| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Fujishima, H Hara, M Shimazawa, K Yokota, T Sukamot. [The effects of a novel Ca2+ channel blocker, KB-2796, on 5-HT-induced responses]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 104. issue 1. 1994-10-04. PMID:8076888. |
in rat cortical membrane, kb-2796 inhibited specific [3h]spiperone binding to 5-ht2 receptors in a competitive manner (ki = 0.57 microm), but exhibited negligible affinity for radioligand binding to other 5-ht receptor subtypes such as 5-ht1, 5-ht1a, 5-ht1b, 5-ht1c and 5-ht3 at a concentration of 10 or 100 microm. |
1994-10-04 |
2023-08-12 |
rat |
| M J Millan, J M Rivet, A Gobert, H Canton, S Veiga, K Bervoet. 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. The Journal of pharmacology and experimental therapeutics. vol 269. issue 1. 1994-06-02. PMID:7909555. |
the facilitatory actions of cirazoline and st 587 were selective in that they did not permit the induction of stfs by agonists at other 5-ht receptor subtypes (5-ht1b, 5-ht1c, 5-ht2 or 5-ht3). |
1994-06-02 |
2023-08-12 |
rat |
| F Hery, M Hamo. [Neuroleptics and serotonin]. L'Encephale. vol 19. issue 5. 1994-03-14. PMID:7905821. |
these studies not only demonstrate the existence of several classes of serotonin receptors called 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, 5-ht3 and 5-ht4, but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them. |
1994-03-14 |
2023-08-12 |
Not clear |
| M Félétou, O Dellazuana, J Duhaul. Serotoninergic receptor subtype in coronary artery smooth muscle from young and atherosclerotic rabbit. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301547. |
nan 190, a 5ht1a antagonist, ly 53857, a 5ht1c and 5ht2 antagonist, cyanopindolol, a 5ht1a and 5ht1b antagonist and ics 205-930, a 5ht3 and 5ht4 antagonist (up to 10(-6) m) did not inhibit the contractile response to 5ht. |
1994-03-10 |
2023-08-12 |
rabbit |
| W Pinto, G Battagli. In vivo EEDQ dose-dependently inactivates rat brain 5-HT receptors but not 5-HT uptake sites. Neuroreport. vol 5. issue 1. 1994-02-14. PMID:8280861. |
the rank order of sensitivity to eedq inactivation was: 5-ht1a > 5-ht1b > 5-ht2 approximately 5-ht2/1c >>> 5-ht uptake sites. |
1994-02-14 |
2023-08-12 |
rat |
| P Trouilla. The cerebellar serotoninergic system and its possible involvement in cerebellar ataxia. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 20 Suppl 3. 1993-08-26. PMID:8334597. |
serotoninergic receptors have been described: 5-ht1b in the molecular layer and 5-ht2 in the inferior olive. |
1993-08-26 |
2023-08-12 |
human |
| J C Tinajero, A Fabbri, M L Dufa. Serotonergic inhibition of rat Leydig cell function by propranolol. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8391422. |
the beta-adrenergic antagonist propranolol binds to serotonin (5ht) receptors (5ht1b > 5ht1a > 5ht2) in brain membranes. |
1993-08-03 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
5-ht1a, 5-ht1b, 5ht1nonab and 5-ht2 sites were labeled with [3h]8-oh-dpat, [125i]cyanopindolol, [3h]5-ht and [125i]doi, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. |
1993-06-14 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
even though the exact cause(s) of these receptor increases could not be determined, their anatomical distribution suggested that they were somehow related to the initial dopamine denervation in the case of the 5-ht1b and 5-ht1nonab receptors, and more tightly linked to the 5-ht hyperinnervation in the case of the 5-ht2 receptors. |
1993-06-14 |
2023-08-12 |
rat |
| M J Millan, J M Rivet, H Canton, S Le Marouille-Girardon, A Gober. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450471. |
agonists at 5-ht1b, 5-ht1c, 5-ht2 and/or 5-ht3 receptors did not elicit hypothermia, and drugs releasing 5-ht elicited hyperthermia. |
1993-04-14 |
2023-08-12 |
rat |
| F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:7680751. |
within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-ht)] receptors: 5-ht2 > 5-ht1d > 5-ht1c > 5-ht1b > 5-ht1a > 5-ht1e. |
1993-04-13 |
2023-08-12 |
rat |
| J Sawynok, A Rei. Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. European journal of pharmacology. vol 223. issue 1. 1993-02-05. PMID:1362158. |
