| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H W Clement, D Gemsa, W Weseman. Serotonin-norepinephrine interactions: a voltammetric study on the effect of serotonin receptor stimulation followed in the N. raphe dorsalis and the Locus coeruleus of the rat. Journal of neural transmission. General section. vol 88. issue 1. 1992-06-10. PMID:1374260. |
the voltammetric dopac signal in the locus coeruleus, used as a measure of ne neuronal activity, was increased after systemic application of the 5-ht1b agonist cgs-12066b, the 5-ht2 antagonist ritanserin, and, to a lesser extent, by ipsapirone, a 5-ht1a agonist. |
1992-06-10 |
2023-08-11 |
rat |
| H W Clement, D Gemsa, W Weseman. Serotonin-norepinephrine interactions: a voltammetric study on the effect of serotonin receptor stimulation followed in the N. raphe dorsalis and the Locus coeruleus of the rat. Journal of neural transmission. General section. vol 88. issue 1. 1992-06-10. PMID:1374260. |
the findings suggest that the ne neuronal system of the locus coeruleus is stimulated by 5-ht1a and 5-ht1b receptor activation and inhibited by 5-ht2 receptors. |
1992-06-10 |
2023-08-11 |
rat |
| R A Foy, J L Myles, R D Wilkerso. Characterization of 5-hydroxytryptamine receptors in bovine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1533667. |
concentration-response relationships for 8-hydroxy-2-(di-n-propylamino)-tetralin (5-ht1a agonist) (0.3-100 microm), cgs-12066b maleate (5-ht1b agonist) (0.01-30 microm), alpha-methylserotonin maleate (5-ht2 agonist) (0.01-30 microm), 1-(m-chlorophenyl)-biguanide (5-ht3 agonist) (0.1-100 microm) and serotonin (0.1-300 microm) were studied in vitro using 2-mm segments of bovine proximal left anterior descending coronary artery. |
1992-06-05 |
2023-08-11 |
cattle |
| R A Foy, J L Myles, R D Wilkerso. Characterization of 5-hydroxytryptamine receptors in bovine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1533667. |
contractions induced by 8-hydroxy-2-(di-n-propylamino)-tetralin or alpha-methylserotonin maleate were attenuated by pretreatment with s(-)propranolol (2.6 microm), a relatively selective 5-ht1a and 5-ht1b receptor antagonist, and ketanserin (0.3 microm), a selective 5-ht2 receptor antagonist, respectively. |
1992-06-05 |
2023-08-11 |
cattle |
| S W Johnson, N B Mercuri, R A Nort. 5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 5. 1992-06-05. PMID:1578282. |
(+/-)-cyanopindolol (100 nm), a 5-ht1b antagonist, blocked the effect of 5-ht (10 microm); spiperone (1 microm), which is an antagonist at 5-ht1a and 5-ht2 receptors, had no effect. |
1992-06-05 |
2023-08-11 |
rat |
| J Ulrichse. Alterations in serotonin receptor subtypes in ethanol-dependent rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 26. issue 5-6. 1992-05-01. PMID:1839497. |
[3h]ketanserin binding to 5-ht2 receptors in the cortex, (-)[125i]-iodo-cyanopindolol [( 125i]cyp) binding to 5-ht1b receptors in the striatum and hypothalamus, and [3h] 8-oh-dpat binding in the cortex were not affected by chronic ethanol administration. |
1992-05-01 |
2023-08-11 |
rat |
| M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology. vol 115. issue 3. 1992-04-02. PMID:1537397. |
no 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, or 5-ht uptake sites were found in any of the tumors, although all were detected in human or rat brain. |
1992-04-02 |
2023-08-11 |
human |
| T Crisp, J L Stafinsky, M Uram, V C Perni, M F Weaver, L J Spano. Serotonin contributes to the spinal antinociceptive effects of morphine. Pharmacology, biochemistry, and behavior. vol 39. issue 3. 1992-03-19. PMID:1686100. |
the serotonin receptor antagonists spiroxatrine (5-ht1a), pindolol (5-ht1b), ritanserin (5-ht2) and ics 205-930 (5-ht3) attenuated the spinal analgesic effects of morphine. |
1992-03-19 |
2023-08-11 |
rat |
| E A Audi, R M de Oliveira, F G Graef. Microinjection of propranolol into the dorsal periaqueductal gray causes an anxiolytic effect in the elevated plus-maze antagonized by ritanserin. Psychopharmacology. vol 105. issue 4. 1992-02-27. PMID:1685253. |
the present as well as previously reported results suggest that the anxiolytic effect of propranolol injected into the dpag is due to increased release of 5-ht acting on post-synaptic 5-ht2 receptors, resultant from blockade of 5-ht1b autoreceptors that inhibit amine release from serotonergic nerve endings. |
1992-02-27 |
2023-08-11 |
rat |
| P Hedlund, G von Euler, K Fux. Activation of 5-hydroxytryptamine1A receptors increases the affinity of galanin receptors in di- and telencephalic areas of the rat. Brain research. vol 560. issue 1-2. 1992-02-11. PMID:1836971. |
since galanin in vitro selectively increases the kd value of 5-ht1a receptors without altering the binding of 5-ht1b or 5-ht2 receptors, we have studied whether 5-ht1a receptor activation in turn may affect galanin binding in the ventral di- and telencephalon and the substantia nigra of the rat. |
1992-02-11 |
2023-08-11 |
rat |
