| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Przegaliński, B Budziszewska, A Warchoł-Kania, E Błaszczyńsk. Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Pharmacology, biochemistry, and behavior. vol 33. issue 2. 1989-12-19. PMID:2530590. |
it is concluded that 8-oh-dpat-induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5-ht1a receptors, whereas other subtypes (5-ht1b, 5-ht2, 5-ht3) of 5-ht receptors do not participate in this response. |
1989-12-19 |
2023-08-11 |
rat |
| W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences. vol 45. issue 16. 1989-12-05. PMID:2811600. |
the present findings demonstrate the presence of a high-affinity [3h]5-ht binding site in rabbit cn, designated 5-ht1r, that is different from previously defined 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 sites. |
1989-12-05 |
2023-08-11 |
rabbit |
| P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2552330. |
gr 43175 displayed the following order of affinity for 5-ht recognition sites (pkd values, -log mol/l, in parentheses): 5-ht1d (7.54) greater than 5-ht1b (6.35) greater than 5-ht1a (6.13) much greater than 5-ht1c (4.13) greater than 5-ht2 (3.67). |
1989-11-08 |
2023-08-11 |
human |
| S Gleeson, S T Ahlers, R S Mansbach, J M Foust, J E Barret. Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2476547. |
ru 24969, with high affinity for both 5-ht1a and 5-ht1b receptors, and 1-(2-methoxyphenyl)piperazine, a 5-ht1 compound, increased punished responding to a lesser extent, as did the 5-ht2 antagonists ketanserin and ritanserin. |
1989-10-17 |
2023-08-11 |
Not clear |
| G A Kennett, P Whitton, K Shah, G Curzo. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. European journal of pharmacology. vol 164. issue 3. 1989-10-05. PMID:2767117. |
the effect of mcpp on social interaction was blocked by three antagonists which share a high affinity for 5-ht1c and 5-ht2 receptors: mianserin, cyproheptadine and metergoline but not by the 5-ht2 antagonists ketanserin or ritanserin or the 5-ht1a and 5-ht1b antagonists cyanopindolol and (-)-propranolol. |
1989-10-05 |
2023-08-11 |
rat |
| J Arn. Characterization of the discriminative stimulus properties induced by 5-HT1 and 5-HT2 agonists in rats. Pharmacology & toxicology. vol 64. issue 2. 1989-09-05. PMID:2526950. |
5-ht1b (tfmpp and ru 24969) and 5-ht2 agonists (dom, doi and quipazine) were ineffective and induced disruption of responding. |
1989-09-05 |
2023-08-11 |
rat |
| M A Geyer, G S Tapso. Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 1. issue 2. 1989-08-03. PMID:3150805. |
the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin, ipsapirone, and 5-methoxy-n,n-dimethyltryptamine, the 5-ht1b agonist m-trifluoromethylphenylpiperazine, and the 5-ht2 agonist quipazine affected startle reactivity rather than having specific effects on habituation. |
1989-08-03 |
2023-08-11 |
rat |
| R Samanin, T Mennini, C Bendotti, D Barone, S Caccia, S Garattin. Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of D-fenfluramine in the rat. Neuropharmacology. vol 28. issue 5. 1989-07-11. PMID:2566947. |
the results suggest that 5-ht receptors, other than 5-ht2, possibly 5-ht1b, are involved in the anorectic effect of d-fenfluramine in food-deprived rats. |
1989-07-11 |
2023-08-11 |
rat |
| L D Van de Kar, S A Lorens, J H Urban, C L Bethe. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology. vol 28. issue 3. 1989-07-03. PMID:2524677. |
by deduction, these data suggest that 5-ht1b receptors, or as yet undefined 5-ht receptor subtypes may be involved in the stimulation of the secretion of prolactin by endogenously released 5-ht, and that 5-ht2 receptors may play a minor role in the serotonergic regulation of the secretion of prolactin. |
1989-07-03 |
2023-08-11 |
rat |
| K P Nanry, H A Tilso. The role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524858. |
