7991214. |
at a time when low dose (80 mg/kg) p,p'-ddt elicited stimulus-sensitive and spontaneous myoclonus, there were no significant changes in bmax or kd of 5-ht1a, 5-ht1b, 5-ht1c sites in cortex, striatum, brainstem or spinal cord, agonist- or antagonist-labelled 5-ht2 sites in cortex, or 5-ht uptake sites. |
1995-01-12 |
2023-08-12 |
rat |
| G Spurlock, P Buckland, M O'Donovan, P McGuffi. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984281. |
we have examined this hypothesis by treating rats over a time course of up to 32 days with either imipramine, mianserin, fluvoxamine, citalopram, amoxapine or saline and measuring the levels of mrnas encoding the 5ht1a, 5ht1b, 5ht1c and 5ht2 receptors, the enzymes tryptophan hydroxylase and aromatic amino acid decarboxylase, and the 5ht transporter. |
1994-12-30 |
2023-08-12 |
rat |
| J A Terrón, F J López-Muñoz, E Hong, C M Villaló. 2-(2-Aminoethyl)-quinoline (D-1997): a novel agonist at 5-hydroxytryptamine1-like receptors in the canine basilar artery. Archives internationales de pharmacodynamie et de therapie. vol 327. issue 1. 1994-10-28. PMID:7944828. |
the effects of d-1997 in the basilar artery were not modified by incubation with either the 5-ht2 receptor antagonist ketanserin (0.01-1 microm), the 5-ht3 and 5-ht4 receptor antagonist ics205930 (tropisetron; 0.1-10 microm), the 5-ht1a receptor antagonist spiroxatrine (0.01-1 microm), the beta-adrenoceptor blocker with high affinity for 5-ht1a and 5-ht1b binding sites (+/-)-pindolol (0.01-1 microm), or the alpha 1-adrenoceptor antagonist prazosin (0.01-1 microm). |
1994-10-28 |
2023-08-12 |
rat |