the present study examined the involvement of spinal noradrenergic mechanisms in spinal antinociception by the 5-hydroxy-tryptamine (5-ht) receptor-selective agonists cgs 12066b (5-ht1b; 7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline), tfmpp (5-ht1c; m-trifluoromethylphenyl-piperazine) and doi (5-ht2; 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) using the rat hot plate test. |
1993-02-05 |
2023-08-11 |
rat |
| T A Pugsley, C L Christofferson, A Corbin, H A DeWald, S Demattos, L T Meltzer, S L Myers, Y H Shih, S Z Whetzel, J N Wile. Pharmacological characterization of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1361570. |
it also had significant affinity for serotonin-(5-ht)1a but not 5-ht1b and 5-ht2 receptors. |
1993-01-22 |
2023-08-11 |
mouse |
| E Chojnacka-Wójci. Functional interaction between 5-HT1B and 5-HT1A or 5-HT2 receptors in mice. Polish journal of pharmacology and pharmacy. vol 44. issue 3. 1993-01-22. PMID:1470563. |
to investigate a possible functional interaction between 5-ht1b and 5-ht1a or 5-ht2 receptors we studied the effects of 5-ht1a selective agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and gepirone, of a 5-ht1a/5-ht2 agonist 5-methoxy-n,n-dimethyltryptamine (5-meodmt) and of a putative 5-ht2 agonist (+/-)1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (+/- doi) on the 5-ht1b receptor-mediated hypothermia induced by m-trifluoromethylphenylpiperazine (tfmpp) (25 mg/kg) or m-chlorophenylpiperazine (m-cpp) (20 mg/kg) in mice. |
1993-01-22 |
2023-08-11 |
mouse |
| G Romero, E Toscano, D Montero, M C De Felipe, J Del Ri. Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain. Journal of neural transmission. General section. vol 90. issue 2. 1993-01-21. PMID:1334416. |
prenatal exposure to tianeptine significantly decreased the density of 3h-imipramine binding sites in the cerebral cortex of the pups without affecting beta-adrenoceptors, serotonin 5-ht2 and 5-ht1b receptors or inositol phosphate formation after a 5-ht challenge. |
1993-01-21 |
2023-08-11 |
rat |
| J L Herndon, M E Pierson, R A Glenno. Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1333084. |
the results of these and other published studies suggest roles for 5-hydroxytryptamine 1b (5-ht1b), 5-ht1c, and, possibly, sigma-receptors in the mediation of the tfmpp stimulus and indicate a lack of involvement of 5-ht1a, 5-ht2, dopaminergic, and adrenergic mechanisms in this behavior. |
1992-12-30 |
2023-08-11 |
rat |
| M O Den Boer, C M Villalón, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1326717. |
the effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-ht1d receptor as well as for the 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors, was studied on the responses to 5-ht and sumatriptan. |
1992-10-22 |
2023-08-11 |
Not clear |
| R Oishi, Y Itoh, K Saek. Inhibition of histamine turnover by 8-OH-DPAT, buspirone and 5-hydroxytryptophan in the mouse and rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1388247. |
injections of the 5-ht1b agonist m-trifluoromethylphenylpiperazine (10 and 20 mg/kg) or the 5-ht2 agonist (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (1, 2 and 5 mg/kg), however, did not affect histamine turnover. |
1992-10-22 |
2023-08-11 |
mouse |
| A Dumuis, H Gozlan, M Sebben, H Ansanay, C A Rizzi, M Turconi, E Monferini, E Giraldo, P Schiantarelli, H Ladinsk. Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 3. 1992-08-05. PMID:1320204. |
no significant binding (ki greater than 10 mumol/l) of dau 6285 to serotonergic 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 receptors as well as to adrenergic alpha 1, alpha 2, dopaminergic d1, d2 or muscarinic m1-m3 receptor subtypes was found. |
1992-08-05 |
2023-08-11 |
mouse |
| J Ulrichsen, J S Partilla, E M Da. Long-term administration of m-chlorophenylpiperazine (mCPP) to rats induces changes in serotonin receptor binding, dopamine levels and locomotor activity without altering prolactin and corticosterone secretion. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1352053. |
long-term mcpp treatment led to a 36% increase in [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) binding to 5-ht1a receptors in hippocampus and a 74% decrease in [3h]ketanserin binding to 5-ht2 receptors in cortex, while (-)[125i]iodocyanopindolol ([125i]cyp) binding to 5-ht1b receptors in hypothalamus and striatum was unchanged. |
1992-07-30 |
2023-08-11 |
rat |