8-hydroxy-2-(di-n-propylamino) tetralin (8-ohdpat) (1,2 and 4 mg/kg, sc) and 5-methoxy-n,n-dimethyltryptamine (5-meodmt) (1,2 and 4 mg/kg, ip), putative 5-ht1a receptor agonists, increased the magnitude of the startle reflex, while quipazine (5, 10 and 20 mg/kg, sc), an agonist with mixed 5-ht2 and 5-ht1b receptor activity, decreased startle responsiveness. |
1989-06-27 |
2023-08-11 |
rat |
| D Scherman, M Hamon, H Gozlan, J P Henry, A Lesage, M Masson, J F Rumign. Molecular pharmacology of niaprazine. Progress in neuro-psychopharmacology & biological psychiatry. vol 12. issue 6. 1989-05-16. PMID:2853885. |
niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (ki = 77 nm) and 5-ht2 (ki = 25 nm) binding sites, but is poorly recognized by 5-ht1a and 5-ht1b binding sites (ki sigma mcirom). |
1989-05-16 |
2023-08-11 |
Not clear |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2975354. |
in contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-ht1a (8-oh-dpat, buspirone), 5-ht1b (21-009, ru 24969), 5-ht1c (mesulergine, mianserin) and 5-ht2 sites (ketanserin, cinanserin). |
1989-03-02 |
2023-08-11 |
human |
| J C Winter, R A Rabi. Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:3211970. |
drugs purported to have selective affinities for 5-ht1a, 5-ht1b, and 5-ht2 receptors were tested in rats trained with 0.1 mg lsd versus saline. |
1989-02-23 |
2023-08-11 |
rat |
| A Dumuis, R Bouhelal, M Sebben, R Cory, J Bockaer. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849052. |
the action of antagonists acting on 5-ht1 or 5-ht2 receptors, such as methiothepin (5-ht1 and 5-ht2), metergoline (5-ht1 and 5-ht2), spiperone (5-ht1a and 5-ht2), (-)-pindolol (5-ht1b), mesulergine (5-ht1c), and ketanserin (5-ht2), were almost inactive in reversing the 5-ht stimulating effect. |
1989-01-23 |
2023-08-11 |
mouse |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
development of 5ht agonists and antagonists selective for different 5ht receptor sub-types (5ht1a, 5ht1b, 5ht2, 5ht3) has opened a new avenue for investigation of the potential role of 5ht in anxiety. |
1988-10-20 |
2023-08-11 |
Not clear |
| C L Kirstein, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in neonatal rat pups. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2970973. |
sprague-dawley rat pups at 3-4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-ohdpat), the 5-ht1b agonist 1-(3-chlorophenyl)piperazine (mcpp), or the 5-ht2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi). |
1988-10-18 |
2023-08-11 |
rat |
| C L Kirstein, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in neonatal rat pups. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2970973. |
conversely, the 5-ht2 agonist doi and the 5-ht1b agonist mcpp increased mouthing and decreased probing. |
1988-10-18 |
2023-08-11 |
rat |
| P H Hutson, C T Dourish, G Curzo. Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A receptors. European journal of pharmacology. vol 150. issue 3. 1988-10-18. PMID:2970974. |
8-oh-dpat-induced feeding was blocked by metergoline which has comparable affinity for 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors. |
1988-10-18 |
2023-08-11 |
rat |
| K Seuwen, I Magnaldo, J Pouysségu. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature. vol 335. issue 6187. 1988-10-12. PMID:3045568. |
we show that the mitogenicity of 5-hydroxytryptamine can be uncoupled from phospholipase c activation that is mediated by 5-ht2 receptors, but correlates perfectly with inhibition of adenylate cyclase through 5-ht1b receptor. |
1988-10-12 |
2023-08-11 |
Not clear |
| D E Nichols, D H Lloyd, M P Johnson, A J Hoffma. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:3385733. |
to probe structure-activity relationships of serotonin receptors, affinities of the alpha-methyltryptamine enantiomers were then measured at the 5-ht2 antagonist receptor subtype, with displacement of [3h]ketanserin, and were estimated at the 5-ht1b receptor, with displacement of [3h]serotonin, respectively, in rat frontal cortex homogenates. |
1988-08-05 |
2023-08-11 |
rat |