| R M Danzebrink, G F Gebhar. Intrathecal coadministration of clonidine with serotonin receptor agonists produces supra-additive visceral antinociception in the rat. Brain research. vol 555. issue 1. 1991-12-20. PMID:1933328. |
coadministration of sub-antinociceptive doses of clonidine, an alpha 2-adrenoceptor agonist, with doi or ru-24969 (5-ht2 or 5-ht1b receptor agonists, respectively) produced dose-dependent supra-additive antinociceptive effects in a model of visceral pain. |
1991-12-20 |
2023-08-11 |
rat |
| F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1834802. |
[3h]5-ht competition studies performed in the presence of 100 nm 8-oh-dpat and 10 nm ru 24969 (to block 5-ht1a and 5-ht1b receptors, respectively) indicated that the remaining 49% of [3h]5-ht binding did not possess the pharmacologic profile previous reported for 5-ht1c, 5-ht1d, 5-ht1e, 5-ht2, or 5-ht3 receptors. |
1991-12-18 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
the anti-immobility effect of gepirone (10 mg/kg) was dose-dependently antagonized by the 5-ht1a receptor and alpha 1-adrenoceptor antagonist, nan-190 (0.25 and 0.5 mg/kg), the beta-adrenoceptor blocker with the affinity for 5-ht1a and 5-ht1b receptors, pindolol (2 and 4 mg/kg), the 5-ht1a, 5-ht2 and dopamine receptor blocker spiperone (0.01 and 0.03 mg/kg) and by the dopamine receptor antagonist, haloperidol (0.125 and 0.25 mg/kg). |
1991-11-04 |
2023-08-11 |
rat |
| L Marlier, J R Teilhac, C Cerruti, A Priva. Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain research. vol 550. issue 1. 1991-10-17. PMID:1832328. |
autoradiographic mapping of 5-ht1, 5-ht1a, 5-ht1b and 5-ht2 receptors in the rat spinal cord. |
1991-10-17 |
2023-08-11 |
rat |
| L Marlier, J R Teilhac, C Cerruti, A Priva. Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain research. vol 550. issue 1. 1991-10-17. PMID:1832328. |
the distribution of 5-ht1, 5-ht1a, 5-ht1b and 5-ht2 receptors in the rat spinal cord was investigated with quantitative autoradiography. |
1991-10-17 |
2023-08-11 |
rat |
| H Tamir, K P Liu, S C Hsiung, P Y Yu, A L Kirchgessner, M D Gersho. Identification of serotonin receptors recognized by anti-idiotypic antibodies. Journal of neurochemistry. vol 57. issue 3. 1991-09-04. PMID:1861158. |
it is concluded that the anti-idiotypic antibodies generated with anti-5-ht serum recognize the 5-ht1b, 5-ht1c, and 5-ht2 receptor subtypes; however, neither 5-ht1a receptors nor 5-ht uptake sites appear to react with these antibodies. |
1991-09-04 |
2023-08-11 |
Not clear |
| H I Jacoby, A C Bonfilio, R B Raff. Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility. Neuroscience letters. vol 122. issue 1. 1991-08-01. PMID:2057128. |
administration was produced by 8-oh-dpat (5-ht1a), ru-24969 (5-ht1b), and 2-methyl serotonin (5-ht3), but not doi (5-ht2) which augmented propulsion. |
1991-08-01 |
2023-08-11 |
mouse |
| T Crisp, J L Stafinsky, L J Spanos, M Uram, V C Perni, H B Donepud. Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord. General pharmacology. vol 22. issue 2. 1991-07-31. PMID:1829046. |
the 5-ht receptor agonists examined in this study included the 5-ht1a agonist 8-hydroxy-n,n-dipropyl-2-aminotetralin (8-oh-dpat), the 5-ht1b agonist m-trifluoromethylphenylpiperazine (tfmpp), the 5-ht2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and the 5-ht3 agonist phenylbiguanide (pbg). |
1991-07-31 |
2023-08-11 |
rat |
| M J Millan, K Bervoets, F C Colpaer. 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. The Journal of pharmacology and experimental therapeutics. vol 256. issue 3. 1991-04-24. PMID:1826033. |
the response could not be elicited by cgs 12066b [7-trifluormethyl-4-(4-methyl-l-piperazonyl)-pyrrolol- [1-2-a] quinoxaline dimaleate], mcpp 1-(3-chlorophenyl)-piperazine-2-hcl, tfmppm-trifluromethylphenylpiperazine hcl, mk 212 [6-chloro-2-(l-piperzinyl)pyrazine], quipazine and doi (+-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane hcl, which act in vivo as agonists at 5-ht1b, 5-ht1c and/or 5-ht2 receptors, or by the 5-ht3 agonist, 2-methyl-5-ht. |
1991-04-24 |
2023-08-11 |
rat |
| E Edwards, K Harkins, C R Ashby, R Y Wan. Effect of 5-hydroxytryptamine3 receptor agonists on phosphoinositides hydrolysis in the rat fronto-cingulate and entorhinal cortices. The Journal of pharmacology and experimental therapeutics. vol 256. issue 3. 1991-04-24. PMID:1848625. |
the stimulatory action of 2-me-5-ht and phenylbiguanide was blocked completely by granisetron, ondansetron and ics 205-930 but not by other receptor antagonists such as (+/-)-pindolol (a beta, 5-ht1a and 5-ht1b receptor antagonist), methy-sergide (a 5-ht1 and 5-ht2 receptor antagonist), ritanserin (a 5-ht1c and 5-ht2 receptor antagonist), sr 95103 (gamma-aminobutyric acida receptor antagonist), scopolamine (a muscarinic antagonist), (-)-eticlopride (a d2 receptor antagonist), sch 23390 (a d1 5-ht2/1c receptor antagonist) and prazosin (an alpha-1 receptor antagonist). |
1991-04-24 |
2023-08-11 |
rat |